메뉴 건너뛰기




Volumn 5, Issue 2, 2010, Pages

Genetic and physiological activation of osmosensitive gene expression mimics transcriptional signatures of pathogen infection in C. elegans

Author keywords

[No Author keywords available]

Indexed keywords

RNA; TRANSCRIPTION FACTOR GATA; CAENORHABDITIS ELEGANS PROTEIN; ELT 2 PROTEIN, C ELEGANS; ELT 3 PROTEIN, C ELEGANS; ELT-2 PROTEIN, C ELEGANS; ELT-3 PROTEIN, C ELEGANS; SODIUM CHLORIDE;

EID: 77749305020     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009010     Document Type: Article
Times cited : (60)

References (51)
  • 1
    • 11844262607 scopus 로고    scopus 로고
    • Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans
    • Kim DH, Ausubel FM (2005) Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans. Curr Opin Immunol 17: 4-10.
    • (2005) Curr Opin Immunol , vol.17 , pp. 4-10
    • Kim, D.H.1    Ausubel, F.M.2
  • 2
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124: 783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 3
    • 20644433073 scopus 로고    scopus 로고
    • ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity
    • Matsuzawa A, Saegusa K, Noguchi T, Sadamitsu C, Nishitoh H, et al. (2005) ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol 6: 587-592.
    • (2005) Nat Immunol , vol.6 , pp. 587-592
    • Matsuzawa, A.1    Saegusa, K.2    Noguchi, T.3    Sadamitsu, C.4    Nishitoh, H.5
  • 4
    • 45549095755 scopus 로고    scopus 로고
    • Models of Caenorhabditis elegans infection by bacterial and fungal pathogens
    • Powell JR, Ausubel FM (2008) Models of Caenorhabditis elegans infection by bacterial and fungal pathogens. Methods Mol Biol 415: 403-427.
    • (2008) Methods Mol Biol , vol.415 , pp. 403-427
    • Powell, J.R.1    Ausubel, F.M.2
  • 5
    • 0033582314 scopus 로고    scopus 로고
    • Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis
    • Tan MW, Mahajan-Miklos S, Ausubel FM (1999) Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis. Proc Natl Acad Sci U S A 96: 715-720.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 715-720
    • Tan, M.W.1    Mahajan-Miklos, S.2    Ausubel, F.M.3
  • 6
    • 33846837395 scopus 로고    scopus 로고
    • Infection in a dish: High-throughput analyses of bacterial pathogenesis
    • Kurz CL, Ewbank JJ (2007) Infection in a dish: high-throughput analyses of bacterial pathogenesis. Curr Opin Microbiol 10: 10-16.
    • (2007) Curr Opin Microbiol , vol.10 , pp. 10-16
    • Kurz, C.L.1    Ewbank, J.J.2
  • 7
    • 0033534534 scopus 로고    scopus 로고
    • Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model
    • Mahajan-Miklos S, Tan MW, Rahme LG, Ausubel FM (1999) Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell 96: 47-56.
    • (1999) Cell , vol.96 , pp. 47-56
    • Mahajan-Miklos, S.1    Tan, M.W.2    Rahme, L.G.3    Ausubel, F.M.4
  • 8
    • 3342901591 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins
    • Huffman DL, Abrami L, Sasik R, Corbeil J, van der Goot FG, et al. (2004) Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins. Proc Natl Acad Sci U S A 101: 10995-11000.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10995-11000
    • Huffman, D.L.1    Abrami, L.2    Sasik, R.3    Corbeil, J.4    van der Goot, F.G.5
  • 9
    • 3342899839 scopus 로고    scopus 로고
    • Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase
    • Kim DH, Liberati NT, Mizuno T, Inoue H, Hisamoto N, et al. (2004) Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase. Proc Natl Acad Sci U S A 101: 10990-10994.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10990-10994
    • Kim, D.H.1    Liberati, N.T.2    Mizuno, T.3    Inoue, H.4    Hisamoto, N.5
  • 10
    • 33751382748 scopus 로고    scopus 로고
    • Troemel ER, Chu SW, Reinke V, Lee SS, Ausubel FM, et al. (2006) p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet 2: e183.
    • Troemel ER, Chu SW, Reinke V, Lee SS, Ausubel FM, et al. (2006) p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet 2: e183.
  • 11
    • 48249137383 scopus 로고    scopus 로고
    • Pujol N, Zugasti O, Wong D, Couillault C, Kurz CL, et al. (2008) Anti-fungal innate immunity in C. elegans is enhanced by evolutionary diversification of antimicrobial peptides. PLoS Pathog 4: e1000105.
    • Pujol N, Zugasti O, Wong D, Couillault C, Kurz CL, et al. (2008) Anti-fungal innate immunity in C. elegans is enhanced by evolutionary diversification of antimicrobial peptides. PLoS Pathog 4: e1000105.
  • 12
    • 33749014641 scopus 로고    scopus 로고
    • A conserved role for a GATA transcription factor in regulating epithelial innate immune responses
    • Shapira M, Hamlin BJ, Rong J, Chen K, Ronen M, et al. (2006) A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Proc Natl Acad Sci U S A 103: 14086-14091.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14086-14091
    • Shapira, M.1    Hamlin, B.J.2    Rong, J.3    Chen, K.4    Ronen, M.5
  • 14
    • 0036668278 scopus 로고    scopus 로고
    • The GATA family (vertebrates and invertebrates)
    • Patient RK, McGhee JD (2002) The GATA family (vertebrates and invertebrates). Curr Opin Genet Dev 12: 416-422.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 416-422
    • Patient, R.K.1    McGhee, J.D.2
  • 15
    • 33750492939 scopus 로고    scopus 로고
    • GATA factors participate in tissue-specific immune responses in Drosophila larvae
    • Senger K, Harris K, Levine M (2006) GATA factors participate in tissue-specific immune responses in Drosophila larvae. Proc Natl Acad Sci U S A 103: 15957-15962.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 15957-15962
    • Senger, K.1    Harris, K.2    Levine, M.3
  • 16
    • 0033565677 scopus 로고    scopus 로고
    • Serpent regulates Drosophila immunity genes in the larval fat body through an essential GATA motif
    • Petersen UM, Kadalayil L, Rehorn KP, Hoshizaki DK, Reuter R, et al. (1999) Serpent regulates Drosophila immunity genes in the larval fat body through an essential GATA motif. Embo J 18: 4013-4022.
    • (1999) Embo J , vol.18 , pp. 4013-4022
    • Petersen, U.M.1    Kadalayil, L.2    Rehorn, K.P.3    Hoshizaki, D.K.4    Reuter, R.5
  • 17
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl HL (1999) Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18: 6853-6866.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 18
    • 33747083190 scopus 로고    scopus 로고
    • Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression
    • Lamitina T, Huang CG, Strange K (2006) Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression. Proc Natl Acad Sci U S A 103: 12173-12178.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12173-12178
    • Lamitina, T.1    Huang, C.G.2    Strange, K.3
  • 20
    • 33745606008 scopus 로고    scopus 로고
    • Shen X, Ellis RE, Sakaki K, Kaufman RJ (2005) Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet 1: e37.
    • Shen X, Ellis RE, Sakaki K, Kaufman RJ (2005) Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet 1: e37.
  • 21
    • 20144362749 scopus 로고    scopus 로고
    • Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans
    • Shen C, Nettleton D, Jiang M, Kim SK, Powell-Coffman JA (2005) Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans. J Biol Chem 280: 20580-20588.
    • (2005) J Biol Chem , vol.280 , pp. 20580-20588
    • Shen, C.1    Nettleton, D.2    Jiang, M.3    Kim, S.K.4    Powell-Coffman, J.A.5
  • 22
    • 33751351093 scopus 로고    scopus 로고
    • Identification of a novel gene family involved in osmotic stress response in Caenorhabditis elegans
    • Wheeler JM, Thomas JH (2006) Identification of a novel gene family involved in osmotic stress response in Caenorhabditis elegans. Genetics 174: 1327-1336.
    • (2006) Genetics , vol.174 , pp. 1327-1336
    • Wheeler, J.M.1    Thomas, J.H.2
  • 23
    • 50249096721 scopus 로고    scopus 로고
    • OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development
    • Komatsu H, Chao MY, Larkins-Ford J, Corkins ME, Somers GA, et al. (2008) OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. PLoS Biol 6: e196.
    • (2008) PLoS Biol , vol.6
    • Komatsu, H.1    Chao, M.Y.2    Larkins-Ford, J.3    Corkins, M.E.4    Somers, G.A.5
  • 24
    • 0442272485 scopus 로고    scopus 로고
    • Crosstalk between the EGFR and LIN-12/ Notch pathways in C. elegans vulval development
    • Yoo AS, Bais C, Greenwald I (2004) Crosstalk between the EGFR and LIN-12/ Notch pathways in C. elegans vulval development. Science 303: 663-666.
    • (2004) Science , vol.303 , pp. 663-666
    • Yoo, A.S.1    Bais, C.2    Greenwald, I.3
  • 25
    • 33746727711 scopus 로고    scopus 로고
    • O'Rourke D, Baban D, Demidova M, Mott R, Hodgkin J (2006) Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum. Genome Res 16: 1005-1016.
    • O'Rourke D, Baban D, Demidova M, Mott R, Hodgkin J (2006) Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum. Genome Res 16: 1005-1016.
  • 26
    • 41549093748 scopus 로고    scopus 로고
    • Genomewide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection
    • Wong D, Bazopoulou D, Pujol N, Tavernarakis N, Ewbank JJ (2007) Genomewide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection. Genome Biol 8: R194.
    • (2007) Genome Biol , vol.8
    • Wong, D.1    Bazopoulou, D.2    Pujol, N.3    Tavernarakis, N.4    Ewbank, J.J.5
  • 27
    • 0034649644 scopus 로고    scopus 로고
    • A novel bacterial pathogen, Microbacterium nematophilum, induces morphological change in the nematode C. elegans
    • Hodgkin J, Kuwabara PE, Corneliussen B (2000) A novel bacterial pathogen, Microbacterium nematophilum, induces morphological change in the nematode C. elegans. Curr Biol 10: 1615-1618.
    • (2000) Curr Biol , vol.10 , pp. 1615-1618
    • Hodgkin, J.1    Kuwabara, P.E.2    Corneliussen, B.3
  • 28
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, et al. (2003) Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424: 277-283.
    • (2003) Nature , vol.424 , pp. 277-283
    • Murphy, C.T.1    McCarroll, S.A.2    Bargmann, C.I.3    Fraser, A.4    Kamath, R.S.5
  • 29
    • 33846818720 scopus 로고    scopus 로고
    • The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine
    • McGhee JD, Sleumer MC, Bilenky M, Wong K, McKay SJ, et al. (2007) The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine. Dev Biol 302: 627-645.
    • (2007) Dev Biol , vol.302 , pp. 627-645
    • McGhee, J.D.1    Sleumer, M.C.2    Bilenky, M.3    Wong, K.4    McKay, S.J.5
  • 30
    • 0032526161 scopus 로고    scopus 로고
    • The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine
    • Fukushige T, Hawkins MG, McGhee JD (1998) The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine. Dev Biol 198: 286-302.
    • (1998) Dev Biol , vol.198 , pp. 286-302
    • Fukushige, T.1    Hawkins, M.G.2    McGhee, J.D.3
  • 31
    • 0033485823 scopus 로고    scopus 로고
    • Yersinia enterocolitica type III secretion-translocation system: Channel formation by secreted Yops
    • Tardy F, Homble F, Neyt C, Wattiez R, Cornelis GR, et al. (1999) Yersinia enterocolitica type III secretion-translocation system: channel formation by secreted Yops. Embo J 18: 6793-6799.
    • (1999) Embo J , vol.18 , pp. 6793-6799
    • Tardy, F.1    Homble, F.2    Neyt, C.3    Wattiez, R.4    Cornelis, G.R.5
  • 32
    • 33846829776 scopus 로고    scopus 로고
    • Pore-forming toxins and cellular non-immune defenses (CNIDs)
    • Aroian R, van der Goot FG (2007) Pore-forming toxins and cellular non-immune defenses (CNIDs). Curr Opin Microbiol 10: 57-61.
    • (2007) Curr Opin Microbiol , vol.10 , pp. 57-61
    • Aroian, R.1    van der Goot, F.G.2
  • 33
    • 41949132625 scopus 로고    scopus 로고
    • Piecing together the type III injectisome of bacterial pathogens
    • Moraes TF, Spreter T, Strynadka NC (2008) Piecing together the type III injectisome of bacterial pathogens. Curr Opin Struct Biol 18: 258-266.
    • (2008) Curr Opin Struct Biol , vol.18 , pp. 258-266
    • Moraes, T.F.1    Spreter, T.2    Strynadka, N.C.3
  • 34
    • 3242674944 scopus 로고    scopus 로고
    • NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment
    • Go WY, Liu X, Roti MA, Liu F, Ho SN (2004) NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment. Proc Natl Acad Sci U S A 101: 10673-10678.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10673-10678
    • Go, W.Y.1    Liu, X.2    Roti, M.A.3    Liu, F.4    Ho, S.N.5
  • 35
    • 0037111409 scopus 로고    scopus 로고
    • The osmoprotective function of the NFAT5 transcription factor in T cell development and activation
    • Trama J, Go WY, Ho SN (2002) The osmoprotective function of the NFAT5 transcription factor in T cell development and activation. J Immunol 169: 5477-5488.
    • (2002) J Immunol , vol.169 , pp. 5477-5488
    • Trama, J.1    Go, W.Y.2    Ho, S.N.3
  • 36
    • 13044250453 scopus 로고    scopus 로고
    • Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity
    • Miyakawa H, Woo SK, Dahl SC, Handler JS, Kwon HM (1999) Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity. Proc Natl Acad Sci U S A 96: 2538-2542.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 2538-2542
    • Miyakawa, H.1    Woo, S.K.2    Dahl, S.C.3    Handler, J.S.4    Kwon, H.M.5
  • 37
    • 66249115983 scopus 로고    scopus 로고
    • Salty dog, an SLC5 symporter, modulates Drosophila response to salt stress
    • Stergiopoulos K, Cabrero P, Davies SA, Dow JA (2009) Salty dog, an SLC5 symporter, modulates Drosophila response to salt stress. Physiol Genomics 37: 1-11.
    • (2009) Physiol Genomics , vol.37 , pp. 1-11
    • Stergiopoulos, K.1    Cabrero, P.2    Davies, S.A.3    Dow, J.A.4
  • 38
    • 60549094760 scopus 로고    scopus 로고
    • ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult
    • McGhee JD, Fukushige T, Krause MW, Minnema SE, Goszczynski B, et al. (2009) ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult. Dev Biol 327: 551-565.
    • (2009) Dev Biol , vol.327 , pp. 551-565
    • McGhee, J.D.1    Fukushige, T.2    Krause, M.W.3    Minnema, S.E.4    Goszczynski, B.5
  • 39
    • 38949208736 scopus 로고    scopus 로고
    • Oxidative stress in Caenorhabditis elegans: Protective effects of the Omega class glutathione transferase (GSTO-1)
    • Burmeister C, Luersen K, Heinick A, Hussein A, Domagalski M, et al. (2008) Oxidative stress in Caenorhabditis elegans: protective effects of the Omega class glutathione transferase (GSTO-1). Faseb J 22: 343-354.
    • (2008) Faseb J , vol.22 , pp. 343-354
    • Burmeister, C.1    Luersen, K.2    Heinick, A.3    Hussein, A.4    Domagalski, M.5
  • 40
    • 38149059054 scopus 로고    scopus 로고
    • An iron enhancer element in the FTN-1 gene directs iron-dependent expression in Caenorhabditis elegans intestine
    • Romney SJ, Thacker C, Leibold EA (2008) An iron enhancer element in the FTN-1 gene directs iron-dependent expression in Caenorhabditis elegans intestine. J Biol Chem 283: 716-725.
    • (2008) J Biol Chem , vol.283 , pp. 716-725
    • Romney, S.J.1    Thacker, C.2    Leibold, E.A.3
  • 41
    • 0033569919 scopus 로고    scopus 로고
    • Regulation of metallothionein gene transcription. Identification of upstream regulatory elements and transcription factors responsible for cell-specific expression of the metallothionein genes from Caenorhabditis elegans
    • Moilanen LH, Fukushige T, Freedman JH (1999) Regulation of metallothionein gene transcription. Identification of upstream regulatory elements and transcription factors responsible for cell-specific expression of the metallothionein genes from Caenorhabditis elegans. J Biol Chem 274: 29655-29665.
    • (1999) J Biol Chem , vol.274 , pp. 29655-29665
    • Moilanen, L.H.1    Fukushige, T.2    Freedman, J.H.3
  • 42
    • 47549100826 scopus 로고    scopus 로고
    • An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans
    • Budovskaya YV, Wu K, Southworth LK, Jiang M, Tedesco P, et al. (2008) An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell 134: 291-303.
    • (2008) Cell , vol.134 , pp. 291-303
    • Budovskaya, Y.V.1    Wu, K.2    Southworth, L.K.3    Jiang, M.4    Tedesco, P.5
  • 43
    • 40849118472 scopus 로고    scopus 로고
    • Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
    • Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132: 1025-1038.
    • (2008) Cell , vol.132 , pp. 1025-1038
    • Tullet, J.M.1    Hertweck, M.2    An, J.H.3    Baker, J.4    Hwang, J.Y.5
  • 44
    • 25844490465 scopus 로고    scopus 로고
    • The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response
    • Inoue H, Hisamoto N, An JH, Oliveira RP, Nishida E, et al. (2005) The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev 19: 2278-2283.
    • (2005) Genes Dev , vol.19 , pp. 2278-2283
    • Inoue, H.1    Hisamoto, N.2    An, J.H.3    Oliveira, R.P.4    Nishida, E.5
  • 45
    • 28044446334 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3
    • An JH, Vranas K, Lucke M, Inoue H, Hisamoto N, et al. (2005) Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A 102: 16275-16280.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 16275-16280
    • An, J.H.1    Vranas, K.2    Lucke, M.3    Inoue, H.4    Hisamoto, N.5
  • 46
    • 66349105688 scopus 로고    scopus 로고
    • The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans
    • Choe KP, Przybysz AJ, Strange K (2009) The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Mol Cell Biol 29: 2704-2715.
    • (2009) Mol Cell Biol , vol.29 , pp. 2704-2715
    • Choe, K.P.1    Przybysz, A.J.2    Strange, K.3
  • 47
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restriction-induced longevity in C. elegans
    • Bishop NA, Guarente L (2007) Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447: 545-549.
    • (2007) Nature , vol.447 , pp. 545-549
    • Bishop, N.A.1    Guarente, L.2
  • 49
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher VG, Tibshirani R, Chu G (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 98: 5116-5121.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 50
    • 0036707816 scopus 로고    scopus 로고
    • Identification of transcription factor binding sites in the human genome sequence
    • Levy S, Hannenhalli S (2002) Identification of transcription factor binding sites in the human genome sequence. Mamm Genome 13: 510-514.
    • (2002) Mamm Genome , vol.13 , pp. 510-514
    • Levy, S.1    Hannenhalli, S.2
  • 51
    • 0035860551 scopus 로고    scopus 로고
    • A gene expression map for Caenorhabditis elegans
    • Kim SK, Lund J, Kiraly M, Duke K, Jiang M, et al. (2001) A gene expression map for Caenorhabditis elegans. Science 293: 2087-2092.
    • (2001) Science , vol.293 , pp. 2087-2092
    • Kim, S.K.1    Lund, J.2    Kiraly, M.3    Duke, K.4    Jiang, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.