Nitric oxide donors or nitrite counteract copper-[dithiocarbamate] 2-mediated tumor cell death and inducible nitric oxide synthase down-regulation: Possible role of a nitrosyl-copper [dithiocarbamate] 2 complex

Journal of Medicinal Chemistry

Volumn 53, Issue 4, 2010, Pages 1627-1635

  Rhenals, Maricela Viola ^a   Strasberg Rieber, Mary ^a   Rieberst, Manuel ^a  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 CARBOXYPHENYL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 1 OXYL 3 OXIDE; COBALT CHLORIDE; DIETHYLDITHIOCARBAMIC ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; N ACETYL S NITROSOPENICILLAMINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE DONOR; NITRITE; NITROPRUSSIDE SODIUM; NITROSYL COPPER [DITHIOCARBAMATE]2 COMPLEX; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CYTOTOXICITY; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFICACY; DRUG MECHANISM; HUMAN; HUMAN CELL; HYPOXIA; MITOCHONDRION; PROTEIN CLEAVAGE; STEREOCHEMISTRY;

CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; COBALT; CYCLIC N-OXIDES; DOWN-REGULATION; FREE RADICAL SCAVENGERS; HUMANS; IMIDAZOLES; MELANOMA; MITOCHONDRIA; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; NITROPRUSSIDE; NITROSO COMPOUNDS; ORGANOMETALLIC COMPOUNDS; POLY(ADP-RIBOSE) POLYMERASES; S-NITROSO-N-ACETYLPENICILLAMINE; SODIUM NITRITE;

EID: 77649222534     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901314r     Document Type: Article

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