Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers

Diabetic Medicine

Volumn 19, Issue 6, 2002, Pages 440-447

  Jude, E B ^a,b   Blakytny, R ^a   Bulmer, J ^a   Boulton, A J M ^a   Ferguson, M W J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

Chronic venous ulcer; Diabetes mellitus; Diabetic foot ulcer; Diabetic neuropathy; Transforming growth factor

Indexed keywords

RECEPTOR SUBTYPE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; ACTIVIN RECEPTOR 1; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TGFB1 PROTEIN, HUMAN; TGFB2 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ADULT; AGED; ARTICLE; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM; FEMALE; FOOT ULCER; HUMAN; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN BLOOD LEVEL; SKIN BIOPSY; VEIN DISEASE; WESTERN BLOTTING; COMPARATIVE STUDY; CYTOLOGY; DIABETIC FOOT; DIABETIC NEUROPATHY; IMMUNOLOGY; MIDDLE AGED; PATHOLOGY; REFERENCE VALUE; SKIN; VARICOSIS;

ACTIVIN RECEPTORS, TYPE I; BLOTTING, WESTERN; COMPARATIVE STUDY; DIABETIC FOOT; DIABETIC NEUROPATHIES; FEMALE; FOOT ULCER; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGE; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REFERENCE VALUES; SKIN; SUPPORT, NON-U.S. GOV'T; TRANSFORMING GROWTH FACTOR BETA; VARICOSE ULCER; HUMANS; MIDDLE AGED; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

EID: 0035985215     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-5491.2002.00692.x     Document Type: Article

References (29)

1. The pathway to ulceration: Aetiopathogenesis
2. Common complications of wound healing. Prevention and management
3. Impaired leucocyte functions in diabetic patients
4. Morbidity and mortality associated with diabetic foot disease: A 12-month prospective survey of hospital admissions in a single UK centre
5. Foot problems in patients with diabetes mellitus
6. Increased mortality associated with diabetic foot ulcer
7. The role of growth factors in wound healing
8. Transforming growth factor βs and wound healing
9. TGF-βs and TGF-β Type II receptor in human epidermis: Differential expression in acute and chronic skin wounds
10. Insulin like growth factors in diabetic foot ulcers
11. Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (Becaplermin) in patients with chronic neuropathic diabetic ulcers
12. Mitogenic effect of transforming growth factor β1 on human fibroblasts involves the induction of platelet-derived growth factor α receptors
13. Matrix protein synthesis by glomerular mesangial cells in culture: Effects of transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF) on fibronectin and collagen type IV mRNA
14. Regulation of platelet-derived growth factor A and B chain gene expression in bone marrow stromal cells
15. Multicenter study of the incidence and predictive risk factors for diabetic foot ulceration
16. Classification and management of neuropathic and neuroischaemic ulcers
17. The diabetic rat as an impaired wound healing model: Stimulatory effects of transforming growth factor-β and basic fibroblast growth factor
18. Control of scarring in adult wounds by neutralising antibody to transforming growth factor β
19. Transforming growth factor: Activity and efficacy in animal models of wound healing
20. One systemic administration of transforming growth factor β1 reverses age- or glucocorticoid-impaired wound healing
21. Transforming growth factor β reverses the glucocorticoid-induced wound healing deficit in rats: Possible regulation in macrophages by platelet-derived growth factor
22. Immunocytochemical localisation and serologic detection of transforming growth factor β1. Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea and Raynaud's phenomenon
23. The transforming growth factor βs
24. Direct evidence for spatial and temporal regulation of transforming growth factor β1 expression during cutaneous wound healing
25. Delayed wound healing in immunodeficient TGFβ1 knockout mice
26. TGF-beta3 stimulates and regulates collagen synthesis through TGF-beta-1-dependent and independent mechanisms
27. Transforming growth factor beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing
28. Enhanced expression of transforming growth factor-β type I and type II receptors in wound granulation tissue and hypertrophic scar
29. Mechanism of action of hormones that act at the cell surface