Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 15, 2007, Pages 4173-4177

  Hikishima, Sadao ^a   Hashimoto, Mariko ^a   Magnowska, Lucyna ^b   Bzowska, Agnieszka ^b   Yokomatsu, Tsutomu ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b UNIVERSITY OF WARSAW   (Poland)

Author keywords

9 Deazaguanine; Difluoromethylene phosphonic acids; Multi substrate analogue inhibitors; Purine nucleoside phosphorylase; Sonogashira reactions

Indexed keywords

9 (5',5' DIFLUOR 5' PHOSPHONOPENTYL)GUANINE; 9 (5',5' DIFLUORO 5' PHOSPHONOPENTYL) 9 DEAZAGUANINE; 9 DEAZA 9 IODOGUANINE DERIVATIVE; DIFLUOROMETHYLENE PHOSPHONIC ACID; GUANINE DERIVATIVE; OMEGA ALKYNYLDIFLUOROMETHYLENE PHOSPHONIC ACID DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PURINE NUCLEOSIDE PHOSPHORYLASE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ERYTHROCYTE; HUMAN; HUMAN CELL; NONHUMAN; SPLEEN; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATTLE; CLODRONIC ACID; ENZYME INHIBITORS; ERYTHROCYTES; GUANINE; HUMANS; MODELS, MOLECULAR; PURINE-NUCLEOSIDE PHOSPHORYLASE; SPLEEN; SUBSTRATE SPECIFICITY;

EID: 34347374647     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.054     Document Type: Article

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