Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation

International Journal of Biochemistry and Cell Biology

Volumn 42, Issue 5, 2010, Pages 725-735

  Hjerpe, Roland ^a   Aillet, Fabienne ^a   Lopitz Otsoa, Fernando ^a   Lang, Valerie ^a   Torres Ramos, Mónica ^a   Farrás, Rosa ^c   Hay, Ronald T ^d   Rodríguez, Manuel S ^a,b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^c CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Degradation; Mdm2; p53; Polyubiquitylation; Proteasome

Indexed keywords

HYBRID PROTEIN; MONOMER; PROTEASOME; PROTEIN MDM2; PROTEIN P53; PROTEIN SUBUNIT; TETRAMER;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OLIGOMERIZATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UBIQUITINATION; WILD TYPE;

ANIMALS; CELL LINE, TUMOR; CELL NUCLEUS; GENES, REPORTER; HUMANS; MICE; MICE, KNOCKOUT; POLYUBIQUITIN; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-MDM2; RECOMBINANT FUSION PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASE COMPLEXES; UBIQUITINATION;

EID: 77649341348     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2010.01.010     Document Type: Article

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