Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues

Toxicology Letters

Volumn 158, Issue 1, 2005, Pages 50-60

  Karp, Jeffrey M ^a   Rodrigo, Kapila A ^a   Pei, Ping ^a   Pavlick, Matthew D ^a   Andersen, Jeffrey D ^a   McTigue, Dennis J ^a   Fields, Henry W ^a   Mallery, Susan R ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Bioactivation; Carcinogen metabolism; Cytochrome P450s; Phase I and II enzymes

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; EPOXIDE; MUTAGENIC AGENT; POLYCYCLIC AROMATIC HYDROCARBON; SANGUINARINE;

ADULT; AGED; ARTICLE; CELL ACTIVATION; CELL METABOLISM; COMPLEX FORMATION; CONTROLLED STUDY; DRUG EXPOSURE; DRUG SAFETY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME METABOLISM; FEMALE; GENE EXPRESSION; GENE INDUCTION; GENETIC RISK; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; LIVER MICROSOME; MALE; MOTIVATION; MUTAGENIC ACTIVITY; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TISSUE METABOLISM; UPREGULATION;

ADULT; AGED; ALKALOIDS; ARYL HYDROCARBON HYDROXYLASES; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BENZO(A)PYRENE; BENZOPHENANTHRIDINES; CARCINOGENS; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; HUMANS; ISOQUINOLINES; KERATINOCYTES; MALE; MIDDLE AGED; MOUTH MUCOSA; MOUTHWASHES; PHENANTHRIDINES; RECEPTORS, ARYL HYDROCARBON; TRANSCRIPTION FACTORS; UP-REGULATION;

MAMMALIA; NICOTIANA TABACUM;

EID: 21344452114     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2005.02.007     Document Type: Article

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