A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: Comparison with histidyl-tRNA synthetase

Journal of Molecular Biology

Volumn 309, Issue 4, 2001, Pages 989-1002

  Yaremchuk, Anna ^a,b   Tukalo, Michael ^a,b   Grøtli, Morton ^c   Cusack, Stephen ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^b INSTITUTE OF MOLECULAR BIOLOGY AND GENETICS   (Ukraine)

^c Calsberg Laboratory   (Denmark)

Author keywords

Amino acid specificity; Class IIa synthetase; Histidyl tRNA synthetase; Induced fit; Prolyl tRNA synthetase

Indexed keywords

BACTERIAL ENZYME; HISTIDINE TRANSFER RNA LIGASE; PROLINE TRANSFER RNA; SYNTHETASE;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; THERMUS THERMOPHILUS;

THERMUS THERMOPHILUS;

EID: 0035875882     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4712     Document Type: Article

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