Human osteoblasts survive and deposit new bone when human bone is implanted in SCID mouse

Bone

Volumn 18, Issue 4, 1996, Pages 321-326

  Boynton, E ^a   Aubin, J ^b   Gross, A ^a   Hozumi, N ^a   Sandhu, J ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Bone remodeling; Bone transplantation; Hematopoiesis; Histology; Histomorphometry; SCID mice

Indexed keywords

ANTIBODY; HLA ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; TETRACYCLINE;

AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE NECROSIS; BONE TRANSPLANTATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL ISOLATION; CELL SURVIVAL; CHILD; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; FEMALE; HISTOCHEMISTRY; HUMAN; HUMAN CELL; MACROPHAGE; MALE; MESENCHYME CELL; MORPHOMETRICS; MOUSE; NATURAL KILLER CELL; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; RADIATION;

EID: 0029872672     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/8756-3282(96)00015-4     Document Type: Article

References (17)

1. Burwell, R. G. Studies in the transplantation of bone. V. The capacity of fresh and treated homografts of bone to evoke transplantation immunity. J Bone Joint Surg Br 45B:386-401; 1963.
2. Chambers, T. J. The cellular basis of bone resorption. Clin Orthop Rel Res 151:283-293; 1980.
3. Eriksen, E. F. Normal and pathological remodeling of human trabecular bone: Three dimensional reconstruction of the remodeling sequence in normal and in metabolic bone tissue. Endocr Rev 7:379-408; 1986.
4. Friedlaender, G. E. and Strong, D. M. Studies on the antigenicity of bone. I. Freeze-dried and deep-frozen bone allografts in rabbits. J Bone Joint Surg 58:854-858; 1976.
5. Hirano, H. and Finerman, G. A. M. Induction of new-bone formation in the host bed by human bone-tumor transplants in athymic nude mice. J Bone Joint Surg 61A; 1207-1216; 1979.
6. Hirano, H. and Urist, M. R. Induced bone development in transplants of fresh human pseudomalignant heterotopic ossification tissue in athymic nude mice. Clin Orthop 263:113-120; 1991.
7. Hozumi, N., Gorczynski, R., Peters, W., and Sandhu, J. SCID mouse model for human immune response and disease. Res Immunol 145:370-379; 1994.
8. Kahn, A., Gibbons, R., Perkins, S., and Gazit, D. Age-related bone loss: A hypothesis and initial assessment in mice. Clin Orthop Rel Res 313:69-75; 1995.
9. Kenzora, R. E., Steele, R. E., Yosipovitch, B., and Glimcher, M. J. Experimental osteonecrosis of the femoral head in adult rabbits. Clin Orthop 130:8-46; 1978.
10. Kliman, M., Halloran, P. F., Lee, E., Esses, S., Fortner, P., and Langer, F. Orthotopic bone transplantation in mice. III. Methods of reducing the immune response and their effect on healing. Transplant 31:34-40; 1981.
11. Kyoizumi, S., Baum, C. M., Kaneshima, H., McCune, J. M., Yee, E. J., and Namikawa, R. Implantation and maintenance of functional human bone marrow in SCID-hu mice. Blood 79:1704-1711; 1992.
12. Nishida, Y., Kondo, S., Miura, Y., Iwata, H., and Isobe, K. I. Survival of syngeneic and allogenic grafted bone in transgenic mice. Biochem. Biophys Res Commun 196:1081-1085; 1993.
13. Raisz, L. G. Local and systemic factors in the pathogenesis of osteoporosis. N Engl J Med 318:818-828; 1988.
14. Sandhu, J. S., Clark, B., Boynton, E., Keating, A., and Hozumi, N. Human hematopoiesis in SCID mice implanted with human adult cancellous bone. Unpublished.
15. Sandhu, J. S., Shpitz, B., Gallinger, S., and Hozumi, N. Human primary immune response in SCID mice engrafted with HuPBLs. J Immunol 152:3806-3813; 1994.
16. Turksen, K., Bhargave, U., Moe, H. K., and Aubin, J. E. Isolation of monoclonal antibodies recognizing rat bone-associated molecules in vitro and in vivo. J Histochem Cytochem 40:1339-1352; 1992.
17. Zheng, M. H., Wood, D. J., and Papadimitriou, J. What's new in the role of cytokines on osteoblast proliferation and differentiation. Pathol Res Pract 188:1104-1121; 1992.