Sensibility of the quorum growth thresholds controlling local immune responses

Mathematical and Computer Modelling

Volumn 47, Issue 7-8, 2008, Pages 714-725

  Burroughs, N J ^a   Oliveira, B M P M ^b   Pinto, A A ^b   Sequeira, H J T ^b  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Cytokines; Growth model; Immunology; ODE model; Quorum threshold; Secretion inhibition; Tregs

Indexed keywords

ENZYME INHIBITION; GROWTH RATE; MATHEMATICAL MODELS; PROTEINS;

QUORUM THRESHOLD; SECRETION INHIBITION; TREGS;

IMMUNOLOGY;

EID: 40249116758     PISSN: 08957177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcm.2007.06.007     Document Type: Article

References (26)

1. + T cell receptors. Immunity 21 (2004) 267-277
2. + regulatory T cells for immunological self-tolerance and negative control of immune responses. Annual Review of Immunology 22 (2004) 531-562
3. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukine 2 production. The Journal of Experimental Medicine 188 2 (1998) 287-296
4. Shevach E.M., McHugh R.S., Piccirillo C.A., and Thornton A.M. Control of T-cell activation by CD4(+)CD25(+) suppressor T cells. Immunological Reviews 182 (2001) 58-67
5. + regulatory T cell function. The Journal of Experimental Medicine 196 6 (2002) 851-857
6. + regulatory T cells function. European Journal of Immunology 34 9 (2004) 2480-2488
7. Thornton A.M., Donovan E.E., Piccirillo C.A., and Shevach E.M. Cutting edge: IL-2 is critically required for the in vitro activation of CD4(+)CD25(+) T cell suppressor function. The Journal of Immunology 172 (2004) 6519-6523
8. + immunoregulatory T cells is antigen nonspecific. The Journal of Immunology 164 (2000) 183-190
9. Tanchot C., Vasseur F., Pontoux C., Garcia C., and Sarukhan A. Immune regulation by self-reactive T cells is antigen specific. The Journal of Immunology 172 (2004) 4285-4291
10. Burroughs N.J., Oliveira B.M.P.M., and Pinto A.A. Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses. Journal of Theoretical Biology 241 (2006) 134-141
11. Schluns K.S., Kieper W.C., Jameson S.C., and Lefrancois L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nature Immunology 1 (2000) 426-432
12. Nagata S. Fas ligand-induced apoptosis. Annual Review of Genetics 33 (1999) 29-55
13. Michie C., McLean A., Alcock C., and Beverley P. Life-span of human lymphocyte subsets defined by CD45 isoforms. Nature 360 (1992) 264-265
14. Moskophidis D., Battegay M., van den Broek M., Laine E., Hoffmann-Rohrer U., and Zinkernagel R. Role of virus and host variables in virus persistence or immunopathological disease caused by a noncytolytic virus. The Journal of General Virology 76 (1995) 381
15. + T cells to antigen stimulation in vivo. Nature Immunology 1 (2000) 47-53
16. Anderson P.M., and Sorenson M.A. Effects of route and formulation on clinical pharmacokinetics of interleukine-2. Clinical Pharmacokinetics 27 (1994) 19-31
17. Lowenthal J.W., and Greene W.C. Contrasting interleukine 2 binding properties of the alpha (p55) and beta (p70) protein subunits of the human high-affinity interleukine 2 receptor. The Journal of Experimental Medicine 166 (1987) 1156-1161
18. de Boer R.J., and Hogeweg P. Immunological discrimination between self and non-self by precursor depletion and memory accumulation. Journal of Theoretical Biology 124 (1987) 343
19. McLean A.R. Modelling T cell memory. Journal of Theoretical Biology 170 (1994) 63-74
20. Utzny C., and Burroughs N.J. Perturbation theory analysis of competition in a heterogeneous population. Physica D 175 (2003) 109-126
21. Callard R.E., Stark J., and Yates A.J. Fratricide: A mechanism for T memory-cell homeostasis. Trends in Immunology 24 (2003) 370-375
22. Leon K., Perez R., Lage A., and Carneiro J. Modelling T-cell-mediated suppression dependent on interactions in multicellular conjugates. Journal of Theoretical Biology 207 (2000) 231-254
23. Leon K., Lage A., and Carneiro J. Tolerance and immunity in a mathematical model of T-cell mediated suppression. Journal of Theoretical Biology 225 (2003) 107-126
24. N.J. Burroughs, B.M.P.M. Oliveira, A.A. Pinto, H. Sequeira, Stability analysis of a model of local immune responses with regulatory T cells (submitted for publication)
25. van Stipdonk M.J.B., Lemmens E.E., and Schoenberger S.P. Naive ctls require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nature Immunology 2 (2001) 423-429
26. Chan C., Lechler R.I., and George A.J.T. Tolerance mechanisms and recent progress. Transplantation Proceedings 36 (2004) 561S-569S