Early transcriptional response to chloroquine of the Plasmodium falciparum antioxidant defence in sensitive and resistant clones

Acta Tropica

Volumn 114, Issue 2, 2010, Pages 109-115

  Nogueira, Fátima ^a,b   Diez, Amalia ^a   Radfar, Azar ^a   Pérez Benavente, Susana ^a   Rosario, Virgilio E do ^b   Puyet, Antonio ^a   Bautista, José M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

Author keywords

Chloroquine; G6PD; Glutathione; Malaria; MRP; Oxidative stress; Plasmodium falciparum; Quantitative RT PCR; Thioredoxin

Indexed keywords

CHLOROQUINE; GLUTATHIONE SYNTHASE; MESSENGER RNA; OXIDOREDUCTASE; PROTEIN PFFE SOD; PROTEIN PFG6PD; PROTEIN PFGAMMA GCS; PROTEIN PFGPX; PROTEIN PFGR; PROTEIN PFMRP1; PROTEIN PFMRP2; PROTEIN PFTPX1; PROTEIN PFTRXR; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANTIOXIDANT; DISEASE CONTROL; DRUG RESISTANCE; GENE EXPRESSION; MALARIA; PARASITE;

ANTIMALARIAL DRUG RESISTANCE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL CYCLE REGULATION; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; IC 50; NONHUMAN; OXIDATIVE STRESS; PLASMODIUM FALCIPARUM; REGULATORY MECHANISM; UPREGULATION;

ANIMALS; ANTIMALARIALS; CHLOROQUINE; DRUG RESISTANCE; GENE EXPRESSION PROFILING; INHIBITORY CONCENTRATION 50; MODELS, BIOLOGICAL; OXIDATIVE STRESS; PLASMODIUM FALCIPARUM; STRESS, PHYSIOLOGICAL; TIME FACTORS;

PLASMODIUM FALCIPARUM;

EID: 77649185865     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2010.01.013     Document Type: Article

References (34)

1. Aravind L., Iyer L.M., Wellems T.E., and Miller L.H. Plasmodium biology: genomic gleanings. Cell 115 (2003) 771-785
2. Atamna H., and Ginsburg H. The malaria parasite supplies glutathione to its host cell--investigation of glutathione transport and metabolism in human erythrocytes infected with Plasmodium falciparum. Eur. J. Biochem. 250 (1997) 670-679
3. Bozdech Z., and Ginsburg H. Antioxidant defense in Plasmodium falciparum-data mining of the transcriptome. Malar. J. 3 (2004) 23
4. Bray P.G., Martin R.E., Tilley L., Ward S.A., Kirk K., and Fidock D.A. Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance. Mol. Microbiol. 56 (2005) 323-333
5. Bustamante L.Y., Crooke A., Martinez J., Diez A., and Bautista J.M. Dual-function stem molecular beacons to assess mRNA expression in AT-rich transcripts of Plasmodium falciparum. Biotechniques 36 (2004) 488-492 494
6. Crooke A., Diez A., Mason P.J., and Bautista J.M. Transient silencing of Plasmodium falciparum bifunctional glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase. FEBS J. 273 (2006) 1537-1546
7. Dive D., Gratepanche S., Yera H., Becuwe P., Daher W., Delplace P., Odberg-Ferragut C., Capron M., and Khalife J. Superoxide dismutase in Plasmodium: a current survey. Redox. Rep. 8 (2003) 265-267
8. Filosa S., Fico A., Paglialunga F., Balestrieri M., Crooke A., Verde P., Abrescia P., Bautista J.M., and Martini G. Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stress. Biochem. J. 370 (2003) 935-943
9. Gunasekera A.M., Myrick A., Le Roch K., Winzeler E., and Wirth D.F. Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment. Exp. Parasitol. 117 (2007) 87-92
10. Gunasekera A.M., Patankar S., Schug J., Eisen G., and Wirth D.F. Drug-induced alterations in gene expression of the asexual blood forms of Plasmodium falciparum. Mol. Microbiol. 50 (2003) 1229-1239
11. Guyatt H.L., and Snow R.W. Impact of malaria during pregnancy on low birth weight in sub-Saharan Africa. Clin. Microbiol. Rev. 17 (2004) 760-769
12. Harwaldt P., Rahlfs S., and Becker K. Glutathione S-transferase of the malarial parasite Plasmodium falciparum: characterization of a potential drug target. Biol. Chem. 383 (2002) 821-830
13. Krnajski Z., Gilberger T.W., Walter R.D., Cowman A.F., and Muller S. Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages. J. Biol. Chem. 277 (2002) 25970-25975
14. Kultz D. Molecular and evolutionary basis of the cellular stress response. Annu. Rev. Physiol. 67 (2005) 225-257
15. Lambros C., and Vanderberg J.P. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J. Parasitol. 65 (1979) 418-420
16. Le Roch K.G., Zhou Y., Blair P.L., Grainger M., Moch J.K., Haynes J.D., De La Vega P., Holder A.A., Batalov S., Carucci D.J., and Winzeler E.A. Discovery of gene function by expression profiling of the malaria parasite life cycle. Science 301 (2003) 1503-1508
17. Liebau E., Bergmann B., Campbell A.M., Teesdale-Spittle P., Brophy P.M., Luersen K., and Walter R.D. The glutathione S-transferase from Plasmodium falciparum. Mol. Biochem. Parasitol. 124 (2002) 85-90
18. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25 (2001) 402-408
19. Luersen K., Walter R.D., and Muller S. Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione. Biochem. J. 346 Pt 2 (2000) 545-552
20. Llinas M., Bozdech Z., Wong E.D., Adai A.T., and Derisi J.L. Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains. Nucleic Acids Res. 34 (2006) 1166-1173
21. Meierjohann S., Walter R.D., and Muller S. Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. Biochem. J. 368 (2002) 761-768
22. Militello K.T., Patel V., Chessler A.D., Fisher J.K., Kasper J.M., Gunasekera A., and Wirth D.F. RNA polymerase II synthesizes antisense RNA in Plasmodium falciparum. RNA 11 (2005) 365-370
23. Muller S. Redox and antioxidant systems of the malaria parasite Plasmodium falciparum. Mol. Microbiol. 53 (2004) 1291-1305
24. Nickel C., Rahlfs S., Deponte M., Koncarevic S., and Becker K. Thioredoxin networks in the malarial parasite Plasmodium falciparum. Antioxid. Redox Signal. 8 (2006) 1227-1239
25. Notaro R., Afolayan A., and Luzzatto L. Human mutations in glucose 6-phosphate dehydrogenase reflect evolutionary history. FASEB J. 14 (2000) 485-494
26. Oduola A.M., Weatherly N.F., Bowdre J.H., and Desjardins R.E. Plasmodium falciparum: cloning by single-erythrocyte micromanipulation and heterogeneity in vitro. Exp. Parasitol. 66 (1988) 86-95
27. Olliaro P. Drug resistance hampers our capacity to roll back malaria. Clin. Infect. Dis. 41 Suppl. 4 (2005) S247-257
28. Radfar A., Diez A., and Bautista J.M. Chloroquine mediates specific proteome oxidative damage across the erythrocytic cycle of resistant Plasmodium falciparum. Free Radic. Biol. Med. 44 (2008) 2034-2042
29. Radfar A., Mendez D., Moneriz C., Linares M., Marín-García P., Puyet A., Diez A., and Bautista J.M. Synchronous culture of Plasmodium falciparum at high parasitaemia levels. Nat. Protoc. 4 (2009) 1828-1844
30. Raj D.K., Mu J., Jiang H., Kabat J., Singh S., Sullivan M., Fay M.P., Mccutchan T.F., and Su X.Z. Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PFMRP) alters its fitness and transport of antimalarial drugs and glutathione. J. Biol. Chem. 284 (2008) 7687-7696
31. Rosario V. Cloning of naturally occurring mixed infections of malaria parasites. Science 212 (1981) 1037-1038
32. Sanchez C.P., Mclean J.E., Rohrbach P., Fidock D.A., Stein W.D., and Lanzer M. Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum. Biochemistry 44 (2005) 9862-9870
33. Schmittgen T.D., and Zakrajsek B.A. Effect of experimental treatment on housekeeping gene expression: validation by real-time, quantitative RT-PCR. J. Biochem. Biophys. Methods 46 (2000) 69-81
34. Trager W., and Jensen J.B. Human malaria parasites in continuous culture. Science 193 (1976) 673-675