메뉴 건너뛰기




Volumn 24, Issue 1, 2010, Pages 95-106

Activated recombinant factor VII (rFVIIa)

Author keywords

blood; coagulation trauma; haemorrhage; perioperative; recombinant activated factor VIIa

Indexed keywords

ACENOCOUMAROL; ANTIVITAMIN K; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 7 INHIBITOR; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 INHIBITOR; BLOOD CLOTTING INHIBITOR; EPTACOG ALFA; FIBRINOGEN; FRESH FROZEN PLASMA; PLACEBO; PROTHROMBIN; RECOMBINANT BLOOD CLOTTING FACTOR 7A; THROMBOPLASTIN; UNCLASSIFIED DRUG; WARFARIN;

EID: 77649106855     PISSN: 15216896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpa.2009.09.005     Document Type: Review
Times cited : (16)

References (109)
  • 2
    • 33746021125 scopus 로고    scopus 로고
    • Mechanism of action, development and clinical experience of recombinant FVIIa
    • Hedner U. Mechanism of action, development and clinical experience of recombinant FVIIa. Journal of Biotechnology 124 (2006) 747-757
    • (2006) Journal of Biotechnology , vol.124 , pp. 747-757
    • Hedner, U.1
  • 3
    • 0035200558 scopus 로고    scopus 로고
    • The action of high-dose factor VIIa (FVIIa) in a cell-based model of hemostasis
    • Hoffman M., and Monroe III D.M. The action of high-dose factor VIIa (FVIIa) in a cell-based model of hemostasis. Seminars in Hematology 38 (2001) 6-9
    • (2001) Seminars in Hematology , vol.38 , pp. 6-9
    • Hoffman, M.1    Monroe III, D.M.2
  • 4
    • 0030695063 scopus 로고    scopus 로고
    • Platelet activity of high-dose factor VIIa is independent of tissue factor
    • Monroe D.M., Hoffman M., Oliver J.A., et al. Platelet activity of high-dose factor VIIa is independent of tissue factor. British Journal of Haematology 99 (1997) 542-547
    • (1997) British Journal of Haematology , vol.99 , pp. 542-547
    • Monroe, D.M.1    Hoffman, M.2    Oliver, J.A.3
  • 5
    • 23044514300 scopus 로고    scopus 로고
    • Recombinant factor VIIa enhances platelet adhesion and activation under flow conditions at normal and reduced platelet count
    • Lisman T., Adelmeijer J., Cauwenberghs S., et al. Recombinant factor VIIa enhances platelet adhesion and activation under flow conditions at normal and reduced platelet count. Journal of Thrombosis and Haemostasis 3 (2005) 742-745
    • (2005) Journal of Thrombosis and Haemostasis , vol.3 , pp. 742-745
    • Lisman, T.1    Adelmeijer, J.2    Cauwenberghs, S.3
  • 6
    • 33644797001 scopus 로고    scopus 로고
    • High dose factor VIIa improves clot structure and stability in a model of haemophilia B
    • Wolberg A.S., Allen G.A., Monroe D.M., et al. High dose factor VIIa improves clot structure and stability in a model of haemophilia B. British Journal of Haematology 131 (2005) 645-655
    • (2005) British Journal of Haematology , vol.131 , pp. 645-655
    • Wolberg, A.S.1    Allen, G.A.2    Monroe, D.M.3
  • 7
    • 39649106357 scopus 로고    scopus 로고
    • Tissue factor and factor VIIa as therapeutic targets in disorders of hemostasis
    • Hedner U., and Ezban M. Tissue factor and factor VIIa as therapeutic targets in disorders of hemostasis. Annual Review of Medicine 59 (2008) 29-41
    • (2008) Annual Review of Medicine , vol.59 , pp. 29-41
    • Hedner, U.1    Ezban, M.2
  • 8
    • 0020521843 scopus 로고
    • Use of human factor VIIa in the treatment of two hemophilia A patients with high-titer inhibitors
    • Hedner U., and Kisiel W. Use of human factor VIIa in the treatment of two hemophilia A patients with high-titer inhibitors. The Journal of Clinical Investigation 71 (1983) 1836-1841
    • (1983) The Journal of Clinical Investigation , vol.71 , pp. 1836-1841
    • Hedner, U.1    Kisiel, W.2
  • 9
    • 0023763216 scopus 로고
    • Successful use of recombinant factor VIIa in patient with severe haemophilia A during synovectomy
    • Hedner U., Glazer S., Pingel K., et al. Successful use of recombinant factor VIIa in patient with severe haemophilia A during synovectomy. Lancet 2 (1988) 1193
    • (1988) Lancet , vol.2 , pp. 1193
    • Hedner, U.1    Glazer, S.2    Pingel, K.3
  • 10
    • 0032725116 scopus 로고    scopus 로고
    • Treatment of patients with factor VII and factor IX inhibitors with special focus on the use of recombinant factor VIIa
    • Hedner U. Treatment of patients with factor VII and factor IX inhibitors with special focus on the use of recombinant factor VIIa. Thrombosis and Haemostasis 82 (1999) 531-539
    • (1999) Thrombosis and Haemostasis , vol.82 , pp. 531-539
    • Hedner, U.1
  • 11
    • 67650645256 scopus 로고    scopus 로고
    • Traumatic coagulopathy: where are the good experimental models?
    • Parr M.J., Bouillon B., Brohi K., et al. Traumatic coagulopathy: where are the good experimental models?. The Journal of Trauma 65 (2008) 766-771
    • (2008) The Journal of Trauma , vol.65 , pp. 766-771
    • Parr, M.J.1    Bouillon, B.2    Brohi, K.3
  • 12
    • 0037452134 scopus 로고    scopus 로고
    • Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomised trial
    • Friederich P.W., Henny C.P., Messelink E.J., et al. Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomised trial. Lancet 361 (2003) 201-205
    • (2003) Lancet , vol.361 , pp. 201-205
    • Friederich, P.W.1    Henny, C.P.2    Messelink, E.J.3
  • 13
    • 18144393811 scopus 로고    scopus 로고
    • Use of activated recombinant coagulation factor VII in patients undergoing reconstruction surgery for traumatic fracture of pelvis or pelvis and acetabulum: a double-blind, randomized, placebo-controlled trial
    • Raobaikady R., Redman J., Ball J.A., et al. Use of activated recombinant coagulation factor VII in patients undergoing reconstruction surgery for traumatic fracture of pelvis or pelvis and acetabulum: a double-blind, randomized, placebo-controlled trial. British Journal Of Anaesthesia 94 (2005) 586-591
    • (2005) British Journal Of Anaesthesia , vol.94 , pp. 586-591
    • Raobaikady, R.1    Redman, J.2    Ball, J.A.3
  • 14
    • 40549089223 scopus 로고    scopus 로고
    • Recombinant activated factor VIIa for the treatment of bleeding in major abdominal surgery including vascular and urological surgery: a review and meta-analysis of published data
    • Von Heymann C., Jonas S., Spies C., et al. Recombinant activated factor VIIa for the treatment of bleeding in major abdominal surgery including vascular and urological surgery: a review and meta-analysis of published data. Critical Care 12 (2008) R14
    • (2008) Critical Care , vol.12
    • Von Heymann, C.1    Jonas, S.2    Spies, C.3
  • 15
    • 41149168687 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant activated factor vii in major surgical procedures: systematic review and meta-analysis of randomized clinical trials
    • Ranucci M., Isgrò G., Soro G., et al. Efficacy and safety of recombinant activated factor vii in major surgical procedures: systematic review and meta-analysis of randomized clinical trials. Archives of Surgery 143 (2008) 296-304
    • (2008) Archives of Surgery , vol.143 , pp. 296-304
    • Ranucci, M.1    Isgrò, G.2    Soro, G.3
  • 16
    • 33646099838 scopus 로고    scopus 로고
    • Recombinant factor VIIa in major abdominal surgery and liver transplantation
    • da Silva Viana J. Recombinant factor VIIa in major abdominal surgery and liver transplantation. Transplantation Proceedings 38 (2006) 818-819
    • (2006) Transplantation Proceedings , vol.38 , pp. 818-819
    • da Silva Viana, J.1
  • 17
    • 0035865124 scopus 로고    scopus 로고
    • Reduced transfusion requirements by recombinant factor VIIa in orthotopic liver transplantation: a pilot study
    • Hendriks H.G., Meijer K., de Wolf J.T., et al. Reduced transfusion requirements by recombinant factor VIIa in orthotopic liver transplantation: a pilot study. Transplantation 71 (2001) 402-405
    • (2001) Transplantation , vol.71 , pp. 402-405
    • Hendriks, H.G.1    Meijer, K.2    de Wolf, J.T.3
  • 18
    • 33745007623 scopus 로고    scopus 로고
    • Recombinant factor VIIa reduces transfusion requirements in liver transplant patients with high MELD scores
    • Niemann C.U., Behrends M., Quan D., et al. Recombinant factor VIIa reduces transfusion requirements in liver transplant patients with high MELD scores. Transfusion Medicine 16 (2006) 93-100
    • (2006) Transfusion Medicine , vol.16 , pp. 93-100
    • Niemann, C.U.1    Behrends, M.2    Quan, D.3
  • 19
    • 23744438763 scopus 로고    scopus 로고
    • Safety and efficacy of a single bolus administration of recombinant factor VIIa in liver transplantation due to chronic liver disease
    • Planinsic R.M., van der Meer J., Testa G., et al. Safety and efficacy of a single bolus administration of recombinant factor VIIa in liver transplantation due to chronic liver disease. Liver Transplantation 11 (2005) 895-900
    • (2005) Liver Transplantation , vol.11 , pp. 895-900
    • Planinsic, R.M.1    van der Meer, J.2    Testa, G.3
  • 20
    • 23744440522 scopus 로고    scopus 로고
    • Efficacy and safety of repeated perioperative doses of recombinant factor VIIa in liver transplantation
    • Lodge J.P., Jonas S., Jones R.M., et al. Efficacy and safety of repeated perioperative doses of recombinant factor VIIa in liver transplantation. Liver Transplantation 11 (2005) 973-979
    • (2005) Liver Transplantation , vol.11 , pp. 973-979
    • Lodge, J.P.1    Jonas, S.2    Jones, R.M.3
  • 21
    • 29544441018 scopus 로고    scopus 로고
    • Benefits of recombinant activated factor VII in complicated liver transplantation
    • Gala B., Quintela J., Aguirrezabalaga J., et al. Benefits of recombinant activated factor VII in complicated liver transplantation. Transplantation Proceedings 37 (2005) 3919-3921
    • (2005) Transplantation Proceedings , vol.37 , pp. 3919-3921
    • Gala, B.1    Quintela, J.2    Aguirrezabalaga, J.3
  • 22
    • 19944433743 scopus 로고    scopus 로고
    • Recombinant coagulation factor VIIa in major liver resection: a randomized, placebo-controlled, double-blind clinical trial
    • Lodge J.P., Jonas S., Oussoultzoglou E., et al. Recombinant coagulation factor VIIa in major liver resection: a randomized, placebo-controlled, double-blind clinical trial. Anesthesiology 102 (2005) 269-275
    • (2005) Anesthesiology , vol.102 , pp. 269-275
    • Lodge, J.P.1    Jonas, S.2    Oussoultzoglou, E.3
  • 23
    • 31444433052 scopus 로고    scopus 로고
    • Safety and hemostatic effect of recombinant activated factor VII in cirrhotic patients undergoing partial hepatectomy: a multicenter, randomized, double-blind, placebo-controlled trial
    • Shao Y.F., Yang J.M., Chau G.Y., et al. Safety and hemostatic effect of recombinant activated factor VII in cirrhotic patients undergoing partial hepatectomy: a multicenter, randomized, double-blind, placebo-controlled trial. American Journal of Surgery 191 (2006) 245-249
    • (2006) American Journal of Surgery , vol.191 , pp. 245-249
    • Shao, Y.F.1    Yang, J.M.2    Chau, G.Y.3
  • 24
    • 33846443612 scopus 로고    scopus 로고
    • Recombinant activated factor VII in cardiac surgery: a systematic review
    • Warren O., Mandal K., Hadjianastassiou V., et al. Recombinant activated factor VII in cardiac surgery: a systematic review. The Annals of Thoracic Surgery 83 (2007) 707-714
    • (2007) The Annals of Thoracic Surgery , vol.83 , pp. 707-714
    • Warren, O.1    Mandal, K.2    Hadjianastassiou, V.3
  • 25
    • 33746712294 scopus 로고    scopus 로고
    • Is recombinant activated factor VII useful for intractable bleeding after cardiac surgery?
    • Tanos M.D.J. Is recombinant activated factor VII useful for intractable bleeding after cardiac surgery?. Interactive Cardiovascular and Thoracic Surgery 5 (2006) 493-498
    • (2006) Interactive Cardiovascular and Thoracic Surgery , vol.5 , pp. 493-498
    • Tanos, M.D.J.1
  • 26
    • 33750698658 scopus 로고    scopus 로고
    • Audit of factor VIIa for bleeding resistant to conventional therapy following complex cardiac surgery
    • McCall P., Story D.A., and Karapillai D. Audit of factor VIIa for bleeding resistant to conventional therapy following complex cardiac surgery. Canadian Journal of Anaesthesia 53 (2006) 926-933
    • (2006) Canadian Journal of Anaesthesia , vol.53 , pp. 926-933
    • McCall, P.1    Story, D.A.2    Karapillai, D.3
  • 27
    • 33244488533 scopus 로고    scopus 로고
    • The use of recombinant activated factor VII for refractory bleeding post complex cardiothoracic surgery
    • Walsham J., Fraser J.F., Mullany D., et al. The use of recombinant activated factor VII for refractory bleeding post complex cardiothoracic surgery. Anaesthesia and Intensive Care 34 (2006) 13-20
    • (2006) Anaesthesia and Intensive Care , vol.34 , pp. 13-20
    • Walsham, J.1    Fraser, J.F.2    Mullany, D.3
  • 28
    • 33646176439 scopus 로고    scopus 로고
    • Small-dose recombinant activated factor VII (NovoSeven) in cardiac surgery
    • Romagnoli S., Bevilacqua S., Gelsomino S., et al. Small-dose recombinant activated factor VII (NovoSeven) in cardiac surgery. Anesthesia and Analgesia 102 (2006) 1320-1326
    • (2006) Anesthesia and Analgesia , vol.102 , pp. 1320-1326
    • Romagnoli, S.1    Bevilacqua, S.2    Gelsomino, S.3
  • 29
    • 37249052687 scopus 로고    scopus 로고
    • Treatment of refractory bleeding after cardiac operations with low-dose recombinant activated factor VII (NovoSeven): a propensity score analysis
    • Gelsomino S., Lorusso R., Romagnoli S., et al. Treatment of refractory bleeding after cardiac operations with low-dose recombinant activated factor VII (NovoSeven): a propensity score analysis. European Journal of Cardio-Thoracic Surgery 33 (2008) 64-71
    • (2008) European Journal of Cardio-Thoracic Surgery , vol.33 , pp. 64-71
    • Gelsomino, S.1    Lorusso, R.2    Romagnoli, S.3
  • 30
    • 34250901460 scopus 로고    scopus 로고
    • Recombinant activated factor VII for refractory bleeding after acute aortic dissection surgery: a propensity score analysis
    • Tritapepe L., De Santis V., Vitale D., et al. Recombinant activated factor VII for refractory bleeding after acute aortic dissection surgery: a propensity score analysis. Critical Care Medicine 35 (2007) 1685-1690
    • (2007) Critical Care Medicine , vol.35 , pp. 1685-1690
    • Tritapepe, L.1    De Santis, V.2    Vitale, D.3
  • 31
    • 62349083053 scopus 로고    scopus 로고
    • Efficacy and safety of activated recombinant factor VII in cardiac surgical patients
    • Hardy J.F., Bélisle S., and Van der Linden P. Efficacy and safety of activated recombinant factor VII in cardiac surgical patients. Current Opinion in Anaesthesiology 22 (2009) 95-99
    • (2009) Current Opinion in Anaesthesiology , vol.22 , pp. 95-99
    • Hardy, J.F.1    Bélisle, S.2    Van der Linden, P.3
  • 32
    • 27744513120 scopus 로고    scopus 로고
    • Activated recombinant factor VII after cardiopulmonary bypass reduces allogeneic transfusion in complex noncoronary cardiac surgery: randomized double-blind placebocontrolled pilot study
    • Diprose P., Herbertson M.J., O'Shaughnessy D., et al. Activated recombinant factor VII after cardiopulmonary bypass reduces allogeneic transfusion in complex noncoronary cardiac surgery: randomized double-blind placebocontrolled pilot study. British Journal of Anaesthesia 95 (2005) 596-602
    • (2005) British Journal of Anaesthesia , vol.95 , pp. 596-602
    • Diprose, P.1    Herbertson, M.J.2    O'Shaughnessy, D.3
  • 33
    • 33745431704 scopus 로고    scopus 로고
    • Elective administration in infants of low-dose recombinant activated factor VII (rFVIIa) in cardiopulmonary bypass surgery for congenital heart disease does not shorten time to chest closure or reduce blood loss and need for transfusions: a randomized, double-blind, parallel group
    • Ekert H., Brizard C., Eyers R., et al. Elective administration in infants of low-dose recombinant activated factor VII (rFVIIa) in cardiopulmonary bypass surgery for congenital heart disease does not shorten time to chest closure or reduce blood loss and need for transfusions: a randomized, double-blind, parallel group, placebo-controlled study of rFVIIa and standard haemostatic replacement therapy versus standard haemostatic replacement therapy. Blood Coagulation & Fibrinolysis 17 (2006) 389-395
    • (2006) Blood Coagulation & Fibrinolysis , vol.17 , pp. 389-395
    • Ekert, H.1    Brizard, C.2    Eyers, R.3
  • 34
    • 77649117060 scopus 로고    scopus 로고
    • Available at: [accessed June 2009]
    • Available at:. http://clinicaltrials.gov/ct2/show/NCT00154427 [accessed June 2009]
  • 35
    • 0028909841 scopus 로고
    • Epidemiology of trauma deaths: a reassessment
    • Sauaia A., Moore F.A., Moore E.E., et al. Epidemiology of trauma deaths: a reassessment. Journal of Trauma 38 (1995) 185-193
    • (1995) Journal of Trauma , vol.38 , pp. 185-193
    • Sauaia, A.1    Moore, F.A.2    Moore, E.E.3
  • 36
    • 31744443130 scopus 로고    scopus 로고
    • The epidemiology and modern management of traumatic hemorrhage: US and international perspectives
    • Kauvar D.S., and Wade C.E. The epidemiology and modern management of traumatic hemorrhage: US and international perspectives. Critical Care 9 (2005) 1-9
    • (2005) Critical Care , vol.9 , pp. 1-9
    • Kauvar, D.S.1    Wade, C.E.2
  • 37
    • 0033610715 scopus 로고    scopus 로고
    • Treatment of traumatic bleeding with recombinant factor VIIa
    • Kenet G., Walden R., Eldad A., et al. Treatment of traumatic bleeding with recombinant factor VIIa. Lancet 354 (1999) 1879
    • (1999) Lancet , vol.354 , pp. 1879
    • Kenet, G.1    Walden, R.2    Eldad, A.3
  • 38
    • 33845790028 scopus 로고    scopus 로고
    • Recombinant activated coagulation factor VII and bleeding trauma patients
    • Rizoli S.B., Nascimento Jr. B., Osman F., et al. Recombinant activated coagulation factor VII and bleeding trauma patients. Journal of Trauma 61 (2006) 1419-1425
    • (2006) Journal of Trauma , vol.61 , pp. 1419-1425
    • Rizoli, S.B.1    Nascimento Jr., B.2    Osman, F.3
  • 39
    • 7244221863 scopus 로고    scopus 로고
    • Factor VIIa for correction of traumatic coagulopathy
    • Dutton R.P., McCunn M., Hyder M., et al. Factor VIIa for correction of traumatic coagulopathy. Journal of Trauma 57 (2004) 709-718
    • (2004) Journal of Trauma , vol.57 , pp. 709-718
    • Dutton, R.P.1    McCunn, M.2    Hyder, M.3
  • 40
    • 24644498683 scopus 로고    scopus 로고
    • "Low-dose" recombinant activated factor VII results in less blood and blood product use in traumatic hemorrhage
    • Harrison T.D., Laskosky J., Jazaeri O., et al. "Low-dose" recombinant activated factor VII results in less blood and blood product use in traumatic hemorrhage. Journal of Trauma 59 (2005) 150-154
    • (2005) Journal of Trauma , vol.59 , pp. 150-154
    • Harrison, T.D.1    Laskosky, J.2    Jazaeri, O.3
  • 41
    • 14744286988 scopus 로고    scopus 로고
    • The role of recombinant factor VIIa in the treatment of life-threatening haemorrhage in blunt trauma
    • Geeraedts Jr. L.M., Kamphuisen P.W., Kaasjager H.A., et al. The role of recombinant factor VIIa in the treatment of life-threatening haemorrhage in blunt trauma. Injury 36 (2005) 495-500
    • (2005) Injury , vol.36 , pp. 495-500
    • Geeraedts Jr., L.M.1    Kamphuisen, P.W.2    Kaasjager, H.A.3
  • 42
    • 17144382514 scopus 로고    scopus 로고
    • Recombinant activated factor VIIa use in massive transfusion and coagulopathy unresponsive to conventional therapy
    • Gowers C.J., and Parr M.J. Recombinant activated factor VIIa use in massive transfusion and coagulopathy unresponsive to conventional therapy. Anaesthesia and Intensive Care 33 (2005) 196-200
    • (2005) Anaesthesia and Intensive Care , vol.33 , pp. 196-200
    • Gowers, C.J.1    Parr, M.J.2
  • 43
    • 19944389258 scopus 로고    scopus 로고
    • The use of recombinant activated factor VII in the control of haemorrhage following blunt pelvic trauma
    • Udy A., Vaghela M., Lawton G., et al. The use of recombinant activated factor VII in the control of haemorrhage following blunt pelvic trauma. Anaesthesia 60 (2005) 613-616
    • (2005) Anaesthesia , vol.60 , pp. 613-616
    • Udy, A.1    Vaghela, M.2    Lawton, G.3
  • 44
    • 21444452237 scopus 로고    scopus 로고
    • The Israeli Multidisciplinary rFVIIa Task Force Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: a report by the Israeli Multidisciplinary rFVIIa Task Force
    • Martinowitz U.M.M. The Israeli Multidisciplinary rFVIIa Task Force Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: a report by the Israeli Multidisciplinary rFVIIa Task Force. Journal of Thrombosis and Haemostasis 3 (2005) 640-648
    • (2005) Journal of Thrombosis and Haemostasis , vol.3 , pp. 640-648
    • Martinowitz, U.M.M.1
  • 45
    • 43149120223 scopus 로고    scopus 로고
    • The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion
    • Spinella P.C., Perkins J.G., McLaughlin D.F., et al. The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion. Journal of Trauma 64 (2008) 286-293
    • (2008) Journal of Trauma , vol.64 , pp. 286-293
    • Spinella, P.C.1    Perkins, J.G.2    McLaughlin, D.F.3
  • 46
    • 24644491444 scopus 로고    scopus 로고
    • NovoSeven Trauma Study Group. Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials
    • Boffard K.D., Riou B., Warren B., et al. NovoSeven Trauma Study Group. Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials. Journal of Trauma 5 (2005) 8-15
    • (2005) Journal of Trauma , vol.5 , pp. 8-15
    • Boffard, K.D.1    Riou, B.2    Warren, B.3
  • 47
    • 34548295999 scopus 로고    scopus 로고
    • Safety of rFVIIa in hemodynamically unstable polytrauma patients with traumatic brain injury: post hoc analysis of 30 patients from a prospective, randomized, placebo-controlled, double-blind clinical trial
    • Kluger Y., Riou B., Rossaint R., et al. Safety of rFVIIa in hemodynamically unstable polytrauma patients with traumatic brain injury: post hoc analysis of 30 patients from a prospective, randomized, placebo-controlled, double-blind clinical trial. Critical Care 11 (2007) R85
    • (2007) Critical Care , vol.11
    • Kluger, Y.1    Riou, B.2    Rossaint, R.3
  • 48
    • 77649083224 scopus 로고    scopus 로고
    • Available at: [accessed June 2009]
    • Available at:. http://clinicaltrials.gov/ct2/show/NCT00184548 [accessed June 2009]
  • 49
    • 34247551016 scopus 로고    scopus 로고
    • Recommendations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding-a European perspective
    • Vincent J.L., Rossaint R., Riou B., et al. Recommendations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding-a European perspective. Critical Care 10 (2006) R120
    • (2006) Critical Care , vol.10
    • Vincent, J.L.1    Rossaint, R.2    Riou, B.3
  • 50
    • 33748957178 scopus 로고    scopus 로고
    • Lancet maternal survival series steering group. Maternal mortality: who, when, where, and why
    • Ronsmans C., and Graham W.J. Lancet maternal survival series steering group. Maternal mortality: who, when, where, and why. Lancet 368 (2006) 1189-1200
    • (2006) Lancet , vol.368 , pp. 1189-1200
    • Ronsmans, C.1    Graham, W.J.2
  • 52
    • 34447329837 scopus 로고    scopus 로고
    • An open non-randomized study of recombinant activated factor VII in major postpartum haemorrhage
    • 929-936
    • Ahonen J., Jokela R., and Korttila K. An open non-randomized study of recombinant activated factor VII in major postpartum haemorrhage. Acta Anaesthesiologica Scandinavica 51 (2007) 929-936
    • (2007) Acta Anaesthesiologica Scandinavica , vol.51
    • Ahonen, J.1    Jokela, R.2    Korttila, K.3
  • 53
    • 43149113247 scopus 로고    scopus 로고
    • A critical review on the use of recombinant factor VIIa in life-threatening obstetric postpartum hemorrhage
    • Franchini M., Franchi M., Bergamini V., et al. A critical review on the use of recombinant factor VIIa in life-threatening obstetric postpartum hemorrhage. Seminars in Thrombosis and Hemostasis 34 (2008) 104-112
    • (2008) Seminars in Thrombosis and Hemostasis , vol.34 , pp. 104-112
    • Franchini, M.1    Franchi, M.2    Bergamini, V.3
  • 54
    • 34848876646 scopus 로고    scopus 로고
    • Recombinant activated factor VII in spinal surgery: a multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial
    • Sachs B., Delacy D., Green J., et al. Recombinant activated factor VII in spinal surgery: a multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial. Spine 32 (2007) 2285-2293
    • (2007) Spine , vol.32 , pp. 2285-2293
    • Sachs, B.1    Delacy, D.2    Green, J.3
  • 55
    • 34247877441 scopus 로고    scopus 로고
    • Recombinant FVIIa decreases perioperative blood transfusion requirement in burn patients undergoing excision and skin grafting-results of a single centre pilot study
    • Johansson P.I., Eriksen K., Nielsen S.L., et al. Recombinant FVIIa decreases perioperative blood transfusion requirement in burn patients undergoing excision and skin grafting-results of a single centre pilot study. Burns 33 (2007) 435-440
    • (2007) Burns , vol.33 , pp. 435-440
    • Johansson, P.I.1    Eriksen, K.2    Nielsen, S.L.3
  • 57
    • 56149089116 scopus 로고    scopus 로고
    • Perioperative hemostatic management of patients treated with vitamin K antagonists
    • Levy J.H., Tanaka K.A., and Dietrich W. Perioperative hemostatic management of patients treated with vitamin K antagonists. Anesthesiology 109 (2008) 918-926
    • (2008) Anesthesiology , vol.109 , pp. 918-926
    • Levy, J.H.1    Tanaka, K.A.2    Dietrich, W.3
  • 58
    • 38349096220 scopus 로고    scopus 로고
    • Role of prothrombin complex concentrates in reversing warfarin anticoagulation: a review of the literature
    • Leissinger C.A., Blatt P.M., Hoots W.K., et al. Role of prothrombin complex concentrates in reversing warfarin anticoagulation: a review of the literature. American Journal of Hematology 83 (2008) 137-143
    • (2008) American Journal of Hematology , vol.83 , pp. 137-143
    • Leissinger, C.A.1    Blatt, P.M.2    Hoots, W.K.3
  • 59
    • 49149099325 scopus 로고    scopus 로고
    • An evaluation of eptacog alfa in nonhaemophiliac conditions
    • Mallarkey G., Brighton T., Thomson A., et al. An evaluation of eptacog alfa in nonhaemophiliac conditions. Drugs 68 (2008) 1665-1689
    • (2008) Drugs , vol.68 , pp. 1665-1689
    • Mallarkey, G.1    Brighton, T.2    Thomson, A.3
  • 60
    • 0031926569 scopus 로고    scopus 로고
    • Population pharmacokinetics of recombinant factor VIIa in volunteers anticoagulated with acenocoumarol
    • Girard P., Nony P., Erhardtsen E., et al. Population pharmacokinetics of recombinant factor VIIa in volunteers anticoagulated with acenocoumarol. Thrombosis and Haemostasis 80 (1998) 109-113
    • (1998) Thrombosis and Haemostasis , vol.80 , pp. 109-113
    • Girard, P.1    Nony, P.2    Erhardtsen, E.3
  • 61
    • 33746712273 scopus 로고    scopus 로고
    • Reversal of elevated international normalized ratios and bleeding with low-dose recombinant activated factor VII in patients receiving warfarin
    • Dager W.E., King J.H., Regalia R.C., et al. Reversal of elevated international normalized ratios and bleeding with low-dose recombinant activated factor VII in patients receiving warfarin. Pharmacotherapy 26 (2006) 1091-1098
    • (2006) Pharmacotherapy , vol.26 , pp. 1091-1098
    • Dager, W.E.1    King, J.H.2    Regalia, R.C.3
  • 62
    • 63149114682 scopus 로고    scopus 로고
    • Emergency reversal of antithrombotic treatment
    • Levi M. Emergency reversal of antithrombotic treatment. Internal and Emergency Medicine 4 (2009) 137-145
    • (2009) Internal and Emergency Medicine , vol.4 , pp. 137-145
    • Levi, M.1
  • 63
    • 0842320982 scopus 로고    scopus 로고
    • Recombinant factor VIIa as an antidote for anticoagulant treatment
    • Levi M., Bijsterveld N.R., and Keller T.T. Recombinant factor VIIa as an antidote for anticoagulant treatment. Seminars in Hematology 41 (2004) 65-69
    • (2004) Seminars in Hematology , vol.41 , pp. 65-69
    • Levi, M.1    Bijsterveld, N.R.2    Keller, T.T.3
  • 64
    • 33644862002 scopus 로고    scopus 로고
    • British committee for standards in haematology. Guidelines on oral anticoagulation (warfarin)
    • -2005 update
    • Baglin T.P., Keeling D.M., and Watson H.G. British committee for standards in haematology. Guidelines on oral anticoagulation (warfarin). -2005 update. British Journal of Haematology 132 (2006) 277-285
    • (2006) British Journal of Haematology , vol.132 , pp. 277-285
    • Baglin, T.P.1    Keeling, D.M.2    Watson, H.G.3
  • 65
    • 33645573977 scopus 로고    scopus 로고
    • A prospective randomized trial of high and standard dosages of re-combinant factor VIIa for treatment of hemarthroses in hemophiliacs with inhibitors
    • Santagostino E., Mancuso M.E., Rocino A., et al. A prospective randomized trial of high and standard dosages of re-combinant factor VIIa for treatment of hemarthroses in hemophiliacs with inhibitors. Journal of Thrombosis and Haemostasis 4 (2006) 367-371
    • (2006) Journal of Thrombosis and Haemostasis , vol.4 , pp. 367-371
    • Santagostino, E.1    Mancuso, M.E.2    Rocino, A.3
  • 66
    • 33750077687 scopus 로고    scopus 로고
    • Secondary prophylactic treatment with rFVIIA in patients with haemophilia A or B and inhibitors with high requirements for on-demand treatment
    • Konkle B., Friedrich U., and Abrams Z. Secondary prophylactic treatment with rFVIIA in patients with haemophilia A or B and inhibitors with high requirements for on-demand treatment. Haemophilia 12 (2006) 363
    • (2006) Haemophilia , vol.12 , pp. 363
    • Konkle, B.1    Friedrich, U.2    Abrams, Z.3
  • 67
    • 18944361867 scopus 로고    scopus 로고
    • Management of bleeding in a multi-transfused patient with positive HLA Class I alloantibodies and thrombocytopenia associated with platelets dysfunction refractory to transfusion of cross matched platelets
    • Heuer L., and Blumenberg D. Management of bleeding in a multi-transfused patient with positive HLA Class I alloantibodies and thrombocytopenia associated with platelets dysfunction refractory to transfusion of cross matched platelets. Blood Coagulation Fibrinolysis 16 (2005) 287-290
    • (2005) Blood Coagulation Fibrinolysis , vol.16 , pp. 287-290
    • Heuer, L.1    Blumenberg, D.2
  • 69
    • 54949106943 scopus 로고    scopus 로고
    • Factor VIIa and its potential therapeutic use in bleeding-associated pathologies
    • Hedner U. Factor VIIa and its potential therapeutic use in bleeding-associated pathologies. Thrombosis and Haemostasis 100 (2008) 557-562
    • (2008) Thrombosis and Haemostasis , vol.100 , pp. 557-562
    • Hedner, U.1
  • 70
    • 0033758789 scopus 로고    scopus 로고
    • Pharmacokinetics of recombinant activated factor VII (rFVIIa)
    • Erhardtsen E. Pharmacokinetics of recombinant activated factor VII (rFVIIa). Seminars in Thrombosis and Hemostasis 26 (2000) 385-391
    • (2000) Seminars in Thrombosis and Hemostasis , vol.26 , pp. 385-391
    • Erhardtsen, E.1
  • 72
    • 38349116191 scopus 로고    scopus 로고
    • Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia
    • CD005011
    • Stanworth S.J., Birchall J., Doree C.J., et al. Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia. Cochrane Database of Systermic Reviews 2 (2007) CD005011
    • (2007) Cochrane Database of Systermic Reviews , vol.2
    • Stanworth, S.J.1    Birchall, J.2    Doree, C.J.3
  • 73
    • 48949118955 scopus 로고    scopus 로고
    • Use of recombinant activated factor VII in patients without hemophilia: a meta-analysis of randomized control trials
    • Hsia C.C., Chin-Yee I.H., and McAlister V.C. Use of recombinant activated factor VII in patients without hemophilia: a meta-analysis of randomized control trials. Annals of Surgery 248 (2008) 61-68
    • (2008) Annals of Surgery , vol.248 , pp. 61-68
    • Hsia, C.C.1    Chin-Yee, I.H.2    McAlister, V.C.3
  • 74
    • 0348163468 scopus 로고    scopus 로고
    • The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients
    • Meng Z.H., Wolberg A.S., Monroe III D.M., et al. The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. Journal of Trauma 55 (2003) 886-891
    • (2003) Journal of Trauma , vol.55 , pp. 886-891
    • Meng, Z.H.1    Wolberg, A.S.2    Monroe III, D.M.3
  • 76
    • 23844442531 scopus 로고    scopus 로고
    • Coagulopathy and blood component transfusion in trauma
    • Spahn D.R., and Rossaint R. Coagulopathy and blood component transfusion in trauma. British Journal of Anaesthesia 95 (2005) 130-139
    • (2005) British Journal of Anaesthesia , vol.95 , pp. 130-139
    • Spahn, D.R.1    Rossaint, R.2
  • 77
    • 10244270631 scopus 로고    scopus 로고
    • The use of recombinant factor VIIa in the treatment of bleeding disorders
    • Roberts H.R., Monroe D.M., and White G.C. The use of recombinant factor VIIa in the treatment of bleeding disorders. Blood 104 (2004) 3858-3864
    • (2004) Blood , vol.104 , pp. 3858-3864
    • Roberts, H.R.1    Monroe, D.M.2    White, G.C.3
  • 78
    • 5644273165 scopus 로고    scopus 로고
    • Recombinant activated factor VII for the treatment of life-threatening haemorrhage
    • Eikelboom J.W., Bird R., Blythe D., et al. Recombinant activated factor VII for the treatment of life-threatening haemorrhage. Blood Coagulation & Fibrinolysis 14 (2003) 713-717
    • (2003) Blood Coagulation & Fibrinolysis , vol.14 , pp. 713-717
    • Eikelboom, J.W.1    Bird, R.2    Blythe, D.3
  • 79
    • 0033825540 scopus 로고    scopus 로고
    • Recombinant factor VIIa treatment of bleeding associated with acute renal failure
    • Moisescu E., Ardelean L., Simion I., et al. Recombinant factor VIIa treatment of bleeding associated with acute renal failure. Blood Coagulation & Fibrinolysis 11 (2000) 575-577
    • (2000) Blood Coagulation & Fibrinolysis , vol.11 , pp. 575-577
    • Moisescu, E.1    Ardelean, L.2    Simion, I.3
  • 80
    • 4544344500 scopus 로고    scopus 로고
    • Recombinant factor VIIa: clinical applications for an intravenous hemostatic agent with broad-spectrum potential
    • Carr Jr. M.E., and Martin E. Recombinant factor VIIa: clinical applications for an intravenous hemostatic agent with broad-spectrum potential. Expert Review of Cardiovascular Theraphy 2 (2004) 661-674
    • (2004) Expert Review of Cardiovascular Theraphy , vol.2 , pp. 661-674
    • Carr Jr., M.E.1    Martin, E.2
  • 81
    • 0024834211 scopus 로고
    • Mechanism by which recombinant factor VIIa shortens the aPTT: activation of factor X in the absence of tissue factor
    • Telgt D.S., Macik B.G., McCord D.M., et al. Mechanism by which recombinant factor VIIa shortens the aPTT: activation of factor X in the absence of tissue factor. Thrombosis Research 56 (1989) 603-609
    • (1989) Thrombosis Research , vol.56 , pp. 603-609
    • Telgt, D.S.1    Macik, B.G.2    McCord, D.M.3
  • 82
    • 0025217848 scopus 로고
    • Factor VIIa-catalyzed activation of factor X independent of tissue factor: its possible significance for control of hemophilic bleeding by infused factor VIIa
    • Rao L.V., and Rapaport S.I. Factor VIIa-catalyzed activation of factor X independent of tissue factor: its possible significance for control of hemophilic bleeding by infused factor VIIa. Blood 75 (1990) 1069-1073
    • (1990) Blood , vol.75 , pp. 1069-1073
    • Rao, L.V.1    Rapaport, S.I.2
  • 83
    • 0842342599 scopus 로고    scopus 로고
    • Understanding the hemostatic effects of recombinant factor VIIa by clot wave form analysis
    • Shima M. Understanding the hemostatic effects of recombinant factor VIIa by clot wave form analysis. Seminars in Hematology 41 (2004) 125-131
    • (2004) Seminars in Hematology , vol.41 , pp. 125-131
    • Shima, M.1
  • 84
    • 0038554771 scopus 로고    scopus 로고
    • Whole blood coagulation thromboelastographic profiles employing minimal tissue factor activation
    • Sørensen B., Johansen P., Christiansen K., et al. Whole blood coagulation thromboelastographic profiles employing minimal tissue factor activation. Journal of Thrombosis and Haemostasis 1 (2003) 551-558
    • (2003) Journal of Thrombosis and Haemostasis , vol.1 , pp. 551-558
    • Sørensen, B.1    Johansen, P.2    Christiansen, K.3
  • 85
    • 47649108091 scopus 로고    scopus 로고
    • Thrombelastographic monitoring of recombinant factor VIIa in acquired haemophilia
    • Dehmel H., Werwitzke S., Trummer A., et al. Thrombelastographic monitoring of recombinant factor VIIa in acquired haemophilia. Haemophilia 14 (2008) 736-742
    • (2008) Haemophilia , vol.14 , pp. 736-742
    • Dehmel, H.1    Werwitzke, S.2    Trummer, A.3
  • 86
    • 43449092203 scopus 로고    scopus 로고
    • Evaluation of thromboelastography for monitoring recombinant activated factor VII ex vivo in haemophilia A and B patients with inhibitors: a multicentre trial
    • Young G., Ebbesen L.S., Viuff D., et al. Evaluation of thromboelastography for monitoring recombinant activated factor VII ex vivo in haemophilia A and B patients with inhibitors: a multicentre trial. Blood Coagulation & Fibrinolysis 19 (2008) 276-282
    • (2008) Blood Coagulation & Fibrinolysis , vol.19 , pp. 276-282
    • Young, G.1    Ebbesen, L.S.2    Viuff, D.3
  • 87
    • 0842342603 scopus 로고    scopus 로고
    • Monitoring coagulation and the clinical effects of recombinant factor VIIa
    • Gabriel D.A., Carr M., and Roberts H.R. Monitoring coagulation and the clinical effects of recombinant factor VIIa. Seminars in Hematology 41 (2004) 20-24
    • (2004) Seminars in Hematology , vol.41 , pp. 20-24
    • Gabriel, D.A.1    Carr, M.2    Roberts, H.R.3
  • 88
    • 44349188657 scopus 로고    scopus 로고
    • New advances in the therapeutic and laboratory management of patients with haemophilia and inhibitors
    • Dargaud Y., Lambert T., and Trossaert M. New advances in the therapeutic and laboratory management of patients with haemophilia and inhibitors. Haemophilia 14 (2008) 20-27
    • (2008) Haemophilia , vol.14 , pp. 20-27
    • Dargaud, Y.1    Lambert, T.2    Trossaert, M.3
  • 89
    • 34548361909 scopus 로고    scopus 로고
    • Recombinant activated factor VII effectively reverses the anticoagulant effects of heparin, enoxaparin, fondaparinux, argatroban, and bivalirudin ex vivo as measured using thromboelastography
    • Young G., Yonekawa K.E., Nakagawa P.A., et al. Recombinant activated factor VII effectively reverses the anticoagulant effects of heparin, enoxaparin, fondaparinux, argatroban, and bivalirudin ex vivo as measured using thromboelastography. Blood Coagulation & Fibrinolysis 18 (2007) 547-553
    • (2007) Blood Coagulation & Fibrinolysis , vol.18 , pp. 547-553
    • Young, G.1    Yonekawa, K.E.2    Nakagawa, P.A.3
  • 90
    • 49949112567 scopus 로고    scopus 로고
    • Thromboelastography-guided recombinant factor VIIa administration in a patient with refractory autoimmune idiopathic thrombocytopenia
    • James K.M., Melikian C.N., Chowdary P., et al. Thromboelastography-guided recombinant factor VIIa administration in a patient with refractory autoimmune idiopathic thrombocytopenia. Anesthesia and Analgesia 107 (2008) 402-405
    • (2008) Anesthesia and Analgesia , vol.107 , pp. 402-405
    • James, K.M.1    Melikian, C.N.2    Chowdary, P.3
  • 91
    • 68049094118 scopus 로고    scopus 로고
    • The role of thromboelastometry and recombinant factor VIIa in trauma
    • Bartal C., and Yitzhak A. The role of thromboelastometry and recombinant factor VIIa in trauma. Current Opinion in Anaesthesiology 22 (2009) 281-288
    • (2009) Current Opinion in Anaesthesiology , vol.22 , pp. 281-288
    • Bartal, C.1    Yitzhak, A.2
  • 92
    • 44649109632 scopus 로고    scopus 로고
    • Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients
    • Levrat A., Gros A., Rugeri L., et al. Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. British Journal of Anaesthesia 100 (2008) 792-797
    • (2008) British Journal of Anaesthesia , vol.100 , pp. 792-797
    • Levrat, A.1    Gros, A.2    Rugeri, L.3
  • 93
    • 0035135796 scopus 로고    scopus 로고
    • A comparison of FVII: C and FVIIa assays for the monitoring of recombinant factor VIIa treatment
    • Cid A.R., Lorenzo J.I., Haya S., et al. A comparison of FVII: C and FVIIa assays for the monitoring of recombinant factor VIIa treatment. Haemophilia 7 (2001) 39-41
    • (2001) Haemophilia , vol.7 , pp. 39-41
    • Cid, A.R.1    Lorenzo, J.I.2    Haya, S.3
  • 94
    • 0142072235 scopus 로고    scopus 로고
    • The calibrated automated thrombogram (CAT): a universal routine test for hyper- and hypocoagulability
    • Hemker H.C., Giesen P., AlDieri R., et al. The calibrated automated thrombogram (CAT): a universal routine test for hyper- and hypocoagulability. Pathophysiology of Haemostasis and Thrombosis 32 (2002) 249-253
    • (2002) Pathophysiology of Haemostasis and Thrombosis , vol.32 , pp. 249-253
    • Hemker, H.C.1    Giesen, P.2    AlDieri, R.3
  • 95
    • 31744432115 scopus 로고    scopus 로고
    • Mechanistic implications for the use and monitoring of recombinant activated factor VII in trauma
    • Pusateri A.E., and Park M.S. Mechanistic implications for the use and monitoring of recombinant activated factor VII in trauma. Critical Care 9 (2005) 15-24
    • (2005) Critical Care , vol.9 , pp. 15-24
    • Pusateri, A.E.1    Park, M.S.2
  • 96
    • 17044405174 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant factor VIIa for treatment of severe bleeding: a systematic review
    • Levi M., Peters M., and Büller H.R. Efficacy and safety of recombinant factor VIIa for treatment of severe bleeding: a systematic review. Critical Care Medicine 33 (2005) 883-890
    • (2005) Critical Care Medicine , vol.33 , pp. 883-890
    • Levi, M.1    Peters, M.2    Büller, H.R.3
  • 97
    • 0036820243 scopus 로고    scopus 로고
    • Fatal thrombosis after administration of activated prothrombin complex concentrates in a patient supported by extracorporeal membrane oxygenation who had received activated recombinant factor VII
    • Bui J.D., Despotis G.D., Trulock E.P., et al. Fatal thrombosis after administration of activated prothrombin complex concentrates in a patient supported by extracorporeal membrane oxygenation who had received activated recombinant factor VII. The Journal of Thoracic and Cardiovascular Surgery 124 (2002) 852-854
    • (2002) The Journal of Thoracic and Cardiovascular Surgery , vol.124 , pp. 852-854
    • Bui, J.D.1    Despotis, G.D.2    Trulock, E.P.3
  • 98
    • 0037069334 scopus 로고    scopus 로고
    • Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers
    • Bijsterveld N.R., Moons A.H., Boekholdt S.M., et al. Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers. Circulation 106 (2002) 2550-2554
    • (2002) Circulation , vol.106 , pp. 2550-2554
    • Bijsterveld, N.R.1    Moons, A.H.2    Boekholdt, S.M.3
  • 99
    • 1542359508 scopus 로고    scopus 로고
    • Recombinant factor VIIa reverses the anticoagulant effect of the long-acting pentasaccharide idraparinux in healthy volunteers
    • Bijsterveld N.R., Vink R., van Aken B.E., et al. Recombinant factor VIIa reverses the anticoagulant effect of the long-acting pentasaccharide idraparinux in healthy volunteers. British Journal of Haematology 124 (2004) 653-658
    • (2004) British Journal of Haematology , vol.124 , pp. 653-658
    • Bijsterveld, N.R.1    Vink, R.2    van Aken, B.E.3
  • 100
    • 18944386159 scopus 로고    scopus 로고
    • A study of the pharmacokinetics and safety of recombinant activated factor VII in healthy Caucasian and Japanese subjects
    • Fridberg M.J., Hedner U., Roberts H.R., et al. A study of the pharmacokinetics and safety of recombinant activated factor VII in healthy Caucasian and Japanese subjects. Blood Coagulation & Fibrinolysis 16 (2005) 259-266
    • (2005) Blood Coagulation & Fibrinolysis , vol.16 , pp. 259-266
    • Fridberg, M.J.1    Hedner, U.2    Roberts, H.R.3
  • 101
    • 3042531845 scopus 로고    scopus 로고
    • Effect of recombinant factor VIIa on melagatran-induced inhibition of thrombin generation and platelet activation in healthy volunteers
    • Wolzt M., Levi M., Sarich T.C., et al. Effect of recombinant factor VIIa on melagatran-induced inhibition of thrombin generation and platelet activation in healthy volunteers. Thrombosis and Haemostasis 91 (2004) 1090-1096
    • (2004) Thrombosis and Haemostasis , vol.91 , pp. 1090-1096
    • Wolzt, M.1    Levi, M.2    Sarich, T.C.3
  • 102
    • 0031756987 scopus 로고    scopus 로고
    • Clinical experience with activated factor VII: focus on safety aspects
    • Roberts H.R. Clinical experience with activated factor VII: focus on safety aspects. Blood Coagulation & Fibrinolysis 9 (1998) 115-118
    • (1998) Blood Coagulation & Fibrinolysis , vol.9 , pp. 115-118
    • Roberts, H.R.1
  • 103
    • 0035198825 scopus 로고    scopus 로고
    • Recombinant factor VIIa (Novoseven) and the safety of treatment
    • Roberts H.R. Recombinant factor VIIa (Novoseven) and the safety of treatment. Seminars in Hematology 38 (2001) 48-50
    • (2001) Seminars in Hematology , vol.38 , pp. 48-50
    • Roberts, H.R.1
  • 104
  • 105
    • 77649124885 scopus 로고    scopus 로고
    • Available at: [accessed June 2009]
    • Available at:. www.emea.europa.eu//humandocs/PDFs/EPAR/Novoseven/072995en8b [accessed June 2009]
  • 106
    • 34547905714 scopus 로고    scopus 로고
    • Management of massive operative blood loss
    • Kozek-Langenecker S. Management of massive operative blood loss. Minerva Anestesiologica 73 (2007) 401-415
    • (2007) Minerva Anestesiologica , vol.73 , pp. 401-415
    • Kozek-Langenecker, S.1
  • 108
    • 35848943443 scopus 로고    scopus 로고
    • Acute coagulopathy of trauma: mechanism, identification and effect
    • Brohi K., Cohen M.J., and Davenport R.A. Acute coagulopathy of trauma: mechanism, identification and effect. Current Opinion in Critical Care 13 (2007) 680-685
    • (2007) Current Opinion in Critical Care , vol.13 , pp. 680-685
    • Brohi, K.1    Cohen, M.J.2    Davenport, R.A.3
  • 109
    • 34248228655 scopus 로고    scopus 로고
    • Task Force for Advanced Bleeding Care in Trauma. Management of bleeding following major trauma: a European guideline
    • Spahn D.R., Cerny V., Coats T.J., et al. Task Force for Advanced Bleeding Care in Trauma. Management of bleeding following major trauma: a European guideline. Critical Care 11 (2007) R17
    • (2007) Critical Care , vol.11
    • Spahn, D.R.1    Cerny, V.2    Coats, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.