The effect of calcipotriol on the expression of human β defensin-2 and LL-37 in cultured human keratinocytes

Clinical and Developmental Immunology

Volumn 2009, Issue , 2009, Pages

  Seo, Seong Jun ^a   Kim, Beom Joon ^a   Rho, Yong Kwan ^a   Lee, Hye In ^a   Jeong, Mi Sook ^a   Li, Kapsok ^a   Kim, Myeung Nam ^a   Hong, Chang Kwun ^a  

^a Chung Ang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 2; CALCIPOTRIOL; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; LIPOPOLYSACCHARIDE; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; ANTIMICROBIAL CATIONIC PEPTIDE; BETA DEFENSIN; CALCITRIOL; CAP18 LIPOPOLYSACCHARIDE BINDING PROTEIN; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; DEFB4 PROTEIN, HUMAN; DRUG DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DENSITOMETRY; DRUG EFFECT; ELECTROPHORESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULTRAVIOLET B RADIATION; UPREGULATION; WESTERN BLOTTING; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY; ULTRAVIOLET RADIATION;

ANTIMICROBIAL CATIONIC PEPTIDES; BETA-DEFENSINS; CALCITRIOL; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; KERATINOCYTES; LIPOPOLYSACCHARIDES; TUMOR NECROSIS FACTOR-ALPHA; ULTRAVIOLET RAYS;

EID: 77749314934     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2009/645898     Document Type: Article

References (31)

1. Fulton C., Anderson G. M., Zasloff M., Bull R., Quinn A. G., Expression of natural peptide antibiotics in human skin The Lancet 1997 350 9093 1750 1751
2. Harder J., Bartels J., Christophers E., Schroder J.-M., A peptide antibiotic from human skin Nature 1997 387 6636 861
3. Schauber J., Gallo R. L., Expanding the roles of antimicrobial peptides in skin: alarming and arming keratinocytes Journal of Investigative Dermatology 2007 127 3 510 512
4. Yang D., Chertov O., Oppenheim J. J., Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37) Journal of Leukocyte Biology 2001 69 5 691 697
5. Fulton C., Anderson G. M., Zasloff M., Bull R., Quinn A. G., Expression of natural peptide antibiotics in human skin The Lancet 1997 350 9093 1750 1751
6. Ong P. Y., Ohtake T., Brandt C.,et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis The New England Journal of Medicine 2002 347 15 1151 1160
7. Schauber J., Gallo R. L., Antimicrobial peptides and the skin immune defense system Journal of Allergy and Clinical Immunology 2008 122 2 261 266
8. Lande R., Gregorio J., Facchinetti V.,et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide Nature 2007 449 7162 564 569
9. Harder J., Meyer-Hoffert U., Teran L. M.,et al. Mucoid Pseudomonas aeruginosa, TNF-α, and IL-β, but not IL-6, induce human β-defensin-2 in respiratory epithelia American Journal of Respiratory Cell and Molecular Biology 2000 22 6 714 721
10. Liu A. Y., Destoumieux D., Wong A. V.,et al. Human β-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation Journal of Investigative Dermatology 2002 118 2 275 281
11. Liu P. T., Stenger S., Li H.,et al., Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response Science 2006 311 5768 1770 1773
12. Harder J., Meyer-Hoffert U., Wehkamp K., Schwichtenberg L., Schröder J.-M., Differential gene induction of human β-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid Journal of Investigative Dermatology 2004 123 3 522 529
13. Segaert S., Simonart T., The epidermal vitamin D system and innate immunity: some more light shed on this unique photoendocrine system? Dermatology 2008 217 1 7 11
14. Weber G., Heilborn J. D., Jimenez C. I. C., Hammarsjö A., Törmä H., Ståhle M., Vitamin D induces the antimicrobial protein hCAP18 in human skin Journal of Investigative Dermatology 2005 124 5 1080 1082
15. Wang T.-T., Nestel F. P., Bourdeau V.,et al., Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression Journal of Immunology 2004 173 5 2909 2912
16. Yang D., Chertov O., Bykovskaia S. N.,et al. β-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6 Science 1999 286 5439 525 528
17. Harder J., Meyer-Hoffert U., Wehkamp K., Schwichtenberg L., Schröder J.-M., Differential gene induction of human β-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid Journal of Investigative Dermatology 2004 123 3 522 529
18. Murakami M., Lopez-Garcia B., Braff M., Dorschner R. A., Gallo R. L., Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense Journal of Immunology 2004 172 5 3070 3077
19. Wu H., Zhang G., Minton J. E., Ross C. R., Blecha F., Regulation of cathelicidin gene expression: induction by lipopolysaccharide, interleukin-6, retinoic acid, and Salmonella enterica serovar typhimurium infection Infection and Immunity 2000 68 10 5552 5558
20. Schauber J., Dorschner R. A., Coda A. B.,et al. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism Journal of Clinical Investigation 2007 117 3 803 811
21. Howell M. D., Boguniewicz M., Pastore S.,et al. Mechanism of HBD-3 deficiency in atopic dermatitis Clinical Immunology 2006 121 3 332 338
22. Hong S. P., Kim M. J., Jung M.-Y.,et al. Biopositive effects of low-dose UVB on epidermis: coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement Journal of Investigative Dermatology 2008 128 12 2880 2887
23. Gombart A. F., Borregaard N., Koeffler H. P., Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3 FASEB Journal 2005 19 9 1067 1077
24. Schauber J., Oda Y., Büchau A. S.,et al. Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3 Journal of Investigative Dermatology 2008 128 4 816 824
25. Yamasaki K., Di Nardo A., Bardan A.,et al. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea Nature Medicine 2007 13 8 975 980
26. Hollox E. J., Huffmeier U., Zeeuwen P. L. J. M., Psoriasis is associated with increased β-defensin genomic copy number Nature Genetics 2008 40 1 23 25
27. Schauber J., Gallo R. L., Expanding the roles of antimicrobial peptides in skin: alarming and arming keratinocytes Journal of Investigative Dermatology 2007 127 3 510 512
28. Koczulla R., von Degenfeld G., Kupatt C.,et al. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18 Journal of Clinical Investigation 2003 111 11 1665 1672
29. Carretero M., Escámez M. J., García M.,et al. In vitro and in vivo wound healing-promoting activities of human cathelicidin LL-37 Journal of Investigative Dermatology 2008 128 1 223 236
30. Lebwohl M., Menter A., Koo J., Feldman S. R., Combination therapy to treat moderate to severe psoriasis Journal of the American Academy of Dermatology 2004 50 3 416 430
31. Peric M., Koglin S., Dombrowski Y.,et al. Vitamin D analogs differentially control antimicrobial peptide/alarmin expression in psoriasis PLoS ONE 2009 4 7, article e6340