Neuroprotective effect of dauricine in cortical neuron culture exposed to hypoxia and hypoglycemia: Involvement of correcting perturbed calcium homeostasis

Canadian Journal of Physiology and Pharmacology

Volumn 85, Issue 6, 2007, Pages 621-627

  Li, Yan Hong ^a,b   Gong, Pei Li ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Ca2+ i; Dauricine; Hypoglycemia; Hypoxia; Mitochondrial membrane potential; Neurotoxicity

Indexed keywords

CALCIUM; DAURICINE; FURA 2; GLUTAMIC ACID; THAPSIGARGIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL CULTURE; CELL HYPOXIA; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; FLOW CYTOMETRY; HYPOGLYCEMIA; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ALKALOIDS; ANIMALS; ANIMALS, NEWBORN; BENZYLISOQUINOLINES; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; ENDOPLASMIC RETICULUM; EXTRACELLULAR SPACE; HOMEOSTASIS; HYPOGLYCEMIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEURONS; NEUROPROTECTIVE AGENTS; NIMODIPINE; RATS; RATS, WISTAR; TETRAHYDROISOQUINOLINES;

EID: 34948910813     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y07-056     Document Type: Article

References (26)

1. Brookes, P.S., Yoon, Y., Robotham, J.L., Anders, M.W., and Sheu, S.S. 2004. Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am. J. Physiol. Cell. Physiol. 287: C817-C833. doi:10.1152/ajpcell.00139.2004.
2. Dubinsky, J.M., and Levi, Y. 1998. Calcium-induced activation of the mitochondrial permeability transition in hippocampal neurons. J. Neurosci. Res. 53: 728-741. doi:10.1002/(SICI)1097-4547(19980915)53:6〈728::AID- JNR10〉3.0.CO;2-U.
3. Gaspar, T., Kis, B., Snipes, J.A., Lenzser, G., Mayanagi, K., Bari, F., and Busija, D.W. 2006. Transient glucose and amino acid deprivation induces delayed preconditioning in cultured rat cortical neurons. J. Neurochem. 2: 555-565.
4. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440-3450.
5. Guo, D.L., Zeng, F.D., and Hu, C.J. 1997a. Effects of dauricine, quinidine, and sotlol on action potential duration of papillary muscles in vitro. Zhongguo Yao Li Xue Bao. 18: 348-350.
6. Guo, D.L., Zhou, Z.N., Zeng, F.D., and Hu, C.J. 1997b. Dauricine inhibited L-type calcium in single cardiomyocyte of guinea pig. Acta Pharmacol. Sin. 18: 419-421.
7. Halestrap, A.P. 2006. Calcium, mitochondria and reperfusion injury: a pore way to die. Biochem. Soc. Trans. 34: 232-327.
8. He, L.Y., Li, L.Z., Wu, J.L., Liu, Z.M., Min, Q., Zheng, M., and Chen, J.E. 1997. Experimental studies on the antioxidation effect of dauricine. Chin. Tral. And. Herb. Drus. 28: 479-481.
9. Hong, H., and Liu, G.Q. 2004. Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by scutellarin. Life Sci. 24: 2959-2973.
10. 2+ concentration in cultivated hippocampal neurons. Pharmazie, 49: 202-205.
11. Kass, G.E., and Orrenius, S. 1999. Calcium signaling and cytotoxicity. Environ. Health. Environ. Health Perspect. 107: 25-35. doi:10.2307/3434469.
12. Kristian, T., and Siesjo, B.K. 1998. Calcium in ischemia cell death. Stroke, 29: 705-718.
13. Li, Y.H., and Gong, P.L. 2004. The protective effect of dauricine on cerebral ischemia in mice. Chin. Pharmacol. Bull. 20: 564-567.
14. Li, Y.H., and Gong, P.L. 2007. Neuroprotective effects of dauricine on apoptosis induced by transient focal cerebral ischemia in rats via mitochondrial pathway. Clin. Exp. Pharmacol. Physiol. 34: 177-184. doi:10.1111/j.1440-1681.2007.04569.x.
15. 2+ concentration in dissociated rat brain cells using Fura-2/AM. Yao Xue Xue Bao. 26: 890-894.
16. Li, Y.H., Huang, X.J., Lu, H.H., Wang, L., Wu, W.G., and Gong, P.L. 2005. Protective effects of dauricine on focal cerebral ischemia and oxidative damages to mitochondria in rats. Acta Med. Univ. Tongji. 34: 270-273.
17. 2+ rise induced by oxygen/glucose deprivation in cortical neurons. Stroke, 29: 196-202.
18. Polster, B.M., and Fiskum, G. 2004. Mitochondrial mechanisms of neural cell apoptosis. J. Neurochem. 90: 1281-1289. doi:10.1111/J.1471-4159. 2004.02572.x.
19. Qian, J.Q. 2002. Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives. Acta Pharmacol. Sin. 23: 1086-1092.
20. Rymer, M.M., and Thrutchley, D.E. 2005. Organizing regional networks to increase acute stroke intervention. Neurol. Res. 27: S9-S16. doi:10.1179/016164105X25315.
21. Siesjo, B.K., and Bengtsson, F. 1989. Calcium fluxes, calcium antagonists and calcium-related pathology in brain ischemia, hypoglycemia and spreading depression: a unifying hypothesis. J. Cereb. Blood Flow Metab. 9: 127-140.
22. Smith, W.S. 2004. Pathophysiology of focal cerebral ischemia: a therapeutic perspective. J. Vasc. Interv. Radiol. 15: S3-S12.
23. Wulf, P. 2000. Role of calcium in neuronal cell injury: Which subcellular compartment is involved? Brain Res. 53: 409-413.
24. 2+-dependent proteases in ischemic neuronal death: a conserved 'calpain-cathepsin cascade' from nematodes to primates. Cell Calcium, 36: 285-293. doi:10.1016/j.ceca.2004.03.001.
25. Yang, X.Y., Zhou, B., Cai, J.B., Liu, Y.L., and Gong, P.L. 2005. Therapeutic effects of dauricine on focal cerebral ischemia/reperfusion injury in rats. Chin. Pharmacol. Bull. 21: 1112-1115.
26. Zeng, G.Q., and Rui, Y.C. 1991. Effects of anisodamine and dauricine on proliferation, DNA synthesis and calcium influx in bovine anterior cerebral smooth muscle cells in culture. Acta Pharmacol. Sin. 12: 8-11.