Recombinant activated factor VIIa use in massive transfusion and coagulopathy unresponsive to conventional therapy

Anaesthesia and Intensive Care

Volumn 33, Issue 2, 2005, Pages 196-200

  Gowers, C J D ^a   Parr, M J A ^a  

^a LIVERPOOL HOSPITAL   (Australia)

Author keywords

Transfusion, Haemorrhage: recombinant factor VIIa, coagulopathy, trauma, cardiac surgery

Indexed keywords

ANTICOAGULANT AGENT; FRESH FROZEN PLASMA; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

ABDOMINAL INJURY; ADOLESCENT; ADULT; AGED; ANEURYSM RUPTURE; ARTICLE; BLEEDING DISORDER; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TEST; BLOOD TRANSFUSION; BLUNT TRAUMA; CAUSE OF DEATH; CESAREAN SECTION; CLINICAL ARTICLE; CONTROLLED STUDY; CRYOPRECIPITATE; DEMOGRAPHY; DISEASE COURSE; DOSE RESPONSE; DRUG RESPONSE; ERYTHROCYTE TRANSFUSION; FATTY LIVER; FEMALE; GUNSHOT INJURY; HEART SURGERY; HOSPITAL DISCHARGE; HUMAN; ILIAC ARTERY; INTENSIVE CARE UNIT; LUNG EMBOLISM; MALE; MULTIPLE TRAUMA; PH; PLASMA TRANSFUSION; POSTOPERATIVE PERIOD; PROTHROMBIN TIME; RETROSPECTIVE STUDY; TEMPERATURE MEASUREMENT; THROMBOCYTE TRANSFUSION; TREATMENT FAILURE;

EID: 17144382514     PISSN: 0310057X     EISSN: None     Source Type: Journal    
DOI: 10.1177/0310057x0503300207     Document Type: Article

References (10)

1. Kenet G, Walden R, Eldad A, Martinowitz U. Treatment of traumatic bleeding with recombinant factor VIIa. Lancet 1999; 354:1879.
2. Martinowitz U, Kenet G, Segal E et al. Recombinant activated factor VII for adjunctive hemorrhage control in trauma. J Trauma 2001; 51:431-438.
3. Dutton RP, Hess JR Scalea TM. Recombinant factor VIIa for control of hemorrhage: early experience in critically ill trauma patients. J Clin Anesth. 2003; 15:184-188.
4. Lynn M, Jeroukhimov I, Klein Y, Martinowitz U. Updates in the management of severe coagulopathy in trauma patients. Intensive Care Med 2002; 28:S241-S247.
5. O'Neill PA, Bluth M, Gloster ES et al. Succesful use of recombinant activated factor VII for trauma-associated hemorrhage in a patient without preexisting coagulopathy. J Trauma 2002; 52:400-405.
6. Zupancic Salek S, Sokolic V et al. Successful use of recombinant factor VIIa for massive bleeding after caesarean section due to HELLP syndrome. Acta Haematol 2002;108:162-163.
7. Hendriks H, van der Maaten J et al. An effective treatment of severe intractable bleeding after valve repair by one single dose of activated recombinant factor VII. Anesth Analg 2001; 93:287-289.
8. Meng ZH, Wolberg AS, Monroe DM 3rd, Hoffman M. The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. J Trauma 2003; 55:886-891.
9. Roberts HR, Monroe DM 3rd, Hoffman M. Safety Profile of Recombinant Factor VIIa. Semin Hematol 2004; 41:S101-S108.
10. Erhardtsen E. Ongoing NovoSeven trials. Intensive Care Med 2002; 28:S248-S255.