Dehydration of theophylline monohydrate - A two step process

International Journal of Pharmaceutics

Volumn 158, Issue 1, 1997, Pages 47-55

  Suihko, Eero ^a,b   Ketolainen, Jarkko ^a,c   Poso, Antti ^a   Ahlgren, Markku ^a   Gynther, Jukka ^a   Paronen, Petteri ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b ORION CORPORATION   (Finland)

^c Oy Medfiles Ltd   (Finland)

Author keywords

Calorimetry; Crystal structure; Dehydration; Hydration; Molecular modelling; Theophylline

Indexed keywords

THEOPHYLLINE;

ARTICLE; CALORIMETRY; CRYSTAL STRUCTURE; DEHYDRATION; HYDROGEN BOND; MOLECULAR MODEL; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; X RAY DIFFRACTION;

EID: 0030822981     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00239-1     Document Type: Article

References (23)

1. Agbada, C.O., York, P., 1994. Dehydration of theophylline monohydrate powder-effects of particle size and sample weight. Int. J. Pharm. 106, 33-40.
2. Burger, A., Ramberger, R., 1979. On the polymorphism of pharmaceuticals and other molecular crystals. II. Mikrochim. Acta II, 273-316.
3. Bruns, S., Reichelt, J., Cammenga, H.K., 1984. Thermochemical investigation of theophylline, theophylline hydrate and their aqueous solutions. Thermochim. Acta 72, 31-40.
4. Dewar, M.J.S., Zoebisch, E.G., Healy, E.F., Stewart, J.J.P., 1985. AM1: a new general purpose quantum mechanical molecular model. J. Am. Chem. Soc. 107, 3902-3909.
5. Duddu, S.P., Das, N.G., Kelly, T.P., Sokoloski, T.D., 1995. Microcalorimetric investigation of phase transitions: I. Is water desorption from theophylline · HOH a single-step process?. Int. J. Pharm. 114, 247-256.
6. Fokkens, J.G., van Amelsfoort, J.G.M., de Blaey, C.J., de Kruif, C.G., Wilting, J., 1983. A thermodynamic study of the solubility of theophylline and its hydrate. Int. J. Pharm. 14, 79-93.
7. Giron, D., 1995. Thermal analysis and calorimetric methods in the characterisation of polymorphs and solvates. Thermochim. Acta 248, 1-59.
8. Haleblian, J., McCrone, W., 1969. Pharmaceutical applications of polymorphism. J. Pharm. Sci. 58, 911-929.
9. HyperChem, Release 4.0, Hypercube, Waterloo, Ontario, Canada.
10. Ketolainen, J., Poso, A., Viitasaari, V., Gynther, J., Pirttimäki, J., Laine, E., Paronen, P., 1995. Changes in solid-state structure of cyclophosphamide monohydrate induced by mechanical treatment and storage. Pharm. Res. 12, 299-304.
11. Naqvi, A.A., Bhattacharyya, G.C., 1981. Crystal data for anhydrous theophylline. J. Appl. Cryst. 14, 464.
12. Otsuka, M., Kaneniwa, N., Kawakami, K., Umesawa, O., 1990. Effect of surface characteristics of theophylline anhydrate powder on hygroscopic stability. J. Pharm. Pharmacol. 42, 606-610.
13. Perrier, P.R., Byrn, S.R., 1982. Influence of crystal packing on the solid-state desolvation of purine and pyrimidine hydrates: loss of water of crystallization from thymine monohydrate, cytosine monohydrate, 5-nitrourasil monohydrate, and 2′-deoxyadenosine monohydrate. J. Org. Chem. 47, 4671-4676.
14. Phadnis, N.V., Suryanarayanan, R., 1995. In situ phase transition in theophylline tablets - effect on dissolution rate. Pharm. Res. 12, S7.
15. Puttipipatkhachorn, S., Yonemochi, E., Oguchi, T., Yamamoto, K., Nakai, Y., 1990. Effect of grinding on dehydration of crystal water of theophylline. Chem. Pharm. Bull. 38, 2233-2236.
16. Scheiner, S., 1991. Calculating the properties of hydrogen bonds by ab initio methods. In: Lipkowitz, K.B., Boyd, D.P. (Eds.), Reviews in Computational Chemistry, Vol. II, VCH, New York, pp. 165-218.
17. Shefter, E., Higuchi, T., 1963. Dissolution behavior of crystalline solvated and nonsolvated forms of some pharmaceuticals. J. Pharm. Sci. 52, 781-791.
18. Sheldrick, G.M., 1990. SHELXTL-Plus, Release 4.11/V; Siemens Analytical X-ray Instruments, Madison, WI.
19. de Smidt, J.H., Fokkens, J.G., Grijseels, H., Crommelin, D.J.A., 1986. Dissolution of theophylline monohydrate and anhydrous theophylline in buffer solutions. J. Pharm. Sci. 75, 497-501.
20. Sutor, D.J., 1958. The structures of the pyrimidines and purines. VI. The crystal structure of theophylline. Acta Cryst. 11, 83-87.
21. Suzuki, E., Shimomura, K., Sekiguchi, K., 1989. Thermochemical study of theophylline and its hydrate. Chem. Pharm. Bull. 37, 493-497.
22. York, P., 1983. Solid-state properties of powders in the formulation and processing of solid dosage forms. Int. J. Pharm. 14, 1-28.
23. Zhu, H., Khankari, R.K., Padden, B.E., Munson, E.J., Gleason, W.B., Grant, D.J.W., 1996. Physicochemical characterization of Nedocromil bivalent metal salt hydrates. 1. Nedocromil magnesium. J. Pharm. Sci. 85, 1026-1034.