Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 5, 2010, Pages 2019-2028

  Youssef, Amal M ^a   Sydney White, M ^b   Villanueva, Erika B ^b   El Ashmawy, Ibrahim M ^a   Klegeris, Andis ^b  

^a Alexandria University Faculty of Pharmacy   (Egypt)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Anti inflammatory drugs; Neuroprotection; Pyrazoles; Thiazolidinediones

Indexed keywords

2,4 THIAZOLIDINEDIONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 3 (3 BROMOBENZYL) 5 [(1,3 DIPHENYL 1H PYRAZOL 4 YL)ETHYLENE]THIAZOLIDINE 2,4 DIONE; 3 (4 CHLOROBENZYL) 5 [(1,3 DIPHENYL 1H PYRAZOL 4 YL)METHYLENE]THIAZOLIDINE 2,4 DIONE; 3 ALLYL 5 [(1,3 DIPHENYL 1H PYRAZOL 4 YL)METHYLENE]THIAZOLIDINE 2,4 DIONE; 3 ALLYL 5 [(3 1 PHENYL 1H PYRAZOL 4 YL)METHYLENE] 2,4 DIONE DERIVATIVE; 3 ALLYL 5 [[3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]THIAZOLIDINE 2,4 DIONE; 3 BENZYL 5 [(1,3 DIPHENYL 1H PYRAZOL 4 YL)METHYLENE] THIAZOLIDINE 2,4 DIONE; 3 BENZYL 5 [(3 1 PHENYL 1H PYRAZOL 4 YL)METHYLENE]THIAZOLIDINE 2,4 DIONE DERIVATIVE; 3 BENZYLTHIAZOLIDINE 2,4 DIONE DERIVATIVE; 5 [(1 ARYL 1H PYRAZOL 4 YL)METHYLENE]THIAZOLIDINE 2,4 DIONE DERIVATIVE; 5 [(1,3 DIPHENYL 1H PYRAZOL 4 YL)METHYLENE] 3 PROPYLTHIAZOLIDINE 2,4 DIONE; 5 [(1,3 DIPHENYL 1H PYRAZOL 4 YL)METHYLENE]THIAZOLIDINE 2,4 DIONE; 5 [[3 (4 CHLOROPHENYL) 1 (4-NITROPHENYL) 1H PYRAZOL 4 YL]METHYLENE]THIAZOLIDINE 2,4 DIONE; 5 [[3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 3 PROPYLTHIAZOLIDINE 2,4 DIONE; 5 [[3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]THIAZOLIDINE 2,4 DIONE; [(3 1 PHENYL 1H PYRAZOL 4 YL)METHYLENE] 3 PROPYLTHIAZOLIDINE 2,4 DIONE DERIVATIVE; ALDEHYDE DERIVATIVE; ANTIINFLAMMATORY AGENT; BENZYL 2,4 THIAZOLIDINEDIONE DERIVATIVE; CELECOXIB; CHEMOKINE; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; FORMALDEHYDE; NEUROPROTECTIVE AGENT; PYRAZOLE; PYRAZOLECARBOXALDEHYDE DERIVATIVE; PYRAZOLYL 2,4 THIAZOLIDINEDIONE DERIVATIVE; TURPENTINE OIL; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOASSAY; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GRANULOMA; HUMAN; HUMAN CELL; HYBRIDIZATION; INFLAMMATION; MONOCYTE; NEUROPROTECTION; PAW EDEMA; PROTEIN SECRETION; SUBSTITUTION REACTION; ULCEROGENESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE, TUMOR; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; EDEMA; GRANULOMA; HL-60 CELLS; HUMANS; NEUROPROTECTIVE AGENTS; RATS; THIAZOLIDINEDIONES;

ANIMALIA;

EID: 77249133540     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.021     Document Type: Article

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