Increased parasite resistance and recurrent airway obstruction in horses of a high-prevalence family

Journal of Veterinary Internal Medicine

Volumn 24, Issue 2, 2010, Pages 407-413

  Neuhaus, S ^a   Bruendler, P ^a   Frey, C F ^a   Gottstein, B ^a   Doherr, M G ^a   Gerber, V ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Equine; Genetic; Hygiene hypothesis

Indexed keywords

ANTHELMINTIC AGENT;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; FECES; FEMALE; GENETIC PREDISPOSITION; GENETICS; HORSE; HORSE DISEASE; IMMUNOLOGY; ISOLATION AND PURIFICATION; MALE; PARASITE IDENTIFICATION; PARASITOLOGY; PREVALENCE; STATISTICAL MODEL; STRONGYLE INFECTION; STRONGYLOIDEA;

ANIMALS; ANTHELMINTICS; FECES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HORSE DISEASES; HORSES; LOGISTIC MODELS; LUNG DISEASES, OBSTRUCTIVE; MALE; PARASITE EGG COUNT; PREVALENCE; STRONGYLIDA; STRONGYLIDA INFECTIONS;

ANIMALIA; EQUIDAE; STRONGYLIDA;

EID: 77649094963     PISSN: 08916640     EISSN: 19391676     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2009.0465.x     Document Type: Article

References (32)

1. Lavoie JP, Maghni K, Desnoyers M, et al. Neutrophilic airway inflammation in horses with heaves is characterized by a Th2type cytokine profile. Am J Respir Crit Care Med 2001;164:1410-1413.
2. Herzberg B, Ramos-Barbon D, Tamaoka M, et al. Heaves, an asthma-like equine disease, involves airway smooth muscle remodeling. J Allergy Clin Immunol 2006;118:382-388.
3. Kirschvink N, Reinhold P. Use of alternative animals as asthma models. Curr Drug Targets 2008;9:470-484.
4. Robinson NE. International workshop on equine chronic airway disease, Michigan State University, 16-18 June 2000. Equine Vet J 2001;33:5-19.
5. Gerber V, Lindberg A, Berney C, Robinson NE. Airway mucus in recurrent airway obstruction-short-term response to evironmental challenge. J Vet Intern Med 2004;18:92-97.
6. Marti E, Gerber H, Essich G. Genetic basis of equine allergic diseases. 1. Chronic hypersensitivity bronchitis. Equine Vet J 1991;23:457-460.
7. Ramseyer A, Gaillard C, Burger D, et al. Effects of genetic and environmental factors on Horse Owner Asessed Respiratory Signs Index (HOARSI). J Vet Intern Med 2007;21:149-156.
8. Gerber V, Baleri D, Klukowska-Rotzler J, et al. Mixed inheritance of equine recurrent airway obstruction. J Vet Intern Med 2009;23:626-630.
9. Jost U, Klukowska-Rotzler J, Dolf G, et al. A region on equine chromosome 13 is linked to recurrent airway obstruction in horses. Equine Vet J 2007;39:236-241.
10. Hershey GK, Friedrich MF, Esswein LA, et al. The association of atopy with a gain-of-function mutation in the a subunit of the interleucin-4 receptor. N Eng J Med 1997;337:1720-1725.
11. Ober C, Leavitt SA, Tsalenko A, et al. Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations. Am J Hum Genet 2000;66:517-526.
12. Scales HE, Ierna MX, Lawrence CE. The role of IL-4, IL-13 and IL-4Ra in the development of protective and pathological responses to Trichinella spiralis. Parasite Immunology 2007;29:81-91.
13. Strachan DP. Hay fever, hygiene, and household size. BMJ 1989;299:1259-1260.
14. Fallon PG, Mangan NE. Suppression of TH2-type allergic reactions by helminth infection. Nat Rev Immunol 2007;7:220-230.
15. Barnes KC, Grant AV, Gao P. A review of the genetic epidemiology of resistance to parasitic disease and atopic asthma: Common variants for common phenotypes? Curr Opin Allergy Clin Immunol 2005;5:379-385.
16. Eysker M, Bakker J, van den Berg M, et al. The use of ageclustered pooled faecal samples for monitoring worm control in horses. Vet Parasitol 2008;151:249-255.
17. Herd RP, Gabel AA. Reduced efficacy of anthelmintics in young compared with adult horses. Equine Vet J 1990;22:164-169.
18. Boersema HH, Eysker M, Maas J, et al. Comparison of the reappearance of strongyle eggs in foals, yearlings and adult horses after treatment with ivermectin or pyrantel. Vet Quart 1996;18:7-9.
19. Von Samson-Himmelstjerna G. Helminthosen der Equiden. In: Schnieder T, ed. Veterinarmedizinische Parasitologie, 6th ed. Stuttgart, PA: Parey; 2006:303-347.
20. Bauer C. Nachweis von Parasitenstadien im Kot. In: Schnieder T, ed. Veterinarmedizinische Parasitologie, 6th ed. Stuttgart, PA: Parey; 2006: 88-96.
21. McKay DM. The beneficial helminth parasite? Parasitology 2006;132:1-12.
22. Arruda LK, Santos AB. Immunologic responses to common antigens in helminthic infections and allergic disease. Curr Opin Allergy Clin Immunol 2005;5:399-402.
23. Carvalho EM, Bastos LS, Araujo MI. Worms and allergy. Parasite Immunol 2006;28:525-534.
24. Leonardi-Bee J, Pritschard D, Britton J. Asthma and current intestinal parasite infection: Systemic review and meta-analysis. Am J Respir Crit Care Med 2006;174:514-523.
25. Meier A, Hertzberg H. Strongyliden beim Pferd. II. Vorkommen von Anthelminthika-Resistenzen in der Schweiz. Schweiz Arch Tierheilk 2005;147:389-396.
26. Grove DI, Forbes IJ. Increased resistance to helminth infestation in an atopic population. Med J Aust 1975;1:336-338.
27. Pritschard DI, Shakib F, Walsh EA, Smith SJ. Measurement of hookworm infection intensity and circulating levels of IgE and autoantibodies to IgE in atopics and nonatopics living in a parasitized community in Papua New Guinea. J Investig Allergol Clin Immunol 1994;4:238-241.
28. Lynch NR, Hagel IA, Palenque ME, et al. Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment. J Allergy Clin Immunol 1998;101:217-221.
29. Horohov DW, Beadle RE, Mouch S, Pourciau SS. Temporal regulation of cytokine mRNA expression in equine recurrent airway obstruction. Vet Immunol Immunopathol 2005;108:237-245.
30. Grunig G, Warnock M, Wakil AE, et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998;282:2261-2263.
31. Marti E, Gerber V, Wilson AD, et al. Report of the 3rd Havemeyer workshop on allergic diseases of the horse, Holar, Iceland, June 2007. Vet Immunol Immunopathol 2008;126: 351-361.
32. Ramsay CE, Hayden CM, Tiller KJ. Association of polymorphisms in the beta2-adrenoceptor gene with higher levels of parasitic infection. Hum Genet 1999;104:269-274.