Optimal number of regulatory T cells

Journal of Theoretical Biology

Volumn 263, Issue 2, 2010, Pages 210-218

  Saeki, Koichi ^a   Iwasa, Yoh ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Antigen presenting cells; Co localization; Regulatory T cells; Self tolerance

Indexed keywords

ANTIGEN;

ANTIGEN; BLOOD; CELL ORGANELLE; IMMUNITY; OPTIMIZATION; PATHOGEN; SPATIAL DISTRIBUTION;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL INTERACTION; EFFECTOR CELL; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE COUNT; MATHEMATICAL MODEL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

ANTIGEN-PRESENTING CELLS; HUMANS; T-LYMPHOCYTES, REGULATORY;

VERTEBRATA;

EID: 77649342306     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2009.11.012     Document Type: Article

References (36)

1. Abbas A.K., Lichtman A.H. Basic Immunology: Functions and Disorders of the Immune System 2007, Elsevier, Amsterdam. second updated ed.
2. Bautista J.L., Lio C.W.J., Lathrop S.K., Forbush K., Liang Y., Luo J., Rudensky A.Y., Hsieh C.S. Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nat. Immunol. 2009, 10:610-617.
3. Benoist C., Mathis D. Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?. Nat. Immunol. 2001, 2:797-801.
4. Borghans J.A.M., Noest A.J., De Boer R.J. How specific should immunological memory be?. J. Immunol. 1999, 163:569-575.
5. Burroughs N.J., de Oliveira B.M.P.M., Pinto A.A. Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses. J. Theor. Biol. 2006, 241:134-141.
6. Burroughs N.J., de Oliveira B.M.P.M., Pinto A.A., Sequeira H.J.T. Sensibility of the quorum growth thresholds controlling immune responses. Math. Comput. Modelling 2008, 47:714-725.
7. Carneiro J., Leon K., van den Dool C., Gardner R., Oloveira V., Bergman M.L., Sepulveda N., Paixao T. When three is not a crowd: a crossregulation model of the dynamics and repertoire selection of regulatory CD4(+) T cells. Immunol. Rev. 2007, 216:48-68.
8. Cobbold S.P., Adams E., Marshall S.E., Davies J.D., Waldmann H. Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8. Immunol. Rev. 1996, 149:5-33.
9. Cools, N., Ponsaerts, P., Van Tendeloo, V.F.I., Berneman, Z.N., 2007. Regulatory T cells and human disease. Clin. Dev. Immunol., doi:10.1155/2007/89195.
10. Davies J.D., Leong L.Y., Mellor A., Cobbold S.P., Waldmann H. T cell suppression in transplantation tolerance through linked recognition. J. Immunol. 1996, 156:3602-3607.
11. De Boer R.J., Perelson A.S. How diverse should the immune system be?. Proc. R. Soc. London B Biol. Sci. 1993, 252:171-175.
12. Frasca L., Carmichael P., Lechler R., Lombardi G. Anergic T cells effect linked suppression. Eur. J. Immunol. 1997, 27:3191-3197.
13. Hsieh C.S., Zheng Y., Fontenot J.D., Rudensky A.Y. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertories. Nat. Immunol. 2006, 7:401-410.
14. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2001, 2:301-306.
15. Kappler J.W., Roehm N., Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987, 49:273-280.
16. Leon K., Perez R., Lage A., Carneiro J. Modeling T-cell-mediated suppression dependent on interactions in multicellular conjugates. J. Theor. Biol. 2000, 207:231-254.
17. Leon K., Lage A., Carneiro J. Tolerance and immunity in a mathematical model of T-cell mediated suppression. J. Theor. Biol. 2003, 225:107-126.
18. Miyara M., Sakaguchi S. Natural regulatory T cells: mechanism of suppression. Trends Mol. Med. 2007, 13:108-116.
19. Modigliani Y., Bandeira A., Coutinho A. A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens. Immunol. Rev. 1996, 149:155-220.
20. Ohashi P.S., Oehen S., Buerki K., Pircher H., Ohashi C.T., Odermatt B., Malissen B., Zinkernagel R.M., Henartner H. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 1991, 65:305-317.
21. Perelson A.S., Oster G.F. Theoretical studies of clonal selection: minimal antibody repertoire size and reliability of self-non-self discrimination. J. Theor. Biol. 1979, 81:645-670.
22. Saeki K., Iwasa Y. Advantage of having regulatory T cells requires localized suppression of immune reactions. J. Theor. Biol. 2009, 260:392-401.
23. Sakaguchi S. Naturally arising CD4(+) regulatory T cells for immunologic self tolerance and negative control of immune responses. Annu. Rev. Immunol. 2004, 22:531-562.
24. Sakaguchi S., Sakaguchi N. Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease. J. Exp. Med. 1990, 172:537-545.
25. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Break down of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995, 155:1151-1164.
26. Schwartz R.H. T cell clonal anergy. Curr. Opin. Immunol. 1997, 9:351-357.
27. Seddon B., Mason D. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J. Exp. Med. 1999, 189:877-881.
28. Shudo E., Iwasa Y. Inducible defense against pathogens and parasites: optimal choice among multiple options. J. Theor. Biol. 2001, 209:233-247.
29. Shudo E., Iwasa Y. Optimal defense strategy: storage versus new production. J. Theor. Biol. 2002, 219:309-323.
30. Shudo E., Iwasa Y. Dynamic optimization of defense, immune memory, and post-infection pathogen levels in mammals. J. Theor. Biol. 2004, 228:17-29.
31. Shudo E., Haccou P., Iwasa Y. Optimal choice between feedforward and feedback control in gene expression to cope with unpredictable danger. J. Theor. Biol. 2003, 223:149-160.
32. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 2000, 164:183-190.
33. Van Santen H.M., Benoist C., Mathis D. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 2004, 200:1221-1230.
34. Vukmanovic-Stejic M., Zhang Y., Cook J.E., Flecher J.M., McQuaid A., Masters J.E., Rustin M.H.A., Taams L.S., Beverley P.C.L., Macalan D.C., Akbar A.N. Human CD4+CD25hiFoxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J. Clin. Invest. 2006, 116:2423-2433.
35. Wise M.P., Bemelman F., Cobbold S.P., Waldmann H. Linked suppression of skin graft rejection can operate through indirect recognition. J. Immunol. 1998, 161:5813-5816.
36. Yata J. Textbook of Immunology for Medical Students and Physicians 2007, Chugai-Igaku, Tokyo, (in Japanese). tenth ed.