Improvement of cephalosporin c production by recombinant DNA integration in acremonium chrysogenum

Molecular Biotechnology

Volumn 44, Issue 2, 2010, Pages 101-109

  Liu, Yan ^a   Gong, Guihua ^a   Xie, Liping ^a   Yuan, Ning ^a   Zhu, Chunbao ^a   Zhu, Baoquan ^a   Hu, Youjia ^a  

^a SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY   (China)

Author keywords

Acremonium chrysogenum; Cephalosporin C; Molecular breeding; Strain improvement

Indexed keywords

ABSORBANCES; ACREMONIUM; ANTI-INFECTIOUS; BACTERIAL HEMOGLOBIN; BIOLOGICAL ACTIVITIES; CEPHALOSPORIN C; EFFLUX PUMPS; FERMENTATION BROTHS; HPLC ANALYSIS; INDUSTRIAL STRAIN; MOLECULAR BREEDING; PARENTAL STRAINS; PRODUCTION LEVEL; RECOMBINANT DNA; SOUTHERN BLOTTING; STRAIN IMPROVEMENT; SYNERGY EFFECT; TRANSFORMANTS; VITREOSCILLA HEMOGLOBIN;

BIOCHEMISTRY; CARBON MONOXIDE; CORROSION PREVENTION; DNA; FERMENTATION; GENES; GENETIC ENGINEERING; HEMOGLOBIN; SEWAGE TREATMENT PLANTS;

SOLAR CONCENTRATORS;

CEPHALOSPORIN C; HEMOGLOBIN; RECOMBINANT DNA;

ARTICLE; BIOLOGICAL ACTIVITY; CEFEF GENE; CEFG GENE; CEPHALOSPORIUM ACREMONIUM; CHROMOSOME; CONTROLLED STUDY; DNA INTEGRATION; FERMENTATION; FUNGAL GENE; FUNGAL STRAIN; GENE EXPRESSION; GENETIC CODE; GENETIC STABILITY; NONHUMAN; NUCLEOTIDE SEQUENCE; RECOMBINANT PLASMID; VGB GENE; VITREOSCILLA;

ACREMONIUM; CEPHALOSPORINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA, RECOMBINANT; FERMENTATION; GENE EXPRESSION REGULATION, FUNGAL; MODELS, GENETIC;

ACREMONIUM CHRYSOGENUM; BACTERIA (MICROORGANISMS); VITREOSCILLA;

EID: 77649239095     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12033-009-9214-4     Document Type: Article

References (25)

1. S Gutierrez B Diez E Montenegro JF Martin 1991 Characterization of the Cephalosporium acremonium pcbAB gene encoding alpha-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: linkage to the pcbC gene as a cluster of early cephalosporin biosynthetic genes and evidence of multiple functional domains Journal of Bacteriology 173 2354 2365 1:CAS:528: DyaK3MXlslKitrs%3D
2. S Samsom R Belagaje D Blankenship J Chapman D Perry P Skatrud R van Frank E Abraham J Baldwin S Queener T Ingolia 1985 Isolation, sequence determination and expression in Escherichia coli of the isopenicillin N synthetase gene from Cephalosporium acremonium Nature 318 191 194 10.1038/318191a0 (Pubitemid 16192590)
3. RV Ullan J Casqueiro O Banuelos FJ Fernandez S Gutierrez JF Martin 2002 A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum Journal of Biological Chemistry 277 46216 46225 10.1074/jbc.M207482200 1:CAS:528:DC%2BD38XovFKhsrY%3D (Pubitemid 35417613)
4. JF Martin RV Ullan J Casqueiro 2004 Novel genes involved in cephalosporin biosynthesis: the three-component isopenicillin N epimerase system Advances in Biochemical Engineering/Biotechnology 88 91 109 1:CAS:528:DC%2BD2MXis1GltrY%3D
5. S Samsom J Dotzlaf M Slisz G Becker R Van Frank L Veal WK Yeh J Miller S Queener T Ingolia 1987 Cloning and expression of the fungal expandase/ hydroxylase gene involved in cephalosporin biosynthesis Bio/Technology 5 1207 1214 10.1038/nbt1187-1207 (Pubitemid 18133935)
6. S Gutierrez J Velasco FJ Fernandez JF Martin 1992 The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase Journal of Bacteriology 174 3056 3064 1:CAS:528: DyaK3sXitVKgt7s%3D
7. JE Dotzlaf WK Yeh 1987 Copurification and characterization of deacetoxycephalosporin C synthetase/hydroxylase from Cephalosporium acremonium Journal of Bacteriology 169 1611 1618 1:CAS:528:DyaL2sXktF2rsrs%3D
8. J Velasco S Gutierrez S Campoy JF Martin 1999 Molecular characterization of the Acremonium chrysogenum cefG gene product: the native deacetylcephalosporin C acetyltransferase is not processed into subunits Biochemical Journal 337 Pt 3 379 385 10.1042/0264-6021:3370379 1:CAS:528:DyaK1MXhsFykuro%3D (Pubitemid 29082350)
9. RV Ullan G Liu J Casqueiro S Gutierrez O Banuelos JF Martin 2002 The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production Mol Genet Genomics 267 673 683 10.1007/s00438-002-0702-5 1:CAS:528:DC%2BD38XntFaksLk%3D (Pubitemid 34824197)
10. P Skatrud A Tietz T Ingolia C Cantwell D Fisher J Chapman S Queener 1989 Use of recombinant DNA to improve production of cephalosporin C by Cephalosporium acremonium Bio/Technology 7 477 485 10.1038/nbt0589-477 1:CAS:528:DyaL1MXkslKnt7Y%3D (Pubitemid 19118880)
11. S Gutierrez J Velasco AT Marcos FJ Fernandez F Fierro JL Barredo B Diez JF Martin 1997 Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum Applied Microbiology and Biotechnology 48 606 614 10.1007/s002530051103 1:CAS:528:DyaK2sXnsl2rsr8%3D (Pubitemid 27511584)
12. JA DeModena S Gutierrez J Velasco FJ Fernandez RA Fachini JL Galazzo DE Hughes JF Martin 1993 The production of cephalosporin C by Acremonium chrysogenum is improved by the intracellular expression of a bacterial hemoglobin Bio/Technology 11 926 929 10.1038/nbt0893-926 1:CAS:528: DyaK3sXms12jtLs%3D (Pubitemid 23218982)
13. Xu, W. Zhu, C.-B. Zhu, B.-Q.and Yao, X.-S. (2004) A new method for isolation of chromosomal DNA from filamentous fungus Cephalosporium acremonium. Journal of Shenyang Pharmaceutical University, 21, 226-229, 236.
14. PL Skatrud SW Queener LG Carr DL Fisher 1987 Efficient integrative transformation of Cephalosporium acremonium Current Genetics 12 337 348 10.1007/BF00405756 1:CAS:528:DyaL2sXmtFaqsLw%3D
15. ES Peterson S Huang J Wang LM Miller G Vidugiris AP Kloek DE Goldberg MR Chance JB Wittenberg JM Friedman 1997 A comparison of functional and structural consequences of the tyrosine B10 and glutamine E7 motifs in two invertebrate hemoglobins (Ascaris suum and Lucina pectinata) Biochemistry 36 13110 13121 10.1021/bi971156n 1:CAS:528:DyaK2sXmsVegs78%3D (Pubitemid 27465427)
16. P-Y Zhang C-B Zhu B-Q Zhu 2004 Cloning of bidirectional pcbAB-pcbC promoter region from Cephalosporium acremonium and its application Acta Microbiologica Sinica 44 255 257 1:CAS:528:DC%2BD2MXitVyktrw%3D
17. D Chen N Yuan Y-J Hu C-B Zhu W-J Zhao B-Q Zhu 2006 Cloning, expression and activity analysis of DAC-acetyltransferase gene from Acremonium chrysogenum Chinese Journal of Antibiotics 31 395 399 1:CAS:528:DC%2BD2sXht1CqurfM
18. V Meyer D Mueller T Strowig U Stahl 2003 Comparison of different transformation methods for Aspergillus giganteus Current Genetics 43 371 377 10.1007/s00294-003-0406-3 1:CAS:528:DC%2BD3sXltFCntLs%3D (Pubitemid 37021064)
19. P Ellaiah K Adinarayana GM Chand GS Subramanyam B Srinivasulu 2002 Strain improvement studies for cephalosporin C production by Cephalosporium acremonium Pharmazie 57 489 490 1:CAS:528:DC%2BD38XlsFSktrw%3D
20. P Ellaiah JP Kumar V Saisha JJ Sumitra P Vaishali 2003 Strain improvement studies on production of cephalosporin C from Acremonium chrysogenum ATCC 48272 Hindustan Antibiot Bull 45-46 11 15
21. MS Lee JS Lim CH Kim KK Oh DR Yang SW Kim 2001 Enhancement of cephalosporin C production by cultivation of Cephalosporium acremonium M25 using a mixture of inocula Letters in Applied Microbiology 32 402 406 10.1046/j.1472-765X.2001.00931.x 1:CAS:528:DC%2BD3MXltVKrtLY%3D (Pubitemid 32521334)
22. A Matsuda H Sugiura K Matsuyama H Matsumoto S Ichikawa K Komatsu 1992 Cloning and disruption of the cefG gene encoding acetyl coenzyme A: deacetylcephalosporin C o-acetyltransferase from Acremonium chrysogenum Biochemical and Biophysical Research Communications 186 40 46 10.1016/S0006-291X(05)80772-7 1:CAS:528:DyaK3sXisVyktb8%3D
23. L Mathison C Soliday T Stepan T Aldrich J Rambosek 1993 Cloning, characterization, and use in strain improvement of the Cephalosporium acremonium gene cefG encoding acetyl transferase Current Genetics 23 33 41 10.1007/BF00336747 1:CAS:528:DyaK3sXisVyqur0%3D (Pubitemid 23006333)
24. JG Nijland A Kovalchuk MA van den Berg RA Bovenberg AJ Driessen 2008 Expression of the transporter encoded by the cefT gene of Acremonium chrysogenum increases cephalosporin production in Penicillium chrysogenum Fungal Genetics and Biology 45 1415 1421 10.1016/j.fgb.2008.07.008 1:CAS:528:DC%2BD1cXht1ejtbbJ
25. M Rodriguez-Saiz M Lembo L Bertetti R Muraca J Velasco A Malcangi JL de la Fuente JL Barredo 2004 Strain improvement for cephalosporin production by Acremonium chrysogenum using geneticin as a suitable transformation marker FEMS Microbiology Letters 235 43 49 1:CAS:528:DC%2BD2cXktF2rsr0%3D