Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling

Molecular and Cellular Biology

Volumn 27, Issue 17, 2007, Pages 6116-6126

  Furuya, Fumihiko ^a   Guigon, Celine J ^a   Zhao, Li ^a   Lu, Changxue ^a   Hanover, John A ^b   Cheng, Sheue Yann ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; NUCLEAR RECEPTOR COREPRESSOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; PROTEIN SH2; SMALL INTERFERING RNA; THYROID HORMONE RECEPTOR BETA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL MOTILITY; CELL NUCLEUS; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME SUBUNIT; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; THYROID CARCINOMA; THYROID FOLLICULAR CARCINOMA; TRANSCRIPTION REGULATION; TRANSCRIPTION REPRESSION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, TRANSGENIC; NUCLEAR PROTEINS; PROTEIN SUBUNITS; PROTO-ONCOGENE PROTEINS C-AKT; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THYROID GLAND; THYROID HORMONE RECEPTORS BETA; THYROID NEOPLASMS;

EID: 34548268059     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00900-07     Document Type: Article

References (24)

1. Araki, O., H. Ying, F. Furuya, X. Zhu, and S. Y. Cheng. 2005. Thyroid hormone receptor β mutants: dominant negative regulators of peroxisome proliferator-activated receptor gamma action. Proc. Natl. Acad. Sci. USA 102:16251-16256.
2. Baek, S. H., K. A. Ohgi, D. W. Rose, E. H. Koo, C. K. Glass, and M. G. Rosenfeld. 2002. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell 110:55-67.
3. Brinckerhoff, C. E., and L. M. Matrisian. 2002. Matrix metalloproteinases: a tail of a frog that became a prince. Nat. Rev. Mol. Cell Biol. 3:207-214.
4. Furumoto, H., H. Ying, G. V. Chandramouli, L. Zhao, R. L. Walker, P. S. Meltzer, M. C. Willingham, and S. Y. Cheng. 2005. An unligandcd thyroid hormone β receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis. Mol. Cell. Biol. 25:124-135.
5. Furuya, F., J. A. Hanover, and S. Y. Cheng. 2006. Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone β receptor. Proc. Natl. Acad. Sci. USA 103:1780-1785.
6. Hermanson, O., K. Jepsen, and M. G. Rosenfeld. 2002. N-CoR controls differentiation of neural stem cells into astrocytes. Nature 419:934-939.
7. Horlein, A. J., A. M. Naar, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Y. Kamei, M. Soderstrom, C. K. Glass, et al. 1995. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377:397-404.
8. Kaneshige, M., K. Kaneshige, X. Zhu, A. Dace, L. Garrett, T. A. Carter, R. Kazlauskaite, D. G. Pankratz, A. Wynshaw-Boris, S. Refetoff, B. Weintraub, M. C. Willingham, C. Barlow, and S. Cheng. 2000. Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone. Proc. Natl. Acad. Sci. USA 97:13209-13214.
9. Kato, Y., H. Ying, L. Zhao, F. Furuya, O. Araki, M. C. Willingham, and S. Y. Cheng. 2006. PPARgamma insufficiency promotes follicular thyroid carcinogenesis via activation of the nuclear factor-kappaB signaling pathway. Oncogene 25:2736-2747.
10. Kim, C. S., V. V. Vasko, Y. Kato, M. Kruhlak, M. Saji, S. Y. Cheng, and M. D. Ringel. 2005. AKT activation promotes metastasis in a mouse model of follicular thyroid carcinoma. Endocrinology 146:4456-4463.
11. Meier, C. A., C. Parkison, A. Chen, K. Ashizawa, S. C. Meier-Heusler, P. Muchmore, S. Y. Cheng, and B. D. Weintraub. 1993. Interaction of human beta 1 thyroid hormone receptor and its mutants with DNA and retinoid X receptor beta. T3 response element-dependent dominant negative potency. J. Clin. Investig. 92:1986-1993.
12. Miyakawa, M., T. Tsushima, H. Murakami, K. Wakai, O. Isozaki, and K. Takano. 2003. Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues. Endocr. J. 50:77-83.
13. Parrilla, R., A. J. Mixson, J. A. McPherson, J. H. McClaskey, and B. D. Weintraub. 1991. Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two "hot spot" regions of the ligand binding domain. J. Clin. Investig. 88:2123-2130.
14. Ramos, H. E., and R. E. Weiss. 2006. Regulation of nuclear coactivator and corepressor expression in mouse cerebellum by thyroid hormone. Thyroid 16:211-216.
15. Rosenfeld, M. G., V. V. Lunyak, and C. K. Glass. 2006. Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev. 20:1405-1428.
16. Sardi, S. P., J. Murtie, S. Koirala, B. A. Patten, and G. Corfas. 2006. Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell 127:185-197.
17. Stambolic, V., and J. R. Woodgett. 2006. Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration. Trends Cell Biol. 16:461-466.
18. Suzuki, H., M. C. Willingham, and S. Y. Cheng. 2002. Mice with a mutation in the thyroid hormone receptor beta gene spontaneously develop thyroid carcinoma: a mouse model of thyroid carcinogenesis. Thyroid 12:963-969.
19. Turpeenniemi-Hujanen, T. 2005. Gelatinases (MMP-2 and -9) and their natural inhibitors as prognostic indicators in solid cancers. Biochimie 87:287-297.
20. Vasko, V., M. Saji, E. Hardy, M. Kruhlak, A. Larin, V. Savchenko, M. Miyakawa, O. Isozaki, H. Murakami, T. Tsushima, K. D. Burman, C. De Micco, and M. D. Ringel. 2004. Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer. J. Med. Genet. 41:161-170.
21. Yen, P. M. 2003. Molecular basis of resistance to thyroid hormone. Trends Endocrinol. Metab. 14:327-333.
22. Ying, H., F. Furuya, M. C. Willingham, J. Xu, B. W. O'Malley, and S. Y. Cheng. 2005. Dual functions of the steroid hormone receptor coactivator 3 in modulating resistance to thyroid hormone. Mol. Cell. Biol. 25:7687-7695.
23. Ying, H., F. Furuya, L. Zhao, O. Araki, B. L. West, J. A. Hanover, M. C. Willingham, and S. Y. Cheng. 2006. Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone β receptor inhibits mitotic progression. J. Clin. Investig. 116:2972-2984.
24. Ying, H., H. Suzuki, H. Furumoto, R. Walker, P. Meltzer, M. C. Willingham, and S. Y. Cheng. 2003. Alterations in genomic profiles during tumor progression in a mouse model of follicular thyroid carcinoma. Carcinogenesis 24:1467-1479.