Association of polymorphisms in the β2-adrenoreceptor gene with higher levels of parasitic infection

Human Genetics

Volumn 104, Issue 3, 1999, Pages 269-274

  Ramsay, Claire E ^a   Hayde, Catherine M ^a   Tiller, Katrina J ^c   Burton, Paul R ^c   Hagel, Isabel ^d   Palenque, Miguel ^e   Lynch, Neil R ^d   Goldblatt, Jack ^b   LeSouëf, Peter N ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d INSTITUTO DE BIOMEDICINA   (Venezuela)

^e Experimental Asthma Clinic   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; IMMUNOGLOBULIN E ANTIBODY; PARASITE ANTIBODY; PARASITE ANTIGEN; ARGININE; GLUTAMINE; IMMUNOGLOBULIN E;

ADOLESCENT; ARTICLE; ASCARIS LUMBRICOIDES; ASTHMA; CHILD; DNA HYBRIDIZATION; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HELMINTHIASIS; HUMAN; MALE; NORMAL HUMAN; PARASITOSIS; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR GENE; SKIN TEST; VENEZUELA; AMINO ACID SUBSTITUTION; ANIMAL; BLOOD; CYTOLOGY; EOSINOPHIL; GENETIC POLYMORPHISM; GENETICS; IMMUNOLOGY; LEUKOCYTE COUNT; PARASITE IDENTIFICATION; PRESCHOOL CHILD; PREVALENCE; SKIN; STATISTICAL ANALYSIS;

ASCARIS LUMBRICOIDES;

ADOLESCENT; AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; ASCARIS LUMBRICOIDES; ASTHMA; CHILD; CHILD, PRESCHOOL; DATA INTERPRETATION, STATISTICAL; EOSINOPHILS; FEMALE; GENOTYPE; GLUTAMINE; HELMINTHIASIS; HUMANS; IMMUNOGLOBULIN E; LEUKOCYTE COUNT; MALE; PARASITE EGG COUNT; POLYMORPHISM, GENETIC; PREVALENCE; RECEPTORS, ADRENERGIC, BETA-2; SKIN; VENEZUELA;

EID: 0032588016     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004390050947     Document Type: Article

References (25)

1. Abel L, Demenais F, Prata A, Souza AE, Dessein A (1991) Evidence for the segregation of a major gene in human susceptibility/resistance to infection by Schistosoma mansoni. Am J Hum Genet 48:959-970
2. Brown HW (1975) Basic clinical parasitology, 4th edn. Appleton-Century-Crofis, New York
3. 2-adrenergic receptor in asthma. Respir Crit Care Med 155:A256
4. 2-Adrenoreceptor polymorphisms are in linkage disequilibrium, but are not associated with asthma in an adult population. Clin Exp Allergy 28:442-448
5. 2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families. J Allergy Clin Immunol 100:261-265
6. 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 33:9414-9419
7. 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol 13:25-33
8. 2-adrenoreceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 345:1213-1214
9. Holgate ST (1997) Asthma genetics: waiting to exhale. Nat Genet 15:227-229
10. 2-adrenergic receptor polymorphism at amino acid 16 as a risk factor for bronchial hyperresponsiveness. Am J Respir Crit Care Med 151:A673
11. 2-adrenergic receptor: a protein with multiple membrane spanning domains encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci USA 84:46-50
12. Leeman BJ, Cabrera MR (1995) No association found between Strongyloides infestation and asthma. J Asthma 32:57-62
13. Lynch NR (1987) Immediate hypersensitivity (allergic) reactions to intestinal helminthic infections. Baillieres Clin Trop Med Commun Dis 2:573-593
14. Lynch NR, Hagel I, Perez M, DiPrisco M, Alvarez N, Rojas E (1992) Bronchoconstriction in helminthic infection. Int Arch Allergy Immunol 98:77-79
15. Lynch NR, Palenque M, Hagel I, DiPrisco MC (1997) Clinical improvement of asthma after anthelminthic treatment in a tropical situation. Am J Respir Crit Care Med 156:50-54
16. Lynch NR. Hagel IA, Palenque ME, DiPrisco MC, Escudero JE, Corao LA, Sandia JA, Ferreira LJ, Botto C, Perez M, LeSouef PN (1998) Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment. J Allergy Clin Immunol 101:217-221
17. Marquet S, Abel L, Hillaire D, Dessein H, Kalil J, Feingold J, Wiessenbach J, Dessein A (1996) Genetic localization of a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31-33. Nat Genet 14:181-184
18. Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Ehrlich-Kautzky E, Schou C, Krishnaswamy G (1994) Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immumoglobulin E concentrations. Science 264:1152-1156
19. 2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 100:3184-3188
20. Moqbel R, Pritchard DI (1990) Parasites and allergy: evidence for a "cause and effect" relationship. Clin Exp Allergy 20:611-618
21. Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CIM, Meyers DA, Levitt RC (1995) Genetic susceptibility to asthma - bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 333:894-900
22. 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 8:334-339
23. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
24. Sutton BJ, Gould HJ (1993) The human IgE network. Nature 336:421-428
25. 2-adrenergic receptor in nocturnal and nonnocturnal asthma. J Clin Invest 95:1635-1641