High dose factor VIIa improves clot structure and stability in a model of haemophilia B

British Journal of Haematology

Volumn 131, Issue 5, 2005, Pages 645-655

  Wolberg, Alisa S ^a,b   Allen, Geoffrey A ^a,b   Monroe, Dougald M ^a,b   Hedner, Ulla ^c   Roberts, Harold R ^a,b   Hoffman, Maureane ^b,d,e  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c NOVO NORDISK A S   (Denmark)

^d DURHAM VA MEDICAL CENTER   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Clot; Fibrin; Fibrinolysis; Haemophilia; Plasmin; Recombinant factor VIIa

Indexed keywords

BLOOD CLOTTING FACTOR 9; PLASMIN; RECOMBINANT BLOOD CLOTTING FACTOR 7A; THROMBIN; BLOOD CLOTTING FACTOR 7A; FIBRIN; HEMOSTATIC AGENT; RECOMBINANT PROTEIN; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING TIME; CONTROLLED STUDY; DATA ANALYSIS; DRUG EFFECT; DRUG MEGADOSE; FIBRIN CLOT; FIBRINOLYSIS; HEMOPHILIA B; HEMOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; NORMAL HUMAN; PLASMA; POLYMERIZATION; PRIORITY JOURNAL; BLOOD; COMPARATIVE STUDY; CULTURE TECHNIQUE; DRUG ADMINISTRATION; METABOLISM; PHOTOMETRY; SCANNING ELECTRON MICROSCOPY;

BLOOD COAGULATION; CELL CULTURE TECHNIQUES; DRUG ADMINISTRATION SCHEDULE; FACTOR IX; FACTOR VIIA; FIBRIN; HEMOPHILIA B; HEMOSTASIS; HEMOSTATICS; HUMANS; MICROSCOPY, ELECTRON, SCANNING; NEPHELOMETRY AND TURBIDIMETRY; PLASMIN; RECOMBINANT PROTEINS; THROMBIN; TISSUE PLASMINOGEN ACTIVATOR;

EID: 33644797001     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2005.05820.x     Document Type: Article

References (35)

1. Al Dieri R. Peyvandi F. Santagostino E. Giansily M. Mannucci P.M. Schved J.F. Beguin S. Hemker H.C. ( 2002) The thrombogram in rare inherited coagulation disorders: its relation to clinical bleeding. Thrombosis and Haemostasis, 88, 576 582.
2. Allen G.A. Hoffman M. Roberts H.R. Monroe D.M.I. ( 2002) Recombinant activated factor VII: its mechanism of action and role in the control of hemorrhage. Canadian Journal of Anaesthesia, 49, S7 S14.
3. Allen G.A. Wolberg A.S. Oliver J.A. Hoffman M. Roberts H.R. Monroe D.M. ( 2004) Impact of procoagulant concentration on rate, peak and total thrombin generation in a model system. Journal of Thrombosis and Hemostasis, 2, 402 413.
4. Antovic J.P. Antovic A. He S. Tengborn L. Blomback M. ( 2002) Overall haemostatic potential can be used for estimation of thrombin-activatable fibrinolysis inhibitor-dependent fibrinolysis in vivo and for possible follow-up of recombinant factor VIIa treatment in patients with inhibitors to factor VIII. Haemophilia, 8, 781 786.
5. Bettigole R.E. Hampton J.W. Bird R.M. ( 1964) Abnormal plasma clots in hemophilia. Thrombosis et Diathesis Haemorrhagica, 12, 331 337.
6. Blomback B. Carlsson K. Fatah K. Hessel B. Procyk R. ( 1994) Fibrin in human plasma: gel architectures governed by rate and nature of fibrinogen activation. Thrombosis Research, 75, 521 538.
7. Boffa M.B. Wang W. Bajzar L. Nesheim M.E. ( 1998) Plasma and recombinant thrombin-activable fibrinolysis inhibitor (TAFI) and activated TAFI compared with respect to glycosylation, thrombin/thrombomodulin-dependent activation, thermal stability, and enzymatic properties. Journal of Biological Chemistry, 273, 2127 2135.
8. Broze G.J. Jr. Higuchi D.A. ( 1996) Coagulation-dependent inhibition of fibrinolysis: role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma. Blood, 88, 3815 3823.
9. Brummel-Ziedins K.E. Pouliot R.L. Mann K.G. ( 2004) Thrombin generation: phenotypic quantitation. Journal of Thrombosis and Haemostasis, 2, 281 288.
10. Butenas S. van't Veer C. Cawthern K. Brummel K.E. Mann K.G. ( 2000) Models of blood coagulation. Blood Coagulation and Fibrinolysis, 11 ( Suppl. 1 S9 S13.
11. Butenas S. Brummel K.E. Branda R.F. Paradis S.G. Mann K.G. ( 2002) Mechanism of factor VIIa-dependent coagulation in hemophilia blood. Blood, 99, 923 930.
12. Carr M.E. Jr. Alving B.M. ( 1995) Effect of fibrin structure on plasmin-mediated dissolution of plasma clots. Blood Coagulation and Fibrinolysis, 6, 567 573.
13. Gabriel D.A. Muga K. Boothroyd E.M. ( 1992) The effect of fibrin structure on fibrinolysis. Journal of Biological Chemistry, 267, 24259 24263.
14. Ghosh K. Shetty S. Jijina F. Mohanty D. ( 2004) Role of tifilon amino caproic acid in the management of haemophilic patients with inhibitors. Haemophilia, 10, 58 62.
15. He S. Blomback M. Jacobsson Ekman G. Hedner U. ( 2003) The role of recombinant factor VIIa (FVIIa) in fibrin structure in the absence of FVIII/FIX. Journal of Thrombosis and Haemostasis, 1, 1215 1219.
16. Hoffman M. Pratt C.W. Corbin L.W. Church F.C. ( 1990) Characteristics of the chemotactic activity of heparin cofactor II proteolysis products. Journal of Leukocyte Biology, 48, 156 162.
17. Hoffman M. Monroe D.M. Roberts H.R. ( 1992) A rapid method for the isolation of platelets from human blood. American Journal of Clinical Pathology, 98, 531 533.
18. Jones A.J. Meunier A.M. ( 1990) A precise and rapid microtitre plate clot lysis assay: methodology, kinetic modeling and measurement of catalytic constants for plasminogen activation during fibrinolysis. Thrombosis and Haemostasis, 64, 455 463.
19. Kjalke M. Monroe D.M. Hoffman M. Oliver J.A. Ezban M. Hedner U. Roberts H.R. ( 1998) The effects of activated factor VII in a cell-based model for tissue factor-initiated coagulation. Blood Coagulation and Fibrinolysis, 9, S21 S25.
20. Kjalke M. Ezban M. Monroe D.M. Hoffman M. Roberts H.R. Hedner U. ( 2001) High-dose factor VIIa increases initial thrombin generation and mediates faster platelet activation in thrombocytopenia-like conditions in a cell-based model system. British Journal of Haematology, 114, 114 120.
21. Kumar R. Beguin S. Hemker H.C. ( 1995) The effect of fibrin clots and clot-bound thrombin on the development of platelet procoagulant activity. Thrombosis and Haemostasis, 74, 962 968.
22. Lisman T. Mosnier L.O. Thierry Lambert T. Mauser-Bunschoten E.P. Meijers J.C.M. Nieuwenhuis H.K. de Groot P.G. ( 2002) Inhibition of fibrinolysis by recombinant factor VIIa in plasma from patients with severe hemophilia A. Blood, 99, 175 179.
23. Lusher J.M. ( 1998) Early treatment with recombinant factor VIIa results in greater efficacy with less product. European Journal of Haematology Supplement, 63, 7 10.
24. Monroe D.M. Roberts H.R. Hoffman M. ( 1994) Platelet procoagulant complex assembly in a tissue factor-initiated system. British Journal of Haematology, 88, 364 371.
25. Monroe D.M. Hoffman M. Oliver J.A. Roberts H.R. ( 1997) Platelet activity of high-dose factor VIIa is independent of tissue factor. British Journal of Haematology, 99, 542 547.
26. Monroe D.M. Hoffman M. Roberts H.R. ( 2002) Platelets and thrombin generation. Arteriosclerosis Thrombosis and Vascular Biology, 22, 1381 1389.
27. Mosnier L.O. Buijtenhuijs P. Marx P.F. Meijers J.C. Bouma B.N. ( 2003) Identification of thrombin activatable fibrinolysis inhibitor (TAFI) in human platelets. Blood, 101, 4844 4846.
28. Oliver J.A. Monroe D.M. Roberts H.R. Hoffman M. ( 1999) Thrombin activates factor XI in activated platelets in the absence of factor XII. Arteriosclerosis Thrombosis and Vascular Biology, 19, 170 177.
29. Redlitz A. Tan A.K. Eaton D.L. Plow E.F. ( 1995) Plasma carboxypeptidases as regulators of the plasminogen system. Journal of Clinical Investigation, 96, 2534 2538.
30. Romp K.G. Monroe D.M. Hoffman M. ( 1993) Platelets contain releasable coagulation factor IX antigen. Blood Coagulation and Fibrinolysis, 4, 905 910.
31. Sixma J.J. van den Berg A. ( 1984) The haemostatic plug in haemophilia A: a morphological study of haemostatic plug formation in bleeding time skin wounds of patients with severe haemophilia A. British Journal of Haematology, 58, 741 753.
32. van't Veer C. Mann K.G. ( 2000) The regulation of the factor VII-dependent coagulation pathway: rationale for the effectiveness of recombinant factor VIIa in refractory bleeding disorders. Seminars in Thrombosis and Hemostasis, 26, 367 372.
33. Vanschoonbeek K. Feijge M.A.H. van Kampen R.J.W. Kenis H. Hemker H.C. Giesen P.L.A. Heemskerk J.W.M. ( 2003) Initiating and potentiating role of platelets in tissue factor-induced thrombin generation in the presence of plasma: subject-dependent variation in thrombogram characteristics. Journal of Thrombosis and Haemostasis, 2, 476 484.
34. Wolberg A.S. Gabriel D.A. Hoffman M. ( 2002) Analyzing fibrin clot structure using a microplate reader. Blood Coagulation and Fibrinolysis, 13, 533 539.
35. Wolberg A.S. Monroe D.M. Roberts H.R. Hoffman M. ( 2003) Elevated prothrombin results in clots with an altered fiber structure: a possible mechanism of the increased thrombotic risk. Blood, 101, 3008 3013.