p8 and prothymosin alpha: Unity is strength

Cell Cycle

Volumn 5, Issue 8, 2006, Pages 829-830

  Malicet, Cédric ^a   Dagorn, Jean Charles ^a   Neira, José Luis ^b,c   Iovanna, Juan L ^a  

^a INSERM   (France)

^b MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^c UNIVERSITY OF ZARAGOZA   (Spain)

Author keywords

Apoptosis; Caspases; Natively unstructured protein; p8; Protein complex; Prothymosin alpha; Two hybrid system

Indexed keywords

HETERODIMER; PROTEIN; PROTEIN P8; PROTHYMOSIN ALPHA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; DRUG INHIBITION; GENE OVEREXPRESSION; HUMAN; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE; PROTEIN FOLDING; PROTEIN STRUCTURE; SHORT SURVEY;

EID: 33746584890     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.8.2686     Document Type: Short Survey

References (15)

1. Weinreb PH, Zhen W, Poon AW, Conway KA, Lansbury PT Jr. NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 1996 35:13709-15.
2. Wright PE, Dyson HJ. Intrinsically unstructured proteins: re-assessing the protein structurefunction paradigm. J Mol Biol 1999 293:321-31.
3. Dunker AK, Lawson JD, Brown CJ, Williams RM, Romero P, Oh JS, Oldfield CJ, Campen AM, Ratliff CM, Hipps KW, Ausio J, Nissen MS, Reeves R, Kang C, Kissinger CR, Bailey RW, Griswold MD, Chiu W, Garner EC, Obradovic Z. Intrinsically disordered protein. J Mol Graph Model 2001 19:26-59.
4. Gamblin TC. Potential structure/function relationships of predicted secondary structural elements of tau. Biochim Biophys Acta 2005 1739:140-9
5. Uversky VN. A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders. J Biomol Struct Dyn 2003 21:211-34.
6. Encinar JA, Mallo GV, Mizyrycki C, Giono L, Gonzalez-Ros JM, Rico M, Canepa E, Moreno S, Neira JL, Iovanna JL. Human p8 is a HMG-I/Y-like protein with DNA binding activity enhanced by phosphorylation. J Biol Chem 2001 276:2742-51.
7. Su SB, Motoo Y, Iovanna JL, Berthezene P, Xie MJ, Mouri H, Ohtsubo K, Matsubara F, Sawabu N. Overexpression of p8 is inversely correlated with apoptosis in pancreatic cancer. Clin Cancer Res 2001 7:1320-4.
8. Vasseur S, Hoffmeister A, Garcia S, Bagnis C, Dagorn JC, Iovanna JL. p8 is critical for tumour development induced by rasV12 mutated protein and E1A oncogene. EMBO Rep 2002 3:165-70.
9. Giroux V, Malicet C, Barthet M, Gironella M, Archange C, Dagorn JC, Vasseur S, Iovanna JL. p8 is a new target of gemcitabine in pancreatic cancer cells. Clin Cancer Res 2006 12:235-41.
10. Malicet C, Giroux V, Vasseur S, Dagorn JC, Neira JL, Iovanna JL. Regulation of apoptosis by the p8/prothymosin {alpha} complex. Proc Natl Acad Sci USA 2006 Feb 14; [Epub ahead of print].
11. Segade F, Gomez-Marquez J. Prothymosin alpha. Int J Biochem Cell Biol 1999 31:1243-8.
12. Rodriguez P, Vinuela JE, Alvarez-Fernandez L, Buceta M, Vidal A, Dominguez F, Gomez-Marquez J. Overexpression of prothymosin alpha accelerates proliferation and retards differentiation in HL-60 cells. Biochem J 1998 331:753-61.
13. Gomez-Marquez J, Rodriguez P. Prothymosin alpha is a chromatin- remodelling protein in mammalian cells. Biochem J 1998 333:1-3.
14. Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC, Rosenberg S, Wang X. Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science 2003 299:223-6.
15. Evstafieva AG, Belov GA, Rubtsov YP, Kalkum M, Joseph B, Chichkova NV, Sukhacheva EA, Bogdanov AA, Pettersson RF, Agol VI, Vartapetian AB. Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha. Exp Cell Res 2003 284:211-23.