Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity?

Journal of Endocrinological Investigation

Volumn 30, Issue 9, 2007, Pages 747-753

  Terruzzi, Ileana ^a   Senesi, P ^a   Fermo, I ^b   Lattuada, G ^a   Luzi, L ^a,c  

^a Section of Nutrition Metabolism   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Betaine:homocysteine methyltransferase; Cystathionine synthase; Methionine synthase; Methionine synthase reductase; Methylene tetrahydrofolate reductase; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; CYSTATHIONINE BETA SYNTHASE; FOLIC ACID; HOMOCYSTEINE; HOMOCYSTEINE METHYLTRANSFERASE; LEPTIN; METHIONINE SYNTHASE; METHIONINE SYNTHASE REDUCTASE; PYRIDOXINE;

ADULT; ARTICLE; BODY MASS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DNA POLYMORPHISM; FOLIC ACID BLOOD LEVEL; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE DETECTION; HUMAN; MAJOR CLINICAL STUDY; OBESITY; RISK ASSESSMENT; RISK FACTOR; VITAMIN BLOOD LEVEL;

EID: 36949031489     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03350812     Document Type: Article

References (38)

1. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998, 395: 763-70.
2. Whitaker RC. Understanding the complex journey to obesity in early adulthood, Ann Intern Med 2002, 136: 923-5.
3. Sowers JR. Obesity as a cardiovascular risk factor. Am J Med 2003, 115 (Suppl 8A): 37S-41S.
4. Zylberstein DE, Bengtsson C, Bjorkelund C. Serum homocysteine in relation to mortality and morbidity from coronary heart disease: a 24-year follow-up of the population study of women in Gothenburg. Circulation 2004, 109: 601-6.
5. Marchesini G, Manini R, Bianchi G, et al. Homocysteine and psychological traits: a study in obesity, Nutrition 2002, 18: 403-7.
6. Fonseca VA, Fink LM, Kern PA. Insulin sensitivity and plasma homocysteine concentrations in non-diabetic obese and normal weight subjects. Atherosclerosis 2003, 167: 105-9.
7. Finkelstein JD, Martin JJ. Homocysteine. Int J Biochem Cell Biol 2000, 32: 385-9.
8. Sunden SL, Renduchintala MS, Park El, Miklasz SD, Garrow TA. Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene. Arch Biochem Biophys 1997, 345: 171-4.
9. Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999, 19: 217-46.
10. Yates Z, Lucock M. Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event. Mol Genet Metab 2003, 79: 201-13.
11. 12, and DNA damage in coronary artery disease. Hum Genet 2003, 112: 171-7.
12. Botto N, Andreassi MG, Manfredi S, et al. Genetic polymorphisms in folate and homocysteine metabolism as risk factors for DNA damage. Eur J Hum Genet 2003, 11: 671-8.
13. Deng HW, Deng H, Liu YJ, et al. A genomewide linkage scan for quantitative-trait loci for obesity phenotypes. Am J Hum Genet 2002, 70: 1138-51.
14. Shmulewitz D, Heath SC, Blundell ML, et al. Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia. Proc Natl Acad Sci U S A 2006, 103: 3502-9.
15. Klein OD, Cotter PD, Albertson DG, et al. Prader-Willi syndrome resulting from an unbalanced translocation: characterization by array comparative genomic hybridization. Clin Genet 2004, 65: 477-82.
16. Goyette P, Sumner JS, Milos R, et al. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet 1994, 7: 195-200.
17. Leclerc D, Campeau E, Goyette P, et al. Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. Hum Mol Genet 1996, 5: 1867-74.
18. Li YN, Gulati S, Baker PJ, Brody LC, Banerjee R, Kruger WD. Cloning, mapping and RNA analysis of the human methionine synthase gene. Hum Mol Genet 1996, 5: 1851-8.
19. Leclerc D, Wilson A, Dumas R, et al. Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Proc Natl Acad Sci U S A 1998, 95: 3059-64.
20. Clinical Guidelines on the identification, evaluation and treatment of overweight, and obesity in adults. At: http://www.nhlbi.nih.gov/ guidelines/obesity/ob_home.htm.
21. Fermo I, Arcelloni C, Mazzola G D'Angelo A, Paroni R. High-performance liquid chromatographic method for measuring total plasma homocysteine levels. J Chromatogr B Biomed Sci Appl 1998, 719: 31-6.
22. Camp VM, Chipponi J, Faraj BA. Radioenzymatic assay for direct measurement of plasma pyridoxal 5′-phosphate. Clin Chem 1983, 29: 642-4.
23. Paz MF, Avila S, Fraga MF, et al. Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. Cancer Res 2002, 62: 4519-24.
24. Van der Put NM, Gabreëls F, Stevens EM, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 1998, 62: 1044-51.
25. Zhang G, Dai C. Gene polymorphisms of homocysteine metabolism-related enzymes in Chinese patients with occlusive coronary artery or cerebral vascular diseases. Thromb Res 2001, 104: 187-95.
26. 12) increases risk for spina bifida. Mol Genet Metab 1999, 67: 317-23.
27. Weisberg IS, Park E, Ballman KV. Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis 2003, 167: 205-14.
28. Bosco P, Gueant-Rodriguez RM, Anello G, et al. Association of IL-1 RN*2 allele and methionine synthase 2756 AA geno-type with dementia severity of sporadic Alzheimer's disease. J Neurol Neurosurg Psychiatry 2004, 75: 1036-8.
29. Bosco P, Gueant-Rodriguez RM, Anello G, et al. Methionine synthase (MTR) 2756 (A → G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome. Am J Med Genet A 2003, 121: 219-24.
30. Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science 2001, 293: 1068-70.
31. Tate PH, Bird AP. Effects of DNA methylation on DNA-binding proteins and gene expression. Curr Opin Genet Dev 1993, 3: 226-31.
32. Boyes J, Bird A. DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein. Cell 1991, 64: 1123-34.
33. Ehrlich M, Wang RY. 5-Methylcytosine in eukaryotic DNA. Science 1981, 212: 1350-7.
34. Yokomori N, Tawata M, Onaya T. DNA demethylation modulates mouse leptin promoter activity during the differentiation of 3T3-L1 cells. Diabetologia 2002, 45: 140-8.
35. Lonnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1995, 1: 950-3.
36. MacDougald OA, Hwang CS, Fan H, Lane MD. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci USA 1995, 92: 9034-7.
37. Zhang Y, Guo KY, Diaz PA, Heo M, Leibel RL. Determinants of leptin gene expression in fat depots of lean mice. Am J Physiol Regul Integr Comp Physiol 2002, 282: R226-34.
38. Duthie SJ. Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull 1999, 55: 578-92.