Serum deprivation-induced apoptosis accompanied by up-regulation of p53 and bax in human aortic vascular smooth muscle cells

Heart and Vessels

Volumn 12, Issue SUPPL. 12, 1997, Pages 71-75

  Aoki, Motokuni ^a   Morishita, Ryuichi ^a   Matsushita, Hidetsugu ^a   Nakano, Nobuaki ^a   Hayashi, Shin Ichiro ^a   Tomita, Naruya ^a   Yamamoto, Kei ^a   Moriguchi, Atsushi ^a   Higaki, Jitsuo ^a   Ogihara, Toshio ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Apoptosis; bax; bcl 2; Cell death; Vascular remodeling

Indexed keywords

PROTEIN BAX; PROTEIN P53; BAX PROTEIN, HUMAN; GROWTH PROMOTOR; ONCOPROTEIN; PROTEIN BCL 2;

AORTA; APOPTOSIS; CELL GROWTH; CONFERENCE PAPER; CORONARY ARTERY ATHEROSCLEROSIS; HUMAN; HUMAN CELL; HYPERTENSION; PRIORITY JOURNAL; SERUM; SMOOTH MUSCLE FIBER; TIME; VASCULAR SMOOTH MUSCLE; ARTICLE; CELL CULTURE; CYTOLOGY; GENETICS; PHYSIOLOGY; PROTO ONCOGENE; TUMOR SUPPRESSOR GENE; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELLS, CULTURED; GENES, BCL-2; GENES, P53; GROWTH SUBSTANCES; HUMANS; MUSCLE, SMOOTH, VASCULAR; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; UP-REGULATION;

EID: 13144253157     PISSN: 09108327     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (20)

1. Dzau VJ (1993) The role of mechanical and humoral factors in growth regulation of vascular smooth muscle cells and cardiac myocytes. Curr Opin Nephrol Hypertens 2:27-32
2. Hamet P, Richard L, Dam TV, Teiger E, Orlov SN, Gaboury L, Gossard F, Tremblay J (1995) Apoptosis in target organs of hypertension. Hypertension 26:642-648
3. Raff M (1992) Social controls on cell survival and cell death. Nature 356:397-400
4. Lane DP (1992) p53, guardian of the genome. Nature 258:15-16
5. Symonds H, Krall L, Remington L, Saenz-Robles M, Lowe S, Jacks T, Van Dyke T (1994) p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78:703-711
6. Mercer WE, Schields MT, Amin M, Sauve GJ, Appella E, Romano JW, Ullrich SJ (1990) Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53. Proc Natl Acad Sci USA 87:6166-6170
7. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzeler KW, Vogelstein B (1993) Cell 75:817-825
8. Shaw P, Bovey R, Tardy S, Sahli R, Sordat B, Costa J (1992) WAF l, a potential mediator of p53 tumor suppression. Proc Natl Acad Sci USA 89:4495-4499
9. Speir E, Modali R, Huang ES, Leon MB, Shawl F, Finkel T, Epstein SE (1994) Potential role of human cytomegalovirus and p53 interaction in coronary restenosis. Science 265:391-394
10. Bennett MR, Evan GI, Newby AC (1994) Deregulated expression of the c-myc oncogene abolishes inhibition of proliferation of rat vascular smooth muscle cells by serum reduction, interferon-gamma, heparin, and cyclic nucleotide analogues and induces apoptosis. Circ Res 74:525-536
11. Bennett MR, Schwartz SM (1995) Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest 95:2266-2274
12. Pollman MJ, Yamada T, Horiuchi M, Gibbons GH (1996) Vasoactive substances regulate vascular smooth muscle cell apoptosis; countervailing influences of nitric oxide and angiotensin II. Circ Res 79:748-756
13. Bonin PD, Leadley RJ, Erickson LA (1993) Growth factor-induced modulation of endothelial-1 binding to human smooth muscle cells. J Cardiovasc Pharmacol 22:5125-127
14. Libby P, O'Brien KV (1983) Culture of quiescent arterial smooth muscle cells in a defined serum-free medium. J Cell Physiol 115:217-223
15. Ishiyama M, Shiga M, Sasamoto K, Mizoguchi M, He P (1993) A new sulfonated tetrazolium salt that produces a highly water-soluble formazan dye. Chem Pharm Bull 41:1118-1122
16. Isner JM, Kearney M, Bortman S, Passeri J (1995) Apoptosis in human atherosclerosis and restenosis. Circulation 91:2703-2711
17. Miyashita T, Harigai M, Hanada M, Reed JC (1994) Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 54:3131-3135
18. Miyashita T, Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human box gene. Cell 80:293-299
19. Selvakumaran M, Lin HK, Miyashita T, Wang HG, Krajewski S, Reed JC, Hoffman B, Liebermann D (1994) Immediate early up-regulation of box expression by p53 but not TGF β1: a paradigm for distinct apoptotic pathways. Oncogene 9:1791-1798
20. Sato T, Hanada M, Bodrugh S, Irie S, Iwama N, Boise L, Thompson C, Golemis E, Fong L, Wang HG, Reed JC (1994) Interactions among members of the bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci USA 91:9238-9242