메뉴 건너뛰기




Volumn 24, Issue 6, 2006, Pages 877-889

Structure of the Papillomavirus DNA-Tethering Complex E2:Brd4 and a Peptide that Ablates HPV Chromosomal Association

Author keywords

DNA; MICROBIO

Indexed keywords

CHROMOSOME PROTEIN; GLYCOPROTEIN E2; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MUTANT PROTEIN; PEPTIDE; PLASMID DNA; PROTEIN BRD4; TRANSACTIVATOR PROTEIN; VIRUS DNA;

EID: 33845626875     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2006.11.002     Document Type: Article
Times cited : (102)

References (49)
  • 1
    • 4043175756 scopus 로고    scopus 로고
    • The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2
    • Abbate E.A., Berger J.M., and Botchan M.R. The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2. Genes Dev. 18 (2004) 1981-1996
    • (2004) Genes Dev. , vol.18 , pp. 1981-1996
    • Abbate, E.A.1    Berger, J.M.2    Botchan, M.R.3
  • 4
    • 12344269394 scopus 로고    scopus 로고
    • The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4
    • Baxter M.K., McPhillips M.G., Ozato K., and McBride A.A. The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4. J. Virol. 79 (2005) 4806-4818
    • (2005) J. Virol. , vol.79 , pp. 4806-4818
    • Baxter, M.K.1    McPhillips, M.G.2    Ozato, K.3    McBride, A.A.4
  • 5
    • 2042538028 scopus 로고    scopus 로고
    • Hitchhiking without covalent integration
    • Botchan M. Hitchhiking without covalent integration. Cell 117 (2004) 280-281
    • (2004) Cell , vol.117 , pp. 280-281
    • Botchan, M.1
  • 6
    • 14544296179 scopus 로고    scopus 로고
    • Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein
    • Brannon A.R., Maresca J.A., Boeke J.D., Basrai M.A., and McBride A.A. Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein. Proc. Natl. Acad. Sci. USA 102 (2005) 2998-3003
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 2998-3003
    • Brannon, A.R.1    Maresca, J.A.2    Boeke, J.D.3    Basrai, M.A.4    McBride, A.A.5
  • 8
    • 33646447971 scopus 로고    scopus 로고
    • Dynamic localization of the human papillomavirus type 11 origin binding protein E2 through mitosis while in association with the spindle apparatus
    • Dao L.D., Duffy A., Van Tine B.A., Wu S.Y., Chiang C.M., Broker T.R., and Chow L.T. Dynamic localization of the human papillomavirus type 11 origin binding protein E2 through mitosis while in association with the spindle apparatus. J. Virol. 80 (2006) 4792-4800
    • (2006) J. Virol. , vol.80 , pp. 4792-4800
    • Dao, L.D.1    Duffy, A.2    Van Tine, B.A.3    Wu, S.Y.4    Chiang, C.M.5    Broker, T.R.6    Chow, L.T.7
  • 10
    • 0031025688 scopus 로고    scopus 로고
    • Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis
    • Desaintes C., Demeret C., Goyat S., Yaniv M., and Thierry F. Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis. EMBO J. 16 (1997) 504-514
    • (1997) EMBO J. , vol.16 , pp. 504-514
    • Desaintes, C.1    Demeret, C.2    Goyat, S.3    Yaniv, M.4    Thierry, F.5
  • 12
    • 0041806599 scopus 로고    scopus 로고
    • The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis
    • Dey A., Chitsaz F., Abbasi A., Misteli T., and Ozato K. The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. Proc. Natl. Acad. Sci. USA 100 (2003) 8758-8763
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8758-8763
    • Dey, A.1    Chitsaz, F.2    Abbasi, A.3    Misteli, T.4    Ozato, K.5
  • 13
    • 0029903007 scopus 로고    scopus 로고
    • Genetic analysis of the activation domain of bovine papillomavirus protein E2: its role in transcription and replication
    • Ferguson M.K., and Botchan M.R. Genetic analysis of the activation domain of bovine papillomavirus protein E2: its role in transcription and replication. J. Virol. 70 (1996) 4193-4199
    • (1996) J. Virol. , vol.70 , pp. 4193-4199
    • Ferguson, M.K.1    Botchan, M.R.2
  • 14
    • 0033522799 scopus 로고    scopus 로고
    • Crystal structure of the human papillomavirus type 18 E2 activation domain
    • Harris S.F., and Botchan M.R. Crystal structure of the human papillomavirus type 18 E2 activation domain. Science 284 (1999) 1673-1677
    • (1999) Science , vol.284 , pp. 1673-1677
    • Harris, S.F.1    Botchan, M.R.2
  • 15
    • 0000557446 scopus 로고    scopus 로고
    • Papillomavirinae: the viruses and their replication
    • Fields B.N., Knipe D.M., Howley P.M., Chanock R.M., Melnick J.L., Monath T.P., Roizman B., and Straus S.E. (Eds), Lippincott-Raven, Philadelphia
    • Howley P.M. Papillomavirinae: the viruses and their replication. In: Fields B.N., Knipe D.M., Howley P.M., Chanock R.M., Melnick J.L., Monath T.P., Roizman B., and Straus S.E. (Eds). Fields Virology (1996), Lippincott-Raven, Philadelphia 2045-2076
    • (1996) Fields Virology , pp. 2045-2076
    • Howley, P.M.1
  • 16
    • 0026671624 scopus 로고
    • Differentiation-induced and constitutive transcription of human papillomavirus type 31b in cell lines containing viral episomes
    • Hummel M., Hudson J.B., and Laimins L.A. Differentiation-induced and constitutive transcription of human papillomavirus type 31b in cell lines containing viral episomes. J. Virol. 66 (1992) 6070-6080
    • (1992) J. Virol. , vol.66 , pp. 6070-6080
    • Hummel, M.1    Hudson, J.B.2    Laimins, L.A.3
  • 17
    • 33645220568 scopus 로고    scopus 로고
    • Brd4 is involved in multiple processes of the bovine papillomavirus type 1 life cycle
    • Ilves I., Maemets K., Silla T., Janikson K., and Ustav M. Brd4 is involved in multiple processes of the bovine papillomavirus type 1 life cycle. J. Virol. 80 (2006) 3660-3665
    • (2006) J. Virol. , vol.80 , pp. 3660-3665
    • Ilves, I.1    Maemets, K.2    Silla, T.3    Janikson, K.4    Ustav, M.5
  • 18
    • 23744514308 scopus 로고    scopus 로고
    • The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
    • Jang M.K., Mochizuki K., Zhou M., Jeong H.S., Brady J.N., and Ozato K. The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol. Cell 19 (2005) 523-534
    • (2005) Mol. Cell , vol.19 , pp. 523-534
    • Jang, M.K.1    Mochizuki, K.2    Zhou, M.3    Jeong, H.S.4    Brady, J.N.5    Ozato, K.6
  • 19
    • 0028937867 scopus 로고
    • Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells
    • Jeon S., Allen-Hoffmann B.L., and Lambert P.F. Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells. J. Virol. 69 (1995) 2989-2997
    • (1995) J. Virol. , vol.69 , pp. 2989-2997
    • Jeon, S.1    Allen-Hoffmann, B.L.2    Lambert, P.F.3
  • 20
    • 84889120137 scopus 로고
    • Improved methods for building protein models in electron density maps and the location of errors in these models
    • Jones T.A., Zou J.Y., Cowan S.W., and Kjeldgaard M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47 Pt 2 (1991) 110-119
    • (1991) Acta Crystallogr. A , vol.47 , Issue.PART 2 , pp. 110-119
    • Jones, T.A.1    Zou, J.Y.2    Cowan, S.W.3    Kjeldgaard, M.4
  • 21
    • 0030852350 scopus 로고    scopus 로고
    • Automated refinement for protein crystallography
    • Lamzin V.S., and Wilson K.S. Automated refinement for protein crystallography. Methods Enzymol. 277 (1997) 269-305
    • (1997) Methods Enzymol. , vol.277 , pp. 269-305
    • Lamzin, V.S.1    Wilson, K.S.2
  • 22
  • 23
    • 0032516030 scopus 로고    scopus 로고
    • Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation
    • Lehman C.W., and Botchan M.R. Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation. Proc. Natl. Acad. Sci. USA 95 (1998) 4338-4343
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 4338-4343
    • Lehman, C.W.1    Botchan, M.R.2
  • 24
    • 0030901534 scopus 로고    scopus 로고
    • A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention
    • Lehman C.W., King D.S., and Botchan M.R. A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention. J. Virol. 71 (1997) 3652-3665
    • (1997) J. Virol. , vol.71 , pp. 3652-3665
    • Lehman, C.W.1    King, D.S.2    Botchan, M.R.3
  • 25
    • 33746191826 scopus 로고    scopus 로고
    • Brd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomaviruses
    • McPhillips M.G., Oliveira J.G., Spindler J.E., Mitra R., and McBride A.A. Brd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomaviruses. J. Virol. 80 (2006) 9530-9543
    • (2006) J. Virol. , vol.80 , pp. 9530-9543
    • McPhillips, M.G.1    Oliveira, J.G.2    Spindler, J.E.3    Mitra, R.4    McBride, A.A.5
  • 26
    • 0025613266 scopus 로고
    • Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator
    • Mohr I.J., Clark R., Sun S., Androphy E.J., MacPherson P., and Botchan M.R. Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator. Science 250 (1990) 1694-1699
    • (1990) Science , vol.250 , pp. 1694-1699
    • Mohr, I.J.1    Clark, R.2    Sun, S.3    Androphy, E.J.4    MacPherson, P.5    Botchan, M.R.6
  • 28
    • 31944442800 scopus 로고    scopus 로고
    • Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin
    • Nishiyama A., Dey A., Miyazaki J., and Ozato K. Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. Mol. Biol. Cell 17 (2006) 814-823
    • (2006) Mol. Biol. Cell , vol.17 , pp. 814-823
    • Nishiyama, A.1    Dey, A.2    Miyazaki, J.3    Ozato, K.4
  • 29
    • 32244439372 scopus 로고    scopus 로고
    • Variations in the association of papillomavirus E2 proteins with mitotic chromosomes
    • Oliveira J.G., Colf L.A., and McBride A.A. Variations in the association of papillomavirus E2 proteins with mitotic chromosomes. Proc. Natl. Acad. Sci. USA 103 (2006) 1047-1052
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 1047-1052
    • Oliveira, J.G.1    Colf, L.A.2    McBride, A.A.3
  • 30
    • 0031059866 scopus 로고    scopus 로고
    • Processing of X-ray diffraction data collected in oscillation mode
    • Otwinowski Z., and Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276 (1997) 307-326
    • (1997) Methods Enzymol. , vol.276 , pp. 307-326
    • Otwinowski, Z.1    Minor, W.2
  • 31
    • 0036246659 scopus 로고    scopus 로고
    • Mutational analysis of a human immunodeficiency virus type 1 Tat protein transduction domain which is required for delivery of an exogenous protein into mammalian cells
    • Park J., Ryu J., Kim K.A., Lee H.J., Bahn J.H., Han K., Choi E.Y., Lee K.S., Kwon H.Y., and Choi S.Y. Mutational analysis of a human immunodeficiency virus type 1 Tat protein transduction domain which is required for delivery of an exogenous protein into mammalian cells. J. Gen. Virol. 83 (2002) 1173-1181
    • (2002) J. Gen. Virol. , vol.83 , pp. 1173-1181
    • Park, J.1    Ryu, J.2    Kim, K.A.3    Lee, H.J.4    Bahn, J.H.5    Han, K.6    Choi, E.Y.7    Lee, K.S.8    Kwon, H.Y.9    Choi, S.Y.10
  • 32
    • 0030048803 scopus 로고    scopus 로고
    • Cis and trans requirements for stable episomal maintenance of the BPV-1 replicator
    • Piirsoo M., Ustav E., Mandel T., Stenlund A., and Ustav M. Cis and trans requirements for stable episomal maintenance of the BPV-1 replicator. EMBO J. 15 (1996) 1-11
    • (1996) EMBO J. , vol.15 , pp. 1-11
    • Piirsoo, M.1    Ustav, E.2    Mandel, T.3    Stenlund, A.4    Ustav, M.5
  • 33
    • 0030069004 scopus 로고    scopus 로고
    • Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions
    • Sakai H., Yasugi T., Benson J.D., Dowhanick J.J., and Howley P.M. Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions. J. Virol. 70 (1996) 1602-1611
    • (1996) J. Virol. , vol.70 , pp. 1602-1611
    • Sakai, H.1    Yasugi, T.2    Benson, J.D.3    Dowhanick, J.J.4    Howley, P.M.5
  • 34
    • 27544513633 scopus 로고    scopus 로고
    • Gene bookmarking: keeping the pages open
    • Sarge K.D., and Park-Sarge O.K. Gene bookmarking: keeping the pages open. Trends Biochem. Sci. 30 (2005) 605-610
    • (2005) Trends Biochem. Sci. , vol.30 , pp. 605-610
    • Sarge, K.D.1    Park-Sarge, O.K.2
  • 35
    • 33646205576 scopus 로고    scopus 로고
    • Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function
    • Schweiger M.R., You J., and Howley P.M. Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. J. Virol. 80 (2006) 4276-4285
    • (2006) J. Virol. , vol.80 , pp. 4276-4285
    • Schweiger, M.R.1    You, J.2    Howley, P.M.3
  • 36
    • 0029617680 scopus 로고
    • Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro
    • Sedman J., and Stenlund A. Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro. EMBO J. 14 (1995) 6218-6228
    • (1995) EMBO J. , vol.14 , pp. 6218-6228
    • Sedman, J.1    Stenlund, A.2
  • 37
    • 0027400464 scopus 로고
    • Bovine papilloma virus (BPV)-encoded E2 protein enhances binding of E1 protein to the BPV replication origin
    • Seo Y.S., Muller F., Lusky M., Gibbs E., Kim H.Y., Phillips B., and Hurwitz J. Bovine papilloma virus (BPV)-encoded E2 protein enhances binding of E1 protein to the BPV replication origin. Proc. Natl. Acad. Sci. USA 90 (1993) 2865-2869
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2865-2869
    • Seo, Y.S.1    Muller, F.2    Lusky, M.3    Gibbs, E.4    Kim, H.Y.5    Phillips, B.6    Hurwitz, J.7
  • 38
    • 0024591199 scopus 로고
    • Properties of a non-tumorigenic human cervical keratinocyte cell line
    • Stanley M.A., Browne H.M., Appleby M., and Minson A.C. Properties of a non-tumorigenic human cervical keratinocyte cell line. Int. J. Cancer 43 (1989) 672-676
    • (1989) Int. J. Cancer , vol.43 , pp. 672-676
    • Stanley, M.A.1    Browne, H.M.2    Appleby, M.3    Minson, A.C.4
  • 39
    • 3042613550 scopus 로고    scopus 로고
    • Likelihood-enhanced fast rotation functions
    • 10.1107/S0907444903028956 Published online February 25, 2004
    • Storoni L.C., McCoy A.J., and Read R.J. Likelihood-enhanced fast rotation functions. Acta Crystallogr. D Biol. Crystallogr. 60 (2004) 432-438 10.1107/S0907444903028956 Published online February 25, 2004
    • (2004) Acta Crystallogr. D Biol. Crystallogr. , vol.60 , pp. 432-438
    • Storoni, L.C.1    McCoy, A.J.2    Read, R.J.3
  • 40
    • 0031687934 scopus 로고    scopus 로고
    • Transactivation by the E2 protein of oncogenic human papillomavirus type 31 is not essential for early and late viral functions
    • Stubenrauch F., Colbert A.M., and Laimins L.A. Transactivation by the E2 protein of oncogenic human papillomavirus type 31 is not essential for early and late viral functions. J. Virol. 72 (1998) 8115-8123
    • (1998) J. Virol. , vol.72 , pp. 8115-8123
    • Stubenrauch, F.1    Colbert, A.M.2    Laimins, L.A.3
  • 42
    • 27144433485 scopus 로고    scopus 로고
    • Brd2/RING3 interacts with a chromatin-binding domain in the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1
    • Viejo-Borbolla A., Ottinger M., Bruning E., Burger A., Konig R., Kati E., Sheldon J.A., and Schulz T.F. Brd2/RING3 interacts with a chromatin-binding domain in the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1. J. Virol. 79 (2005) 13618-13629
    • (2005) J. Virol. , vol.79 , pp. 13618-13629
    • Viejo-Borbolla, A.1    Ottinger, M.2    Bruning, E.3    Burger, A.4    Konig, R.5    Kati, E.6    Sheldon, J.A.7    Schulz, T.F.8
  • 43
    • 0036118402 scopus 로고    scopus 로고
    • E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes
    • Voitenleitner C., and Botchan M. E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes. J. Virol. 76 (2002) 3440-3451
    • (2002) J. Virol. , vol.76 , pp. 3440-3451
    • Voitenleitner, C.1    Botchan, M.2
  • 44
    • 0034614650 scopus 로고    scopus 로고
    • The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway
    • Webster K., Parish J., Pandya M., Stern P.L., Clarke A.R., and Gaston K. The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway. J. Biol. Chem. 275 (2000) 87-94
    • (2000) J. Biol. Chem. , vol.275 , pp. 87-94
    • Webster, K.1    Parish, J.2    Pandya, M.3    Stern, P.L.4    Clarke, A.R.5    Gaston, K.6
  • 46
    • 0025989907 scopus 로고
    • Activation of BPV-1 replication in vitro by the transcription factor E2
    • Yang L., Li R., Mohr I.J., Clark R., and Botchan M.R. Activation of BPV-1 replication in vitro by the transcription factor E2. Nature 353 (1991) 628-632
    • (1991) Nature , vol.353 , pp. 628-632
    • Yang, L.1    Li, R.2    Mohr, I.J.3    Clark, R.4    Botchan, M.R.5
  • 47
    • 23744467035 scopus 로고    scopus 로고
    • Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4
    • Yang Z., Yik J.H., Chen R., He N., Jang M.K., Ozato K., and Zhou Q. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol. Cell 19 (2005) 535-545
    • (2005) Mol. Cell , vol.19 , pp. 535-545
    • Yang, Z.1    Yik, J.H.2    Chen, R.3    He, N.4    Jang, M.K.5    Ozato, K.6    Zhou, Q.7
  • 48
    • 2042468820 scopus 로고    scopus 로고
    • Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes
    • You J., Croyle J.L., Nishimura A., Ozato K., and Howley P.M. Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. Cell 117 (2004) 349-360
    • (2004) Cell , vol.117 , pp. 349-360
    • You, J.1    Croyle, J.L.2    Nishimura, A.3    Ozato, K.4    Howley, P.M.5
  • 49
    • 33748484257 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes
    • You J., Srinivasan V., Denis G.V., Harrington Jr. W.J., Ballestas M.E., Kaye K.M., and Howley P.M. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J. Virol. 80 (2006) 8909-8919
    • (2006) J. Virol. , vol.80 , pp. 8909-8919
    • You, J.1    Srinivasan, V.2    Denis, G.V.3    Harrington Jr., W.J.4    Ballestas, M.E.5    Kaye, K.M.6    Howley, P.M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.