Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity

Molecular Cell

Volumn 12, Issue 1, 2003, Pages 63-74

  Yang, Shen Hsi ^a   Jaffray, Ellis ^b   Hay, Ron T ^b   Sharrocks, Andrew D ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN; SUMO PROTEIN; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONJUGATION; CONTROLLED STUDY; ENZYME ACTIVITY; MOLECULAR DYNAMICS; NONHUMAN; PHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN MOTIF; TRANSCRIPTION INITIATION;

ANIMALIA; CERVUS ELAPHUS;

EID: 0041669469     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(03)00265-X     Document Type: Article

References (39)

1. Bailey D., O'Hare P. Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease. J. Gen. Virol. 83:2002;2951-2964.
2. Bies J., Markus J., Wolff L. Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity. J. Biol. Chem. 277:2002;8999-9009.
3. Chakrabarti S.R., Sood R., Nandi S., Nucifora G. Posttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into nuclear bodies. Proc. Natl. Acad. Sci. USA. 97:2000;13281-13285.
4. Colombo R., Boggio R., Seiser C., Draetta G.F., Chiocca S. The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1. EMBO Rep. 3:2002;1062-1068.
5. Criqui-Filipe P., Ducret C., Maira S.M., Wasylyk B. Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. EMBO J. 18:1999;3392-3403.
6. David G., Neptune M.A., DePinho R.A. SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities. J. Biol. Chem. 277:2002;23658-23663.
7. Desterro J.M., Rodriguez M.S., Hay R.T. SUMO-1 modification of IκBα inhibits NF-kappaB activation. Mol. Cell. 2:1998;233-239.
8. Eloranta J., Hurst H.C. Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. J. Biol. Chem. 277:2002;30798-30804.
9. Gille H., Kortenjann M., Thomae O., Moomaw C., Slaughter C., Cobb M.H., Shaw P.E. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J. 14:1995;951-962.
10. Girdwood D., Bumpass D., Vaughan O.A., Thain A., Anderson L.A., Snowden A.W., Garcia-Wilson E., Perkins N.D., Hay R.T. p300 transcriptional repression is mediated by SUMO modification. Mol. Cell. in press:2003.
11. Hay R.T. Protein modification by SUMO. Trends Biochem. Sci. 26:2001;332-333.
12. Iniguez-Lluhi J.A., Pearce D. A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy. Mol. Cell. Biol. 20:2000;6040-6050.
13. Jackson P.K. A new RING for SUMO. wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases Genes Dev. 15:2001;3053-3058.
14. Janknecht R., Nordheim A. MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem. Biophys. Res. Commun. 228:1996;831-837.
15. Janknecht R., Ernst W.H., Pingoud V., Nordheim A. Activation of ternary complex factor Elk-1 by MAP kinases. EMBO J. 12:1993;5097-5104.
16. Kim J., Cantwell C.A., Johnson P.F., Pfarr C.M., Williams S.C. Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation. J. Biol. Chem. 277:2002;38037-38044.
17. Kirsh O., Seeler J.S., Pichler A., Gast A., Muller S., Miska E., Mathieu M., Harel-Bellan A., Kouzarides T., Melchior F., Dejean A. The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J. 21:2002;2682-2691.
18. Kotaja N., Karvonen U., Janne O.A., Palvimo J.J. The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1. J. Biol. Chem. 277:2002;30283-30288.
19. Li Q.-J., Yang S.-H., Maeda Y., Sladek F.M., Sharrocks A.D., Martins-Green M. MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the coactivator p300. EMBO J. in press:2003.
20. Maira S.M., Wurtz J.M., Wasylyk B. Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. EMBO J. 15:1996;5849-5865.
21. Marais R., Wynne J., Treisman R. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell. 73:1993;381-393.
22. Muller S., Berger M., Lehembre F., Seeler J.S., Haupt Y., Dejean A. c-Jun and p53 activity is modulated by SUMO-1 modification. J. Biol. Chem. 275:2000;13321-13329.
23. Muller S., Hoege C., Pyrowolakis G., Jentsch S. SUMO, ubiquitin's mysterious cousin. Nat. Rev. Mol. Cell. Biol. 2:2001;202-210.
24. Pichler A., Gast A., Seeler J.S., Dejean A., Melchior F. The nucleoporin RanBP2 has SUMO1 E3 ligase activity. Cell. 108:2002;109-120.
25. Poukka H., Karvonen U., Janne O.A., Palvimo J.J. Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1). Proc. Natl. Acad. Sci. USA. 97:2000;14145-14150.
26. Rodriguez M.S., Desterro J.M., Lain S., Midgley C.A., Lane D.P., Hay R.T. SUMO-1 modification activates the transcriptional response of p53. EMBO J. 18:1999;6455-6461.
27. Ross S., Best J.L., Zon L.I., Gill G. SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol. Cell. 10:2002;831-842.
28. Sachdev S., Bruhn L., Sieber H., Pichler A., Melchior F., Grosschedl R. PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev. 15:2001;3088-3103.
29. Sapetschnig A., Rischitor G., Braun H., Doll A., Schergaut M., Melchior F., Suske G. Transcription factor Sp3 is silenced through SUMO modification by PIAS1. EMBO J. 21:2002;5206-5215.
30. Schreiber E., Matthias P., Muller M.M., Schaffner W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17:1989;6419.
31. Sharrocks A.D. Complexities in ETS-domain transcription factor function and regulation; lessons from the TCF subfamily. Biochem. Soc. Trans. 30:2002;1-9.
32. Snowden A.W., Anderson L.A., Webster G.A., Perkins N.D. A novel transcriptional repression domain mediates p21(WAF1/CIP1)induction of p300 transactivation. Mol. Cell. Biol. 20:2000;2676-2686.
33. Stevens J.L., Cantin G.T., Wang G., Shevchenko A., Shevchenko A., Berk A.J. Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. Science. 296:2002;755-758.
34. Tatham M.H., Jaffray E., Vaughan O.A., Desterro J.M., Botting C.H., Naismith J.H., Hay R.T. Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. J. Biol. Chem. 276:2001;35368-35374.
35. Treisman R. Ternary complex factors. growth regulated transcriptional activators Curr. Opin. Genet. Dev. 4:1994;96-101.
36. Yang S.-H., Yates P.R., Whitmarsh A.J., Davis R.J., Sharrocks A.D. The Elk-1 ETS-domain transcription factor contains a MAP kinase targeting motif. Mol. Cell. Biol. 18:1998;710-720.
37. Yang S.-H., Shore P., Willingham N., Lakey J.H., Sharrocks A.D. Mechanism of phosphorylation-inducible activation of the ETS-domain transcription factor Elk-1. EMBO J. 18:1999;5666-5674.
38. Yang S.-H., Vickers E., Brehm A., Kouzarides T., Sharrocks A.D. Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS-domain transcription factor, Elk-1. Mol. Cell. Biol. 21:2001;2802-2814.
39. Yang S.-H., Bumpass D.C., Perkins N.D., Sharrocks A.D. The ETS-domain transcription factor Elk-1 contains a novel class of repression domain. Mol. Cell. Biol. 22:2002;5036-5046.