Attenuation of the transforming growth factor β-signaling pathway in chronic venous ulcers

Molecular Medicine

Volumn 16, Issue 3-4, 2010, Pages 92-101

  Pastar, Irena ^a   Stojadinovic, Olivera ^a   Krzyzanowska, Agata ^b   Barrientos, Stephan ^c   Stuelten, Christina ^d   Zimmerman, Karen ^e   Blumenberg, Miroslav ^e   Brem, Harold ^e   Tomic Canic, Marjana ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; SMAD2 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; TRISTETRAPROLIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DOWN REGULATION; EPIDERMIS; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TONGUE; ULCER;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY; CHRONIC DISEASE; DOWN-REGULATION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; POLYMERASE CHAIN REACTION; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SKIN; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA; VARICOSE ULCER;

EID: 77649154304     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2009.00149     Document Type: Article

References (63)

1. Harsha A, et al. (2008) ADAM12: a potential target for the treatment of chronic wounds. J. Mol. Med. 86:961-9.
2. Stojadinovic O, et al. (2008) Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers. J. Cell Mol. Med. 12:2675-90.
3. Kim BC, et al. (2003) Fibroblasts from chronic wounds show altered TGF-beta-signaling and decreased TGF-beta type II receptor expression. J. Cell Physiol. 195:331-6.
4. Hasan A, et al. (1997) Dermal fibroblasts from venous ulcers are unresponsive to the action of transforming growth factor-beta 1. Dermatol. Sci. 16:59-66.
5. Agren MS, Steenfos HH, Dabelsteen S, Hansen JB, Dabelsteen E. (1999) Proliferation and mitogenic response to PDGF-BB of fibroblasts isolated from chronic venous leg ulcers is ulcer-age dependent. J. Invest. Dermatol. 112:463-9.
6. Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. (2008) Growth factors and cytokines in wound healing. Wound Repair Regen. 16:585-601.
7. Siegel PM, Massague J. (2003) Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat. Rev. Cancer. 3:807-21.
8. O'Kane S, Ferguson MW. (1997) Transforming growth factor beta s and wound healing. Int. J. Biochem. Cell Biol. 29:63-78.
9. Verrecchia F, Mauviel A. (2002) Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J. Invest. Dermatol. 118:211-5.
10. Zambruno G, et al. (1995) Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing. J. Cell Biol. 129:853-65.
11. Montesano R, Orci L. (1988) Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing. Proc. Natl. Acad. Sci. U. S. A. 85:4894-7.
12. Schiller M, Javelaud D, Mauviel A. (2004) TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing. J. Dermatol. Sci. 35:83-92.
13. Shi Y, Massague J. (2003) Mechanisms of TGFbeta signaling from cell membrane to the nucleus. Cell. 113:685-700.
14. Inman GJ, Nicolas FJ, Hill CS. (2002) Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity. Mol. Cell. 10:283-94.
15. Nicolas FJ, De Bosscher K, Schmierer B, Hill CS. (2004) Analysis of Smad nucleocytoplasmic shuttling in living cells. J. Cell Sci. 117:4113-25.
16. Piek E, Heldin CH, Ten Dijke P. (1999) Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J. 13:2105-24.
17. Massague J. (2000) How cells read TGF-beta signals. Nat. Rev. Mol. Cell Biol. 1:169-78.
18. Faler BJ, et al. (2006) Transforming growth factorbeta and wound healing. Perspect. Vasc. Surg. Endovasc. Ther. 18:55-62.
19. Schmid P, et al. (1993) TGF-beta s and TGF-beta type II receptor in human epidermis: differential expression in acute and chronic skin wounds. J. Pathol. 171:191-7.
20. Cowin AJ, et al. (2001) Effect of healing on the expression of transforming growth factor beta(s) and their receptors in chronic venous leg ulcers. J. Invest. Dermatol. 117:1282-9.
21. Jude EB, Blakytny R, Bulmer J, Boulton AJ, Ferguson MW. (2002) Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. Diabet. Med. 19:440-7.
22. Cooper DM, Yu EZ, Hennessey P, Ko F, Robson MC. (1994) Determination of endogenous cytokines in chronic wounds. Ann. Surg. 219:688-91; discussion 691-2.
23. Mustoe TA, et al. (1987) Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science. 237:1333-6.
24. Shah M, Foreman DM, Ferguson MW. (1995) Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J. Cell Sci. 108:985-1002.
25. Salomon GD, et al. (1990) Gene expression in normal and doxorubicin-impaired wounds: importance of transforming growth factor-beta. Surgery. 108:318-22; discussion 322-3.
26. Beck LS, et al. (1993) One systemic administration of transforming growth factor-beta 1 reverses age- or glucocorticoid-impaired wound healing. J. Clin. Invest. 92:2841-9.
27. Sporn MB, Roberts AB. (1993) A major advance in the use of growth factors to enhance wound healing. J. Clin. Invest. 92:2565-6.
28. Robson MC, et al. (1995) Safety and effect of transforming growth factor-beta(2) for treatment of venous stasis ulcers. Wound Repair Regen. 3:157-67.
29. Bennett SP, et al. (2003) Growth factors in the treatment of diabetic foot ulcers. Br. J. Surg. 90:133-46.
30. Stojadinovic O, et al. (2005) Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing. Am. J. Pathol. 167:59-69.
31. Lee B, et al. (2005) From an enhanceosome to a repressosome: molecular antagonism between glucocorticoids and EGF leads to inhibition of wound healing. J. Mol. Biol. 345:1083-97.
32. Stojadinovic O, et al. (2007) Novel genomic effects of glucocorticoids in epidermal keratinocytes: Inhibition of apoptosis, interferon-gamma pathway, and wound healing along with promotion of terminal differentiation. J. Biol. Chem. 282:4021-34.
33. Tomic-Canic M, et al. (2007) Streptolysin O enhances keratinocyte migration and proliferation and promotes skin organ culture wound healing in vitro. Wound Repair Regen. 15:71-9.
34. Kratz G. (1998) Modeling of wound healing processes in human skin using tissue culture. Microsc. Res. Tech. 42:345-50.
35. Pullar CE, Grahn JC, Liu W, Isseroff RR. (2006) Beta2-adrenergic receptor activation delays wound healing. FASEB J. 20:76-86.
36. Heilborn JD, et al. (2003) The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium. J. Invest. Dermatol. 120:379-89.
37. Roupe KM, et al. (2009) Injury is a major inducer of epidermal innate immune responses during wound healing. J. Invest. Dermatol. 2009, Sep 3 [Epub ahead of print].
38. Randolph RK, Simon M. (1993) Characterization of retinol metabolism in cultured human epidermal keratinocytes. J. Biol. Chem. 268:9198-205.
39. Jho S, et al. (2005) The book of opposites: the role of the nuclear receptor co-regulators in the suppression of epidermal genes by retinoic acid and thyroid hormone receptors. J. Invest. Dermatol. 124:1034-43.
40. Cahan P, et al. (2005) List of lists-annotated (LOLA): a database for annotation and comparison of published microarray gene lists. Gene. 360:78-82.
41. Lee DD, Zavadil J, Tomic-Canic M, Blumenberg M. (2010) Comprehensive transcriptional profiling of human epidermis, reconstituted epidermal equivalents and cultured keratinocytes, using DNA microarray chips. Methods Mol. Biol. 585:193-223.
42. Banno T, Gazel A, Blumenberg M. (2005) Pathway-specific profiling identifies the NF-kappa B-dependent tumor necrosis factor alpha-regulated genes in epidermal keratinocytes. J. Biol. Chem. 280:18973-80.
43. Maeda T, et al. (2002) GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. J. Invest. Dermatol. 119:22-6.
44. Kang Y, Chen CR, Massague J. (2003) A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol. Cell. 11:915-26.
45. Gomis RR, et al. (2006) A FoxO-Smad synexpression group in human keratinocytes. Proc. Natl. Acad. Sci. U. S. A. 103:12747-52.
46. Madsen P, Rasmussen HH, Leffers H, Honore B, Celis JE. (1992) Molecular cloning and expression of a novel keratinocyte protein (psoriasisassociated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. J Invest Dermatol 99:299-305.
47. O'Shaughnessy RF, Seery JP, Celis JE, Frischauf A, Watt FM. (2000) PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation. FEBS Lett 486, 149-54.
48. Keppler D. (2006) Towards novel anti-cancer strategies based on cystatin function. Cancer Lett. 235:159-76.
49. Rahimi F, Hsu K, Endoh Y, Geczy CL. (2005) FGF-2, IL-1beta and TGF-beta regulate fibroblast expression of S100A8. FEBS J. 272:2811-27.
50. Pierce GF, et al. (1989) Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms. J. Cell Biol. 109:429-40.
51. Bitar MS, Labbad ZN. (1996) Transforming growth factor-beta and insulin-like growth factor-I in relation to diabetes-induced impairment of wound healing. J. Surg. Res. 61:113-9.
52. Hebda PA, Sandulache VC. (2004) The Biochemistry of Epidermal Healing. In: The Epidermis in Wound Healing. Rovee DT, Maibach HI (eds) CRC Press, Boca Raton, pp. 59-86.
53. Alexandrow MG, Moses HL. (1995) Transforming growth factor beta and cell cycle regulation. Cancer Res. 55:1452-7.
54. Massague J, Blain SW, Lo RS. (2000) TGFbeta signaling in growth control, cancer, and heritable disorders. Cell. 103:295-309.
55. Takekawa M, et al. (2002) Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta. EMBO J. 21:6473-82.
56. Hai T, Wolfgang CD, Marsee DK, Allen AE, Sivaprasad U. (1999) ATF3 and stress responses. Gene. Expr. 7:321-35.
57. Harper EG, Alvares SM, Carter WG. (2005) Wounding activates p38 map kinase and activation transcription factor 3 in leading keratinocytes. J. Cell Sci. 118:3471-85.
58. Derynck R, Akhurst RJ, Balmain A. (2001) TGFbeta signaling in tumor suppression and cancer progression. Nat. Genet. 29:117-29.
59. Kirsner RS, et al. (1996) Squamous cell carcinoma arising in osteomyelitis and chronic wounds. Treatment with Mohs micrographic surgery vs amputation. Dermatol. Surg. 22:1015-8.
60. Guasch G, et al. (2007) Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell. 12:313-27.
61. Strojan P, et al. (2000) Prognostic significance of cysteine proteinases cathepsins B and L and their endogenous inhibitors stefins A and B in patients with squamous cell carcinoma of the head and neck. Clin. Cancer Res. 6:1052-62.
62. Schmidtchen A, Holst E, Tapper H, Bjorck L. (2003) Elastase-producing pseudomonas aeruginosa degrade plasma proteins and extracellular products of human skin and fibroblasts, and inhibit fibroblast growth. Microb. Pathog. 34:47-55.
63. Reynolds LE, et al. (2008) Alpha3beta1 integrincontrolled Smad7 regulates reepithelialization during wound healing in mice. J. Clin. Invest. 118:965-74.