-
1
-
-
0020545035
-
Biotransformation of 7-ethoxycoumarin in isolated perfused rainbow trout liver
-
Andersson T, Förlin L, Hansson T. 1983. Biotransformation of 7-ethoxycoumarin in isolated perfused rainbow trout liver. Drug Metab Disposit 11:494-498.
-
(1983)
Drug Metab Disposit
, vol.11
, pp. 494-498
-
-
Andersson, T.1
Förlin, L.2
Hansson, T.3
-
2
-
-
0019491161
-
Use of the partition coefficient as an indicator of bioaccumulation tendency of dyestuffs in fish
-
Anliker R, Clarke EA, Moser P. 1981. Use of the partition coefficient as an indicator of bioaccumulation tendency of dyestuffs in fish. Chemosphere 10:263-74.
-
(1981)
Chemosphere
, vol.10
, pp. 263-274
-
-
Anliker, R.1
Clarke, E.A.2
Moser, P.3
-
3
-
-
34250172720
-
A terrestrial food-chain bioaccumulation model for POPs
-
Armitage J, Gobas FAPC. 2007. A terrestrial food-chain bioaccumulation model for POPs. Environ Sci Technol 41:4019-4025.
-
(2007)
Environ Sci Technol
, vol.41
, pp. 4019-4025
-
-
Armitage, J.1
Gobas, F.A.P.C.2
-
4
-
-
77249112810
-
-
Society of Environmental Toxicology and Chemistry (SETAC), SETAC Globe, March-April 2007
-
Arnot J, Domoradzki J, Dyer S, Eickhoff C, Erhardt S, Escher B, Han X, Halder M, Hutchinson T, Leonard M, Panter G, Parkerton T, Sahi J, Segner H, Thomas K, Weisbrod A. 2007. Considerations for chemical selection supporting in vitro biotransformation and prediction of bioaccumulation in fish. Society of Environmental Toxicology and Chemistry (SETAC), SETAC Globe, March-April 2007, p 25-26.
-
(2007)
Considerations for Chemical Selection Supporting in Vitro Biotransformation and Prediction of Bioaccumulation in Fish
, pp. 25-26
-
-
Arnot, J.1
Domoradzki, J.2
Dyer, S.3
Eickhoff, C.4
Erhardt, S.5
Escher, B.6
Han, X.7
Halder, M.8
Hutchinson, T.9
Leonard, M.10
Panter, G.11
Parkerton, T.12
Sahi, J.13
Segner, H.14
Thomas, K.15
Weisbrod, A.16
-
5
-
-
0037501161
-
A generic QSAR for assessing the bioaccumulation potential of organic chemicals in aquatic food webs
-
Arnot JA, Gobas FAPC. 2003. A generic QSAR for assessing the bioaccumulation potential of organic chemicals in aquatic food webs. QSAR Comb Sci 22:337-345.
-
(2003)
QSAR Comb Sci
, vol.22
, pp. 337-345
-
-
Arnot, J.A.1
Gobas, F.A.P.C.2
-
6
-
-
4644229906
-
A food web bioaccumulation model for organic chemicals in aquatic ecosystems
-
Arnot JA, Gobas FAPC. 2004. A food web bioaccumulation model for organic chemicals in aquatic ecosystems. Environ Toxicol Chem 23:2343-2355.
-
(2004)
Environ Toxicol Chem
, vol.23
, pp. 2343-2355
-
-
Arnot, J.A.1
Gobas, F.A.P.C.2
-
7
-
-
33847026208
-
A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in fish
-
Arnot JA, Gobas FAPC. 2006. A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in fish. Environ Rev 14:257-297.
-
(2006)
Environ Rev
, vol.14
, pp. 257-297
-
-
Arnot, J.A.1
Gobas, F.A.P.C.2
-
8
-
-
42449132540
-
Estimating metabolic biotransformation rates in fish from laboratory data
-
Arnot JA, Mackay D, Bonnell M. 2008. Estimating metabolic biotransformation rates in fish from laboratory data. Environ Toxicol Chem 27:341-351.
-
(2008)
Environ Toxicol Chem
, vol.27
, pp. 341-351
-
-
Arnot, J.A.1
Mackay, D.2
Bonnell, M.3
-
9
-
-
0034661726
-
Validation of negligible depletion solid-phase microextraction as a tool to determine tissue/blood partition coefficients for semivolatile and nonvolatile organic chemicals
-
Artola-Garicano E, Vaes WHJ, Hermens JLM. 2000. Validation of negligible depletion solid-phase microextraction as a tool to determine tissue/blood partition coefficients for semivolatile and nonvolatile organic chemicals. Toxicol Appl Pharmacol 166:138-144.
-
(2000)
Toxicol Appl Pharmacol
, vol.166
, pp. 138-144
-
-
Artola-Garicano, E.1
Vaes, W.H.J.2
Hermens, J.L.M.3
-
10
-
-
0035286778
-
Caco-2 monolayers in experimental and theoretical predictions of drug transport
-
DOI 10.1016/S0169-409X(00)00128-9, PII S0169409X00001289
-
Artursson P, Palm K, Luthman K. 2001. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Advan Drug Delivery Rev 46:27-43. (Pubitemid 33653412)
-
(2000)
Advanced Drug Delivery Reviews
, vol.46
, Issue.1-3
, pp. 27-43
-
-
Artursson, P.1
Palm, K.2
Luthman, K.3
-
11
-
-
0036891948
-
The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties
-
Austin RP, Barton P, Cockroft SL, Wenlock MC, Riley RJ. 2002. The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties. Drug Metab Dispos 30:1497-1503.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 1497-1503
-
-
Austin, R.P.1
Barton, P.2
Cockroft, S.L.3
Wenlock, M.C.4
Riley, R.J.5
-
12
-
-
14044251501
-
The binding of drugs to hepatocytes and its relationship to physicochemical properties
-
Austin RP, Barton P, Mohmed S, Riley RJ. 2005. The binding of drugs to hepatocytes and its relationship to physicochemical properties. Drug Metab Disposit 33:419-425.
-
(2005)
Drug Metab Disposit
, vol.33
, pp. 419-425
-
-
Austin, R.P.1
Barton, P.2
Mohmed, S.3
Riley, R.J.4
-
14
-
-
84956702415
-
High-throughput solubility, permeability, and the MAD PAMPA model
-
Testa B, Krämer SD, Wunderli-Allenspach H, Folkers G, editors. Zürich (CH): Wiley-VCH
-
Avdeef A. 2006. High-throughput solubility, permeability, and the MAD PAMPA model. In: Testa B, Krämer SD, Wunderli-Allenspach H, Folkers G, editors. Pharmacokinetic profiling in drug research: Biological, physicochemical, and computational strategies. Zürich (CH): Wiley-VCH. p 221-243.
-
(2006)
Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies
, pp. 221-243
-
-
Avdeef, A.1
-
16
-
-
0242382054
-
A review and comparison of models for predicting dynamic chemical bioconcentration in fish
-
Barber MC. 2003. A review and comparison of models for predicting dynamic chemical bioconcentration in fish. Environ Toxicol Chem 22:1963-1992.
-
(2003)
Environ Toxicol Chem
, vol.22
, pp. 1963-1992
-
-
Barber, M.C.1
-
17
-
-
33750617025
-
PAMPA-excipient classification gradient map
-
Bendels S, Tsinman O, Wagner B, Lipp D, Parrilla I, Kansy M, Avdeef A. 2006. PAMPA-excipient classification gradient map. Pharm Res 23:2525-2535.
-
(2006)
Pharm Res
, vol.23
, pp. 2525-2535
-
-
Bendels, S.1
Tsinman, O.2
Wagner, B.3
Lipp, D.4
Parrilla, I.5
Kansy, M.6
Avdeef, A.7
-
18
-
-
0016783378
-
Bioconcentration of 2, 2′, 4, 4′-tetrachlorobiphenyl in rainbow trout as measured in an accelerated test
-
Branson DR, Blau GE, Alexander HC, Neely WB. 1975. Bioconcentration of 2, 2′, 4, 4′-tetrachlorobiphenyl in rainbow trout as measured in an accelerated test. Trans Am Fish Soc 104:785-792.
-
(1975)
Trans Am Fish Soc
, vol.104
, pp. 785-792
-
-
Branson, D.R.1
Blau, G.E.2
Alexander, H.C.3
Neely, W.B.4
-
19
-
-
0019782918
-
Accumulation and elimination kinetics of di-, tri-, and tetra chlorobiphenyls by goldfish after dietary and aqueous exposure
-
Bruggeman WA, Martron LBJM, Kooiman D, Hutzinger O. 1981. Accumulation and elimination kinetics of di-, tri-, and tetra chlorobiphenyls by goldfish after dietary and aqueous exposure. Chemosphere 10:811-832.
-
(1981)
Chemosphere
, vol.10
, pp. 811-832
-
-
Bruggeman, W.A.1
Martron, L.B.J.M.2
Kooiman, D.3
Hutzinger, O.4
-
20
-
-
0031910989
-
Comparison of two models for prediction bioaccumulation of hydrophobic chemicals in Great Lakes foodwebs
-
Burkhard LP. 1998. Comparison of two models for prediction bioaccumulation of hydrophobic chemicals in Great Lakes foodwebs. Environ Toxicol Chem 17:383-393.
-
(1998)
Environ Toxicol Chem
, vol.17
, pp. 383-393
-
-
Burkhard, L.P.1
-
21
-
-
77249124425
-
-
[CEPA] Canadian Environmental Protection Act., Chapter 33. Act assented to September 14, 1999. Accessed 24 September 2008
-
[CEPA] Canadian Environmental Protection Act. 1999. Statutes of Canada 1999, Chapter 33. Act assented to September 14, 1999. laws.justice.gc.ca/en/C- 15.31/text.html. Accessed 24 September 2008.
-
(1999)
Statutes of Canada 1999
-
-
-
22
-
-
0025470967
-
Model of organic chemical uptake and clearance by fish from food and water
-
Clark KE, Gobas FAPC, Mackay D. 1990. Model of organic chemical uptake and clearance by fish from food and water. Environ Sci Technol 24:1203-1213.
-
(1990)
Environ Sci Technol
, vol.24
, pp. 1203-1213
-
-
Clark, K.E.1
Gobas, F.A.P.C.2
Mackay, D.3
-
23
-
-
0024263588
-
Use of polynomial expressions to describe the bioconcentration of hydrophobic chemicals by fish
-
Connell DW, Hawker DW. 1988. Use of polynomial expressions to describe the bioconcentration of hydrophobic chemicals by fish. Ecotoxicol Environ Safety 16:242-257.
-
(1988)
Ecotoxicol Environ Safety
, vol.16
, pp. 242-257
-
-
Connell, D.W.1
Hawker, D.W.2
-
24
-
-
38849178804
-
Approach for extrapolating in vitro metabolism data to refine bioconcentration factor estimates
-
Cowan-Ellsberry CE, Dyer SD, Erhardt S, Bernhard MJ, Roe AL, Dowty ME, Weisbrod AV. 2008. Approach for extrapolating in vitro metabolism data to refine bioconcentration factor estimates. Chemosphere 70:1804-1817.
-
(2008)
Chemosphere
, vol.70
, pp. 1804-1817
-
-
Cowan-Ellsberry, C.E.1
Dyer, S.D.2
Erhardt, S.3
Bernhard, M.J.4
Roe, A.L.5
Dowty, M.E.6
Weisbrod, A.V.7
-
26
-
-
0012932403
-
Comparison of fish bioconcentration models
-
Devillers J, editor, Washington DC: Taylor and Francis
-
Devillers J, Domine D, Bintein S, Karcher W. 1998. Comparison of fish bioconcentration models. In: Devillers J, editor, Comparative QSAR. Washington DC: Taylor and Francis. p 1-50.
-
(1998)
Comparative QSAR
, pp. 1-50
-
-
Devillers, J.1
Domine, D.2
Bintein, S.3
Karcher, W.4
-
27
-
-
33847753464
-
Animal use replacement reduction, and refinement: Development of an integrated testing strategy for bioconcentration of chemicals in fish
-
de Wolf W, Comber M, Douben P, Gimeno S, Holt M, Léonard M, Lillicrap A, Sijm D, van Egmond R, Weisbrod A, Whale G. 2007. Animal use replacement reduction, and refinement: Development of an integrated testing strategy for bioconcentration of chemicals in fish. Integr Environ Assess Manag 3:3-17.
-
(2007)
Integr Environ Assess Manag
, vol.3
, pp. 3-17
-
-
De Wolf, W.1
Comber, M.2
Douben, P.3
Gimeno, S.4
Holt, M.5
Léonard, M.6
Lillicrap, A.7
Sijm, D.8
Van Egmond, R.9
Weisbrod, A.10
Whale, G.11
-
28
-
-
0026749967
-
Influence of biotransformation on the relationship between bioconcentration factors and octanol-water partition coefficients
-
de Wolf W, de Bruijn JHM, Seinen W, Hermens J. 1992. Influence of biotransformation on the relationship between bioconcentration factors and octanol-water partition coefficients. Environ Sci Technol 26:1197-1201.
-
(1992)
Environ Sci Technol
, vol.26
, pp. 1197-1201
-
-
De Wolf, W.1
De Bruijn, J.H.M.2
Seinen, W.3
Hermens, J.4
-
29
-
-
0027276296
-
Biotransformation and toxicokinetics of trichloroanilines in fish in relation to their hydrophobicity
-
de Wolf W, Seinen W, Hermens JLM. 1993. Biotransformation and toxicokinetics of trichloroanilines in fish in relation to their hydrophobicity. Arch Environ Contam Toxicol 25:110-117.
-
(1993)
Arch Environ Contam Toxicol
, vol.25
, pp. 110-117
-
-
De Wolf, W.1
Seinen, W.2
Hermens, J.L.M.3
-
30
-
-
0036579820
-
Quantitative prediction of biodegradability, metabolite distribution and toxicity of stable metabolites
-
Dimitrov S, Breton R, MacDonald D, Walker JD, Mekenyan O. 2002. Quantitative prediction of biodegradability, metabolite distribution and toxicity of stable metabolites. SAR QSAR Environ Res 13:445-455.
-
(2002)
SAR QSAR Environ Res
, vol.13
, pp. 445-455
-
-
Dimitrov, S.1
Breton, R.2
MacDonald, D.3
Walker, J.D.4
Mekenyan, O.5
-
31
-
-
23844491976
-
A stepwise approach for defining the applicability domain of SAR and QSAR models
-
Dimitrov S, Dimitrova G, Pavlov T, Dimitrova D, Patlewicz G, Niemela J, Mekenyan O. 2005. A stepwise approach for defining the applicability domain of SAR and QSAR models. J Chem Inf Model 45:839-849.
-
(2005)
J Chem Inf Model
, vol.45
, pp. 839-849
-
-
Dimitrov, S.1
Dimitrova, G.2
Pavlov, T.3
Dimitrova, D.4
Patlewicz, G.5
Niemela, J.6
Mekenyan, O.7
-
32
-
-
31544476573
-
Base-line model for identifying the bioaccumulation potential of chemicals
-
Dimitrov S, Dimitrova N, Parkerton T, Comber M, Bonnell M, Mekenyan O. 2005. Base-line model for identifying the bioaccumulation potential of chemicals. SAR QSAR Environ Res 16:531-554.
-
(2005)
SAR QSAR Environ Res
, vol.16
, pp. 531-554
-
-
Dimitrov, S.1
Dimitrova, N.2
Parkerton, T.3
Comber, M.4
Bonnell, M.5
Mekenyan, O.6
-
33
-
-
0036816654
-
Predicting BCFs of highly hydrophobic chemicals: Effects of molecular size
-
Dimitrov SD, Dimitrova NC, Walker JD, Veith GD, Mekenyan OG. 2002. Predicting BCFs of highly hydrophobic chemicals: Effects of molecular size. Pure Appl Chem 74:1823-1830.
-
(2002)
Pure Appl Chem
, vol.74
, pp. 1823-1830
-
-
Dimitrov, S.D.1
Dimitrova, N.C.2
Walker, J.D.3
Veith, G.D.4
Mekenyan, O.G.5
-
34
-
-
0037600736
-
Bioconcentration potential predictions based on molecular attributes-An early warning approach for chemicals found in humans, birds, fish and wildlife
-
Dimitrov SD, Dimitrova NC, Walker JD, Veith GD, Mekenyan OG. 2003. Bioconcentration potential predictions based on molecular attributes-An early warning approach for chemicals found in humans, birds, fish and wildlife. QSAR Comb Sci 22:58-68.
-
(2003)
QSAR Comb Sci
, vol.22
, pp. 58-68
-
-
Dimitrov, S.D.1
Dimitrova, N.C.2
Walker, J.D.3
Veith, G.D.4
Mekenyan, O.G.5
-
35
-
-
0036490203
-
Non-linear modeling of bioconcentration using partition coefficients for narcotic chemicals
-
Dimitrov SD, Mekenyan OG, Walker JD. 2002. Non-linear modeling of bioconcentration using partition coefficients for narcotic chemicals. SAR QSAR Environ Res 13:177-188.
-
(2002)
SAR QSAR Environ Res
, vol.13
, pp. 177-188
-
-
Dimitrov, S.D.1
Mekenyan, O.G.2
Walker, J.D.3
-
36
-
-
34547542462
-
A kinetic model for predicting biodegradation
-
Dimitrov S, Pavlov T, Nedelcheva D, Reuschenbach P, Silvani M, Bias R, Comber M, Low L, Lee C, Parkerton T, Mekenyan O. 2007. A kinetic model for predicting biodegradation. SAR QSAR Environ Res 18:443-457.
-
(2007)
SAR QSAR Environ Res
, vol.18
, pp. 443-457
-
-
Dimitrov, S.1
Pavlov, T.2
Nedelcheva, D.3
Reuschenbach, P.4
Silvani, M.5
Bias, R.6
Comber, M.7
Low, L.8
Lee, C.9
Parkerton, T.10
Mekenyan, O.11
-
37
-
-
0028991587
-
Membrane-water partitioning of polychlorinated biphenyls in small unilamellar vesicles of 4 saturated phosphatidycholines
-
Dulfer WJ, Govers HAJ. 1995. Membrane-water partitioning of polychlorinated biphenyls in small unilamellar vesicles of 4 saturated phosphatidycholines. Environ Sci Technol 29:1548-2554.
-
(1995)
Environ Sci Technol
, vol.29
, pp. 1548-2554
-
-
Dulfer, W.J.1
Govers, H.A.J.2
-
38
-
-
0031887085
-
Kinetics and conductivity parameters of uptake and transport of polychlorinated biphenyls in the Caco-2 intestinal cell line model
-
Dulfer W, Govers H, Groten J. 1998. Kinetics and conductivity parameters of uptake and transport of polychlorinated biphenyls in the Caco-2 intestinal cell line model. Environ Toxicol Chem 17:493-501.
-
(1998)
Environ Toxicol Chem
, vol.17
, pp. 493-501
-
-
Dulfer, W.1
Govers, H.2
Groten, J.3
-
40
-
-
55149101880
-
-
Chapter R.11: PBT Assessment. Accessed 24 September 2008
-
[ECHA] European Chemicals Agency. 2008. Guidance on information requirements and chemical safety assessment. Chapter R.11: PBT Assessment. guidance.echa.europa.eu/docs/guidance-document/information-requirements-r11-en. pdf?vers530-07-08. Accessed 24 September 2008.
-
(2008)
Guidance on Information Requirements and Chemical Safety Assessment
-
-
-
41
-
-
77249167784
-
-
[ECHC] Environment Canada and Health Canada. Chemical abstracts service registry number 78-63-7. Accessed 11 April 2009
-
[ECHC] Environment Canada and Health Canada. 2008. Screening assessment for the challenge: Peroxide, (1, 1, 4, 4-tetramethyl-1, 4-butanediyl) bis [(1, 1- dimethylethyl)]. Chemical abstracts service registry number 78-63-7. www.ec.gc.ca/substances/ese/eng/challenge/batch1/batch1-78-63-7-en.pdf. Accessed 11 April 2009.
-
(2008)
Screening Assessment for the Challenge: Peroxide, (1, 1, 4, 4-tetramethyl-1, 4-butanediyl) Bis [(1, 1- Dimethylethyl)]
-
-
-
42
-
-
0025268584
-
A simple flow-limited model for exchange of organic chemicals at fish gills
-
Erickson RJ, McKim JM. 1990a. A simple flow-limited model for exchange of organic chemicals at fish gills. Environ Toxicol Chem 9:159-165.
-
(1990)
Environ Toxicol Chem
, vol.9
, pp. 159-165
-
-
Erickson, R.J.1
McKim, J.M.2
-
43
-
-
0025695258
-
A model for exchange of organic chemicals at fish gills: Flow and diffusion limitations
-
Erickson RJ, McKim JM. 1990b. A model for exchange of organic chemicals at fish gills: Flow and diffusion limitations. Aquat Toxicol 18:175-198.
-
(1990)
Aquat Toxicol
, vol.18
, pp. 175-198
-
-
Erickson, R.J.1
McKim, J.M.2
-
45
-
-
0015358676
-
Correlation and prediction of mass transport across membranes. I. Influence of alkyl chain length on flux-determining properties of barrier and diffusant
-
Flynn GL, Yalkowsky SH. 1972. Correlation and prediction of mass transport across membranes. I. Influence of alkyl chain length on flux-determining properties of barrier and diffusant. J Pharm Sci 61:838-851.
-
(1972)
J Pharm Sci
, vol.61
, pp. 838-851
-
-
Flynn, G.L.1
Yalkowsky, S.H.2
-
46
-
-
0019510518
-
Effects of Clophen A50 on the metabolism of paranitroanisole in an in vitro perfused rainbow trout liver
-
Förlin L, Andersson T. 1981. Effects of Clophen A50 on the metabolism of paranitroanisole in an in vitro perfused rainbow trout liver. Comp Biochem Physiol 68C:239-242.
-
(1981)
Comp Biochem Physiol
, vol.68 C
, pp. 239-242
-
-
Förlin, L.1
Andersson, T.2
-
47
-
-
0024524118
-
Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues
-
Gargas ML, Burgess RJ, Voisard DE, Cason GH, Andersen ME. 1989. Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol Appl Pharmacol 98:87-99.
-
(1989)
Toxicol Appl Pharmacol
, vol.98
, pp. 87-99
-
-
Gargas, M.L.1
Burgess, R.J.2
Voisard, D.E.3
Cason, G.H.4
Andersen, M.E.5
-
48
-
-
0031905155
-
No influence after various exposure times on the biotransformation rate constants of benzo(a)anthracene in fathead minnow (Pimephales promelas)
-
Gert-Jan de Maagd P, de Poorte J, Opperhuizen A, Sijm DTHM. 1998. No influence after various exposure times on the biotransformation rate constants of benzo(a)anthracene in fathead minnow (Pimephales promelas). Aquat Toxicol 40:157-169.
-
(1998)
Aquat Toxicol
, vol.40
, pp. 157-169
-
-
Gert-Jan De, M.P.1
De Poorte, J.2
Opperhuizen, A.3
Sijm, D.T.H.M.4
-
49
-
-
0027869009
-
A model for predicting the bioaccumulation of hydrophobic organic chemicals in aquatic food-webs: Application to Lake Ontario
-
Gobas FAPC. 1993. A model for predicting the bioaccumulation of hydrophobic organic chemicals in aquatic food-webs: Application to Lake Ontario. Ecol Model 69:1-17.
-
(1993)
Ecol Model
, vol.69
, pp. 1-17
-
-
Gobas, F.A.P.C.1
-
50
-
-
0024554346
-
Bioconcentration of polybrominated benzenes and biphenyls and related superhydrophobic chemicals in fish: Role of bioavailability and elimination into the feces
-
Gobas FAPC, Clark KE, Shiu WY, Mackay D. 1989. Bioconcentration of polybrominated benzenes and biphenyls and related superhydrophobic chemicals in fish: Role of bioavailability and elimination into the feces. Environ Toxicol Chem 8:231-245.
-
(1989)
Environ Toxicol Chem
, vol.8
, pp. 231-245
-
-
Gobas, F.A.P.C.1
Clark, K.E.2
Shiu, W.Y.3
Mackay, D.4
-
51
-
-
0038515137
-
Quantitative structure-activity relationships for predicting the bioaccumulation of POPs in terrestrial food webs
-
Gobas FAPC, Kelly BC, Arnot JA. 2003. Quantitative structure-activity relationships for predicting the bioaccumulation of POPs in terrestrial food webs. QSAR Comb Sci 22:329-336.
-
(2003)
QSAR Comb Sci
, vol.22
, pp. 329-336
-
-
Gobas, F.A.P.C.1
Kelly, B.C.2
Arnot, J.A.3
-
52
-
-
0023975942
-
A novel method for measuring membrane-water partition coefficients of hydrophobic organic chemicals: Comparison with 1-octanol-water partitioning
-
Gobas FAPC, Lahittete JM, Garofalo G, Shiu WY. 1988. A novel method for measuring membrane-water partition coefficients of hydrophobic organic chemicals: Comparison with 1-octanol-water partitioning. J Pharm Sci 77:265-272.
-
(1988)
J Pharm Sci
, vol.77
, pp. 265-272
-
-
Gobas, F.A.P.C.1
Lahittete, J.M.2
Garofalo, G.3
Shiu, W.Y.4
-
53
-
-
0001643432
-
Dynamics of hydrophobic organic chemical bioconcentration in fish
-
Gobas FAPC, Mackay D. 1987. Dynamics of hydrophobic organic chemical bioconcentration in fish. Environ Toxicol Chem 6:495-504.
-
(1987)
Environ Toxicol Chem
, vol.6
, pp. 495-504
-
-
Gobas, F.A.P.C.1
Mackay, D.2
-
56
-
-
0023903326
-
Dynamics of dietary bioaccumulation and faecal elimination of hydrophobic organic chemicals in fish
-
Gobas FAPC, Muir DCG, Mackay D. 1988. Dynamics of dietary bioaccumulation and faecal elimination of hydrophobic organic chemicals in fish. Chemosphere 17:943-962.
-
(1988)
Chemosphere
, vol.17
, pp. 943-962
-
-
Gobas, F.A.P.C.1
Muir, D.C.G.2
Mackay, D.3
-
57
-
-
0000878436
-
Bioconcentration of hydrophobic chemicals in fish: Relationship with membrane permeation
-
Gobas FAPC, Opperhuizen A, Hutzinger O. 1986. Bioconcentration of hydrophobic chemicals in fish: Relationship with membrane permeation. Environ Toxicol Chem 5:637-646.
-
(1986)
Environ Toxicol Chem
, vol.5
, pp. 637-646
-
-
Gobas, F.A.P.C.1
Opperhuizen, A.2
Hutzinger, O.3
-
59
-
-
77249176675
-
-
Canada Gazette, Accessed 24 September 2008
-
Government of Canada. 2000. Persistence and bioaccumulation regulations (SOR/2000-107). Canada Gazette, Vol. 134. www.ec.gc.ca/CEPARegistry/regulations/ detailReg.cfm?intReg535. Accessed 24 September 2008.
-
(2000)
Persistence and Bioaccumulation Regulations (SOR/2000-107)
, vol.134
-
-
-
61
-
-
84919226766
-
A proposal: Exchange equilibria control the degree chlorinated hydrocarbons are biologically magnified in lentic environments
-
Hamelink JL, Waybrant RC, Ball RC. 1971. A proposal: Exchange equilibria control the degree chlorinated hydrocarbons are biologically magnified in lentic environments. Trans Am Fish Soc 100:207-214.
-
(1971)
Trans Am Fish Soc
, vol.100
, pp. 207-214
-
-
Hamelink, J.L.1
Waybrant, R.C.2
Ball, R.C.3
-
62
-
-
47149086363
-
Xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss): Determination of trout hepatocellularity, optimization of cell concentrations and comparison of serum and serum-free incubations
-
Han X, Mingoia RT, Nabb DL, Yang CH, Snajdr SI, Hoke RA. 2008. Xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss): Determination of trout hepatocellularity, optimization of cell concentrations and comparison of serum and serum-free incubations. Aquat Toxicol 89:11-17.
-
(2008)
Aquat Toxicol
, vol.89
, pp. 11-17
-
-
Han, X.1
Mingoia, R.T.2
Nabb, D.L.3
Yang, C.H.4
Snajdr, S.I.5
Hoke, R.A.6
-
63
-
-
34248207703
-
Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessment
-
Han X, Nabb DL, Mingoia RT, Yang CH. 2007. Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessment. Environ Sci Technol 41:3269-3276.
-
(2007)
Environ Sci Technol
, vol.41
, pp. 3269-3276
-
-
Han, X.1
Nabb, D.L.2
Mingoia, R.T.3
Yang, C.H.4
-
64
-
-
66649121198
-
Liver microsomes and S9 from rainbow trout (Oncorhynchus mykiss): Comparison of basal level enzyme activities with rat and determination of xenobiotic intrinsic clearance in support of bioaccumulation assessment
-
Han X, Nabb DL, Yang CH, Snajdr SI, Mingoia RT. 2009. Liver microsomes and S9 from rainbow trout (Oncorhynchus mykiss): Comparison of basal level enzyme activities with rat and determination of xenobiotic intrinsic clearance in support of bioaccumulation assessment. Environ Toxicol Chem 28:481-488.
-
(2009)
Environ Toxicol Chem
, vol.28
, pp. 481-488
-
-
Han, X.1
Nabb, D.L.2
Yang, C.H.3
Snajdr I, S.4
Mingoia, R.T.5
-
65
-
-
0030770275
-
Red blood cells: A neglected compartment in pharmacokinetics and pharmacodynamics
-
Hinderling PH. 1997. Red blood cells: A neglected compartment in pharmacokinetics and pharmacodynamics. Pharmacol Rev 49:279-295.
-
(1997)
Pharmacol Rev
, vol.49
, pp. 279-295
-
-
Hinderling, P.H.1
-
66
-
-
0028342648
-
Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
-
Houston JB. 1994. Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochem Pharmacol 47:1469-1479.
-
(1994)
Biochem Pharmacol
, vol.47
, pp. 1469-1479
-
-
Houston, J.B.1
-
67
-
-
3543026365
-
Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes
-
Ito K, Houston JB. 2004. Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes. Pharm Res 21:785-792.
-
(2004)
Pharm Res
, vol.21
, pp. 785-792
-
-
Ito, K.1
Houston, J.B.2
-
68
-
-
21844479812
-
Partitioning of polychlorinated biphenyls in octanol/water, triolein/water, and membrane/water systems
-
Jabusch TW, Swackhamer DL. 2005. Partitioning of polychlorinated biphenyls in octanol/water, triolein/water, and membrane/water systems. Chemosphere 60:1270-1278.
-
(2005)
Chemosphere
, vol.60
, pp. 1270-1278
-
-
Jabusch, T.W.1
Swackhamer, D.L.2
-
69
-
-
0036490150
-
Probabilistic assessment of biodegradability based on metabolic pathways: CATABOL system
-
Jaworska J, Dimitrov S, Nikolova N, Mekenyan O. 2002. Probabilistic assessment of biodegradability based on metabolic pathways: CATABOL system. SAR QSAR Environ Res 13:307-323.
-
(2002)
SAR QSAR Environ Res
, vol.13
, pp. 307-323
-
-
Jaworska, J.1
Dimitrov, S.2
Nikolova, N.3
Mekenyan, O.4
-
70
-
-
4143108324
-
Substrate depletion approach for determining in vitro metabolic clearance: Time dependencies in hepatocyte and microsomal incubations
-
Jones HM, Houston JB. 2004. Substrate depletion approach for determining in vitro metabolic clearance: Time dependencies in hepatocyte and microsomal incubations. Drug Metab Dispos 32:973-982.
-
(2004)
Drug Metab Dispos
, vol.32
, pp. 973-982
-
-
Jones, H.M.1
Houston, J.B.2
-
71
-
-
35948967162
-
Bioconcentration factor hydrophobicity cutoff: An artificial phenomenon reconstructed
-
Jonker MTO, van der Heijden SA. 2007. Bioconcentration factor hydrophobicity cutoff: An artificial phenomenon reconstructed. Environ Sci Technol 41:7363-7369.
-
(2007)
Environ Sci Technol
, vol.41
, pp. 7363-7369
-
-
Jonker, M.T.O.1
Van Der Heijden, S.A.2
-
72
-
-
0032568397
-
Physicochemical high throughput screening: Parallel artificial membrane permeation assay in the description of passive absorption processes
-
Kansy M, Senner F, Gubernator F. 1998. Physicochemical high throughput screening: Parallel artificial membrane permeation assay in the description of passive absorption processes. J Med Chem 41:1007-1009.
-
(1998)
J Med Chem
, vol.41
, pp. 1007-1009
-
-
Kansy, M.1
Senner, F.2
Gubernator, F.3
-
73
-
-
0035863581
-
Bioaccumulation of persistent organic pollutants in lichen-caribou-wolf food chains of Canada's central and western arctic
-
Kelly BC, Gobas FAPC. 2001. Bioaccumulation of persistent organic pollutants in lichen-caribou-wolf food chains of Canada's central and western arctic. Environ Sci Technol 35:325-334.
-
(2001)
Environ Sci Technol
, vol.35
, pp. 325-334
-
-
Kelly, B.C.1
Gobas, F.A.P.C.2
-
74
-
-
0038110063
-
An Arctic terrestrial food chain bioaccumulation model for persistent organic pollutants
-
Kelly BC, Gobas FAPC. 2003. An Arctic terrestrial food chain bioaccumulation model for persistent organic pollutants. Environ Sci Technol 37:2966-2974.
-
(2003)
Environ Sci Technol
, vol.37
, pp. 2966-2974
-
-
Kelly, B.C.1
Gobas, F.A.P.C.2
-
75
-
-
34447503810
-
Food web-specific biomagnification of persistent organic pollutants
-
Kelly BC, Ikonomou MG, Blair JD, Morin AE, Gobas FAPC. 2007. Food web-specific biomagnification of persistent organic pollutants. Science 317:236-238.
-
(2007)
Science
, vol.317
, pp. 236-238
-
-
Kelly, B.C.1
Ikonomou, M.G.2
Blair, J.D.3
Morin, A.E.4
Gobas, F.A.P.C.5
-
76
-
-
85053943133
-
Response of the teleost gastrointestinal system to xenobiotics
-
Schlenk D, Benson WH, editors. London (UK): Taylor and Francis
-
Kleinow KM, James MO. 2001. Response of the teleost gastrointestinal system to xenobiotics. In: Schlenk D, Benson WH, editors. Target organ toxicity in marine and freshwater teleosts. Vol. 1. London (UK): Taylor and Francis. p 269-362.
-
(2001)
Target Organ Toxicity in Marine and Freshwater Teleosts
, vol.1
, pp. 269-362
-
-
Kleinow, K.M.1
James, M.O.2
-
77
-
-
0031966002
-
Bioavailability and biotransformation of benzo(a)pyrene in isolated perfused intestinal preparation from control and β-naphthoflavone-induced catfish
-
Kleinow KM, James MO, Tong Z. 1998. Bioavailability and biotransformation of benzo(a)pyrene in isolated perfused intestinal preparation from control and β-naphthoflavone-induced catfish. Environ Health Perspect 106:155-166.
-
(1998)
Environ Health Perspect
, vol.106
, pp. 155-166
-
-
Kleinow, K.M.1
James, M.O.2
Tong, Z.3
-
78
-
-
85038078757
-
Toxicokinetics in fishes
-
Di Giulio RT, Hinton DE, editors. Boca Raton (FL): CRC
-
Kleinow KM, Nichols JW, Hayton WL, McKim JM, Barron MG. 2008. Toxicokinetics in fishes. In: Di Giulio RT, Hinton DE, editors. The toxicology of fishes. Boca Raton (FL): CRC. p 55-152.
-
(2008)
The Toxicology of Fishes
, pp. 55-152
-
-
Kleinow, K.M.1
Nichols, J.W.2
Hayton, W.L.3
McKim, J.M.4
Barron, M.G.5
-
79
-
-
33646353437
-
Bioaccumulation, biotransformation, and metabolite formation of fipronil and chiral legacy pesticides in rainbow trout
-
Konwick BJ, Garrison AW, Black MC, Avants JK, Fish AT. 2006. Bioaccumulation, biotransformation, and metabolite formation of fipronil and chiral legacy pesticides in rainbow trout. Environ Sci Technol 40:2930-2936.
-
(2006)
Environ Sci Technol
, vol.40
, pp. 2930-2936
-
-
Konwick, B.J.1
Garrison, A.W.2
Black, M.C.3
Avants, J.K.4
Fish, A.T.5
-
80
-
-
84956674798
-
Lipid bilayers in ADME: Permeation barriers and distribution compartments
-
Testa B, Krämer SD, Wunderli-Allenspach H, Folkers G, editors, Zürich (CH): Wiley-VCH
-
Krämer S. 2006. Lipid bilayers in ADME: Permeation barriers and distribution compartments. In: Testa B, Krämer SD, Wunderli-Allenspach H, Folkers G, editors. Pharmacokinetic profiling in drug research: Biological, physicochemical, and computational strategies. Zürich (CH): Wiley-VCH. p 203-220.
-
(2006)
Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies
, pp. 203-220
-
-
Krämer, S.1
-
81
-
-
4644295797
-
Predicting plasma protein binding of drugs-Revisited
-
Kratochwil NA, Huber W, Muller F, Kansy M, Gerber PR. 2004. Predicting plasma protein binding of drugs-Revisited. Curr Opin Drug Discov Dev 7:507-512.
-
(2004)
Curr Opin Drug Discov Dev
, vol.7
, pp. 507-512
-
-
Kratochwil, N.A.1
Huber, W.2
Muller, F.3
Kansy, M.4
Gerber, P.R.5
-
82
-
-
40949107782
-
A modified parallel artificial membrane permeability assay for evaluating bioconcentration of highly hydrophobic chemicals in fish
-
Kwon J-H, Escher BI. 2008. A modified parallel artificial membrane permeability assay for evaluating bioconcentration of highly hydrophobic chemicals in fish. Environ Sci Technol 42:1787-1793.
-
(2008)
Environ Sci Technol
, vol.42
, pp. 1787-1793
-
-
Kwon, J.-H.1
Escher, B.I.2
-
83
-
-
33846263676
-
Use of a parallel artificial membrane system to evaluate passive absorption and elimination in small fish
-
Kwon J-H, Katz LE, Liljestrand HM. 2006. Use of a parallel artificial membrane system to evaluate passive absorption and elimination in small fish. Environ Toxicol Chem 25:3083-3092.
-
(2006)
Environ Toxicol Chem
, vol.25
, pp. 3083-3092
-
-
Kwon, J.-H.1
Katz, L.E.2
Liljestrand, H.M.3
-
84
-
-
34548555798
-
Dynamic permeation method to determine partition coefficients of highly hydrophobic chemicals between poly(dimethylsiloxane) (PDMS) and water
-
Kwon J-H, Wüthrich T, Mayer P, Escher BI. 2007. Dynamic permeation method to determine partition coefficients of highly hydrophobic chemicals between poly(dimethylsiloxane) (PDMS) and water. Anal Chem 79:6816-6822.
-
(2007)
Anal Chem
, vol.79
, pp. 6816-6822
-
-
Kwon, J.-H.1
Wüthrich, T.2
Mayer, P.3
Escher, B.I.4
-
85
-
-
67349172147
-
Development of a dynamic delivery method for in vitro bioassays
-
Kwon J-H, Wüthrich T, Mayer P, Escher BI. 2009. Development of a dynamic delivery method for in vitro bioassays. Chemosphere 76:83-90.
-
(2009)
Chemosphere
, vol.76
, pp. 83-90
-
-
Kwon, J.-H.1
Wüthrich, T.2
Mayer, P.3
Escher, B.I.4
-
87
-
-
0020128914
-
Correlation of bioconcentration factors
-
Mackay D. 1982. Correlation of bioconcentration factors. Environ Sci Technol 16:274-278.
-
(1982)
Environ Sci Technol
, vol.16
, pp. 274-278
-
-
Mackay, D.1
-
88
-
-
0033867207
-
Bioaccumulation of persistent organic chemicals: Mechanisms and models
-
Mackay D, Fraser A. 2000. Bioaccumulation of persistent organic chemicals: Mechanisms and models. Environ Pollut 110:375-391.
-
(2000)
Environ Pollut
, vol.110
, pp. 375-391
-
-
Mackay, D.1
Fraser, A.2
-
89
-
-
0021986855
-
Absorption dynamics of organic chemical transport across trout gills as related to octanol-water partition coefficient
-
McKim JM, Schmieder P, Veith G. 1985. Absorption dynamics of organic chemical transport across trout gills as related to octanol-water partition coefficient. Toxicol Appl Pharmacol 77:1-10.
-
(1985)
Toxicol Appl Pharmacol
, vol.77
, pp. 1-10
-
-
McKim, J.M.1
Schmieder, P.2
Veith, G.3
-
90
-
-
33644782607
-
Metabolic activation of chemicals: In-silico simulation
-
Mekenyan O, Dimitrov S, Dimitrova N, Dimitrova G, Pavlov T, Chankov G, Kotov S, Vasilev K, Vasilev R. 2006. Metabolic activation of chemicals: In-silico simulation. SAR QSAR Environ Res 17:107-120.
-
(2006)
SAR QSAR Environ Res
, vol.17
, pp. 107-120
-
-
Mekenyan, O.1
Dimitrov, S.2
Dimitrova, N.3
Dimitrova, G.4
Pavlov, T.5
Chankov, G.6
Kotov, S.7
Vasilev, K.8
Vasilev, R.9
-
91
-
-
1842430781
-
A systematic approach to simulating metabolism in computational toxicology. I. The TIMES heuristic modelling framework
-
Mekenyan OG, Dimitrov SD, Pavlov TS, Veith GD. 2004. A systematic approach to simulating metabolism in computational toxicology. I. The TIMES heuristic modelling framework. Curr Pharm Design 10:1273-1293.
-
(2004)
Curr Pharm Design
, vol.10
, pp. 1273-1293
-
-
Mekenyan, O.G.1
Dimitrov, S.D.2
Pavlov, T.S.3
Veith, G.D.4
-
92
-
-
0033037957
-
Improved method for estimating bioconcentration/bioaccumulation factor from octanol/water partition coefficient
-
Meylan WM, Howard PH, Boethling RS, Aronson D, Printup H, Gouchie S. 1999. Improved method for estimating bioconcentration/bioaccumulation factor from octanol/water partition coefficient. Environ Toxicol Chem 18:664-672.
-
(1999)
Environ Toxicol Chem
, vol.18
, pp. 664-672
-
-
Meylan, W.M.1
Howard, P.H.2
Boethling, R.S.3
Aronson, D.4
Printup, H.5
Gouchie, S.6
-
93
-
-
0028918285
-
An in vitro method for determination of tissue partition coefficients of non-volatile chemicals such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and estradiol
-
Murphy JE, Janszen DB, Gargas ML. 1995. An in vitro method for determination of tissue partition coefficients of non-volatile chemicals such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and estradiol. J Appl Toxicol 15:147-152.
-
(1995)
J Appl Toxicol
, vol.15
, pp. 147-152
-
-
Murphy, J.E.1
Janszen, D.B.2
Gargas, M.L.3
-
94
-
-
0018631486
-
Estimating rate constants for uptake and clearance of chemicals by fish
-
Neely WB. 1979. Estimating rate constants for uptake and clearance of chemicals by fish. Environ Sci Technol 13:1506-1510.
-
(1979)
Environ Sci Technol
, vol.13
, pp. 1506-1510
-
-
Neely, W.B.1
-
95
-
-
0016189181
-
Partition coefficients to measure bioconcentration potential of organic chemicals in fish
-
Neely WB, Branson DR, Blau GE. 1974. Partition coefficients to measure bioconcentration potential of organic chemicals in fish. Environ Sci Technol 8:1113-1115.
-
(1974)
Environ Sci Technol
, vol.8
, pp. 1113-1115
-
-
Neely, W.B.1
Branson, D.R.2
Blau, G.E.3
-
96
-
-
36248980976
-
Workshop report: Use of in vitro absorption, distribution, metabolism and excretion (ADME) data in bioaccumulation assessments for fish
-
Nichols J, Erhardt S, Dyer S, James M, Moore M, Plotzke K, Segner H, Schultz I, Vasiluk L, Weisbroad A. 2007. Workshop report: Use of in vitro absorption, distribution, metabolism and excretion (ADME) data in bioaccumulation assessments for fish. Human Ecol Risk Assess 13:1164-1191.
-
(2007)
Human Ecol Risk Assess
, vol.13
, pp. 1164-1191
-
-
Nichols, J.1
Erhardt, S.2
Dyer, S.3
James, M.4
Moore, M.5
Plotzke, K.6
Segner, H.7
Schultz, I.8
Vasiluk, L.9
Weisbroad, A.10
-
97
-
-
34247528772
-
In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. II. Modeled effects on chemical bioaccumulation
-
Nichols JW, Fitzsimmons PN, Burkhard LP. 2007. In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. II. Modeled effects on chemical bioaccumulation. Environ Toxicol Chem 26:1304-1319.
-
(2007)
Environ Toxicol Chem
, vol.26
, pp. 1304-1319
-
-
Nichols, J.W.1
Fitzsimmons, P.N.2
Burkhard, L.P.3
-
98
-
-
1342310168
-
A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish. I. Feeding studies with 2, 2′, 5, 5′-tetrachlorobiphenyl
-
Nichols JW, Fitzsimmons PN, Whiteman FW. 2004. A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish. I. Feeding studies with 2, 2′, 5, 5′-tetrachlorobiphenyl. Toxicol Sci 77:206-218.
-
(2004)
Toxicol Sci
, vol.77
, pp. 206-218
-
-
Nichols, J.W.1
Fitzsimmons, P.N.2
Whiteman, F.W.3
-
99
-
-
33747630506
-
In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. I. A review of methods, and strategies for incorporating intrinsic clearance estimates into chemical kinetic models
-
Nichols JW, Schultz IR, Fitzsimmons PN. 2006. In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. I. A review of methods, and strategies for incorporating intrinsic clearance estimates into chemical kinetic models. Aquat Toxicol 78:74-90.
-
(2006)
Aquat Toxicol
, vol.78
, pp. 74-90
-
-
Nichols, J.W.1
Schultz, I.R.2
Fitzsimmons, P.N.3
-
100
-
-
0022130886
-
Bioconcentration factors of some halogenated organics for rainbow trout: Limitations in their use for prediction of environmental residues
-
Oliver BG, Niimi AJ. 1985. Bioconcentration factors of some halogenated organics for rainbow trout: Limitations in their use for prediction of environmental residues. Environ Sci Technol 19:842-849.
-
(1985)
Environ Sci Technol
, vol.19
, pp. 842-849
-
-
Oliver, B.G.1
Niimi, A.J.2
-
101
-
-
0023993569
-
Trophodynamic analysis of polychlorinated biphenyl congeners and other chlorinated hydrocarbons in the Lake Ontario ecosystem
-
Oliver BG, Niimi AJ. 1988. Trophodynamic analysis of polychlorinated biphenyl congeners and other chlorinated hydrocarbons in the Lake Ontario ecosystem. Environ Sci Technol 22:388-397.
-
(1988)
Environ Sci Technol
, vol.22
, pp. 388-397
-
-
Oliver, B.G.1
Niimi, A.J.2
-
102
-
-
0034858302
-
Availability of polychlorinated biphenyls (PCBs) and lindane for uptake by intestinal Caco-2 cells
-
Oomen AG, Tolls J, Kruidenier M, Bosgra SSD, Sips A, Groten JP. 2001. Availability of polychlorinated biphenyls (PCBs) and lindane for uptake by intestinal Caco-2 cells. Environ Health Perspect 109:731-737.
-
(2001)
Environ Health Perspect
, vol.109
, pp. 731-737
-
-
Oomen, A.G.1
Tolls, J.2
Kruidenier, M.3
Bosgra, S.S.D.4
Sips, A.5
Groten, J.P.6
-
103
-
-
0022313308
-
Relationship between bioconcentration in fish and steric factors of hydrophobic chemicals
-
Opperhuizen A, van der Velde EW, Gobas FAPC, Liem DAK, van der Steen JMD. 1985. Relationship between bioconcentration in fish and steric factors of hydrophobic chemicals. Chemosphere 14:1871-1896.
-
(1985)
Chemosphere
, vol.14
, pp. 1871-1896
-
-
Opperhuizen, A.1
Van Der Velde, E.W.2
Gobas, F.A.P.C.3
Liem, D.A.K.4
Van Der Steen, J.M.D.5
-
104
-
-
0026457029
-
Methods of determining plasma and tissue binding of drugs
-
Pacifici GM, Viani A. 1992. Methods of determining plasma and tissue binding of drugs. Clin Pharmacokinet 23:449-468.
-
(1992)
Clin Pharmacokinet
, vol.23
, pp. 449-468
-
-
Pacifici, G.M.1
Viani, A.2
-
105
-
-
49049093700
-
Guidance for evaluating in vivo fish bioaccumulation data
-
Parkerton TF, Arnot JA, Weisbrod AV, Russom C, Hoke RA, Woodburn K, Traas T, Bonnell M, Burkhard LP, Lampi MA. 2008. Guidance for evaluating in vivo fish bioaccumulation data. Integr Environ Assess Manag 4:139-155.
-
(2008)
Integr Environ Assess Manag
, vol.4
, pp. 139-155
-
-
Parkerton, T.F.1
Arnot, J.A.2
Weisbrod, A.V.3
Russom, C.4
Hoke, R.A.5
Woodburn, K.6
Traas, T.7
Bonnell, M.8
Burkhard, L.P.9
Lampi, M.A.10
-
106
-
-
38849168166
-
Review of literature-based quantitative structure-activity relationship models for bioconcentration
-
Pavan M, Netzeva TI, Worth AP. 2008. Review of literature-based quantitative structure-activity relationship models for bioconcentration. QSAR Comb Sci 27:21-31.
-
(2008)
QSAR Comb Sci
, vol.27
, pp. 21-31
-
-
Pavan, M.1
Netzeva, T.I.2
Worth, A.P.3
-
107
-
-
77249087741
-
Use of quantitative structure activity relationships (QSARs) in the categorization of discrete organic substances on Canada's Domestic Substances List (DSL)
-
Robinson P, MacDonald D, Davidson N, Okonski A, Sene A. 2004. Use of quantitative structure activity relationships (QSARs) in the categorization of discrete organic substances on Canada's Domestic Substances List (DSL). Environ Informat Arch 2:69-78.
-
(2004)
Environ Informat Arch
, vol.2
, pp. 69-78
-
-
Robinson, P.1
MacDonald, D.2
Davidson, N.3
Okonski, A.4
Sene, A.5
-
108
-
-
84945443800
-
Biotransformation in fishes
-
Di Giulio RT, Hinton DE, editors. Boca Raton (FL): CRC
-
Schlenk, D, Celander M, Gallagher EP, George S, James M, Kullman SW, van den Hurk P, Willett K. 2008. Biotransformation in fishes. In: Di Giulio RT, Hinton DE, editors. The toxicology of fishes. Boca Raton (FL): CRC. p 153-234.
-
(2008)
The Toxicology of Fishes
, pp. 153-234
-
-
Schlenk, D.1
Celander, M.2
Gallagher, E.P.3
George, S.4
James, M.5
Kullman, S.W.6
Van Den Hurk, P.7
Willett, K.8
-
109
-
-
0025284647
-
QSAR analysis of the acute toxicity of organic phosphorothionates using theoretically derived molecular descriptors
-
Schüürmann G. 1990. QSAR analysis of the acute toxicity of organic phosphorothionates using theoretically derived molecular descriptors. Environ Toxicol Chem 9:417-428.
-
(1990)
Environ Toxicol Chem
, vol.9
, pp. 417-428
-
-
Schüürmann, G.1
-
110
-
-
32344446760
-
Role of Caco-2 cell monolayers in prediction of intestinal drug absorption
-
Shah P, Jogani V, Bagchi T, Misra A. 2006. Role of Caco-2 cell monolayers in prediction of intestinal drug absorption. Biotechnol Prog 22:186-198.
-
(2006)
Biotechnol Prog
, vol.22
, pp. 186-198
-
-
Shah, P.1
Jogani, V.2
Bagchi, T.3
Misra, A.4
-
111
-
-
0036968265
-
Sorption of polycyclic aromatic hydrocarbons into liposomes (artificial cell membranes) and effects of dissolved natural organic matter
-
Shimizu Y, Takahashi J, Matsubara J, Ikeda K, Matsui S. 2002. Sorption of polycyclic aromatic hydrocarbons into liposomes (artificial cell membranes) and effects of dissolved natural organic matter. Lakes Reservoir Res Manage 7:295-299.
-
(2002)
Lakes Reservoir Res Manage
, vol.7
, pp. 295-299
-
-
Shimizu, Y.1
Takahashi, J.2
Matsubara, J.3
Ikeda, K.4
Matsui, S.5
-
112
-
-
0025052154
-
Biotransformation and tissue distribution of 1, 2, 3, 7-tetrachlorodibenzo- p-dioxin, 1, 2, 3, 4, 7-pentachlorodibenzo-p-dioxin and 2, 3, 4, 7, 8-pentachlorodibenzo- p-dioxin in rainbow trout
-
Sijm DTHM, Yarechewski AL, Muir DCG, Webster GRB, Seinen W, Opperhuizen A. 1990. Biotransformation and tissue distribution of 1, 2, 3, 7-tetrachlorodibenzo- p-dioxin, 1, 2, 3, 4, 7-pentachlorodibenzo-p-dioxin and 2, 3, 4, 7, 8-pentachlorodibenzo- p-dioxin in rainbow trout. Chemosphere 21:845-866.
-
(1990)
Chemosphere
, vol.21
, pp. 845-866
-
-
Sijm, D.T.H.M.1
Yarechewski, A.L.2
Muir, D.C.G.3
Webster, G.R.B.4
Seinen, W.5
Opperhuizen, A.6
-
113
-
-
0019122657
-
Potential and realized bioconcentration. A comparison of observed and predicted bioconcentration of azaarenes in the fathead minnow (Pimephales promelas)
-
Southworth GR, Keffer CC, Beauchamp JJ. 1980. Potential and realized bioconcentration. A comparison of observed and predicted bioconcentration of azaarenes in the fathead minnow (Pimephales promelas). Environ Sci Technol 14:1529-1531.
-
(1980)
Environ Sci Technol
, vol.14
, pp. 1529-1531
-
-
Southworth, G.R.1
Keffer, C.C.2
Beauchamp, J.J.3
-
114
-
-
0024679710
-
Bioaccumulation model of organic chemical distribution in aquatic food chains
-
Thomann RV. 1989. Bioaccumulation model of organic chemical distribution in aquatic food chains. Environ Sci Technol 23:699-707.
-
(1989)
Environ Sci Technol
, vol.23
, pp. 699-707
-
-
Thomann, R.V.1
-
115
-
-
0026692804
-
An equilibrium model of organic chemical accumulation in aquatic food webs with sediment interaction
-
Thomann RV, Connolly JP, Parkerton TF. 1992. An equilibrium model of organic chemical accumulation in aquatic food webs with sediment interaction. Environ Toxicol Chem 11:615-629.
-
(1992)
Environ Toxicol Chem
, vol.11
, pp. 615-629
-
-
Thomann, R.V.1
Connolly, J.P.2
Parkerton, T.F.3
-
117
-
-
0036908023
-
Free drug faction vs. Free drug concentration: A matter of frequent confusion
-
Toutain PL, Bousquet-Melou A. 2007. Free drug faction vs. free drug concentration: A matter of frequent confusion. J Vet Pharmcol Therap 25:460-463.
-
(2007)
J Vet Pharmcol Therap
, vol.25
, pp. 460-463
-
-
Toutain, P.L.1
Bousquet-Melou, A.2
-
118
-
-
77249089854
-
-
[UNEP] United Nations Environment Programme. Accessed 24 September 2008
-
[UNEP] United Nations Environment Programme. 2004. Stockholm Convention on Persistent Organic Pollutants. www.pops.int. Accessed 24 September 2008.
-
(2004)
Stockholm Convention on Persistent Organic Pollutants
-
-
-
120
-
-
0030410633
-
Measurement of the free concentration using solid-phase microextraction: Binding to protein
-
Vaes WHJ, Urrestarazu Ramos E, Verhaar HJM, Seinen W, Hermes JLM. 1996. Measurement of the free concentration using solid-phase microextraction: Binding to protein. Anal Chem 68:4463-4467.
-
(1996)
Anal Chem
, vol.68
, pp. 4463-4467
-
-
Vaes, W.H.J.1
Urrestarazu, R.E.2
Verhaar, H.J.M.3
Seinen, W.4
Hermes, J.L.M.5
-
121
-
-
0023860970
-
Effect of preexposure to dietary benzo[a]pyrene (BP) on the first-pass metabolism of BP by the intestine of toadfish (Opsanus tau): In vivo studies using portal vein-catheterized fish
-
Van Veld PA, Patton JS, Lee RF. 1988. Effect of preexposure to dietary benzo[a]pyrene (BP) on the first-pass metabolism of BP by the intestine of toadfish (Opsanus tau): In vivo studies using portal vein-catheterized fish. Toxicol Appl Pharmacol 92:255-265.
-
(1988)
Toxicol Appl Pharmacol
, vol.92
, pp. 255-265
-
-
Van Veld, P.A.1
Patton, J.S.2
Lee, R.F.3
-
122
-
-
77249096066
-
Integrated approach to PBT and POP prioritization and risk assessment
-
van Wijk D, Chénier R, Henry T, Hernando MD, Schulte C. 2009. Integrated approach to PBT and POP prioritization and risk assessment. Integr Environ Assess Manag 5:697-711.
-
(2009)
Integr Environ Assess Manag
, vol.5
, pp. 697-711
-
-
Van Wijk, D.1
Chénier, R.2
Henry, T.3
Hernando, M.D.4
Schulte, C.5
-
123
-
-
0018712770
-
Measuring and estimating the bioconcentration factor of chemicals on fish
-
Veith GD, DeFoe DL, Bergstedt BV. 1979. Measuring and estimating the bioconcentration factor of chemicals on fish. J Fish Res Bd Can 36:1040-1048.
-
(1979)
J Fish Res Bd Can
, vol.36
, pp. 1040-1048
-
-
Veith, G.D.1
DeFoe, D.L.2
Bergstedt, B.V.3
-
124
-
-
31144432913
-
Potential of degradable organic chemicals for absolute and relative enrichment in the Arctic
-
Wania F. 2006. Potential of degradable organic chemicals for absolute and relative enrichment in the Arctic. Environ Sci Technol 40:569-577.
-
(2006)
Environ Sci Technol
, vol.40
, pp. 569-577
-
-
Wania, F.1
-
125
-
-
31944435095
-
Weight of evidence: A review of concepts and methods
-
Weed DL. 2005. Weight of evidence: A review of concepts and methods. Risk Anal 25:1545-1557.
-
(2005)
Risk Anal
, vol.25
, pp. 1545-1557
-
-
Weed, D.L.1
-
126
-
-
33847048614
-
Workgroup report: Review of fish bioaccumulation databases used to identify persistent, bioaccumulative, toxic substances
-
Weisbrod AV, Burkhard LP, Arnot J, Mekenyan O, Howard PH, Russom C, Boethling R, Sakuratani Y, Traas T, Bridges T, Lutz C, Bonnell M, Woodburn K, Parkerton T. 2007. Workgroup report: Review of fish bioaccumulation databases used to identify persistent, bioaccumulative, toxic substances. Environ Health Perspect 115:255-261.
-
(2007)
Environ Health Perspect
, vol.115
, pp. 255-261
-
-
Weisbrod, A.V.1
Burkhard, L.P.2
Arnot, J.3
Mekenyan, O.4
Howard, P.H.5
Russom, C.6
Boethling, R.7
Sakuratani, Y.8
Traas, T.9
Bridges, T.10
Lutz, C.11
Bonnell, M.12
Woodburn, K.13
Parkerton, T.14
-
128
-
-
0028272183
-
The relationship between permeant size and permeability in lipid bilayer membranes
-
Xiang T-X, Anderson BD. 1994. The relationship between permeant size and permeability in lipid bilayer membranes. J Membrane Biol 140:111-122.
-
(1994)
J Membrane Biol
, vol.140
, pp. 111-122
-
-
Xiang, T.-X.1
Anderson, B.D.2
-
129
-
-
33847411025
-
Misuse of the well-stirred model of hepatic drug clearance
-
Yang J, Jamei M, Yeo KR, Rostami-Hodjegan A, Tucker GT. 2007. Misuse of the well-stirred model of hepatic drug clearance. Drug Metab Dispos 35:501-502.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 501-502
-
-
Yang, J.1
Jamei, M.2
Yeo, K.R.3
Rostami-Hodjegan, A.4
Tucker, G.T.5
|