Genetic polymorphisms in peroxisome proliferator-activated receptor γ are associated with Type 2 diabetes mellitus and obesity in the Korean population

Diabetic Medicine

Volumn 22, Issue 9, 2005, Pages 1161-1166

  Moon, M K ^a,b   Cho, Y M ^a,b   Jung, H S ^a,b   Park, Y J ^a   Yoon, K H ^c   Sung, Y A ^d   Park, B L ^e   Lee, H K ^a   Park, Kyong Soo ^a,b   Shin, H D ^e  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c The Catholic University of Korea College of Medicine   (South Korea)

^d Ewha Womans University School of Medicine   (South Korea)

^e SNP Genetics Inc   (South Korea)

Author keywords

Korean; Obesity; Peroxisome proliferator activated receptor ; Polymorphism; Type 2 diabetes

Indexed keywords

ALANINE; CYTOSINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROLINE; THYMINE;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DISEASE ASSOCIATION; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HAPLOTYPE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; RISK FACTOR; SOUTH KOREA; TRIACYLGLYCEROL BLOOD LEVEL;

ALLELES; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; KOREA; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, GENETIC; POPULATION SURVEILLANCE; PPAR GAMMA; TRIGLYCERIDES;

EID: 24044534766     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2005.01599.x     Document Type: Article

References (25)

1. Auwerx J. PPARγ, the ultimate thrifty gene. Diabetologia 1999; 42: 1033-1049.
2. Barroso I, Gurnell M, Crowley VEF, Agostini M, Schwabel JW, Soos MA et al. Dominant negative mutations in human PPAR-γ associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 1999; 402: 880-883.
3. Ristow M, Muller-Wieland D, Pfeiffer A, Krone W, Kahn CR. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N Engl J Med 1998; 339: 953-959.
4. Yen CJ, Beamer BA, Negri C, Silver K, Brown KA, Yarnall DP et al. Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: identification of a Pro12Ala PPARγ2 missense mutation. Biochem Biophys Res Commun 1997; 241: 270-274.
5. Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J et al. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000; 26: 76-80.
6. Mori H, Ikegami H, Kawaguchi Y, Seino S, Yokoi N, Takeda J et al. The Pro12 → Ala substitution in PPAR-γ is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes. Diabetes 2001; 50: 891-894.
7. Douglas JA, Erdos MR, Watanabe RM, Braun A, Johnston CL, Oeth P The peroxisome proliferator-activated receptor-γ2 Pro12Ala variant: association with type 2 diabetes and trait differences. Diabetes 2001; 50: 886-890.
8. Wang XL, Oosterhof J, Duarte N. Peroxisome proliferator-activated receptor γ C161 → T polymorphism and coronary artery disease. Cardiovasc Res 1999; 44: 588-594.
9. Knoblauch H, Busjahn A, Muller-Myhsok B, Faulhaber HD, Schuster H, Uhlmann R et al. Peroxisome proliferator-activated receptor γ gene locus is related to body mass index and lipid values in healthy nonobese subjects. Arterioscler Thromb Vasc Biol 1999; 19: 2940-2944.
10. Meirhaeghe A, Fajas L, Helbecque N, Cottel D, Lebel P, Dallongeville J et al. A genetic polymorphism of the peroxisome proliferator-activated receptor γ gene influences plasma leptin levels in obese humans. Hum Mol Genet 1998; 7: 435-440.
11. Valve R, Sivenius K, Miettinen R, Pihlajamaki J, Rissanen A, Deeb SS et al. Two polymorphisms in the peroxisome proliferator-activated receptor-γ gene are associated with severe overweight among obese women. J Clin Endocrinol Metab 1999; 84: 3708-3712.
12. Doney A, Fischer B, Frew D, Cumming A, Flavell DM, World M et al. Haplotype analysis of the PPARγ Pro12Ala and C1431T variants reveals opposing associations with body weight. BMC Genet 2002; 3: 21.
13. Meirhaeghe A, Fajas L, Helbecque N, Cottel D, Auwerx J, Deeb SS et al. Impact of the peroxisome proliferator activated receptor γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus. Int J Obes Relat Metab Disord 2000; 24: 195-199.
14. Evans D, de Heer J, Hagemann C, Wendt D, Wolf A, Beisiegel U et al. Association between the P12A and c1431t polymorphisms in the peroxisome proliferator activated receptor γ (PPAR γ) gene and type 2 diabetes. Exp Clin Endocrinol Diabetes 2001; 109: 151-154.
15. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997; 20: 1183-1197.
16. Stumvoll M, Haring H. Insulin resistance and insulin sensitizers. Horm Res 2001; 55: 3-13.
17. Hedrick PW. Gametic disequilibrium measures: proceed with caution. Genetics 1987; 117: 331-341.
18. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68: 978-989.
19. Oh EY, Min KM, Chung JH, Min YK, Lee MS, Kim KW et al. Significance of Pro12Ala mutation in peroxisome proliferator-activated receptor-γ2 in Korean diabetic and obese subjects. J Clin Endocrinol Metab 2000; 85: 1801-1804.
20. Beamer BA, Yen CJ, Andersen RE, Muller D, Elahi D, Cheskin LJ et al. Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-γ2 gene with obesity in two Caucasian populations. Diabetes 1998; 47: 1806-1808.
21. Koch M, Rett K, Maerker E, Volk A, Haist K, Deninger M et al. The silent PPARγ exon 6 CAC (His) → CAT (His) polymorphism does not affect the plasma leptin levels in a collective of first degree relatives of type 2 diabetes patients from South West Germany. Exp Clin Endocrinol Diabetes 2000; 108: 341346.
22. Doney AS, Fischer B, Cecil JE, Boylan K, McGuigan FE, Ralston SH et al. Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes. Diabetologia 2004; 47: 555-558.
23. 3-adrenergic receptor and peroxisome proliferator-activated receptor-γ2 genes and obesity. Diabetes Care 2001; 24: 672-677.
24. Nemoto M, Sasaki T, Deeb SS, Fujimoto WY, Tajima N. Differential effect of PPARγ2 variants in the development of type 2 diabetes between native Japanese and Japanese Americans. Diabetes Res Clin Pract 2002; 57: 131-137.
25. Luan J, Browne PO, Harding AH, Halsall DJ, O'Rahilly S, Chatterjee VK et al. Evidence for gene-nutrient interaction at the PPARγ locus. Diabetes 2001; 50: 686-689.