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Volumn 7, Issue 1, 2010, Pages 56-62

The PPARγ Pro12Ala variant is associated with insulin sensitivity in Russian normoglycaemic and type 2 diabetic subjects

Author keywords

Insulin resistance; Insulin sensitivity; Peroxisome proliferator activated receptor ; PPARG Pro12Ala gene variant; Susceptibility; Type 2 diabetes

Indexed keywords

ALANINE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PROLINE; TRIACYLGLYCEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 77949416113     PISSN: 14791641     EISSN: None     Source Type: Journal    
DOI: 10.1177/1479164109347689     Document Type: Article
Times cited : (24)

References (37)
  • 1
    • 33745214257 scopus 로고    scopus 로고
    • Energy balance and food intake: The role of PPARγ gene polymorphisms
    • Cecil JE, Watt P, Palmer CN, Hetherington M. (2006) Energy balance and food intake: the role of PPARγ gene polymorphisms. Physiol Behav 88: 227-233.
    • (2006) Physiol Behav , vol.88 , pp. 227-233
    • Cecil, J.E.1    Watt, P.2    Palmer, C.N.3    Hetherington, M.4
  • 2
    • 4744340732 scopus 로고    scopus 로고
    • Impact of genetic variation of PPARγ in humans
    • Meirhaeghe A, Amouyel P. (2004) Impact of genetic variation of PPARγ in humans. Mol Genet Metab 83: 93-102.
    • (2004) Mol Genet Metab , vol.83 , pp. 93-102
    • Meirhaeghe, A.1    Amouyel, P.2
  • 3
    • 0036007024 scopus 로고    scopus 로고
    • C/EBPa induces adipogenesis through PPARγ: A unified pathway
    • Rosen ED, Hsu CH, Wang X, et al. (2002) C/EBPa induces adipogenesis through PPARγ: a unified pathway. Genes Dev 16: 22-26.
    • (2002) Genes Dev , vol.16 , pp. 22-26
    • Rosen, E.D.1    Hsu, C.H.2    Wang, X.3
  • 4
    • 0345164399 scopus 로고    scopus 로고
    • Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: Identification of a Pro12Ala PPARγ2 missense mutation
    • Yen CY, Beamer BA, Negri C. (1997) Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: identification of a Pro12Ala PPARγ2 missense mutation. Biochem Biophys Res Commun 241: 270-274.
    • (1997) Biochem Biophys Res Commun , vol.241 , pp. 270-274
    • Yen, C.Y.1    Beamer, B.A.2    Negri, C.3
  • 5
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb SS, Fajas L, Nemoto M, et al. (1998) A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20: 284-287.
    • (1998) Nat Genet , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3
  • 6
    • 0034607051 scopus 로고    scopus 로고
    • Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator activated receptor-γ2 on thiazolidinedione- induced adipogenesis
    • Masugi J, Tamori Y, Mori H, Koike T, Kasuga M. (2000) Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator activated receptor-γ2 on thiazolidinedione- induced adipogenesis. Biochem Biophys Res Commun 268: 178-182.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 178-182
    • Masugi J1    Tamori Y2    Mori H3    Koike T4    Kasuga, M.5
  • 7
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M, et al. (2000) The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26: 76-80.
    • (2000) Nat Genet , vol.26 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3
  • 8
    • 0034745185 scopus 로고    scopus 로고
    • The Pro12Ala substitution in PPAR-γ is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes
    • Mori H, Ikegami H, Kawaguchi Y, et al. (2001) The Pro12Ala substitution in PPAR-γ is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes. Diabetes 50: 891-894.
    • (2001) Diabetes , vol.50 , pp. 891-894
    • Mori H1    Ikegami H2    Kawaguchi, Y.3
  • 9
    • 0036329369 scopus 로고    scopus 로고
    • Association of the Pro12Ala polymorphism in the PPAR-γ2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study
    • Lindi VI, Uusitupa MI, Lindstrom J, et al. (2002) Association of the Pro12Ala polymorphism in the PPAR-γ2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study. Diabetes 51: 2581-2586.
    • (2002) Diabetes , vol.51 , pp. 2581-2586
    • Lindi, V.I.1    Uusitupa, M.I.2    Lindstrom, J.3
  • 10
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • Scott LJ, Mohlke KL, Bonnycastle LL, et al. (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316: 1341-1345.
    • (2007) Science , vol.316 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3
  • 11
    • 34250674020 scopus 로고    scopus 로고
    • The role of the Pro12Ala polymorphism in peroxisome proliferator- activated receptor γ in diabetes risk
    • Tonjes A, Stumvoll M. (2007) The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ in diabetes risk. Curr Opin Clin Nutr Metab Care 10: 410-414.
    • (2007) Curr Opin Clin Nutr Metab Care , vol.10 , pp. 410-414
    • Tonjes, A.1    Stumvoll, M.2
  • 12
    • 0036320603 scopus 로고    scopus 로고
    • The peroxisome proliferator- activated receptor-γ2 Pro12Ala polymorphism
    • Stumvoll M, Haring H. (2002) The peroxisome proliferator- activated receptor-γ2 Pro12Ala polymorphism. Diabetes 51: 2341-2347.
    • (2002) Diabetes , vol.51 , pp. 2341-2347
    • Stumvoll, M.1    Haring, H.2
  • 14
    • 0031851293 scopus 로고    scopus 로고
    • WHO consultation. Definition, diagnosis and classification of diabetes mellitus and its complications
    • Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation
    • Alberti KGMM, Zimmet PZ. (1998) WHO Consultation. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation. Diabet Med 15: 539-553.
    • (1998) Diabet Med , vol.15 , pp. 539-553
    • Alberti, K.G.M.M.1    Zimmet, P.Z.2
  • 15
    • 0032709705 scopus 로고    scopus 로고
    • Comment on the provisional report from the WHO consultation
    • European Group for the Study of Insulin Resistance (EGIR)
    • Balkau B, Charles MA. (1999) Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR). Diabet Med 16: 442-443.
    • (1999) Diabet Med , vol.16 , pp. 442-443
    • Balkau, B.1    Charles, M.A.2
  • 16
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald WT, Levy RI, Fredrickson DS. (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 17
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher, DF, Turner RC. (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 18
    • 0035095052 scopus 로고    scopus 로고
    • Diagnosing insulin resistance in the general population
    • McAuley KA, Williams SM, Mann JI, et al. (2001) Diagnosing insulin resistance in the general population. Diabetes Care 24: 460-464.
    • (2001) Diabetes Care , vol.24 , pp. 460-464
    • McAuley, K.A.1    Williams, S.M.2    Mann, J.I.3
  • 19
    • 28444478107 scopus 로고    scopus 로고
    • Effects of two common polymorphisms of peroxisome proliferator-activated receptor-γ gene on metabolic syndrome
    • Rhee EJ, Oh KW, Lee WY, et al. (2006) Effects of two common polymorphisms of peroxisome proliferator-activated receptor-γ gene on metabolic syndrome. Arch Med Res 37: 86-94.
    • (2006) Arch Med Res , vol.37 , pp. 86-94
    • Rhee, E.J.1    Oh, K.W.2    Lee, W.Y.3
  • 20
    • 12244264435 scopus 로고    scopus 로고
    • Genetic Power Calculator: Design of linkage and association genetic mapping studies of complex traits
    • Purcell S, Cherny SS, Sham PC. (2003) Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19: 149-150.
    • (2003) Bioinformatics , vol.19 , pp. 149-150
    • Purcell, S.1    Cherny, S.S.2    Sham, P.C.3
  • 21
    • 4243353569 scopus 로고    scopus 로고
    • Comment: Studies of thePro12Ala polymorphism of the PPAR-γ gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome
    • Frederiksen L, Brodbaek K, Fenger M, et al. (2002) Comment: studies of thePro12Ala polymorphism of the PPAR-γ gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. J Clin Endocrinol Metab 87: 3989-3992.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3989-3992
    • Frederiksen, L.1    Brodbaek, K.2    Fenger, M.3
  • 22
    • 0036772369 scopus 로고    scopus 로고
    • Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population
    • Gonzalez Sanchez JL, Serrano Rios M, Fernandez PC, Laakso M, Martinez Larrad MT. (2002) Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population. Eur J Endocrinol147: 495-501.
    • (2002) Eur J Endocrinol147 , pp. 495-501
    • Gonzalez Sanchez, J.L.1    Serrano Rios, M.2    Fernandez, P.C.3    Laakso, M.4    Martinez Larrad, M.T.5
  • 23
    • 0037407432 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ2 gene polymorphism (Pro12Ala) beneficially influences insulin resistance and its tracking from childhood to adulthood: The bogalusa heart study
    • Li, S, Chen W, Srinivasan SR, Boerwinkle E, Berenson GS. (2003) The peroxisome proliferator-activated receptor-γ2 gene polymorphism (Pro12Ala) beneficially influences insulin resistance and its tracking from childhood to adulthood: the Bogalusa Heart Study. Diabetes 52: 1265-1269.
    • (2003) Diabetes , vol.52 , pp. 1265-1269
    • Li, S.1    Chen, W.2    Srinivasan, S.R.3    Boerwinkle, E.4    Berenson, G.S.5
  • 24
    • 0037221208 scopus 로고    scopus 로고
    • Impact of two common polymorphisms in the PPARγ gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?
    • Poulsen P, Andersen G, Fenger M, et al. (2003) Impact of two common polymorphisms in the PPARγ gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both? Diabetes 52: 194-198.
    • (2003) Diabetes , vol.52 , pp. 194-198
    • Poulsen, P.1    Andersen, G.2    Fenger, M.3
  • 25
    • 10044291717 scopus 로고    scopus 로고
    • The common PPAR-γ2 Pro12Ala variant is associated with greater insulin sensitivity
    • Buzzetti R, Petrone A, Ribaudo MC, et al. (2004) The common PPAR-γ2 Pro12Ala variant is associated with greater insulin sensitivity. Eur J Hum Genet 12: 1050-1054.
    • (2004) Eur J Hum Genet , vol.12 , pp. 1050-1054
    • Buzzetti, R.1    Petrone, A.2    Ribaudo, M.C.3
  • 26
    • 26444588777 scopus 로고    scopus 로고
    • Implication of the Pro12Ala polymorphism of the PPAR-γ2 gene in type 2 diabetes and obesity in the French population
    • Ghoussaini M, Meyre D, Lobbens S, et al. (2005) Implication of the Pro12Ala polymorphism of the PPAR-γ2 gene in type 2 diabetes and obesity in the French population. BMC Med Genet 6: 11.
    • (2005) BMC Med Genet , vol.6 , pp. 11
    • Ghoussaini, M.1    Meyre, D.2    Lobbens, S.3
  • 27
    • 9144269700 scopus 로고    scopus 로고
    • The frequency of alleles of the Pro12Ala polymorphism in PPARγ2 is different between healthy controls and patients with type 2 diabetes
    • Pinterova D, Cerna M, Kolostova K, et al. (2004) The frequency of alleles of the Pro12Ala polymorphism in PPAR?2 is different between healthy controls and patients with type 2 diabetes. Folia Biol (Praha) 50: 153-156.
    • (2004) Folia Biol (Praha) , vol.50 , pp. 153-156
    • Pinterova, D.1    Cerna, M.2    Kolostova, K.3
  • 28
    • 0142199870 scopus 로고    scopus 로고
    • The Pro12Ala polymorphism of PPARγ2 gene and susceptibility to type 2 diabetes mellitus in a Polish population
    • Malecki MT, Frey J, Klupa T, et al. (2003) The Pro12Ala polymorphism of PPARγ2 gene and susceptibility to type 2 diabetes mellitus in a Polish population. Diabetes Res Clin Pract 62: 105-111.
    • (2003) Diabetes Res Clin Pract , vol.62 , pp. 105-111
    • Malecki, M.T.1    Frey, J.2    Klupa, T.3
  • 29
    • 0034728762 scopus 로고    scopus 로고
    • The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes
    • Hara K, Okada T, Tobe K, et al. (2000) The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun 271: 212-216.
    • (2000) Biochem Biophys Res Commun , vol.271 , pp. 212-216
    • Hara, K.1    Okada, T.2    Tobe, K.3
  • 30
    • 0035163768 scopus 로고    scopus 로고
    • Siblingbased association study of the PPARγ2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: A SAPPHIRe study
    • Stanford Asian-Pacific Program in Hypertension and Insulin Resistance
    • Chuang LM., Hsiung, CA, Chen YD, et al. (2001) Siblingbased association study of the PPARγ2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: a SAPPHIRe study. Stanford Asian-Pacific Program in Hypertension and Insulin Resistance. J Mol Med 79: 656-664.
    • (2001) J Mol Med , vol.79 , pp. 656-664
    • Chuang, L.M.1    Hsiung, C.A.2    Chen, Y.D.3
  • 31
    • 24044534766 scopus 로고    scopus 로고
    • Genetic polymorphisms in peroxisome proliferator-activated receptor gamma are associated with Type 2 diabetes mellitus and obesity in the Korean population
    • Moon MK, Cho YM, Jung HS, et al. (2005) Genetic polymorphisms in peroxisome proliferator-activated receptor gamma are associated with Type 2 diabetes mellitus and obesity in the Korean population. Diabet Med 22: 1161-1166.
    • (2005) Diabet Med , vol.22 , pp. 1161-1166
    • Moon, M.K.1    Cho, Y.M.2    Jung, H.S.3
  • 32
    • 0031737373 scopus 로고    scopus 로고
    • Correct homeostasis model assessment (HOMA) evaluation uses the computer program
    • Levy JC, Matthews DR, Hermans MP. (1998) Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 21: 2191-2192.
    • (1998) Diabetes Care , vol.21 , pp. 2191-2192
    • Levy, J.C.1    Matthews, D.R.2    Hermans, M.P.3
  • 33
    • 33845472305 scopus 로고    scopus 로고
    • Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals
    • Tonjes A, Scholz M, Loeffler M, Stumvoll M. (2006) Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals. Diabetes Care 29: 2489-2497.
    • (2006) Diabetes Care , vol.29 , pp. 2489-2497
    • Tonjes, A.1    Scholz, M.2    Loeffler, M.3    Stumvoll, M.4
  • 34
    • 0033212964 scopus 로고    scopus 로고
    • PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
    • Kubota N, Terauchi Y, Miki H, et al. (1999) PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 4: 597-609.
    • (1999) Mol Cell , vol.4 , pp. 597-609
    • Kubota, N.1    Terauchi, Y.2    Miki, H.3
  • 35
    • 0035798713 scopus 로고    scopus 로고
    • The mechanisms by which both heterozygous peroxisome proliferatoractivated receptor γ (PPARγ) deficiency and PPARγ agonist improve insulin resistance
    • Yamauchi T, Kamon J, Waki H, et al. (2001) The mechanisms by which both heterozygous peroxisome proliferatoractivated receptor γ (PPARγ) deficiency and PPARγ agonist improve insulin resistance. J Biol Chem 276: 41245-41254.
    • (2001) J Biol Chem , vol.276 , pp. 41245-41254
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 36
    • 0033973843 scopus 로고    scopus 로고
    • Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency
    • Miles PD, Barak Y, He W, Evans RM, Olefsky JM. (2000) Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency. J Clin Invest 105: 287-292.
    • (2000) J Clin Invest , vol.105 , pp. 287-292
    • Miles, P.D.1    Barak, Y.2    He, W.3    Evans, R.M.4    Olefsky, J.M.5
  • 37
    • 33847006604 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ and adipose tissue-understanding obesityrelated changes in regulation of lipid and glucose metabolism
    • Sharma AM, Staels B. (2007) Peroxisome proliferator-activated receptor γ and adipose tissue-understanding obesityrelated changes in regulation of lipid and glucose metabolism. J Clin Endocrinol Metab 92: 386-395.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 386-395
    • Sharma, A.M.1    Staels, B.2


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