The cell cycle effects of docosahexaenoic acid on human metastatic hepatocellular carcinoma proliferation

International Journal of Oncology

Volumn 36, Issue 4, 2010, Pages 991-998

  Lee, Carol Yee Ki ^a   Sit, Wai Hung ^a   Fan, Sheung Tat ^a   Man, Kwan ^a   Jor, Irene Wing Yan ^a   Wong, Leo Lap Yan ^a   Wan, Murphy Lam Yim ^a   Tan Un, Kian Cheng ^a   Wan, Jennifer Man Fan ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cell cycle; Cyclooxygenase 2; Docosahexaenoic acid; Hepatocellular carcinoma; 3 fatty acids

Indexed keywords

CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYCLOOXYGENASE 2; DOCOSAHEXAENOIC ACID; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN 27; POLYUNSATURATED FATTY ACID; SUPEROXIDE DISMUTASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER METASTASIS; ONCOGENE C MYB; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN A; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLOOXYGENASE 2; DNA REPLICATION; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAT-SHOCK PROTEINS; HSP27 HEAT-SHOCK PROTEINS; HUMANS; LIVER NEOPLASMS; PROTO-ONCOGENE PROTEINS C-MYC; RNA, MESSENGER; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 77749299218     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000579     Document Type: Article

References (55)

1. German JB, Roberts MA and Watkins SM: Genomics and metabolomics as markers for the interaction of diet and health: lessons from lipids. J Nutr 133: S2078-S2083, 2003.
2. Heller AR, Rössel T, Gottschlich B, Tiebel O, Menschikowski M, Litz RJ, Zimmermann T and Koch T: Omega-3 fatty acids improve liver and pancreas function in postoperative cancer patients. Int J Cancer 111: 611-616, 2004.
3. Norrish AE, Skeaff CE, Arribas GL, Sharpe SJ and Jackson RT: Prostate cancer risk and consumption of fish oils: a dietary biomarker-based case-control study. Br J Cancer 81: 1238-1242, 1999.
4. Reddy BS: Chemoprevention of colon cancer by dietary fatty acids. Cancer Metastasis Rev 13: 285-302, 1994.
5. Rose DP, Connolly JM, Rayburn J and Coleman M: Influence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude mice. J Natl Cancer Inst 87: 587-592, 1995.
6. Smith LC, Dauchy EM, Dauchy RT, Sauer LA, Blask DE, Davidson LK, Krause JA and Lynch DT: Dietary fish oil deactivates a growth-promoting signaling pathway in hepatoma 7288CTC in Buffalo rats. Nutr Cancer 56: 204-213, 2006.
7. Calviello G, Palozza P, Piccioni E, Maggiano N, Frattucci A, Franceschell P and Bartoli GM: Dietary supplementation with eicosapentaenoic and docosahexaenoic acid inhibits growth of Morris hepatocarcinoma 3924A in rats: effects on proliferation and apoptosis. Int J Cancer 75: 699-705, 1998.
8. Coleman WB: Mechanisms of human hepatocarcinogenesis. Curr Mol Med 3: 573-588, 2003.
9. Seitz HK and Stickel F: Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chem 387: 349-360, 2006.
10. Bosch FX, Ribes J and Borràs J: Epidemiology of primary liver cancer. Semin Liver Dis 19: 271-285, 1999.
11. Lee M and Bae MA: Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun Nterminal protein kinase related mitochondrial damage. J Nutr Biochem 18: 348-354, 2007.
12. Simopoulos AP, Kifer RR and Martin RE: Health effects of polyunsaturated fatty acids in seafoods. Academic Press Inc., New York, pp319-531, 1986.
13. Stubbs CD and Smith AD: The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim Biophys Acta 779: 89-137, 1984.
14. Bandyopadhyay GK, Hwang S, Imagawa W and Nandi S: Role of polyunsaturated fatty acids as signal transducers: amplification of signals from growth factor receptors by fatty acids in mammary epithelial cells. Prostaglandins Leukot Essent Fatty Acids 48: 71-78, 1993.
15. Istfan NW, Wan JM, Bistrian BR and Chen ZY: DNA replication time accounts for tumor growth variation induced by dietary fat in a breast carcinoma model. Cancer Lett 86: 177-186, 1994.
16. Albino AP, Juan G, Traganos F, Reinhart L, Connolly J, Rose DP and Darzynkiewicz Z: Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic acid: association with decreased pRb phosphorylation. Cancer Res 60: 4139-4145, 2000.
17. Chen ZY and Istfan NW: Docosahexaenoic acid, a major constituent of fish oil diets, prevents activation of cyclin-dependent kinases and S-phase entry by serum stimulation in HT-29 cells. Prostaglandins Leukot Essent. Fatty Acids 64: 67-73, 2001.
18. Terano T, Tanaka T, Tamura Y, Kitagawa M, Higashi H, Saito Y and Hirai A: Eicosapentaenoic acid and docosahexaenoic acid inhibit vascular smooth muscle cell proliferation by inhibiting phosphorylation of Cdk2-cyclinE complex. Biochem Biophys Res Commun 254: 502-506, 1999.
19. Lundberg AS and Weinberg RA: Control of the cell cycle and apoptosis. Eur J Cancer 35: 531-539, 1999.
20. Rao CV and Reddy BS: Modulating effect of amount and types of dietary fat on ornithine decarboxylase, tyrosine protein kinase and prostaglandins production during colon carcinogenesis in male F344 rats. Carcinogenesis 14: 1327-1333, 1993.
21. Tian J, Tang ZY, Ye SL, Liu YK, Lin ZY, Chen J and Xue Q: New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis. Br J Cancer 81: 814-821, 1999.
22. Li Y, Tang Z, Ye S, Liu B, Liu Y, Chen J and Xue Q: Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray. J Cancer Res Clin Oncol 129: 43-51, 2003.
23. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63, 1983.
24. Wan JMF, Sit WH and Louie JCY: Polysaccharopeptide enhances the anticancer activity of doxorubicin and etoposide on human breast cancer cells ZR-75-30. Int J Oncol 32: 689-699, 2008.
25. Dolbeare F, Gratzner H, Pallavicini MG and Gray JW: Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. Proc Natl Acad Sci USA 80: 5573-5577, 1983.
26. Begg AC, McNally NJ, Shrieve DC and Kärcher H: A method to measure the duration of DNA synthesis and the potential doubling time from a single sample. Cytometry 6: 620-626, 1985.
27. White RA, Terry NH and Meistrich ML: New methods for calculating kinetic properties of cells in vitro using pulse labelling with bromodeoxyuridine. Cell Tissue Kinet 23: 561-573, 1990.
28. Fogt F, Wan JM, O'Hara C, Bistrain BR, Blackburn GL and Istfan NW: Flow cytometric measurement of cell kinetics in rat walker-256 carcinoma following in vivo and in vitro pulse labelling with bromodeoxyuridine. Cytometry 12: 33-41, 1991.
29. Sherr CJ: G1 phase progression: cycling on cue. Cell 79: 551-555, 1994.
30. Hu KQ: Cyclooxygenase 2 (COX2)-prostanoid pathway and liver diseases. Prostaglandins Leukot Essent Fatty Acids 69: 329-337, 2003.
31. Wu T: Cyclooxygenase-2 in hepatocellular carcinoma. Cancer Treat Rev 32: 28-44, 2006.
32. Jurkowski JJ and Cave WTJ: Dietary effects of menhaden oil on the growth and membrane lipid composition of rat mammary tumors. J Natl Cancer Inst 74: 1145-1150, 1985.
33. Tang TCM, Poon RTP and Fan ST: The significance of cyclooxygenase-2 expression in human hepatocellular carcinoma, Biomed Pharmacother 59: S311-S316, 2005.
34. Strillacci A, Griffoni C, Sansone P, Paterini P, Piazzi G, Lazzarini G, Spisni E, Pantaleo MA, Biasco G and Tomasi V: MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells. Exp Cell Res 315: 1439-1447, 2009.
35. Wan JM, Istfan NW, Chu CC, Blackburn GL and Bistrian BR: Comparative effects of omega-3 and omega-6 polyunsaturated fatty acids on protein metabolism in rats bearing the mammary adenocarcinoma. Metabolism 40: 577-584, 1991.
36. Siddiqui RA, Jenski LJ, Harvey KA, Wiesehan JD, Stillwell W and Zaloga GP: Cell-cycle arrest in Jurkat leukaemic cells: a possible role for docosahexaenoic acid. Biochem J 371: 621-629, 2003.
37. Tang ZY, Ye SL, Liu YK, et al: A decade's studies on metastasis of hepatocellular carcinoma. J Cancer Res Clin Oncol 130: 187-196, 2004.
38. Cheng AS, Chan HL, Leung WK, Wong N, Johnson PJ and Sung JJ: Specific COX-2 inhibitor, NS-398, suppresses cellular proliferation and induces apoptosis in human hepatocellular carcinoma cells. Int J Oncol 23: 113-119, 2003.
39. Nagahara T, Okano J and Murawaki Y: Mechanisms of antiproliferative effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on human liver cancer cells. Oncol Rep 18: 1281-1290, 2007.
40. Marui N, Sakai T, Hosokawa N, et al: N-myc suppression and cell cycle arrest at G1 phase by prostaglandins. FEBS Lett 270: 15-18, 1990.
41. Akiba J, Ogasawara S, Kawahara A, et al: N-myc downstream regulated gene 1 (NDRG1)/Cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma. Oncol Rep 20: 1329-1335, 2008.
42. Chua MS, Sun H, Cheung ST, Mason V, Higgins J, Ross DT, Fan ST and So S: Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma. Mod Pathol 20: 76-83, 2007.
43. Ciocca DR, Fanelli MA, Cuello-Carrion F and Calderwoodet SK: Implications of heat shock proteins in carcinogenesis and cancer progression. In: Heat Shock Proteins in Cancer. Springer, Dordrecht, pp31-52, 2007.
44. Yasuda E, Kumada T, Takai S, Ishisaki A, Noda T, Matsushima-Nishiwaki R, Yoshimi N, Kato K, Toyoda H, Kaneoka Y, Yamaguchi A and Kozawa O: Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma. Biochem Biophys Res Commun 337: 337-342, 2005.
45. Lim SO, Park SG, Yoo JH, Park YM, Kim HJ, Jang KT, Cho JW, Yoo BC, Jung GH and Park CK: Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules. World J Gastroenterol 11: 2072-2079, 2005.
46. King KL, Li AF, Chau GY, Chi CW, Wu CW, Huang CL and Lui WY: Prognostic significance of heat shock protein-27 expression in hepatocellular carcinoma and its relation to histologic grading and survival. Cancer 88: 2464-2470, 2000.
47. Baumeister P, Dong D, Fu Y and Lee AS: Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis. Mol Cancer Ther 8: 1086-1094, 2009.
48. Daneshmand S, Quek ML, Lin E, et al: Pinski, glucoseregulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival. Hum Pathol 38: 1547-1552, 2007.
49. Chiang PC, Hsu JL, Yeh TC, Pan SL and Guh JH: Elucidation of susceptible factors to endoplasmic reticulum stress-mediated anticancer activity in human hepatocellular carcinoma. Naunyn Schmiedebergs Arch Pharmacol 377: 167-177, 2008.
50. Satomi A, Murakami S, Hashimoto T, Ishida K, Matsuki M and Sonoda M: Significance of superoxide dismutase (SOD) in human colorectal cancer tissue: correlation with malignant intensity. J Gastroenterol 30: 177-182, 1995.
51. Jeon SH, Park JH and Chang SG: Expression of antioxidant enzymes, catalase, superoxide dismutase, and glutathione peroxidase, in human bladder cancer. Korean J Urol 48: 921-926, 2007.
52. Kumar GS and Das UN: Free radical-dependent suppression of growth of mouse myeloma cells by alpha-linolenic and eicosapentaenoic acids in vitro. Cancer Lett 92: 27-38, 1995.
53. Ding WQ, Vaught JL, Yamauchi H and Lind SE: Differential sensitivity of cancer cells to docosahexaenoic acid-induced cytotoxicity: the potential importance of down-regulation of superoxide dismutase 1 expression. Mol Cancer Ther 3: 1109-1117, 2004.
54. Huang ZZ, Chen C, Zeng Z, et al: Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration. FASEB J 15: 19-21, 2001.
55. Balendiran GK, Dabur R and Fraser D: The role of glutathione in cancer. Cell Biochem Funct 22: 343-352, 2004.