Simvastatin attenuates TNF-α-induced growth inhibition and apoptosis in murine osteoblastic MC3T3-E1 cells

Inflammation Research

Volumn 59, Issue 2, 2010, Pages 151-157

  Yang, Yun Mei ^a   Huang, Wei Dong ^a   Xie, Qiang Min ^b   Xu, Zhe Rong ^a   Zhao, Qi Jiang ^a   Wu, Xi Mei ^b   Li, Fen Fen ^b   Dong, Xin Wei ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Osteoblastic cells; Simvastatin; TNF

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIBIOTIC AGENT; LIPOCORTIN 5; SIMVASTATIN; SYNEXIN; TRYPAN BLUE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL GROWTH; CELL NUCLEUS; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DRUG EFFECT; FLOW CYTOMETRY; GROWTH INHIBITION; MOUSE; NONHUMAN; OSTEOBLAST; STAINING;

ANIMALS; APOPTOSIS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GROWTH INHIBITORS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MICE; MODELS, ANIMAL; OSTEOBLASTS; SIMVASTATIN; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77749309555     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-009-0082-y     Document Type: Article

References (31)

1. P Close A Neuprez JY Reginster 2006 Developments in the pharmacotherapeutic management of osteoporosis Expert Opin Pharmacother 7 12 1603 1615 10.1517/14656566.7.12.1603 1:CAS:528:DC%2BD28Xnt1aiu7Y%3D 16872263 (Pubitemid 44209604)
2. S Ejiri M Tanaka N Watanabe RB Anwar E Yamashita K Yamada M Ikegame 2008 Estrogen deficiency and its effect on the jaw bones J Bone Miner Metab 26 5 409 415 1:CAS:528:DC%2BD1cXhtVGns7fF 18758898
3. P Minaire C Edouard M Arlot PJ Meunier 1984 Marrow changes in paraplegic patients Calcif Tissue Int 36 3 338 340 10.1007/BF02405340 1:STN:280: DyaL2c3ot1Sktw%3D%3D 6432298
4. MY Weng NE Lane 2007 Medication-induced osteoporosis Curr Osteoporos Rep 5 4 139 145 10.1007/s11914-007-0008-y 18430387
5. GK Chan G Duque 2002 Age-related bone loss: old bone, new facts Gerontology 48 2 62 71 10.1159/000048929 11867927 (Pubitemid 34195721)
6. NR Jørgensen P Schwarz 2008 Osteoporosis in chronic obstructive pulmonary disease patients Curr Opin Pulm Med 14 2 122 127 10.1097/MCP. 0b013e3282f4efb6 18303421 (Pubitemid 351323163)
7. GR Mundy 2007 Osteoporosis and inflammation Nutr Rev 65 12 Pt 2 S147 S151 10.1111/j.1753-4887.2007.tb00353.x 18240539
8. X Feng 2005 Regulatory roles and molecular signaling of TNF family members in osteoclasts Gene 350 1 1 13 10.1016/j.gene.2005.01.014 1:CAS:528:DC%2BD2MXjtFOlsLo%3D 15777737
9. MC Horowitz Y Xi K Wilson MA Kacena 2001 Control of osteoclastogenesis and bone resorption by members of the TNF family of receptors and ligands Cytokine Growth Factor Rev 12 1 9 18 10.1016/S1359-6101(00)00030-7 1:CAS:528:DC%2BD3MXjtFOhsb0%3D 11312114 (Pubitemid 32294582)
10. CC Chua BH Chua Z Chen C Landy RC Hamdy 2002 TGF-β1 inhibits multiple caspases induced by TNF-α in murine osteoblastic MC3T3-E1 cells Biochim Biophys Acta 1593 1 1 8 10.1016/S0167-4889(02)00257-4 1:CAS:528:DC%2BD38XosFClsb0%3D 12431778 (Pubitemid 35335906)
11. M Yamashita F Otsuka T Mukai H Otani K Inagaki T Miyoshi J Goto M Yamamura H Makino 2008 Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway J Endocrinol 196 3 601 613 10.1677/JOE-07-0532 1:CAS:528: DC%2BD1cXkt1Cgurc%3D 18310456
12. G Mundy R Garrett S Harris J Chan D Chen G Rossini B Boyce M Zhao G Gutierrez 1999 Stimulation of bone formation in vitro and in rodents by statins Science 286 5446 1946 1949 10.1126/science.286.5446.1946 1:CAS:528: DyaK1MXnvFSiu78%3D 10583956 (Pubitemid 129515901)
13. C Song Z Guo Q Ma Z Chen Z Liu H Jia G Dang 2003 Simvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells Biochem Biophys Res Commun 308 3 458 462 10.1016/S0006-291X(03)01408-6 1:CAS:528:DC%2BD3sXmt1Wru7o%3D 12914771 (Pubitemid 36945513)
14. T Maeda A Matsunuma T Kawane N Horiuchi 2001 Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells Biochem Biophys Res Commun 280 3 874 877 10.1006/bbrc.2000.4232 1:CAS:528:DC%2BD3MXls1aqsw%3D%3D 11162604 (Pubitemid 32924513)
15. X Wu LH Zeng T Taniguchi QM Xie 2007 Activation of PKA and phosphorylation of sodium-dependent vitamin C transporter 2 by prostaglandin E2 promote osteoblast-like differentiation in MC3T3-E1 cells Cell Death Differ 14 10 1792 1801 10.1038/sj.cdd.4402190 17585336 (Pubitemid 47423646)
16. DJ Maron S Fazio MF Linton 2000 Current perspectives on statins Circulation 101 2 207 213 1:CAS:528:DC%2BD3cXptFKlug%3D%3D 10637210
17. U Landmesser N Engberding FH Bahlmann A Schaefer A Wiencke A Heineke S Spiekermann D Hilfiker-Kleiner C Templin D Kotlarz M Mueller M Fuchs B Hornig H Haller H Drexler 2004 Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase Circulation 110 14 1933 1939 10.1161/01.CIR.0000143232.67642.7A 1:CAS:528:DC%2BD2cXnvFamsrg%3D 15466656 (Pubitemid 39331904)
18. T Maeda T Kawane N Horiuchi 2003 Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation Endocrinology 144 2 681 692 10.1210/en.2002-220682 1:CAS:528:DC%2BD3sXhtVWltLY%3D 12538631 (Pubitemid 36205242)
19. T Prueksaritanont JM Vega J Zhao K Gagliano O Kuznetsova B Musser RD Amin L Liu BA Roadcap S Dilzer KC Lasseter JD Rogers 2001 Interactions between simvastatin and troglitazone or pioglitazone in healthy subjects J Clin Pharmacol 41 5 573 581 10.1177/00912700122010311 1:CAS:528:DC%2BD3MXjvVaktrw%3D 11361054 (Pubitemid 32381875)
20. MS Nanes 2003 Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathology Gene 321 1 15 10.1016/S0378-1119(03)00841-2 1:CAS:528:DC%2BD3sXovFGhtro%3D 14636987 (Pubitemid 37421390)
21. I Kitajima Y Soejima I Takasaki H Beppu T Tokioka I Maruyama 1996 Ceramide-induced nuclear translocation of NF-kappa B is a potential mediator of the apoptotic response to TNF-alpha in murine clonal osteoblasts Bone 9 263 270 10.1016/8756-3282(96)00181-0 (Pubitemid 26302610)
22. PA Hill A Tumber MC Meikle 1997 Multiple extracellular signals promote osteoblast survival and apoptosis Endocrinology 138 3849 3858 10.1210/en.138.9.3849 1:CAS:528:DyaK2sXlsFaqt7s%3D 9275074 (Pubitemid 27351939)
23. RL Jilka RS Weinstein T Bellido AM Parfitt SC Manolagas 1998 Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines J Bone Miner Res 13 793 802 10.1359/jbmr.1998.13.5.793 1:CAS:528: DyaK1cXjsVaqurs%3D 9610743 (Pubitemid 28224195)
24. JM Hock V Krishnan JE Onyia JP Bidwell J Milas D Stanislaus 2001 Osteoblast apoptosis and bone turnover J Bone Miner Res 16 975 984 10.1359/jbmr.2001.16.6.975 1:CAS:528:DC%2BD3MXkt1Oru7Y%3D 11393794
25. M Tsuboi A Kawakami T Nakashima N Matsuoka S Urayama Y Kawabe K Fujiyama T Kiriyama T Aoyagi K Maeda K Eguchi 1999 Tumor necrosis factor-alpha and interleukin-1beta increase the Fas-mediated apoptosis of human osteoblasts J Lab Clin Med 134 222 231 10.1016/S0022-2143(99)90201-9 1:CAS:528:DyaK1MXmt1Whtrg%3D 10482306 (Pubitemid 29423094)
26. E Pascher A Perniok A Becker J Feldkamp 1999 Effect of 1alpha, 25(OH)2-vitamin D3 on TNF alpha-mediated apoptosis of human primary osteoblast-like cells in vitro Horm Metab Res 31 653 656 10.1055/s-2007-978815 1:CAS:528:DC%2BD3cXotF2lsQ%3D%3D 10668917
27. CM Hansen D Hansen PK Holm L Binderup 2001 Vitamin D compounds exert anti-apoptotic effects in human osteosarcoma cells in vitro J Steroid Biochem Mol Biol 77 1 11 10.1016/S0960-0760(01)00033-4 1:CAS:528:DC%2BD3MXkvFCgsr4%3D 11358669 (Pubitemid 32455348)
28. T Bellido M Huening M Raval-Pandya SC Manolagas S Christakos 2000 Calbindin-D28 k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase-3 activity J Biol Chem 275 26328 26332 10.1074/jbc.M003600200 1:CAS:528:DC%2BD3cXmt1Oktrc%3D 10835428 (Pubitemid 30676684)
29. HJ Chae SW Chae JS Kang BG Bang SB Cho RK Park HS So YK Kim HM Kim HR Kim 2000 Dexamethasone suppresses tumor necrosis factor-α-induced apoptosis in osteoblasts: possible role for ceramide Endocrinology 141 8 2904 2913 10.1210/en.141.8.2904 1:CAS:528:DC%2BD3cXnt1Cmsb4%3D 10919278 (Pubitemid 32250454)
30. S Chen DC Guttridge E Tang S Shi K Guan CY Wang 2001 Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor kappa B-independent bone morphogenetic protein/Smad signaling J Biol Chem 276 39259 39263 10.1074/jbc.M105335200 1:CAS:528:DC%2BD3MXnvVemsbw%3D 11500509
31. H Kaji J Naito Y Inoue H Sowa T Sugimoto K Chihara 2008 Statin suppresses apoptosis in osteoblastic cells: role of transforming growth factor-β-smad3 pathway Horm Metab Res 40 11 746 751 10.1055/s-0028-1082051 1:CAS:528:DC%2BD1MXlsFWntg%3D%3D 18622892