Terahertz spectroscopy for explosive, pharmaceutical, and biological sensing applications

NATO Science for Peace and Security Series B: Physics and Biophysics

Volumn , Issue , 2007, Pages 251-323

  Liu, Hai Bo ^a   Zhang, Xi Cheng ^a  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

Biological; Cell monolayer; Dehydration; Density functional theory; Diffuse reflection; Explosive; Pharmaceutical; Protein; Pseudopolymorph; Sensing; Small biomolecule; Solid state reaction; Terahertz spectroscopy; THz time domain spectroscopy

Indexed keywords

EID: 77949363616     PISSN: 18746500     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4020-6503-3_17     Document Type: Conference Paper

References (112)

1. G. C. Walker, E. Berry, N. N. Zinovev, A. J. Fitzgerald, R. E. Miles, M. Chamberlain, and M. A. Smith, Terahertz imaging and international safety guidelines, in Medical Imaging 2002: Physics of Medical Imaging, L. E. Antonuk and M. J. Yaffe, Ed., Proceedings of SPIE, vol. 4682, pp. 683-690 (2002).
2. E. Berry, Risk perception and safety issues, J. Biol. Phys., 29, 263-267 (2003).
3. M. C. Kemp, P. F. Taday, B. E. Cole, J. A. Cluff, A. J. Fitzgerald, and W. R. Tribe, Security applications of terahertz technology, in Terahertz for Military and Security Applications, R. J. Hwu and D. L. Woolard, Ed., Proceedings of SPIE, vol. 5070, pp. 44-52 (2003).
4. K. Yamamoto, M. Yamaguchi, F. Miyamaru, M. Tani, M. Hangyo, T. Ikeda, A. Matsushita, K. Koide, M. Tatsuno, and Y. Minami, Noninvasive inspection of C-4 explosive in mails by terahertz time-domain spectroscopy, Jpn. J. of Appl. Phys., 43, L414-L417 (2004).
5. F. Huang, B. Schulkin, H. Altan, J. F. Federici, D. Gary, R. Barat, D. Zimdars, M. Chen, and D. B. Tanner, Terahertz study of 1, 3, 5-trinitro-s-triazine by time-domain and Fourier transform infrared spectroscopy, Appl. Phys. Lett., 85, 5535-5537 (2004).
6. Y. C. Shen, T. Lo, P. F. Taday, B. E. Cole, W. R. Tribe, and M. C. Kemp, Detection and identification of explosives using terahertz pulsed spectroscopic imaging, Appl. Phys. Lett., 86, 241116 (2005).
7. K. Kawase, Terahertz imaging for drug detection and large-scale integrated circuit inspection, Optics and Photonics News, 34-39 (Oct. 2004).
8. P. F. Taday, I. V. Bradley, D. D. Arnone, and M. Pepper, Using terahertz pulse spectroscopy to study the crystalline structure of a drug: a case study of the polymorphs of ranitidine hydrochloride, J. Pharm. Sci., 92(4), 831-838 (2002).
9. C. J. Strachan, T. Rades, D. A. Newnham, K. C. Gordon, M. Pepper, and P. F. Taday, Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials, Chem. Phys. Lett., 390, 20-24 (2004).
10. C. J. Strachan, P. F. Taday, D. A. Newnham, K. C. Gordon, J. A. Zeitler, M. Pepper, and T. Rades, Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity, J. Pharm. Sci., 94(4), 837- 846 (2005).
11. A. J. Fitzgerald, B. E. Cole, P. F. Taday, Nondestructive analysis of tablet coating thicknesses using terahertz pulsed imaging, J. Pharm. Sci., 94, 177-183 (2005).
12. B. M. Fischer, M. Walther, and P. Uhd Jepsen, Far-infrared vibrational modes of DNA components studied by terahertz time-domain spectroscopy, Phys. Med. Biol., 47, 3807-3814 (2002).
13. Y. C. Shen, P. C. Upadhya, E. H. Linfield, and A. G. Davies, Temperature-dependent low-frequency vibrational spectra of purine and adenine, Appl. Phys. Lett., 82(14), 2350-2352 (2003).
14. J. Nishizawa, T. Sasaki, K. Suto, T. Tanabe, K. Saito, T. Yamada, and T. Kimura, THz transmittance measurements of nucleobases and related molecules in the 0.4 to 5.8 THz region using a GaP THz wave generator, Opt. Comm., 246, 229-239 (2005).
15. L. Genzel, L. Santo, and S. C. Shen, Far-infrared Spectroscopy of Biomolecules, in Spectroscopy of Biological Molecules, C. Sandory and T. Theophanides, Ed., pp. 609-619 (D. Reidel, Boston, 1984).
16. J. Bandekar, L. Genzel, F. Kremer, and L. Santo, The temperature dependence of the far-infrared spectra of L-alanine, Spectrochim. Acta A, 39A, 357-366 (1983).
17. B. Yu, F. Zeng, Y. Yang, Q. Xing, A. Chechin, X. Xin, I. Zeylikovich, and R. R. Alfano, Torsional vibrational modes of tryptophan studied by terahertz time-domain spectroscopy, Biophys. J., 86, 1649-1654 (2004).
18. T. M. Korter, R. Balu, M. B. Campbell, M. C. Beard, S. K. Gregurick, and E. J. Heilweil, Terahertz spectroscopy of solid serine and cysteine, Chem. Phys. Lett., 418, 65-70 (2006).
19. M. Yamaguchi, F. Miyamaru, K. Yamamoto, M. Tani, and M. Hangyo, Terahertz absorption spectra of L-, D-, and DL-alanine and their application to determination of enantiometric composition, Appl. Phys. Lett., 86, 053903 (2005).
20. T. M. Korter and D. F. Plusquellic, Continuous-wave terahertz spectroscopy of biotin: vibrational anharmonicity in the far-infrared, Chem. Phys. Lett., 385, 45-51 (2004).
21. P. C. Upadhya, Y. C. Shen, A. G. Davies, and E. H. Linfield, Terahertz time-domain spectroscopy of glucose and uric acid, J. Biol. Phys., 29, 117-121 (2003).
22. J. Nishizawa, K. Suto, T. Sasaki, T. Tanabe, and T. Kimura, Spectral measurement of terahertz vibrations of biomolecules using a GaP terahertz-wave generator with automatic scanning control, J. Phys. D: Appl. Phys., 36, 2958-2961 (2003).
23. M. Walther, B. Fischer, M. Schall, H. Helm, and P. Uhd Jepsen, Far-infrared vibrational spectra of all-trans, 9-cis and 13-cis retinal measured by THz time-domain spectroscopy, Chem. Phys. Lett., 332, 389-395 (2000).
24. M. Walther, P. Plochocka, B. Fischer, H. Helm, and P. Uhd Jepsen, Collective vibrational modes in biological molecules investigated by terahertz time-domain spectroscopy, Biopolymers, 67, 310-313 (2002).
25. R. Nossal and H. Lecar, in Molecular and Cell Biophysics, 1st edn. (Addison-Wesley, Redwood City, CA, , 1991).
26. A. Roitberg, R. B. Gerber, R. Elber, and M. A. Ratner, Anharmonic wave functions of proteins: quantum self-consistent field calculations of BPTI, Science, 268, 1319-1322 (1995).
27. S. Hayward and N. Go, Collective variable description of native protein dynamics, Annu. Rev. Phys. Chem, 46, 223-250 (1995).
28. K. G. Brown, S. C. Erfurth, E. W. Small, and W. L. Peticolas, Conformationally dependent low-frequency motions of proteins by laser Raman spectroscopy, Proc. Nat. Acad. Sci. USA, 69(6), 1467-1469 (1972).
29. L. Genzel, F. Keilmann, T. P. Martin, G. Winterling, Y. Yacoby, and M. W. Makinen, Low-frequency Raman spectra of lysozyme, Biopolymers, 15, 219-225 (1976).
30. A. G. Markelz, A. Roitberg, and E. J. Heilweil, Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz, Chem. Phys. Lett., 320, 42-48 (2000).
31. C. Zhang, E. Tarhan, A. K. Ramdas, A. M. Weiner, and S. M. Durbin, Broadened far-Infrared absorption spectra for hydrated and dehydrated myoglobin, J. Phys. Chem. B, 108, 10077-10082 (2004).
32. D. M. Leitner, Vibrational energy transfer in helices, Phys. Rev. Lett., 87, 188102 (2001).
33. L. Y. Zhu, J. T. Sage, and P. M. Champion, Observation of coherent reaction dynamics in heme proteins, Science, 266, 629-632 (1994).
34. A. Xie, Q. He, L. Miller, B. Sclavi, and M. R. Chance, Low frequency vibrations of amino acid homopolymers observed by synchrotron far-IR absorption spectroscopy: excited state effects dominate the temperature dependence of the spectra, Biopolymers, 49, 591-603 (1999).
35. M. Nagel, P. H. Bolivar, M. Brucherseifer, H. Kurz, A. Bosserhoff, and R. Bu, THz technology for label-free genetic diagnostics, Appl. Phys. Lett., 80, 154-156 (2002).
36. S. P. Mickan, A. Menikh, H.-B. Liu, C. Mannella, R. MacColl, D. Abbott, J. Munch, and X.-C. Zhang, Label-free bioaffinity detection using terahertz technology, Phys. Med. Biol., 47, 3789-3795 (2002).
37. A. Menikh, S. P. Mickan, H.-B. Liu, R. MacColl, X.-C. Zhang, Label-free amplified bioaffinity detection using terahertz wave technology, Biosen. Bioelectron., 20, 658-662 (2004).
38. T. S. Hartwick, D. T. Hodges, D. H. Barker, and F. B. Foote, Far infrared imagery, Appl. Opt., 15(8), 1919-1922, (1976).
39. P. H. Siegel, R. J. Dengler, E. Mueller, C. Readhead, and S. E. Fraser, Scanned Pixel Heterodyne Terahertz Imaging, in the British Royal Soc. Terahertz Gap Meeting (June 3, 2003).
40. K. J. Seibert, T. Loffler, H. Quast, M. Thomson, T. Bauer, R. Leonhardt, S. Czasch, and H. G. Roskos, All-optoelectronic continuous wave THz imaging for biomedical applications, Phys. Med. Biol., 47(21), 3743-3748 (2002).
41. A. J. Fitzgerald, E. Berry, N. N. Zinov'ev, S. Homer-Vanniasinkam, R. E. Miles, J. M. Chamberlain, and M. A. Smith, Catalogue of human tissue optical properties at terahertz frequencies, J. Biol. Phys., 29, 123-128 (2003).
42. T. Loffler, K. Siebert, S. Czasch, T. Bauer, and H. G. Roskos, Visualization and classification in biomedical terahertz pulsed imaging, Phys. Med. Biol., 47(21), 3847-3852,(2002).
43. T. Loffler, T. Bauer, K. J. Siebert, H. G. Roskos, A. Fitzgerald, and S. Czasch, Terahertz dark field imaging of biomedical tissue, Opt. Express, 9(12), 616-621(2001).
44. P. Knobloch, K. Schmalstieg, M. Koch, E. Rehberg, F. Vauti, and K. Donhuijsen, THz imaging of histo-pathological samples, Proceedings of SPIE, vol. 4434, pp. 239-245 (2001).
45. P. Wallace, D. Arnone, R. M. Woodward, and R. J. Pye, Biomedical applications of terahertz pulsed imaging, Proceedings of 2nd Joint EMBS/BMES Conference, Houston, TX, pp. 2333-2334 (2002).
46. R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, Terahertz pulse imaging of ex vivo basal cell carcinoma, J. Investigative Dermatol., 120(1), 72-78 (2003).
47. B. E. Cole, R. Woodward, D. Crawley, V. P. Wallace, D. D. Arnone, and M. Pepper, Terahertz imaging and spectroscopy of human skin, in-vivo, Proceedings of SPIE, vol. 4276, pp. 1-10 (2001).
48. R. M. Woodward, B. E. Cole, V. P. Wallace, R. J. Pye, D. D. Arnone, E. H. Linfield, and M. Pepper, Terahertz pulse imaging in reflection geometry of human skin cancer and skin tissue, Phys. Med. Biol., 47, 3853-3863 (2002).
49. J. C. Oxley JC, J. L. Smith, E. Resende, and E. Pearce, Quantification and aging of the post-blast residue of TNT landmines, J. Forensic. Sci., 48(4), 742-753 (2003).
50. National Research Council, Existing and potential standoff explosives detection techniques (The National Academies Press, 2004); http://www.nap.edu/catalog/10998. html.
51. J. P. Blitz, Diffuse Reflectance Spectroscopy, in Modern Techniques in Applied Molecular Spectroscopy Chapter 5, F. M. Mirabella, Ed., (Wiley, 1998).
52. B. M. Rice and C. F. Chabalowski, Ab initio and nonlocal density functional study of 1, 3, 5-trinitro-s-triazine (RDX) conformers, J. Phys. Chem. A, 101(46), 8720-8726 (1997).
53. Y. A. Gruzdkov and Y. M. Gupta, Vibrational properties and structure of pentaery-thritol tetranitrate, J. Phys. Chem. A, 105(25), 6197-6202 (2001).
54. J. Clarkson, W. E. Smith, D. N. Batchelder, D. A. Smith, and A. M. Coats, A theoretical study of the structure, internal rotations and vibrations of 2, 4, 6-trinitoluene, J. Mol. Struct., 648(3), 203-214 (2003).
55. M. J. Frisch, et al., GAUSSIAN 03 (Revision B.05), Gaussian, Pittsburgh, PA, (2003).
56. A. Becke, Density-functional thermochemistry. III. The role of exact exchange, J. Chem. Phys., 98(7), 5648-5652 (1993).
57. C. Lee, W. Yang, and R. G. Parr, Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density, Phys. Rev. B, 37, 785-789 (1988).
58. A. D. McLean and G. S. Chandler, Contracted Gaussian basis sets for molecular calculations. I. Second row atoms, Z = 11-18, J. Chem. Phys., 72, 5639-5648 (1980).
59. R. Krishnan, J. S. Binkley, R. Seeger, and J. A. Pople, Self-consistent molecular orbital methods. XX. A basis set for correlated wave functions, J. Chem. Phys., 72(1), 650-654 (1980).
60. D. J. Cook, B. K. Decker, G. Maislin, and M. G. Allen, Through container THz sensing: applications for explosive screening, Proceedings of SPIE, vol. 5354, pp. 55-62 (2004).
61. M. C. Kemp, P. F. Taday, B. E. Cole, J. A. Cluff, A. J. Fitzgerald, and W. R. Tribe, Security applications of terahertz technology, in Terahertz for Military and Security Applications, R. J. Hwu and D. L. Woolard, Ed., Proceedings of SPIE, vol. 5070, pp. 44-52 (2003).
62. K. Yamamoto, M. Yamaguchi, F. Miyamaru, M. Tani, M. Hangyo, T. Ikeda, A. Matsushita, K. Koide, M. Tatsuno, and Y. Minami, Noninvasive inspection of C-4 explosive in mails by terahertz time-domain spectroscopy, Jpn. J. Appl. Phys., 43, L414-L417 (2004).
63. Infrared Spectra (Sadtler Research Laboratories, Researchers, Editors & Publishers, Philadelphia, 1980).
64. H.-B. Liu, Y. Chen, G. J. Bastiaans, X.-C. Zhang, Detection and identification of explosive RDX by THz diffuse reflection spectroscopy, Opt. Express, 14(1), 415-423 (2006).
65. Y. Chen, H.-B. Liu, Y. Deng, D. Schauki, M. J. Fitch, R. Osiander, C. Dodson, J. B. Spicer, M. Shur, and X. C. Zhang, THz spectroscopic investigation of 2, 4-dinitrotoluene, Chem. Phys. Lett., 400, 357-361 (2004).
66. S. Nashima, O. Morikawa, K. Takata, and M. Hangyo, Measurement of optical properties of highly doped silicon by terahertz time domain reflection spectroscopy, Appl. Phys. Lett., 79, 3923-3925 (2001).
67. M. Khazan, R. Meissner, and I. Wilke, Convertible transmission-reflection time-domain terahertz spectrometer, Rev. Sci. Instrum., 72, 3427-3430 (2001).
68. A. Pashkin, M. Kempa, H. Nemec, F. Kadlec, and P. Kuzel, Phase-sensitive time-domain terahertz reflection spectroscopy, Rev. Sci. Instrum., 74, 4711-4717 (2003).
69. E. M. Vartiainen, Y. Ino, R. Shimano, M. Kuwata-Gonokami, Y. P. Svirko, and K.-E. Peiponen, Numerical phase correction method for terahertz time-domain reflection spectroscopy, J. Appl. Phys., 96(8), 4171-4175 (2004).
70. F. Stern, in Solid Sate Physics, F. Seitz and D. Turnbull, Ed., vol. 15, p. 299 (Academic Press, New York, 1963).
71. F. M. Mirabella, in Modern Techniques in Applied Molecular Spectroscopy Chapter 5 (Wiley , 1998).
72. M. van Exter, C. Fattinger, and D. Grischkowsky, Terahertz time-domain spectroscopy of water vapor, Opt. Lett., 14, 1128-1130 (1989).
73. T. Yuan, H.-B. Liu, J. Xu, F. Al-Douseri, Y. Hu, and X.-C. Zhang, Terahertz time-domain spectroscopy of atmosphere with different humidity, in Terahertz for Military and Security Applications, R. J. Hwu and D. L. Woolard , Ed., Proceedings of SPIE, vol. 5070, pp. 28-37 (2003).
74. K. R. Khankari and J. W. D. Grant, Pharmaceutical hydrates, Therm. Acta, 248, 61-79 (1995).
75. S. R. Byrn, R. R. Pfeiffer, M. Ganey, C. Hoiberg, G. Poochikian, Pharmaceutical solids: a strategic approach to regulatory considerations, Pharmaceut. Res., 12(7), 945-954 (1995).
76. P. F. Taday, I. V. Bradley, D. D. Arnone, and M. Pepper, Using terahertz pulse spectroscopy to study the crystalline structure of a drug: a case study of the polymorphs of ranitidine hydrochloride, J. Pharm. Sci., 92(4), 831-838 (2002).
77. C. J. Strachan, T. Rades, D. A. Newnham, K. C. Gordon, M. Pepper, and P. F. Taday, Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials, Chem. Phys. Lett., 390, 20-24 (2004).
78. C. J. Strachan, P. F. Taday, D. A. Newnham, K. C. Gordon, J. A. Zeitler, M. Pepper, and T. Rades, Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity, J. Pharm. Sci., 94(4), 837- 846 (2005).
79. H. Bothe, H. K. Cammenga, Compostion, properties, stability and thermal dehydration of crystalline caffeine hydrate, Therm. Acta., 40, 29-39 (1980).
80. S. R. Byrn, and C.-T. Lin, The effect of crystal packing and defects on desolvation of hydate crystals of caffeine and L-(-)-1,4-cyclohexadiene-1- alanine, J. Am. Chem. Soc., 98, 4004-4005 (1976).
81. H. G. M. Edwards, E. Lawson, M. Matas, L. Shields, and P. York, Metamorphosis of caffeine hydrate and anhydrous caffeine, J. Chem. Soc., Perkin Trans., 2(10), 1985-1990 (1997).
82. M. Matas, H. G. M. Edwards, E. E. Lawson, L. Shields L, and P. York, FT-Raman spectroscopic investigation of a pseudopolymorphic transition in caffeine hydrate, J. Mole. Struc., 440, 97-104 (1998).
83. C. Sun, D. Zhou, D. J. W. Grant, and J. V. G. Young, Theophylline monohydrate, Acta. Cryst., E58, O368-O370 (2002).
84. E. Suzuki, K. Shimomura, and K. Sekiguchi, Thermochemical study of theophylline and its hydrate, Chem. Pharm. Bull., 37, 493-497 (1989).
85. E. Suihko, J. Ketolainen, A. Poso, M. Ahlgren, J. Gynther, and P. Paronen, Dehydration of theophylline monohydrate a two step process, Int. J. Pharm., 158, 47-55 (1997).
86. D. J. Sutor, The structures of the pyrimidines and purines. VI. The crystal structure of theophylline, Acta. Cryst., 11, 83-87 (1958).
87. J. Nishizawa, K. Suto, T. Sasaki, T. Tanabe, and T. Kimura, Spectral measurement of terahertz vibrations of biomolecules using a GaP terahertz-wave generator with automatic scanning control, J. Phys. D. Appl. Phys., 36, 2958-2961 (2003).
88. P. C. Upadhya, Y. C. Shen, A. G. Davies, and E. H. Linfield, Terahertz time-domain spectroscopy of glucose and uric acid, J. Biol. Phys., 29, 117-121 (2003).
89. C. L. Liu, S. M. Wu, T. Chang, M. L. Liu, H. J. Chiang, Analysis of a mixture containing ampicillin anhydrate and ampicillin trihydrate by thermogravimetry, oven heating, differential scanning calorimetry, and x-ray diffraction techniques, Anal. Chim. Acta., 517, 237-243 (2004).
90. S. R. Byrn, R. R. Pfeiffer, and J. G. Stowell, in Solid-State Chemistry of Drugs Chapter 1, 2nd edn. (SSCI, 1999).
91. S. R. Byrn, R. R. Pfeiffer, and J. G. Stowell, in Solid-State Chemistry of Drugs Chapter 8, 2nd edn. (SSCI, 1999).
92. G. Buckton and A. E. Beezer, The applications of microcalorimetry in the field of physical pharmacy, Intl. J. Pharm., 72(3), 181-192 (1991).
93. R. K. Khankari and D. J. W. Grant, Pharmaceutical hydrates, Therm. Acta, 248, 61-79 (1995).
94. K. R. Beebe, R. J. Pell, and M. B. Seasholtz, Chemometrics: A Practical Guide, p. 348 (Wiley , New York, 1998).
95. L.Vina, S. Logothetidis, and M. Cardona, Temperature dependence of the dielectric function of germanium, Phys. Rev. B, 30, 1979-1991 (1984).
96. Y. C. Shen, P. C. Upadhya, E. H. Linfield, and A. G. Davies, Temperature-dependent low-frequency vibrational spectra of purine and adenine, Appl. Phys. Lett., 82, 2350-2352 (2003).
97. J. H. Sharp, G. W. Brindley, and B. N. Achar, Numerical data for some commonly used solid state reaction equations, J. Amer. Ceram. Soc., 49, 379-382 (1966).
98. S. R. Byrn, R. R. Pfeiffer, and J. G. Stowell, in Solid-State Chemistry of Drugs Chapter 21, 2nd edn. (SSCI, 1999).
99. J. Han and R. Suryanarayana, Influence of environmental conditions on the kinetics and mechanism of dehydration of carbamazepine dehydrate, Pharm. Develop. Tech., 3(4), 587-96 (1998).
100. S. K. Rastogi, M. Zakrzewski, and R. Suryanarayanan, Investigation of solid-state reactions using variable temperature X-ray powder diffractometry. II. aminophylline monohydrate, Pharm. Res., 19( 9), 1265-1273 (2002).
101. M. C. Beard, G. M. Turner, and C. A. Schmuttenmaer, Progress towards two-dimensional biomedical imaging with THz spectroscopy, Phys. Med. Biol., 47, 3841-3846 (2002).
102. C. Zhang, E. Tarhan, A. K. Ramdas, A. M. Weiner, and S. M. Durbin, Broadened farinfrared absorption spectra for hydrated and dehydrated myoglobin, J. Phys. Chem. B, 108, 10077-10082 (2004).
103. S. E. Whitmire, D. Wolpert, A. G. Markelz, J. R. Hillebrecht, J. Galan, and R. R. Birgey, Protein flexibility and conformational state: a comparison of collective vibrational modes of wild-type and D96N bacteriorhodopsin, Biophys. J., 85, 1269-1277 (2003).
104. A. M. Klibanov, Improving enzymes by using them in organic solvent, Nature, 409, 241-246 (2001).
105. V. M. Paradkar and J. S. Dordick, Mechanism of extraction of chymotrypsin into isooctane at very low concentrations of Aerosol OT in the absence of reversed micelles, Biotechnol. Bioeng., 43, 529-540 (1994).
106. H.-B. Liu, G. Plopper, S. Earley, Y. Chen, B. Ferguson, and X.-C. Zhang, "Sensing the change of biological cell monolayers by THz differential time-domain spectroscopy," in press, Biosensors and Bioelectronics (2006).
107. I. Giaever and C. Keese, A morphological biosensor for mammalian cells, Nature, 366, 591-592 (1993).
108. R. Lisin, B. Z. Ginzburg, M. Schlesinger, and Y. Feldman, Time domain dielectric spectroscopy study of human cells. I. Erythrocytes and ghosts, Bioch. et Biophy. Acta, 1280, 34-40 (1996).
109. Z. Jiang, M. Li, and X.-C. Zhang, Dielectric constant measurement of thin films by differential time-domain spectroscopy, Appl. Phy. Lett., 76, 3221-3223 (2000).
110. C. Ronne, L. Thrane, P. O. Astrand, A. Wallqvist, K. V. Mikkelsen, and S. R. Keiding, Investigation of the temperature dependence of dielectric relaxation in liquid water by THz reflection spectroscopy and molecular dynamics simulation, J. Chem. Phys., 107, 5319-5331 (1997).
111. M. Born and E. Wolf, Principles of Optics Chapter 13, 4nd edn. (Pergamon Press, 1970).
112. I. Giaever and C. Keese, Micromotion of mammalian cells measured electrically, Proceedings of the National Academy of Sciences of the USA, vol. 88, pp. 7896-7900 (1991).