Methylenetetrahydrofolate reductase gene polymorphism in diabetes and obesity

Molecular Biology Reports

Volumn 37, Issue 1, 2010, Pages 105-109

  Tavakkoly Bazzaz, Javad ^a   Shojapoor, Mahnaz ^b   Nazem, Habibollah ^b   Amiri, Parvin ^a   Fakhrzadeh, Hossein ^a   Heshmat, Ramin ^a   Parvizi, Maryam ^a   Hasani Ranjbar, Shirin ^a   Amoli, Mahsa M ^a,c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b PAYAME NOOR UNIVERSITY   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Diabetes; Homocysteine; MTHFR; Obesity; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE;

ADULT; ALLELE; AMINO ACID ANALYSIS; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; ALLELES; DIABETES COMPLICATIONS; FEMALE; GENE FREQUENCY; HOMOCYSTEINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 77949264288     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-009-9545-z     Document Type: Article

References (30)

1. H Refsume PM Ueland 1998 Recent data are not in conflict with homocystein as a cardiovascular risk factor Curr Opin Lipidol 9 533 539 10.1097/00041433-199812000-00004 10.1097/00041433-199812000-00004 (Pubitemid 29041447)
2. PA Outinen SK Sood PC Liaw KD Sarge N Maeda J Hirsh, et al. 1998 Characterization of the stress-inducing effects of homocysteine Biochem J 332 213 221 1:CAS:528:DyaK1cXjslSgtb8%3D 9576870
3. GR Upchurch Jr GN Welch AJ Fabian JE Freedman JL Johnson JF Keaney Jr, et al. 1997 Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase J Biol Chem 272 17012 17017 10.1074/jbc.272.27.17012 10.1074/jbc.272.27.17012 1:CAS:528:DyaK2sXksVeltbs%3D 9202015 (Pubitemid 27289806)
4. AI Freitas I Mendonca G Guerra M Brion RP Reis A Carracedo A Brehm 2008 Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: the A1298C polymprphism does matter. Inferences from a case study (Madeira, Portugal) Thromb Res 122 648 656 10.1016/j.thromres.2008.02.005 10.1016/j.thromres.2008.02.005 1:CAS:528:DC%2BD1cXhtValsrbJ 18384842
5. P Frosst HJ Blom R Milos P Goyette CA Sheppard RG Matthew, et al. 1995 A candidate genetic risk factors for vascular disease: a common mutation in methylenetetrahydrofolate reductase: isolation of Cdna, mapping and mutation identification Nat Genet 10 110 113 10.1038/ng0595-111 10.1038/ng0595-111
6. F Rassoul V Richter B Hentschel J Geisel W Herrmann T Kuntze 2008 Plasma homocysteine levels & 677C→T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity Indian J Med Res 127 154 158 1:CAS:528:DC%2BD1cXlsVeqtbs%3D 18403793
7. M Klerk P Verhoef R Clarke HJ Blom FJ Kok EG Schouten 2002 MTHFR studies collaboration group. MTHFR 677C→T polymorphism and risk of coronary heart disease: a meta-analysis JAMA 288 2023 2031 10.1001/jama.288.16.2023 1:CAS:528:DC%2BD3sXpsFOqsrw%3D 12387655
8. N Inamoto T Katsuya Y Kokubo T Mannami T Asai S Baba, et al. 2003 Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population Stroke 34 1628 1633 10.1161/01.STR.0000075769.09092.82 10.1161/01.STR.0000075769.09092.82 1:CAS:528:DC%2BD3sXkvFyjtbw%3D 12775885 (Pubitemid 36842615)
9. PM Ueland H Refsum SP Stabler MR Malinow A Andersson RH Allen 1993 Total homocysteine in plasma and serum: methods and clinical applications Clin Biochem 93 1764 1779
10. AB Guttormsen PM Ueland I Nesthus O Nygard J Schneede S Vollset, et al. 1996 Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (equal to or greater than 40 micromole/liter): the Hordaland homocysteine study J Clin Invest 98 2174 2183 10.1172/JCI119024 10.1172/JCI119024 1:CAS:528:DyaK28XmvVequ7c%3D 8903338
11. P Frosst Z-X Zhang A Pai R Rozen 1996 The methylenetetrahydrofolate reductase (Mthfr) gene maps to distal mouse chromosome 4 Mamm Genome 7 864 869 10.1007/s003359900255 10.1007/s003359900255 1:CAS:528:DyaK2sXitlKnsw%3D%3D 8875901
12. PF Jacques AG Bostom RR Williams RC Ellison JH Eckfeldt IH Rosenberg J Selhub R Rozen 1996 Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations Circulation 93 7 9 1:CAS:528:DyaK28XhtVyiu7s%3D 8616944 (Pubitemid 26006560)
13. K Thawnashom R Tungtrongchitr S Petmitr P Pongpaew B Phonrat A Tungtrongchitr FP Schelp 2005 Methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) in relation to homocysteine concentration in overweight and obese Thais Southeast Asian J Trop Med Public Health 36 459 466 1:CAS:528:DC%2BD2MXnvFyguro%3D 15916056
14. I Terruzzi P Senesi I Fermo G Lattuada L Luzi 2007 Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity? J Endocrinol Invest 30 747 753 1:CAS:528:DC%2BD1cXitFyktg%3D%3D 17993766
15. C Song D Xing W Tan Q Wei D Lin 2001 Methylenetetrahydrofolate reductase gene polymorphism increase risk of esophageal squamous cell carcinoma in a Chinese population Cancer Res 61 3272 3275 1:CAS:528:DC%2BD3MXjtFSjtLo%3D 11309278
16. O Nygård JE Nordrehaug H Refsum PM Ueland M Farstad SE Vollset 1997 Plasma homocysteine levels and mortality in patients with coronary artery disease N Engl J Med 337 230 236 10.1056/NEJM199707243370403 10.1056/NEJM199707243370403 9227928 (Pubitemid 27310438)
17. AM Molloy S Daly JL Mills, et al. 1997 Thermolabile variant of 5, 10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations Lancet 349 1591 1593 10.1016/S0140-6736(96)12049-3 10.1016/S0140-6736(96)12049-3 1:CAS:528: DyaK2sXjvV2ls78%3D 9174561 (Pubitemid 27229139)
18. J Ma MJ Stampfer E Giovannucci, et al. 1997 Methylenetetrahydrofolate reductase polymorphism, dietary interactions and risk of colorectal cancer Cancer Res 57 1098 1102 1:CAS:528:DyaK2sXhvFOisLg%3D 9067278
19. J Ma MJ Stampfer B Christensen, et al. 1999 A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk Cancer Epidemiol Biomarkers Prev 8 825 829 1:CAS:528:DyaK1MXmsFGktL0%3D 10498402
20. S Gallisti k Sudi H Mangge W Erwa M Borkenstein 2000 Insuline is an independent correlate of plasma homocusteine levels in obese children and adolescents Diabetes Care 23 1348 1352 10.2337/diacare.23.9.1348 10.2337/diacare.23.9.1348
21. JR Ruiz A Hurtig-Wennlof FB Ortega E Patterson TK Nilsson, et al. 2007 Homocysteine levels in children and adolescents are associated with the methylenetetrahydrofolate reductase 677C>T genotype, but not with physical activity, fitness or fatness: the European youth heart study Br J Nutr 97 255 262 10.1017/S0007114507280535 10.1017/S0007114507280535 1:CAS:528: DC%2BD2sXhtV2qu7bP 17298693 (Pubitemid 46671798)
22. K Nakai C Itoh K Nakai W Habano D Gurwitz 2001 Correlation between C677T MTHFR gene polymorphism, plasma homocysteine levels and the incidence of CAD Am J Cardiovasc Drugs 1 353 361 10.2165/00129784-200101050-00005 10.2165/00129784-200101050-00005 1:CAS:528:DC%2BD38Xmt12msro%3D 14728017
23. JK Virtanen S Voutilainen G Alfthan MJ Korhonen TH Rissanen J Mursu GA Kaplan JT Salonen 2005 Homocysteine as a risk factor for CVD mortality in men with other CVD risk factors: the Kuopio ischaemic heart disease risk factor (KIHD) study J Intern Med 257 255 262 10.1111/j.1365-2796.2005.01450.x 10.1111/j.1365-2796.2005.01450.x 1:CAS:528:DC%2BD2MXivFWmsbw%3D 15715682 (Pubitemid 40342128)
24. GE Vrentzos JA Papadakis N Malliaraki EA Zacharis E Mazokopakis A Margioris ES Ganotakis A Kafatos 2004 Diet, serum homocysteine levels and ischaemic heart disease in a Mediterranean population Br J Nutr 91 1013 1019 10.1079/BJN20041145 1:CAS:528:DC%2BD2cXltlGls7o%3D 15182405 (Pubitemid 38931466)
25. ES Ford SJ Smith DF Stroup KK Steinberg PW Mueller SB Thacker 2002 Homocyst(e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies Int J Epidemiol 31 59 70 10.1093/ije/31.1.59 10.1093/ije/31.1.59 11914295
26. S Seshadri A Beiser J Selhub PF Jacques IH Rosenberg RB D'Agostino PW Wilson PA Wolf 2002 Plasma homocysteine as a risk factor for dementia and Alzheimer's disease N Engl J Med 346 476 483 10.1056/NEJMoa011613 10.1056/NEJMoa011613 1:CAS:528:DC%2BD38XhtFCktrw%3D 11844848 (Pubitemid 34441738)
27. RR McLean PF Jacques J Selhub KL Tucker EJ Samelson KE Broe MT Hannan LA Cupples DP Kiel 2004 Homocysteine as a predictive factor for hip fracture in older persons N Engl J Med 350 2042 2049 10.1056/NEJMoa032739 10.1056/NEJMoa032739 1:CAS:528:DC%2BD2cXktVeis7g%3D 15141042 (Pubitemid 38596555)
28. WM Hague 2003 Homocysteine and pregnancy Best Pract Res Clin Obstet Gynaecol 17 459 469 10.1016/S1521-6934(03)00009-9 10.1016/S1521-6934(03)00009-9 12787538 (Pubitemid 36722171)
29. GT Russo A Di Benedetto E Alessi, et al. 2006 Mild hyperhomocysteinemia and the common C677T polymorphism of methylene tetrahydrofolate reductase gene are not associated with the metabolic syndrome in Type 2 diabetes J Endocrinol Invest 29 201 207 1:CAS:528:DC%2BD28XlvVOitbk%3D 16682831
30. L Di Renzo M Bigioni V Del Gobbo, et al. 2007 Interleukin-1 (IL-1) receptor antagonist gene polymorphism in normal weight obese syndrome: relationship to body composition and IL-1 alpha and beta plasma levels Pharmacol Res 55 131 138 10.1016/j.phrs.2006.11.002 10.1016/j.phrs.2006.11.002 1:CAS:528:DC%2BD2sXhtlSjtbk%3D 17174563 (Pubitemid 46186040)