Peripheral administration of fetuin-A attenuates early cerebral ischemic injury in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 30, Issue 3, 2010, Pages 493-504

  Wang, Haichao ^a,b   Li, Wei ^b   Zhu, Shu ^b   Li, Jianhua ^a   D'Amore, Jason ^b   Ward, Mary F ^b   Yang, Huan ^a   Wu, Rongqian ^a   Jahnen Dechent, Willi ^c   Tracey, Kevin J ^a   Wang, Ping ^a   Sama, Andrew E ^a,b  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Fetuin A; Inflammation; Ischemia

Indexed keywords

FETUIN A; HIGH MOBILITY GROUP B1 PROTEIN; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG BRAIN LEVEL; DRUG PENETRATION; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT; TIME;

ANIMALS; BLOOD PROTEINS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; BRAIN ISCHEMIA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE CEREBRAL ARTERY; RATS; RATS, INBRED LEW; REGIONAL BLOOD FLOW;

EID: 77649273279     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.247     Document Type: Article

References (40)

1. Akopov SE, Simonian NA, Grigorian GS (1996) Dynamics of polymorphonuclear leukocyte accumulation in acute cerebral infarction and their correlation with brain tissue damage. Stroke 27:1739-1743
2. Andersson U, Wang H, Palmblad K, Aveberger AC, Bloom O, Erlandsson-Harris H, Janson A, Kokkola R, Zhang M, Yang H, Tracey KJ (2000) High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med 192:565-570
3. Barone FC, Parsons AA (2000) Therapeutic potential of anti-inflammatory drugs in focal stroke. Expert Opin Invest Drugs 9:2281-2306
4. Belayev L, Busto R, Zhao W, Ginsberg MD (1996) Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res 739:88-96
5. Botchkina GI, Meistrell ME, Botchkina IL, Tracey KJ (1997) Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia. Mol Med 3:765-781
6. Czurko A, Nishino H (1994) Appearance of immunog-lobulin G and complement factor C3 in the striatum after transient focal ischemia in the rat. Neurosci Lett 166:51-54
7. Demetriou M, Binkert C, Sukhu B, Tenenbaum HC, Dennis JW (1996) Fetuin/alpha2-HS glycoprotein is a transforming growth factor-beta type II receptor mimic and cytokine antagonist. J Biol Chem 271:12755-12761
8. Dziegielewska KM, Andersen NA, Saunders NR (1998) Modification of macrophage response to lipopolysac-charide by fetuin. Immunol Lett 60:31-35
9. Dziegielewska KM, Brown WM (1995) Fetuin. Austin, Texas: Landes Co., Springer Verlag
10. Feuerstein GZ, Wang X, Barone FC (1998) The role of cytokines in the neuropathology of stroke and neuro-trauma. Neuroimmunomodulation 5:143-159
11. Ivanova S, Botchkina GI, Al-Abed Y, Meistrell M, Batliwalla F, Dubinsky JM, Iadecola C, Wang H, Gregersen PK, Eaton JW, Tracey KJ (1998) Cerebral ischemia enhances polyamine oxidation: identification of enzymatically formed 3-aminopropanal as an endogenous mediator of neuronal and glial cell death. J Exp Med 188:327-340
12. Kim JB, Sig CJ, Yu YM, Nam K, Piao CS, Kim SW, Lee MH, Han PL, Park JS, Lee JK (2006) HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain. J Neurosci 26:6413-6421
13. Lee JM, Zipfel GJ, Choi DW (1999) The changing landscape of ischaemic brain injury mechanisms. Nature 399 (Suppl):A7-14
14. Li W, Li J, Ashok M, Wu R, Chen D, Yang L, Yang H, Tracey KJ, Wang P, Sama AE, Wang H (2007) A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol 178:3856-3864
15. Liu K, Mori S, Takahashi HK, Tomono Y, Wake H, Kanke T, Sato Y, Hiraga N, Adachi N, Yoshino T, Nishibori M (2007) Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats. FASEB J 21:3904-3916
16. Lv B, Wang H, Tang Y, Fan Z, Xiao X, Chen F (2009) High-mobility group box 1 protein induces tissue factor expression in vascular endothelial cells via activation of NF-kappaB and Egr-1. Thromb Haemost 102:352-359
17. Mathews ST, Srinivas PR, Leon MA, Grunberger G (1997) Bovine fetuin is an inhibitor of insulin receptor tyrosine kinase. Life Sci 61:1583-1592
18. Meistrell ME, Botchkina GI, Wang H, Di Santo E, Cockroft KM, Bloom O, Vishnubhakat JM, Ghezzi P, Tracey KJ (1997) Tumor necrosis factor is a brain damaging cytokine in cerebral ischemia. Shock 8:341-348
19. Merenmies J, Pihlaskari R, Laitinen J, Wartiovaara J, Rauvala H (1991) 30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane. J Biol Chem 266:16722-16729
20. Muhammad S, Barakat W, Stoyanov S, Murikinati S, Yang H, Tracey KJ, Bendszus M, Rossetti G, Nawroth PP, Bierhaus A, Schwaninger M (2008) The HMGB1 receptor RAGE mediates ischemic brain damage. J Neurosci 28:12023-12031
21. Muramatsu K, Fukuda A, Togari H, Wada Y, Nishino H (1997) Vulnerability to cerebral hypoxic-ischemic insult in neonatal but not in adult rats is in parallel with disruption of the blood-brain barrier. Stroke 28:2281-2288
22. O'Connor KA, Hansen MK, Rachal PC, Deak MM, Bieden-kapp JC, Milligan ED, Johnson JD, Wang H, Maier SF, Tracey KJ, Watkins LR (2003) Further characterization of high mobility group box 1 (HMGB1) as a proinflamma-tory cytokine: central nervous system effects. Cytokine 24:254-265
23. Olivier E, Soury E, Ruminy P, Husson A, Parmentier F, Daveau M, Salier JP (2000) Fetuin-B, a second member of the fetuin family in mammals. Biochem J 350(Part 2):589-597
24. Ombrellino M, Wang H, Yang H, Zhang M, Vishnubhakat J, Frazier A, Scher LA, Friedman SG, Tracey KJ (2001) Fetuin, a negative acute phase protein, attenuates TNF synthesis and the innate inflammatory response to carrageenan. Shock 15:181-185
25. Qiu J, Nishimura M, Wang Y, Sims JR, Qiu S, Savitz SI, Salomone S, Moskowitz MA (2008) Early release of HMGB-1 from neurons after the onset of brain ischemia. J Cereb Blood Flow Metab 28:927-938
26. Rendon-Mitchell B, Ochani M, Li J, Han J, Wang H, Yang H, Susarla S, Czura C, Mitchell RA, Chen G, Sama AE, Tracey KJ, Wang H (2003) IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism. J Immunol 170:3890-3897
27. Saunders NR, Sheardown SA, Deal A, Mollgard K, Reader M, Dziegielewska KM (1994) Expression and distribution of fetuin in the developing sheep fetus. Histochem-istry 102:457-475
28. Scaffidi P, Misteli T, Bianchi ME (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418:191-195
29. Suzuki M, Shimokawa H, Takagi Y, Sasaki S (1994) Calcium-binding properties of fetuin in fetal bovine serum. J Exp Zool 270:501-507
30. Szweras M, Liu D, Partridge EA, Pawling J, Sukhu B, Clokie C, Jahnen-Dechent W, Tenenbaum HC, Swallow CJ, Grynpas MD, Dennis JW (2002) Alpha 2-HS glycopro-tein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling. J Biol Chem 277:19991-19997
31. Tuttolomondo A, Di Raimondo D, Di Sciacca R, Casuccio A, Bivona G, Bellia C, Barreca L, Serio A, D'Aguanno G, Ciaccio M, Licata G, Pinto A (2009) Fetuin-A and CD40L plasma levels in acute ischemic stroke: differences in relation to TOAST subtype and correlation with clinical and laboratory variables. Atherosclerosis (in press)
32. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J, Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ (1999) HMG-1 as a late mediator of endotoxin lethality in mice. Science 285:248-251
33. Wang H, Ward MF, Sama AE (2009) Novel HMGB1-inhibiting therapeutic agents for experimental sepsis. Shock 32:348-357
34. Wang H, Zhang M, Bianchi M, Sherry B, Sama A, Tracey KJ (1998) Fetuin (alpha2-HS-glycoprotein) opsonizes catio-nic macrophage-deactivating molecules. Proc Natl Acad Sci USA 95:14429-14434
35. Wang H, Zhang M, Soda K, Sama A, Tracey KJ (1997) Fetuin protects the fetus from TNF [letter]. Lancet 350:861-862
36. Weikert C, Stefan N, Schulze MB, Pischon T, Berger K, Joost HG, Haring HU, Boeing H, Fritsche A (2008) Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke. Circulation 118:2555-2562
37. Yang QW, Wang JZ, Li JC, Zhou Y, Zhong Q, Lu FL, Xiang J (2009) High-mobility group protein box-1 and its relevance to cerebral ischemia. J Cereb Blood Flow Metab (in press)
38. Zhang M, Caragine T, Wang H, Cohen PS, Botchkina G, Soda K, Bianchi M, Ulrich P, Cerami A, Sherry B, Tracey KJ (1997) Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counterregu-latory mechanism that restrains the immune response. J Exp Med 185:1759-1768
39. Zhu S, Ashok M, Li J, Li W, Yang H, Wang P, Tracey KJ, Sama AE, Wang H (2009) Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers. Mol Med 15:275-282
40. Zubrow AB, Numagami Y, Fritz KI, Mishra OP, Delivoria-Papadopoulos M (2000) Spermine dependent activation of the N-methyl-D-aspartate receptor and the effect of nitric oxide synthase inhibition during hypoxia in the cerebral cortex of newborn piglets. Brain Res 854:11-18 (Pubitemid 30067655)