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Volumn 30, Issue 1, 2010, Pages 17-25

Pathology of early hepatocellular carcinoma: Conventional and molecular diagnosis

Author keywords

Dysplastic nodule; Glutamine synthetase; Glypican 3; Heat shock protein 70; Hepatocellular carcinoma; Nodule in nodule; Stromal invasion

Indexed keywords

GLUTAMATE AMMONIA LIGASE; GLYPICAN 3; HEAT SHOCK PROTEIN 70; MOLECULAR MARKER;

EID: 77349103260     PISSN: 02728087     EISSN: 10988971     Source Type: Journal    
DOI: 10.1055/s-0030-1247129     Document Type: Review
Times cited : (132)

References (54)
  • 1
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • Practice Guidelines Committee, American Association for the Study of Liver Diseases
    • Bruix J, Sherman M, Practice Guidelines Committee, American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma. Hepatology 2005 42 (5) 1208-1236
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 2
    • 26844544060 scopus 로고    scopus 로고
    • Diagnosis of small HCC
    • Bruix J, Sherman M. Diagnosis of small HCC. Gastroenterology 2005 129 (4) 1364
    • (2005) Gastroenterology , vol.129 , Issue.4 , pp. 1364
    • Bruix, J.1    Sherman, M.2
  • 3
    • 20344399151 scopus 로고    scopus 로고
    • Early hepatocellular carcinoma and dysplastic nodules
    • Kojiro M, Roskams T. Early hepatocellular carcinoma and dysplastic nodules. Semin Liver Dis 2005 25 (2) 133-142
    • (2005) Semin Liver Dis , vol.25 , Issue.2 , pp. 133-142
    • Kojiro, M.1    Roskams, T.2
  • 4
    • 0029155354 scopus 로고
    • Terminology of nodular hepatocellular lesions
    • International Working Party
    • Party I W., International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995 22 (3) 983-993
    • (1995) Hepatology , vol.22 , Issue.3 , pp. 983-993
    • Party, I.W.1
  • 5
    • 61949171989 scopus 로고    scopus 로고
    • Pathologic diagnosis of early hepatocellular carcinoma: A report of the International Consensus Group for Hepatocellular Neoplasia
    • International Consensus Group for Hepatocellular Neoplasia
    • International Consensus Group for Hepatocellular Neoplasia. Pathologic diagnosis of early hepatocellular carcinoma: a report of the International Consensus Group for Hepatocellular Neoplasia. Hepatology 2009 49 (2) 658-664
    • (2009) Hepatology , vol.49 , Issue.2 , pp. 658-664
  • 6
    • 0029810226 scopus 로고    scopus 로고
    • Adult cirrhotic liver explants: Precancerous lesions and undetected small hepatocellular carcinomas
    • Mion F, Grozel L, Boillot O, Paliard P, Berger F. Adult cirrhotic liver explants: precancerous lesions and undetected small hepatocellular carcinomas. Gastroenterology 1996 111 (6) 1587-1592
    • (1996) Gastroenterology , vol.111 , Issue.6 , pp. 1587-1592
    • Mion, F.1    Grozel, L.2    Boillot, O.3    Paliard, P.4    Berger, F.5
  • 7
    • 0027198036 scopus 로고
    • A clinicopathologic study of adenomatous hyperplasia of the liver in 209 consecutive cirrhotic livers examined by autopsy
    • Terada T, Terasaki S, Nakanuma Y. A clinicopathologic study of adenomatous hyperplasia of the liver in 209 consecutive cirrhotic livers examined by autopsy. Cancer 1993 72 (5) 1551-1556
    • (1993) Cancer , vol.72 , Issue.5 , pp. 1551-1556
    • Terada, T.1    Terasaki, S.2    Nakanuma, Y.3
  • 8
    • 0028898433 scopus 로고
    • Macroregenerative nodules in a series of adult cirrhotic liver explants: Issues of classification and nomenclature
    • Hytiroglou P, Theise N D., Schwartz M, Mor E, Miller C, Thung S N. Macroregenerative nodules in a series of adult cirrhotic liver explants: issues of classification and nomenclature. Hepatology 1995 21 (3) 703-708
    • (1995) Hepatology , vol.21 , Issue.3 , pp. 703-708
    • Hytiroglou, P.1    Theise, N.D.2    Schwartz, M.3    Mor, E.4    Miller, C.5    Thung, S.N.6
  • 9
    • 0036712048 scopus 로고    scopus 로고
    • Focal lesions in cirrhotic explant livers: Pathological evaluation and accuracy of pretransplantation imaging examinations
    • Libbrecht L, Bielen D, Verslype C et al. Focal lesions in cirrhotic explant livers: pathological evaluation and accuracy of pretransplantation imaging examinations. Liver Transpl 2002 8 (9) 749-761
    • (2002) Liver Transpl , vol.8 , Issue.9 , pp. 749-761
    • Libbrecht, L.1    Bielen, D.2    Verslype, C.3
  • 10
    • 14544292426 scopus 로고    scopus 로고
    • Preneoplastic lesions in human hepatocarcinogenesis
    • Libbrecht L, Desmet V, Roskams T. Preneoplastic lesions in human hepatocarcinogenesis. Liver Int 2005 25 (1) 16-27
    • (2005) Liver Int , vol.25 , Issue.1 , pp. 16-27
    • Libbrecht, L.1    Desmet, V.2    Roskams, T.3
  • 11
    • 0022474895 scopus 로고
    • Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver. Observations in five cases
    • Arakawa M, Kage M, Sugihara S, Nakashima T, Suenaga M, Okuda K. Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver. Observations in five cases. Gastroenterology 1986 91 (1) 198-208
    • (1986) Gastroenterology , vol.91 , Issue.1 , pp. 198-208
    • Arakawa, M.1    Kage, M.2    Sugihara, S.3    Nakashima, T.4    Suenaga, M.5    Okuda, K.6
  • 12
    • 0015598739 scopus 로고
    • Liver cell dysplasia: A premalignant condition
    • Anthony P P., Vogel C L., Barker L F. Liver cell dysplasia: a premalignant condition. J Clin Pathol 1973 26 (3) 217-223
    • (1973) J Clin Pathol , vol.26 , Issue.3 , pp. 217-223
    • Anthony, P.P.1    Vogel, C.L.2    Barker, L.F.3
  • 13
    • 1942487260 scopus 로고    scopus 로고
    • Morphological changes of early human hepatocarcinogenesis
    • Hytiroglou P. Morphological changes of early human hepatocarcinogenesis. Semin Liver Dis 2004 24 (1) 65-75
    • (2004) Semin Liver Dis , vol.24 , Issue.1 , pp. 65-75
    • Hytiroglou, P.1
  • 14
    • 0024445389 scopus 로고
    • Survey of iron-accumulative macroregenerative nodules in cirrhotic livers
    • Terada T, Nakanuma Y. Survey of iron-accumulative macroregenerative nodules in cirrhotic livers. Hepatology 1989 10 (5) 851-854 (Pubitemid 19270173)
    • (1989) Hepatology , vol.10 , Issue.5 , pp. 851-854
    • Terada, T.1    Nakanuma, Y.2
  • 15
    • 0034569119 scopus 로고    scopus 로고
    • Premalignant lesions of hepatocellular carcinoma: Pathologic viewpoint
    • Kojiro M. Premalignant lesions of hepatocellular carcinoma: pathologic viewpoint. J Hepatobiliary Pancreat Surg 2000 7 (6) 535-541
    • (2000) J Hepatobiliary Pancreat Surg , vol.7 , Issue.6 , pp. 535-541
    • Kojiro, M.1
  • 16
    • 0028792192 scopus 로고
    • Arterial elements and perisinusoidal cells in borderline hepatocellular nodules and small hepatocellular carcinomas
    • Terada T, Nakanuma Y. Arterial elements and perisinusoidal cells in borderline hepatocellular nodules and small hepatocellular carcinomas. Histopathology 1995 27 (4) 333-339
    • (1995) Histopathology , vol.27 , Issue.4 , pp. 333-339
    • Terada, T.1    Nakanuma, Y.2
  • 18
    • 0032712149 scopus 로고    scopus 로고
    • The vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: Implications for diagnosis and classification
    • Roncalli M, Roz E, Coggi G et al. The vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: implications for diagnosis and classification. Hepatology 1999 30 (5) 1174-1178
    • (1999) Hepatology , vol.30 , Issue.5 , pp. 1174-1178
    • Roncalli, M.1    Roz, E.2    Coggi, G.3
  • 19
    • 0033754784 scopus 로고    scopus 로고
    • Molecular changes in hepatocellular dysplastic nodules on microdissected liver biopsies
    • Maggioni M, Coggi G, Cassani B et al. Molecular changes in hepatocellular dysplastic nodules on microdissected liver biopsies. Hepatology 2000 32 (5) 942-946
    • (2000) Hepatology , vol.32 , Issue.5 , pp. 942-946
    • Maggioni, M.1    Coggi, G.2    Cassani, B.3
  • 20
    • 0034991865 scopus 로고    scopus 로고
    • An early lesion in hepatic carcinogenesis: Loss of heterozygosity in human cirrhotic livers and dysplastic nodules at the 1p36-p34 region
    • Sun M, Eshleman J R., Ferrell L D. et al. An early lesion in hepatic carcinogenesis: loss of heterozygosity in human cirrhotic livers and dysplastic nodules at the 1p36-p34 region. Hepatology 2001 33 (6) 1415-1424
    • (2001) Hepatology , vol.33 , Issue.6 , pp. 1415-1424
    • Sun, M.1    Eshleman, J.R.2    Ferrell, L.D.3
  • 21
    • 0036091657 scopus 로고    scopus 로고
    • Chromosomal alterations in hepatocellular nodules by comparative genomic hybridization: High-grade dysplastic nodules represent early stages of hepatocellular carcinoma
    • Tornillo L, Carafa V, Sauter G et al. Chromosomal alterations in hepatocellular nodules by comparative genomic hybridization: high-grade dysplastic nodules represent early stages of hepatocellular carcinoma. Lab Invest 2002 82 (5) 547-553
    • (2002) Lab Invest , vol.82 , Issue.5 , pp. 547-553
    • Tornillo, L.1    Carafa, V.2    Sauter, G.3
  • 22
    • 34247400156 scopus 로고    scopus 로고
    • Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis
    • Plentz R, Park Y N., Lechel A et al. Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis. Hepatology 2007 45 968-976
    • (2007) Hepatology , vol.45 , pp. 968-976
    • Plentz, R.1    Park, Y.N.2    Lechel, A.3
  • 23
    • 0042093775 scopus 로고    scopus 로고
    • Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development
    • Borzio M, Fargion S, Borzio F et al. Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol 2003 39 (2) 208-214
    • (2003) J Hepatol , vol.39 , Issue.2 , pp. 208-214
    • Borzio, M.1    Fargion, S.2    Borzio, F.3
  • 25
    • 0021947111 scopus 로고
    • Dynamic computed tomography during arterial portography: The most sensitive examination for small hepatocellular carcinomas
    • Matsui O, Takashima T, Kadoya M et al. Dynamic computed tomography during arterial portography: the most sensitive examination for small hepatocellular carcinomas. J Comput Assist Tomogr 1985 9 (1) 19-24
    • (1985) J Comput Assist Tomogr , vol.9 , Issue.1 , pp. 19-24
    • Matsui, O.1    Takashima, T.2    Kadoya, M.3
  • 26
    • 0026595112 scopus 로고
    • Small hepatocellular carcinoma: Diagnosis with US angiography with intraarterial CO2 microbubbles
    • Kudo M, Tomita S, Tochio H et al. Small hepatocellular carcinoma: diagnosis with US angiography with intraarterial CO2 microbubbles. Radiology 1992 182 (1) 155-160
    • (1992) Radiology , vol.182 , Issue.1 , pp. 155-160
    • Kudo, M.1    Tomita, S.2    Tochio, H.3
  • 27
    • 0036283861 scopus 로고    scopus 로고
    • Sonographic detection of hepatocellular carcinoma and dysplastic nodules in cirrhosis: Correlation of pretransplantation sonography and liver explant pathology in 200 patients
    • Bennett G L., Krinsky G A., Abitbol R J., Kim S Y., Theise N D., Teperman L W. Sonographic detection of hepatocellular carcinoma and dysplastic nodules in cirrhosis: correlation of pretransplantation sonography and liver explant pathology in 200 patients. AJR Am J Roentgenol 2002 179 (1) 75-80
    • (2002) AJR Am J Roentgenol , vol.179 , Issue.1 , pp. 75-80
    • Bennett, G.L.1    Krinsky, G.A.2    Abitbol, R.J.3    Kim, S.Y.4    Theise, N.D.5    Teperman, L.W.6
  • 28
    • 0035063666 scopus 로고    scopus 로고
    • Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis: Prospective diagnosis with MR imaging and explantation correlation
    • Krinsky G A., Lee V S., Theise N D. et al. Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis: prospective diagnosis with MR imaging and explantation correlation. Radiology 2001 219 (2) 445-454
    • (2001) Radiology , vol.219 , Issue.2 , pp. 445-454
    • Krinsky, G.A.1    Lee, V.S.2    Theise, N.D.3
  • 29
    • 33750438796 scopus 로고    scopus 로고
    • Stepwise carcinogenesis of hepatocellular carcinoma in the cirrhotic liver: Demonstration on serial MR imaging
    • van den Bos I C., Hussain S M., Terkivatan T, Zondervan P E., de Man R A. Stepwise carcinogenesis of hepatocellular carcinoma in the cirrhotic liver: demonstration on serial MR imaging. J Magn Reson Imaging 2006 24 (5) 1071-1080
    • (2006) J Magn Reson Imaging , vol.24 , Issue.5 , pp. 1071-1080
    • Van Den Bos, I.C.1    Hussain, S.M.2    Terkivatan, T.3    Zondervan, P.E.4    De Man, R.A.5
  • 30
    • 0029131938 scopus 로고
    • Pathomorphologic characteristics of small hepatocellular carcinoma: A special reference to small hepatocellular carcinoma with indistinct margins
    • Nakashima O, Sugihara S, Kage M, Kojiro M. Pathomorphologic characteristics of small hepatocellular carcinoma: a special reference to small hepatocellular carcinoma with indistinct margins. Hepatology 1995 22 (1) 101-105
    • (1995) Hepatology , vol.22 , Issue.1 , pp. 101-105
    • Nakashima, O.1    Sugihara, S.2    Kage, M.3    Kojiro, M.4
  • 31
    • 0031059533 scopus 로고    scopus 로고
    • Stromal and blood vessel wall invasion in well-differentiated hepatocellular carcinoma
    • Nakano M, Saito A, Yamamoto M, Doi M, Takasaki K. Stromal and blood vessel wall invasion in well-differentiated hepatocellular carcinoma. Liver 1997 17 (1) 41-46
    • (1997) Liver , vol.17 , Issue.1 , pp. 41-46
    • Nakano, M.1    Saito, A.2    Yamamoto, M.3    Doi, M.4    Takasaki, K.5
  • 32
    • 61949171989 scopus 로고    scopus 로고
    • Pathologic diagnosis of early hepatocellular carcinoma: A report of the international consensus group for hepatocellular neoplasia
    • International Consensus Group for Hepatocellular NeoplasiaThe International Consensus Group for Hepatocellular Neoplasia
    • International Consensus Group for Hepatocellular NeoplasiaThe International Consensus Group for Hepatocellular Neoplasia. Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia. Hepatology 2009 49 (2) 658-664
    • (2009) Hepatology , vol.49 , Issue.2 , pp. 658-664
  • 33
    • 0026451313 scopus 로고
    • An immunohistochemical study of the blood vessels within primary hepatocellular tumours
    • Dhillon A P., Colombari R, Savage K, Scheuer P J. An immunohistochemical study of the blood vessels within primary hepatocellular tumours. Liver 1992 12 (5) 311-318
    • (1992) Liver , vol.12 , Issue.5 , pp. 311-318
    • Dhillon, A.P.1    Colombari, R.2    Savage, K.3    Scheuer, P.J.4
  • 34
    • 0032955759 scopus 로고    scopus 로고
    • Vascularization of small hepatocellular carcinomas: Correlation with differentiation
    • Nakashima Y, Nakashima O, Hsia C C., Kojiro M, Tabor E. Vascularization of small hepatocellular carcinomas: correlation with differentiation. Liver 1999 19 (1) 12-18
    • (1999) Liver , vol.19 , Issue.1 , pp. 12-18
    • Nakashima, Y.1    Nakashima, O.2    Hsia, C.C.3    Kojiro, M.4    Tabor, E.5
  • 35
    • 0031929668 scopus 로고    scopus 로고
    • Angiogenesis in hepatocellular carcinoma as evaluated by CD34 immunohistochemistry
    • Kimura H, Nakajima T, Kagawa K et al. Angiogenesis in hepatocellular carcinoma as evaluated by CD34 immunohistochemistry. Liver 1998 18 (1) 14-19
    • (1998) Liver , vol.18 , Issue.1 , pp. 14-19
    • Kimura, H.1    Nakajima, T.2    Kagawa, K.3
  • 36
    • 0028787106 scopus 로고
    • CD34 expression in endothelial cells of small hepatocellular carcinoma: Its correlation with tumour progression and angiographic findings
    • Maeda T, Adachi E, Kajiyama K et al. CD34 expression in endothelial cells of small hepatocellular carcinoma: its correlation with tumour progression and angiographic findings. J Gastroenterol Hepatol 1995 10 (6) 650-654
    • (1995) J Gastroenterol Hepatol , vol.10 , Issue.6 , pp. 650-654
    • Maeda, T.1    Adachi, E.2    Kajiyama, K.3
  • 37
    • 0028176887 scopus 로고
    • Alpha-smooth muscle actin-positive perisinusoidal stromal cells in human hepatocellular carcinoma
    • Enzan H, Himeno H, Iwamura S et al. Alpha-smooth muscle actin-positive perisinusoidal stromal cells in human hepatocellular carcinoma. Hepatology 1994 19 (4) 895-903
    • (1994) Hepatology , vol.19 , Issue.4 , pp. 895-903
    • Enzan, H.1    Himeno, H.2    Iwamura, S.3
  • 38
    • 33750430854 scopus 로고    scopus 로고
    • Glypican-3 expression distinguishes small hepatocellular carcinomas from cirrhosis, dysplastic nodules, and focal nodular hyperplasia-like nodules
    • Libbrecht L, Severi T, Cassiman D et al. Glypican-3 expression distinguishes small hepatocellular carcinomas from cirrhosis, dysplastic nodules, and focal nodular hyperplasia-like nodules. Am J Surg Pathol 2006 30 (11) 1405-1411
    • (2006) Am J Surg Pathol , vol.30 , Issue.11 , pp. 1405-1411
    • Libbrecht, L.1    Severi, T.2    Cassiman, D.3
  • 39
    • 33750983031 scopus 로고    scopus 로고
    • Glypican-3 expression in hepatocellular tumors: Diagnostic value for preneoplastic lesions and hepatocellular carcinomas
    • Wang X Y., Degos F, Dubois S et al. Glypican-3 expression in hepatocellular tumors: diagnostic value for preneoplastic lesions and hepatocellular carcinomas. Hum Pathol 2006 37 (11) 1435-1441
    • (2006) Hum Pathol , vol.37 , Issue.11 , pp. 1435-1441
    • Wang, X.Y.1    Degos, F.2    Dubois, S.3
  • 40
    • 0038786861 scopus 로고    scopus 로고
    • Glypican-3: A novel serum and histochemical marker for hepatocellular carcinoma
    • Capurro M, Wanless I R., Sherman M et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology 2003 125 (1) 89-97
    • (2003) Gastroenterology , vol.125 , Issue.1 , pp. 89-97
    • Capurro, M.1    Wanless, I.R.2    Sherman, M.3
  • 41
    • 0037428667 scopus 로고    scopus 로고
    • Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling
    • Midorikawa Y, Ishikawa S, Iwanari H et al. Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling. Int J Cancer 2003 103 (4) 455-465
    • (2003) Int J Cancer , vol.103 , Issue.4 , pp. 455-465
    • Midorikawa, Y.1    Ishikawa, S.2    Iwanari, H.3
  • 42
    • 0038054270 scopus 로고    scopus 로고
    • Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker
    • Nakatsura T, Yoshitake Y, Senju S et al. Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker. Biochem Biophys Res Commun 2003 306 (1) 16-25
    • (2003) Biochem Biophys Res Commun , vol.306 , Issue.1 , pp. 16-25
    • Nakatsura, T.1    Yoshitake, Y.2    Senju, S.3
  • 43
    • 0038752042 scopus 로고    scopus 로고
    • Glypican-3 is overexpressed in human hepatocellular carcinoma
    • Sung Y K., Hwang S Y., Park M K. et al. Glypican-3 is overexpressed in human hepatocellular carcinoma. Cancer Sci 2003 94 (3) 259-262
    • (2003) Cancer Sci , vol.94 , Issue.3 , pp. 259-262
    • Sung, Y.K.1    Hwang, S.Y.2    Park, M.K.3
  • 44
    • 33750968283 scopus 로고    scopus 로고
    • The values and limitations of glypican-3 as a novel tumor marker for hepatocellular carcinoma from clinical and economic viewpoints
    • Moriguchi H, Sato C. The values and limitations of glypican-3 as a novel tumor marker for hepatocellular carcinoma from clinical and economic viewpoints. Gastroenterology 2004 127 (2) 679-680
    • (2004) Gastroenterology , vol.127 , Issue.2 , pp. 679-680
    • Moriguchi, H.1    Sato, C.2
  • 45
    • 38449095281 scopus 로고    scopus 로고
    • Glypican-3 immunocytochemistry in liver fine-needle aspirates: A novel stain to assist in the differentiation of benign and malignant liver lesions
    • Kandil D, Leiman G, Allegretta M et al. Glypican-3 immunocytochemistry in liver fine-needle aspirates: a novel stain to assist in the differentiation of benign and malignant liver lesions. Cancer 2007 111 (5) 316-322
    • (2007) Cancer , vol.111 , Issue.5 , pp. 316-322
    • Kandil, D.1    Leiman, G.2    Allegretta, M.3
  • 47
    • 0033724701 scopus 로고    scopus 로고
    • Chaperones in cell cycle regulation and mitogenic signal transduction: A review
    • Helmbrecht K, Zeise E, Rensing L. Chaperones in cell cycle regulation and mitogenic signal transduction: a review. Cell Prolif 2000 33 (6) 341-365
    • (2000) Cell Prolif , vol.33 , Issue.6 , pp. 341-365
    • Helmbrecht, K.1    Zeise, E.2    Rensing, L.3
  • 48
    • 0037223571 scopus 로고    scopus 로고
    • Expression profiling in multistage hepatocarcinogenesis: Identification of HSP70 as a molecular marker of early hepatocellular carcinoma
    • Chuma M, Sakamoto M, Yamazaki K et al. Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma. Hepatology 2003 37 (1) 198-207
    • (2003) Hepatology , vol.37 , Issue.1 , pp. 198-207
    • Chuma, M.1    Sakamoto, M.2    Yamazaki, K.3
  • 49
    • 33947396135 scopus 로고    scopus 로고
    • Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis
    • Di Tommaso L, Franchi G, Park Y N. et al. Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology 2007 45 (3) 725-734
    • (2007) Hepatology , vol.45 , Issue.3 , pp. 725-734
    • Di Tommaso, L.1    Franchi, G.2    Park, Y.N.3
  • 50
    • 0025049516 scopus 로고
    • Expression patterns of mRNAs for ammonia-metabolizing enzymes in the developing rat: The ontogenesis of hepatocyte heterogeneity
    • Moorman A FM, De Boer P A., Das A T., Labruyre W T., Charles R, Lamers W H. Expression patterns of mRNAs for ammonia-metabolizing enzymes in the developing rat: the ontogenesis of hepatocyte heterogeneity. Histochem J 1990 22 (9) 457-468
    • (1990) Histochem J , vol.22 , Issue.9 , pp. 457-468
    • Moorman, A.F.1    De Boer, P.A.2    Das, A.T.3    Labruyre, W.T.4    Charles, R.5    Lamers, W.H.6
  • 51
    • 0024535224 scopus 로고
    • Localization of ammonia-metabolizing enzymes in human liver: Ontogenesis of heterogeneity
    • Moorman A F., Vermeulen J L., Charles R, Lamers W H. Localization of ammonia-metabolizing enzymes in human liver: ontogenesis of heterogeneity. Hepatology 1989 9 (3) 367-372
    • (1989) Hepatology , vol.9 , Issue.3 , pp. 367-372
    • Moorman, A.F.1    Vermeulen, J.L.2    Charles, R.3    Lamers, W.H.4
  • 53
    • 33846846541 scopus 로고    scopus 로고
    • Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas
    • Zucman-Rossi J, Benhamouche S, Godard C et al. Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas. Oncogene 2007 26 (5) 774-780
    • (2007) Oncogene , vol.26 , Issue.5 , pp. 774-780
    • Zucman-Rossi, J.1    Benhamouche, S.2    Godard, C.3
  • 54
    • 0033557619 scopus 로고    scopus 로고
    • Acquisition of glutamine synthetase expression in human hepatocarcinogenesis: Relation to disease recurrence and possible regulation by ubiquitin-dependent proteolysis
    • Osada T, Sakamoto M, Nagawa H et al. Acquisition of glutamine synthetase expression in human hepatocarcinogenesis: relation to disease recurrence and possible regulation by ubiquitin-dependent proteolysis. Cancer 1999 85 (4) 819-831
    • (1999) Cancer , vol.85 , Issue.4 , pp. 819-831
    • Osada, T.1    Sakamoto, M.2    Nagawa, H.3


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