Studies using structural analogs and inbred strain differences to support a role for quinone methide metabolites of butylated hydroxytoluene (BHT) in mouse lung tumor promotion

Toxicology

Volumn 160, Issue 1-3, 2001, Pages 197-205

  Thompson, John A ^a   Carlson, Timothy J ^a   Sun, Yude ^a   Dwyer Nield, Lori D ^a   Malkinson, Alvin M ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Butylated hydroxytoluene; Cytotoxicity; Electrophiles; Lung injury; Lung tumorigenesis

Indexed keywords

2, 6 DI TERT BUTYL 4 METHYLENE 2, 5 CYCLOHEXADIENONE; 6 TERT BUTYL 2 HYDROXY TERT BUTYL 4 METHYLENE 2, 5 CYCLOHEXADIENONE; 6 TERT BUTYL 2 HYDROXY TERT BUTYL 4 METHYLPHENOL; BUTYLCRESOL; PHENOL DERIVATIVE; QUINONE DERIVATIVE; QUINONE METHIDE DERIVATIVE; UNCLASSIFIED DRUG; URETHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HYDROXYLATION; INBRED STRAIN; ISOTOPE LABELING; LUNG ALVEOLUS EPITHELIUM; LUNG METASTASIS; LUNG TUMOR; MALE; METABOLITE; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; STRAIN DIFFERENCE; TUMOR PROMOTION;

ANIMALS; BUTYLATED HYDROXYTOLUENE; CARCINOGENICITY TESTS; CARCINOGENS; DISEASE MODELS, ANIMAL; FEMALE; INDOLEQUINONES; INDOLES; LUNG; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICROSOMES; QUINONES; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; URETHANE;

EID: 0035819930     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00449-2     Document Type: Article

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