Airway Mucus in Recurrent Airway Obstruction - Short-Term Response to Environmental Challenge

Journal of Veterinary Internal Medicine

Volumn 18, Issue 1, 2004, Pages 92-97

  Gerber, V ^a   Lindberg, A ^b   Berney, C ^a   Robinson, N E ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Airway; COPD; Heaves; Horse; Inflammation; Mucus

Indexed keywords

ALLERGEN;

AIRWAY OBSTRUCTION; ALLERGIC REACTION; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCUS; CONTROLLED STUDY; CYTOLOGY; DUST; ENDOSCOPY; ENVIRONMENTAL FACTOR; FEMALE; HORSE DISEASE; INFLAMMATION; LUNG LAVAGE; MALE; MUCUS SECRETION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; RECURRENT DISEASE; RESPIRATORY TRACT DISEASE;

AIRWAY OBSTRUCTION; ALLERGENS; ANIMALS; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; CASE-CONTROL STUDIES; FEMALE; HORSE DISEASES; HORSES; INHALATION EXPOSURE; MALE; MUCUS; RECURRENCE; RESPIRATORY HYPERSENSITIVITY;

ANIMALIA; BRONCHUS; EQUIDAE; EQUUS CABALLUS;

EID: 0842330488     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1892/0891-6640(2004)18<92:AMIRAO>2.0.CO;2     Document Type: Article

References (29)

1. Schatzmann U, Straub R, Gerber H. Bronchialsekretaspiration beim Pferd [Transtracheal aspiration in the horse]. Schweiz Arch Tierheilkd 1972;114:395-403.
2. Dixon PM. Respiratory mucociliary clearance in the horse in health and disease, and its pharmaceutical modification. Vet Rec 1992; 131:229-235.
3. Dixon PM, Railton DI, McGorum BC. Equine pulmonary disease: A case control study of 300 referred cases. Part 2: Details of animals and historical and clinical findings. Equine Vet J 1995;27:422-427.
4. Robinson NE, Derksen FJ, Olszewski MA, Buechner-Maxwell VA. The pathogenesis of chronic obstructive pulmonary disease of horses. Br Vet J 1996;152:283-306.
5. Derksen FJ, Scott JS, Miller DC, et al. Bronchoalveolar lavage in ponies with recurrent airway obstruction (heaves). Am Rev Respir Dis 1985;132:1066-1070.
6. Fairbairn SM, Page CP, Lees P, Cunningham FM. Early neutrophil but not eosinophil or platelet recruitment to the lungs of allergic horses following antigen exposure. Clin Exp Allergy 1993;23:821-828.
7. Tremblay GM, Ferland C, Lapointe JM, et al. Effect of stabling on bronchoalveolar cells obtained from normal and COPD horses. Equine Vet J 1993;25:194-197.
8. Holcombe SJ, Jackson C, Gerber V, et al. Stabling is associated with airway inflammation in young horses. Equine Vet J 2001;33:244-249.
9. Picot R, Das I, Reid L. Pus, deoxyribonucleic acid, and sputum viscosity. Thorax 1978;33:235-242.
10. Nadel JA, Takeyama K, Agusti C. Role of neutrophil elastase in hypersecretion in asthma. Eur Respir J 1999;13:190-196.
11. Gerber V, King M, Schneider DA, Robinson NE. Mucus viscoelasticity and clearability during environmental challenge in horses with recurrent airway obstruction. Equine Vet J 2000;32:411-418.
12. Coombs SL, Webbon PM. Observations on tracheal mucociliary clearance in horses. Tierarztl Prax Suppl 1987;2:5-9.
13. Turgut K, Sasse HH. Influence of clenbuterol on mucociliary transport in healthy horses and horses with chronic obstructive pulmonary disease. Vet Rec 1989;125:526-530.
14. Gerber V, Robinson NE, Venta PJ, et al. Mucin genes in horse airways: MUC5AC, but not MUC2, may play a role in recurrent airway obstruction. Equine Vet J 2003;35:252-257.
15. Jefcoat AM, Hotchkiss JA, Gerber V, et al. Persistent mucin glycoprotein alterations in equine recurrent airway obstruction. Am J Physiol Lung Cell Mol Physiol 2001;281:L704-L712.
16. Robinson NE, Olszewski MA, Boehler D, et al. Relationship between clinical signs and lung function in horses with recurrent airway obstruction (heaves) during a bronchodilator trial. Equine Vet J 2000;32:393-400.
17. Anonymous. International Workshop on Equine Chronic Airway Disease. Michigan State University, June 2000. Equine Vet J 2001;33:5-19.
18. Dieckmann MP. Zur Wirksamkeit von Ambroxolhydrochlorid (Mukovent) bei lungenkranken Pferden - klinische, funktionelle und zytologische Untersuchungen [Efficacy of Ambroxolhydrochloride (Mukovent) in Horses with Lung Disease - Clinical, Functional and Cytological Investigations]. Hannover, Germany: Tieraerztliche Hochschule; 1987. Dissertation.
19. Brunner E, Domhof S, Langer F. Nonparametric analysis of longitudinal data in factorial experiments. New York, NY: Wiley; 2002.
20. Gerber V, Robinson NE, Luethi S, et al. Airway inflammation and mucus in two age groups of asymptomatic well-performing sport horses. Equine Vet J 2003;35:491-495.
21. Sweeney CR, Rossier Y, Ziemer EL, Lindborg SR. Effect of prior lavage on bronchoalveolar lavage fluid cell population of lavaged and unlavaged lung segments in horses. Am J Vet Res 1994;55:1501-1504.
22. Anonymous. International Workshop on Inflammatory Airway Disease: Defining the Syndrome. Boston, October 2002. Equine Vet Educ. In press.
23. Bracher V, von Fellenberg R, Winder CN, et al. An investigation of the incidence of chronic obstructive pulmonary disease (COPD) in random populations of Swiss horses. Equine Vet J 1991;23:136-141.
24. Sasse HHL, Boerma S, Smolders FAA. The relationship between pulmonary function tests and other parameters. Results of a research project into the aethiology of C.O.P.D. in horses. In: Deegen E, Beadle RE, eds. Lung Function and Respiratory Disease in the Horse. Stuttgart, Germany: Hippiatrika Verlagsversellschaft mbH; 1986:46-48.
25. Woods PS, Robinson NE, Swanson MC, et al. Airborne dust and aeroallergen concentration in a horse stable under two different management systems. Equine Vet J 1993;25:208-213.
26. McGorum BC, Ellison J, Cullen RT. Total and respirable airborne dust endotoxin concentrations in three equine management systems. Equine Vet J 1998;30:430-434.
27. Takeyama K, Dabbagh K, Jeong Shim J, et al. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: Role of neutrophils. J Immunol 2000;164:1546-1552.
28. Fischer B, Voynow J. Neutrophil elastase induces MUC5AC messenger RNA expression by an oxidant-dependent mechanism. Chest 2000;117(Suppl 1):317S-320S.
29. Pietra M, Guglielmini C, Forni M, Cinotti S. In vitro mucolytic activity of recombinant human deoxyribonuclease on equine tracheobronchial mucus. Vet Rec 2000;147:627-629.