Homocysteine levels in children and adolescents are associated with the methylenetetrahydrofolate reductase 677C > T genotype, but not with physical activity, fitness or fatness: The European Youth Heart Study

British Journal of Nutrition

Volumn 97, Issue 2, 2007, Pages 255-262

  Ruiz, Jonatan R ^a,b   Hurtig Wennlöf, Anita ^a,c   Ortega, Francisco B ^a,b   Patterson, Emma ^a   Nilsson, Torbjörn K ^c,d   Castillo, Manuel J ^b   Sjöström, Michael ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF GRANADA   (Spain)

^c ÖREBRO UNIVERSITY   (Sweden)

^d ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Body fat; Cardiorespiratory fitness; Homocysteine; Physical activity

Indexed keywords

DNA; HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ADOLESCENT; ARTICLE; BICYCLE ERGOMETRY; BODY FAT; CARDIOVASCULAR RISK; CHILD; CONTROLLED STUDY; DNA SEQUENCE; EUROPE; FEMALE; FITNESS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; MULTIPLE REGRESSION; NORMAL HUMAN; OBESITY; PHYSICAL ACTIVITY; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; SEX DIFFERENCE; SKINFOLD THICKNESS; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE;

ADIPOSE TISSUE; ADOLESCENT; BODY MASS INDEX; CHILD; CROSS-SECTIONAL STUDIES; EXERCISE; FEMALE; GENOTYPE; HOMOCYSTEINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PHYSICAL FITNESS; POLYMORPHISM, GENETIC;

EID: 34247560691     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114507280535     Document Type: Article

References (50)

1. Allison DB, Zhu SK, Plankey M, Faith MS & Heo M (2002) Differential associations of body mass index and adiposity with all-cause mortality among men in the first and second National Health and Nutrition Examination Surveys (NHANES I and NHANES II) follow-up studies. Int J Obes Relat Metab Disord 26, 410-416.
2. Bates CJ, Mansoor MA, Gregory J, Pentiev K & Prentice A (2002) Correlates of plasma homocysteine, cysteine and cysteinyl-glycine in respondents in the British National Diet and Nutrition Survey of young people aged 4-18 years, and a comparison with the survey of people aged 65 years and over. Br J Nutr 87, 71-79.
3. Börjel AK, Yngve A, Sjöström M & Nilsson TK (2006) Novel mutations in the 5′-UTR of the FOLR1 gene. Clin Chem Lab Med 44, 161-167.
4. Brage S, Wedderkopp N, Ekelund U, Franks PW, Wareham NJ, Andersen LB & Froberg K (2004) European Youth Heart Study (EYES): Features of the metabolic syndrome are associated with objectively measured physical activity and fitness in Danish children: the European Youth Heart Study (EYHS). Diabetes Care 27, 2141-2148.
5. Brown KS, Kluijtmans LA, Young IS, et al. (2003) Genetic evidence that nitric oxide modulates homocysteine: the NOS3 894TT genotype is a risk factor for hyperhomocysteinemia. Arterioscler Thromb Vasc Biol 23, 1014-1020.
6. Carnethon MR, Gidding SS, Nehgme R, Sidney S, Jacobs DR & Liu K (2003) Cardiorespiratory fitness in young adulthood and the development of cardiovascular disease risk factors. JAMA 290, 3092-3100.
7. Chrysohoou C, Panagiotakos DB, Pitsavos C, Zeimbekis A, Zampelas A, Papademetriou L, Masoura C & Stefanadis C (2004) The associations between smoking, physical activity, dietary habits and plasma homocysteine levels in cardiovascular disease-free people: The 'ATTICA' study. Vasc Med 9, 117-123.
8. Cole TJ, Bellizzi MC, Flegal M & Dietz WH (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320, 1240-1246.
9. De Laet C, Wautrecht JC, Brasseur D, Dramaix M, Boeynaems JM, Decuyper J & Kahn A (1999) Plasma homocysteine concentration in a Belgian school-age population. Am J Clin Nutr 69, 968-972.
10. Ford ES, Smith SJ, Stroup DF, Steinberg KK, Mueller PW & Thacker SB (2002) Homocyst(e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies. Int J Epidemiol 31, 59-70.
11. Frosst P, Blom HJ, Milos R, et al. (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10, 111-113.
12. Gallistl S, Sudi KM, Erwa W, Aigner R & Borkenstein M (2001) Determinants of homocysteine during weight reduction in obese children and adolescents. Metabolism 50, 1220-1223.
13. Gallistl S, Sudi K, Mangge H, Erwa W & Borkenstein M (2000) Insulin is an independent correlate of plasma homocysteine levels in obese children and adolescents. Diabetes Care 23, 1348-1352.
14. Gutin B, Litaker M, Islam S, Manos T, Smith C & Treiber F (1996) Body-composition measurement in 9-11-y-old children by dual-energy X-ray absorptiometry, skinfold-thickness measurements, and bioimpedance analysis. Am J Clin Nutr 63, 287-292.
15. Hague WM (2003) Homocysteine and pregnancy. Best Practice Res Clin Obstet Gynaecol 17, 459-469.
16. Hansen HS, Froberg K, Nielsen JR & Hyldebrandt N (1989) A new approach to assessing maximal aerobic power in children: the Odense School Child Study. Eur J Appl Physiol Occup Physiol 58; 618-624.
17. Homocysteine Studies Collaboration (2002) Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 288, 2015-2022.
18. Husemoen LL, Thomsen TF, Fenger M & Jorgensen T (2006) Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study. Eur J Clin Nutr 60, 614-622.
19. Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH & Selhub J (2001) Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr 73, 613-621.
20. Kado DM, Bucur A, Selhub J, Rowe JW & Seeman T (2002) Homocysteine levels and decline in physical function: MacArthur. Studies of Successful Aging. Am J Med 113, 537-542.
21. Kaplan GA & Keil JE (1993) Socioeconomic factors and cardiovascular disease: a review of the literature. Circulation 88, 1973-1998.
22. Kohl HW III, Fulton JE & Caspersen CJ (2000) Assessment of physical activity among children and adolescents: a review and synthesis. Prev Med 31, S54-S76.
23. Kuo HK, Yen CJ & Bean JF (2005) Levels of homocysteine are inversely associated with cardiovascular fitness in women, but not in men: data from the National Health and Nutrition Examination Survey 1999-2002. J Intern Med 258, 328-335.
24. Lohman TG, Roche AF & Martorell R (1991) Anthropometric Standardization Reference Manual. pp. 55-70. Champaign, IL: Human Kinetics.
25. McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA & Kiel DP (2004) Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 350, 2042-2049.
26. Mesa JL, Ruiz JR, Ortega FB, Warnberg J, González-Lamuño D, Moreno LA, Gutiérez A & Castillo MJthe AVENA Study Group (2006) Aerobic physical fitness in relation to blood lipids and fasting glycaemia in adolescents. Influence of weight status. Nutr Metab Cardiovasc Dis 16, 285-293.
27. Myers J, Prakash M, Froelicher V, Do D, Partington S & Atwood JE (2002) Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 346, 793-801.
28. Papoutsakis C, Yiannakouris N, Manios Y, Papaconstantinou E, Magkos F, Schulpis KH, Zampelas A & Matalas AL (2005) Plasma homocysteine levels in Greek children are influenced by an interaction between the methylenetetrahydrofolate reductase C677T genotype and folate status. J Nutr 135, 383-388.
29. Poortvliet E, Yngve A, Ekelund U, Hurtig-Wennlöf A, Nilsson A, Hagströmer M & Sjöström M (2003) The European Youth Heart Survey (EYHS). An international study that addresses the multidimensional issues of CVD risk factors. Forum Nutr 56, 254-256.
30. Puyau MR, Adolph AL, Vohra FA, Zakeri I & Butte NF (2004) Prediction of activity energy expenditure using accelerometers in children. Med Sci Sports Exerc 36, 1625-1631.
31. Randeva HS, Lewandowski KC, Drzewoski J, Brooke-Wavell K, O'Callaghan C, Czupryniak L, Hillhouse EW & Prelevic GM (2002) Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome. J Clin Endocrinol Metab 87, 4496-4501.
32. Rennie KL, Livingstone MB, Wells JC, McGloin A, Coward WA, Prentice AM & Jebb SA (2005) Association of physical activity with body-composition indexes in children aged 6-8y at varied risk of obesity. Am J Clin Nutr 82, 13-20.
33. Riddoch C, Edwards D, Page A, et al. (2005) Cardiovascular disease risk factors in children: Rationale, aims, study, design, and validation of methods. J Phys Act Health 2, 115-129.
34. Rodriguez G, Moreno LA, Blay MG, Blay VA, Fleta J, Sarria A & Bueno M (2005) Body fat measurement in adolescents: comparison of skinfold thickness equations with dual-energy X-ray absorptiometry. Eur J Clin Nutr 27, 1-9.
35. Ruiz JR, Ortega FB, Meusel D, Harro M, Oja P & Sjöström M (2006 a) Cardiorespiratory fitness is associated with features of metabolic risk factors in children. Should cardiorespiratory fitness be assessed in a European health monitoring system? The European Youth Heart Study. J Public Health 14, 94-102.
36. Ruiz JR, Rizzo N, Wennlöf A, Ortega FB, Harro M & Sjöström M (2006b) Relations of total physical activity and intensity to fitness and fatness in children; The European Youth Heart Study. Am J Clin Nutr 84, 298-302.
37. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW & Wolf PA (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346, 476-483.
38. Silaste ML, Rantala M, Alfthan G, Aro A & Kesaniemi YA (2003) Plasma homocysteine concentration is decreased by dietary intervention. Br J Nutr 89, 295-301.
39. Strong WB, Malina RM, Blimkie CJ, et al. (2005) Evidence based physical activity for school-age youth. J Pediatr 146, 732-737.
40. Tanner JM & Whitehouse RH (1976) Clinical longitudinal standards for height, weight, height velocity and stages of puberty. Arch Dis Child 51, 170-179.
41. Trost SG, Pate RR, Freedson PS, Sallis JF & Taylor WC (2000) Using objective physical activity measures with youth: how many days of monitoring are needed? Med Sci Sports Exerc 32, 426-431.
42. Trost SG, Pate RR, Sallis JF, Freedson PS, Taylor WC, Dowda M & Sirard J (2002) Age and gender differences in objectively measured physical activity in youth. Med Sci Sports Exerc 34, 350-355.
43. Trost SG, Ward DS, Moorehead SM, Watson PD, Riner W & Burke JR (1998) Validity of the computer science and applications (CSA) activity monitor in children. Med Sci Sports Exerc 30, 629-633.
44. Ueland PM & Monsen AL (2003) Hyperhomocysteinemia and B-vitamin deficiencies in infants and children. Clin Chem Lab Med 41, 1418-1426.
45. van Beynum IM, den Heijer M, Thomas CM, Afman L, Oppenraayvan Emmerzaal D & Blom HJ (2005) Total homocysteine and its predictors in Dutch children. Am J Clin Nutr 81, 1110-1116.
46. Virtanen JK, Voutilainen S, Alfthan G, Korhonen MJ, Rissanen TH, Mursu J, Kaplan GA & Salonen JT (2005) Homocysteine as a risk factor for CVD mortality in men with other CVD risk factors: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study. J Intern Med 257, 255-262.
47. Vrentzos GE, Papadakis JA, Malliaraki N, Zacharis EA, Mazokopakis E, Margioris A, Ganotakis ES & Kafatos A (2004) Diet, serum homocysteine levels and ischaemic heart disease in a Mediterranean population. Br J Nutr 91, 1013-1019.
48. Welch GN & Loscalzo J (1998) Homocysteine and atherothrombosis. N Engl J Med 338, 1042-1050.
49. Wennlöf AH, Yngve A & Sjöström M (2003) Sampling procedure, participation rates and representativeness in the Swedish part of the European Youth Heart Study (EYHS). Public Health Nutr 6, 291-299.
50. Willems HP, Bos GM, Gerrits WB, den Heijer M, Vloet S & Blom HJ (1998) Acidic citrate stabilizes blood samples for assay of total homocysteine. Clin Chem 44, 342-345.