Prolonged osteogenesis from human mesenchymal stem cells implanted in immunodeficient mice by using coralline hydroxyapatite incorporating rhBMP2 microspheres

Journal of Biomedical Materials Research - Part A

Volumn 92, Issue 4, 2010, Pages 1256-1264

  Fu, Kun ^a,b   Xu, Qingguo ^c   Czernuszka, Jan ^c   McKenna, Charles E ^d   Ebetino, Frank H ^e   Russell, R Graham G ^a   Triffitt, James T ^a   Xia, Zhidao ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b HAINAN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e Procter and Gamble Pharm   (United States)

Author keywords

(PLGA); Coralline hydroxyapatite (CHA); Human mesenchymal stem cells (hMSCs); Immunodeficient mice; Poly(lactic co glycolic acid); Recombinant human bone morphogenetic protein 2 (rhBMP2)

Indexed keywords

CORALLINE HYDROXYAPATITE; HUMAN BONE MORPHOGENETIC PROTEIN; HUMAN MESENCHYMAL STEM CELLS (HMSCS); POLY(LACTIC-CO-GLYCOLIC ACID); RHBMP-2;

ACIDS; ANIMAL CELL CULTURE; APATITE; BIOACTIVITY; BIOMATERIALS; BONE; CELL CULTURE; FLUORESCENCE; FLUORESCENCE MICROSCOPY; HISTOLOGY; HYDROXYAPATITE; MONOCLONAL ANTIBODIES; PEPTIDES; SCAFFOLDS;

STEM CELLS;

HYDROXYAPATITE; MICROSPHERE; POLYGLACTIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RISEDRONIC ACID; ROSEOLIC ACID; TISSUE SCAFFOLD; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; SCANNING ELECTRON MICROSCOPY;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE MORPHOGENETIC PROTEIN 2; CERAMICS; COLLAGEN; DRUG COMPOUNDING; HUMANS; HYDROXYAPATITES; LACTIC ACID; MATERIALS TESTING; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, SCID; MICROSPHERES; OSTEOGENESIS; POLYGLYCOLIC ACID; POROSITY; RECOMBINANT PROTEINS; TISSUE SCAFFOLDS; TRANSPLANTATION, HETEROLOGOUS; VIMENTIN;

EID: 77349126917     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32453     Document Type: Article

References (31)

1. Langer R, Vacanti JP. Tissue engineering. Science 1993;260:920-926.
2. Palsson B, Bhatia S. Tissue Engineering. Upper Saddle River, NJ: Pearson; 2004. xviii, 407 p.
3. Triffitt JT. Osteogenic stem cells and orthopedic engineering: summary and update. J Biomed Mater Res 2002;63:384-389.
4. Xia Z, Taylor PR, Locklin RM, Gordon S, Cui Z, Triffitt JT. Innate immune response to human bone marrow fibroblastic cell implantation in CB17 scid/beige mice. J Cell Biochem 2006;98:966-980.
5. Toquet J, Rohanizadeh R, Guicheux J, Couillaud S, Passuti N, Daculsi G, Heymann D. Osteogenic potential in vitro of human bone marrow cells cultured on macroporous biphasic calcium phosphate ceramic. J Biomed Mater Res 1999;44:98-108.
6. Boynton E, Aubin J, Gross A, Hozumi N, Sandhu J. Human osteoblasts survive and deposit new bone when human bone is implanted in SCID mouse. Bone 1996;18:321-326.
7. Mora F, Ouhayoun JP. Clinical evaluation of natural coral and porous hydroxyapatite implants in periodontal bone lesions: Results of a 1-year follow-up. J Clin Periodontol 1995;22:877-884.
8. Hou R, Chen F, Yang Y, Cheng X, Gao Z, Yang HO, Wu W, Mao T. Comparative study between coral-mesenchymal stem cells-rhBMP-2 composite and auto-bone-graft in rabbit critical-sized cranial defect model. J Biomed Mater Res A 2007;80:85-93.
9. Gao T, Lindholm TS, Marttinen A, Urist MR. Composites of bone morphogenetic protein (BMP) and type IV collagen, coral-derived coral hydroxyapatite, and tricalcium phosphate ceramics. Int Orthop 1996;20:321-325.
10. Gao TJ, Lindholm TS, Kommonen B, Ragni P, Paronzini A, Lindholm TC, Jalovaara P, Urist MR. The use of a coral composite implant containing bone morphogenetic protein to repair a segmental tibial defect in sheep. Int Orthop 1997;21:194-200.
11. Rafati H, Lavelle EC, Coombes AG, Stolnik S, Holland J, Davis SS. The immune response to a model antigen associated with PLG microparticles prepared using different surfactants. Vaccine 1997;15(17/18):1888-1897.
12. Lu L, Stamatas GN, Mikos AG. Controlled release of transforming growth factor beta1 from biodegradable polymer microparticles. J Biomed Mater Res 2000;50:440-451.
13. Blankenship DT, Krivanek MA, Ackermann BL, Cardin AD. High-sensitivity amino acid analysis by derivatization with O-phthalaldehyde and 9-fluorenylmethyl chloroformate using fluorescence detection: Applications in protein structure determination. Anal Biochem 1989;178:227-232.
14. Oreffo RO, Bord S, Triffitt JT. Skeletal progenitor cells and ageing human populations. Clin Sci (Lond) 1998;94:549-555.
15. Seeman E. Reduced bone formation and increased bone resorption: Rational targets for the treatment of osteoporosis. Osteoporos Int 2003;14(Suppl 3):S2-S8.
16. Pacifici R. Cytokines, estrogen, and postmenopausal osteoporosis - The second decade. Endocrinology 1998;139:2659-2661.
17. Abrahamsen B, Bonnevie-Nielsen V, Ebbesen EN, Gram J, Beck-Nielsen H. Cytokines and bone loss in a 5-year longitudinal study - Hormone replacement therapy suppresses serum soluble interleukin-6 receptor and increases interleukin-1-receptor antagonist: The Danish Osteoporosis Prevention Study. J Bone Miner Res 2000;15:1545-1554.
18. Leize EM, Hemmerle J, Voegel JC, Leize M. Characterization and histological analyses of a coral-collagen composite used for bone-replacement graft material: A report of clinical cases. J Mater Sci Mater Med 1999;10:47-51.
19. Mygind T, Stiehler M, Baatrup A, Li H, Zou X, Flyvbjerg A, Kassem M, Bunger C. Mesenchymal stem cell ingrowth and differentiation on coralline hydroxyapatite scaffolds. Biomaterials 2007;28:1036-1047.
20. Harris CT, Cooper LF. Comparison of bone graft matrices for human mesenchymal stem cell-directed osteogenesis. J Biomed Mater Res A 2004;68:747-755.
21. Chen F, Mao T, Tao K, Chen S, Ding G, Gu X. Bone graft in the shape of human mandibular condyle reconstruction via seeding marrow-derived osteoblasts into porous coral in a nude mice model. J Oral Maxillofac Surg 2002;60:1155-1159.
22. Arnaud E, De Pollak C, Meunier A, Sedel L, Damien C, Petite H. Osteogenesis with coral is increased by BMP and BMC in a rat cranioplasty. Biomaterials 1999;20:1909-1918.
23. White AP, Vaccaro AR, Hall JA, Whang PG, Friel BC, McKee MD. Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion. Int Orthop 2007;31:735-741.
24. Johnsson R, Stromqvist B, Aspenberg P. Randomized radiostereometric study comparing osteogenic protein-1 (BMP-7) and autograft bone in human noninstrumented posterolateral lumbar fusion: 2002 Volvo Award in clinical studies. Spine 2002;27:2654-2661.
25. Giannoudis PV, Tzioupis C. Clinical applications of BMP-7: The UK perspective. Injury 2005;36(Suppl 3):S47-S50.
26. Jones AL, Bucholz RW, Bosse MJ, Mirza SK, Lyon TR, Webb LX, Pollak AN, Golden JD, Valentin-Opran A. Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial. J Bone Joint Surg Am 2006;88:1431-1441.
27. Chen FM, Wu ZF, Sun HH, Wu H, Xin SN, Wang QT, Dong GY, Ma ZW, Huang S, Zhang YJ, Jin Y. Release of bioactive BMP from dextran-derived microspheres: A novel delivery concept. Int J Pharm 2006;307:23-32.
28. Maire M, Chaubet F, Mary P, Blanchat C, Meunier A, Logeart-Avramoglou D. Bovine BMP osteoinductive potential enhanced by functionalized dextran-derived hydrogels. Biomaterials 2005;26:5085-5092.
29. Russell RG, Xia Z, Dunford JE, Oppermann U, Kwaasi A, Hulley PA, Kavanagh KL, Triffitt JT, Lundy MW, Phipps RJ, Barnett BL, Coxon FP, Rogers MJ, Watts NB, Ebetino FH. Bisphosphonates: An update on mechanisms of action and how these relate to clinical efficacy. Ann NY Acad Sci 2007;1117:209-257.
30. Henneman ZJ, Nancollas GH, Ebetino FH, Russell RG, Phipps RJ. Bisphosphonate binding affinity as assessed by inhibition of carbonated apatite dissolution in vitro. J Biomed Mater Res A 2008;85:993-1000.
31. Gandsman EJ, McCullough RW. Dynamic bone imaging in the differential diagnosis of skeletal lesions. Int J Rad Appl Instrum B 1990;17:533-541.