The suitability of tris(hydroxylmethyl) aminomethane (THAM) as a buffering system for hydroxypropyl methylcellulose (HPMC) hydrophilic matrices containing a weak acid drug

International Journal of Pharmaceutics

Volumn 387, Issue 1-2, 2010, Pages 93-102

  Pygall, Samuel R ^a   Kujawinski, Sarah ^a   Timmins, Peter ^b   Melia, Colin D ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Buffers; HPMC; Matrices; PH modification; THAM; Weak acid drugs

Indexed keywords

CITRATE SODIUM; FELBINAC; HYDROXYPROPYLMETHYLCELLULOSE; TROMETAMOL;

ALKALINIZATION; ARTICLE; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; DRUG DIFFUSION; DRUG RELEASE; DRUG SOLUBILITY; HYDROPHILICITY; PH; PHASE TRANSITION; PRIORITY JOURNAL; TABLET DISINTEGRATION; TABLET DISINTEGRATION TIME; TABLET THICKNESS; TEMPERATURE SENSITIVITY;

BUFFERS; CHEMISTRY, PHARMACEUTICAL; CITRATES; DIFFUSION; EXCIPIENTS; GELS; HYDROGEN-ION CONCENTRATION; METHYLCELLULOSE; PHENYLACETATES; SOLUBILITY; TABLETS; TRANSITION TEMPERATURE; TROMETHAMINE;

EID: 77649179113     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.12.012     Document Type: Article

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