Novel small molecules relieve prothymosin α-mediated inhibition of apoptosome formation by blocking its interaction with Apaf-1

Biochemistry

Volumn 49, Issue 9, 2010, Pages 1923-1930

  Qi, Xin ^a,b   Wang, Lai ^a   Du, Fenghe ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; APOPTOSOMES; CASPASE-3; CASPASE-3 ACTIVATION; CYTOCHROME C; HELA CELL; HETERONUCLEAR; HIGH-THROUGHPUT SCREENING; HUMAN CANCER; IN-VITRO; MECHANISM OF ACTION; NUCLEAR PROTEINS; PROCASPASE; QUANTUM CORRELATIONS; SMALL MOLECULES; STRESS-INDUCED; TARGET PROTEINS;

CELL DEATH; PROTEINS;

DIAGNOSIS;

5 (2 BENZOFURYL) 4 PHENYL 1,2,4 TRIAZOLE 3 THIOL; APOPTOSOME; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; CYTOCHROME C; HEAT SHOCK PROTEIN 70; HLA ANTIGEN; NITROGEN 15; PROCASPASE 3; PROCASPASE 9; PROTHYMOSIN ALPHA; PROTON; PUTATIVE HLA DR ASSOCIATED PROTEIN; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRESS; CONTROLLED STUDY; ENZYME ACTIVATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; REGULATORY MECHANISM;

ANIMALS; APOPTOSIS; APOPTOSOMES; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 3; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; HELA CELLS; HUMANS; MITOCHONDRIA; PROTEIN BINDING; PROTEIN PRECURSORS; RECOMBINANT PROTEINS; SPODOPTERA; THYMOSIN; TRIAZOLES;

EID: 77749259049     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi9022329     Document Type: Article

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