-
1
-
-
0038037735
-
Regulation of angiogenesis by hypoxia: role of the HIF system
-
Pugh C.W., and Ratcliffe P.J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med. 9 (2003) 677-684
-
(2003)
Nat. Med.
, vol.9
, pp. 677-684
-
-
Pugh, C.W.1
Ratcliffe, P.J.2
-
2
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3 (2003) 721-732
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
3
-
-
0036359548
-
Hypoxia - a key regulatory factor in tumour growth
-
Harris A.L. Hypoxia - a key regulatory factor in tumour growth. Nat. Rev. Cancer 2 (2002) 38-47
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
4
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
Pouyssegur J., Dayan F., and Mazure N.M. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441 (2006) 437-443
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouyssegur, J.1
Dayan, F.2
Mazure, N.M.3
-
5
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell P.H., Wiesener M.S., Chang G.W., Clifford S.C., Vaux E.C., Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., and Ratcliffe P.J. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399 (1999) 271-275
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
6
-
-
0023865666
-
Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma
-
Seizinger B.R., Rouleau G.A., Ozelius L.J., Lane A.H., Farmer G.E., Lamiell J.M., Haines J., Yuen J.W., Collins D., Majoor-Krakauer D., et al. Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature 332 (1988) 268-269
-
(1988)
Nature
, vol.332
, pp. 268-269
-
-
Seizinger, B.R.1
Rouleau, G.A.2
Ozelius, L.J.3
Lane, A.H.4
Farmer, G.E.5
Lamiell, J.M.6
Haines, J.7
Yuen, J.W.8
Collins, D.9
Majoor-Krakauer, D.10
-
7
-
-
11244315697
-
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
-
Manalo D.J., Rowan A., Lavoie T., Natarajan L., Kelly B.D., Ye S.Q., Garcia J.G., and Semenza G.L. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105 (2005) 659-669
-
(2005)
Blood
, vol.105
, pp. 659-669
-
-
Manalo, D.J.1
Rowan, A.2
Lavoie, T.3
Natarajan, L.4
Kelly, B.D.5
Ye, S.Q.6
Garcia, J.G.7
Semenza, G.L.8
-
8
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
-
Ivan M., Kondo K., Yang H., Kim W., Valiando J., Ohh M., Salic A., Asara J.M., Lane W.S., and Kaelin Jr. W.G. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292 (2001) 464-468
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
9
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick R.K., and McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294 (2001) 1337-1340
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
10
-
-
0029048985
-
KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2
-
Dong J.T., Lamb P.W., Rinker-Schaeffer C.W., Vukanovic J., Ichikawa T., Isaacs J.T., and Barrett J.C. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 268 (1995) 884-886
-
(1995)
Science
, vol.268
, pp. 884-886
-
-
Dong, J.T.1
Lamb, P.W.2
Rinker-Schaeffer, C.W.3
Vukanovic, J.4
Ichikawa, T.5
Isaacs, J.T.6
Barrett, J.C.7
-
11
-
-
0035394517
-
Overexpression of KAI1 suppresses in vitro invasiveness and in vivo metastasis in breast cancer cells
-
Yang X., Wei L.L., Tang C., Slack R., Mueller S., and Lippman M.E. Overexpression of KAI1 suppresses in vitro invasiveness and in vivo metastasis in breast cancer cells. Cancer Res. 61 (2001) 5284-5288
-
(2001)
Cancer Res.
, vol.61
, pp. 5284-5288
-
-
Yang, X.1
Wei, L.L.2
Tang, C.3
Slack, R.4
Mueller, S.5
Lippman, M.E.6
-
12
-
-
57749169272
-
Tetraspanins: push and pull in suppressing and promoting metastasis
-
Zoller M. Tetraspanins: push and pull in suppressing and promoting metastasis. Nat. Rev. Cancer 9 (2009) 40-55
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 40-55
-
-
Zoller, M.1
-
13
-
-
0034710619
-
Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1
-
Odintsova E., Sugiura T., and Berditchevski F. Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1. Curr. Biol. 10 (2000) 1009-1012
-
(2000)
Curr. Biol.
, vol.10
, pp. 1009-1012
-
-
Odintsova, E.1
Sugiura, T.2
Berditchevski, F.3
-
14
-
-
33746791465
-
Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression
-
Bandyopadhyay S., Zhan R., Chaudhuri A., Watabe M., Pai S.K., Hirota S., Hosobe S., Tsukada T., Miura K., Takano Y., Saito K., Pauza M.E., Hayashi S., Wang Y., Mohinta S., Mashimo T., Iiizumi M., Furuta E., and Watabe K. Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression. Nat. Med. 12 (2006) 933-938
-
(2006)
Nat. Med.
, vol.12
, pp. 933-938
-
-
Bandyopadhyay, S.1
Zhan, R.2
Chaudhuri, A.3
Watabe, M.4
Pai, S.K.5
Hirota, S.6
Hosobe, S.7
Tsukada, T.8
Miura, K.9
Takano, Y.10
Saito, K.11
Pauza, M.E.12
Hayashi, S.13
Wang, Y.14
Mohinta, S.15
Mashimo, T.16
Iiizumi, M.17
Furuta, E.18
Watabe, K.19
-
15
-
-
17244378084
-
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes
-
Kim J.H., Kim B., Cai L., Choi H.J., Ohgi K.A., Tran C., Chen C., Chung C.H., Huber O., Rose D.W., Sawyers C.L., Rosenfeld M.G., and Baek S.H. Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature 434 (2005) 921-926
-
(2005)
Nature
, vol.434
, pp. 921-926
-
-
Kim, J.H.1
Kim, B.2
Cai, L.3
Choi, H.J.4
Ohgi, K.A.5
Tran, C.6
Chen, C.7
Chung, C.H.8
Huber, O.9
Rose, D.W.10
Sawyers, C.L.11
Rosenfeld, M.G.12
Baek, S.H.13
-
16
-
-
13244260735
-
KAI1 promoter activity is dependent on p53, junB and AP2: evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells
-
Marreiros A., Dudgeon K., Dao V., Grimm M.O., Czolij R., Crossley M., and Jackson P. KAI1 promoter activity is dependent on p53, junB and AP2: evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells. Oncogene 24 (2005) 637-649
-
(2005)
Oncogene
, vol.24
, pp. 637-649
-
-
Marreiros, A.1
Dudgeon, K.2
Dao, V.3
Grimm, M.O.4
Czolij, R.5
Crossley, M.6
Jackson, P.7
-
17
-
-
36849051990
-
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation
-
Tsai Y.C., Mendoza A., Mariano J.M., Zhou M., Kostova Z., Chen B., Veenstra T., Hewitt S.M., Helman L.J., Khanna C., and Weissman A.M. The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation. Nat. Med. 13 (2007) 1504-1509
-
(2007)
Nat. Med.
, vol.13
, pp. 1504-1509
-
-
Tsai, Y.C.1
Mendoza, A.2
Mariano, J.M.3
Zhou, M.4
Kostova, Z.5
Chen, B.6
Veenstra, T.7
Hewitt, S.M.8
Helman, L.J.9
Khanna, C.10
Weissman, A.M.11
-
18
-
-
33750037603
-
Beta-catenin overexpression reduces myocardial infarct size through differential effects on cardiomyocytes and cardiac fibroblasts
-
Hahn J.Y., Cho H.J., Bae J.W., Yuk H.S., Kim K.I., Park K.W., Koo B.K., Chae I.H., Shin C.S., Oh B.H., Choi Y.S., Park Y.B., and Kim H.S. Beta-catenin overexpression reduces myocardial infarct size through differential effects on cardiomyocytes and cardiac fibroblasts. J. Biol. Chem. 281 (2006) 30979-30989
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 30979-30989
-
-
Hahn, J.Y.1
Cho, H.J.2
Bae, J.W.3
Yuk, H.S.4
Kim, K.I.5
Park, K.W.6
Koo, B.K.7
Chae, I.H.8
Shin, C.S.9
Oh, B.H.10
Choi, Y.S.11
Park, Y.B.12
Kim, H.S.13
-
19
-
-
39549105786
-
Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction
-
Hahn J.Y., Cho H.J., Kang H.J., Kim T.S., Kim M.H., Chung J.H., Bae J.W., Oh B.H., Park Y.B., and Kim H.S. Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction. J. Am. Coll. Cardiol. 51 (2008) 933-943
-
(2008)
J. Am. Coll. Cardiol.
, vol.51
, pp. 933-943
-
-
Hahn, J.Y.1
Cho, H.J.2
Kang, H.J.3
Kim, T.S.4
Kim, M.H.5
Chung, J.H.6
Bae, J.W.7
Oh, B.H.8
Park, Y.B.9
Kim, H.S.10
-
20
-
-
3142631736
-
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
-
Koshiji M., Kageyama Y., Pete E.A., Horikawa I., Barrett J.C., and Huang L.E. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J. 23 (2004) 1949-1956
-
(2004)
EMBO J.
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
21
-
-
0035884701
-
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
-
Sowter H.M., Ratcliffe P.J., Watson P., Greenberg A.H., and Harris A.L. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 61 (2001) 6669-6673
-
(2001)
Cancer Res.
, vol.61
, pp. 6669-6673
-
-
Sowter, H.M.1
Ratcliffe, P.J.2
Watson, P.3
Greenberg, A.H.4
Harris, A.L.5
-
22
-
-
0036320934
-
Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression
-
Wenger R.H. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J. 16 (2002) 1151-1162
-
(2002)
FASEB J.
, vol.16
, pp. 1151-1162
-
-
Wenger, R.H.1
-
23
-
-
0034255036
-
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
-
Bruick R.K. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc. Natl. Acad. Sci. USA 97 (2000) 9082-9087
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9082-9087
-
-
Bruick, R.K.1
-
24
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P., Dor Y., Herbert J.M., Fukumura D., Brusselmans K., Dewerchin M., Neeman M., Bono F., Abramovitch R., Maxwell P., Koch C.J., Ratcliffe P., Moons L., Jain R.K., Collen D., and Keshert E. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394 (1998) 485-490
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
Koch, C.J.11
Ratcliffe, P.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshert, E.16
-
25
-
-
0038383678
-
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
-
Mack F.A., Rathmell W.K., Arsham A.M., Gnarra J., Keith B., and Simon M.C. Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell 3 (2003) 75-88
-
(2003)
Cancer Cell
, vol.3
, pp. 75-88
-
-
Mack, F.A.1
Rathmell, W.K.2
Arsham, A.M.3
Gnarra, J.4
Keith, B.5
Simon, M.C.6
-
26
-
-
75149165633
-
Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors
-
Henze A.T., Riedel J., Diem T., Wenner J., Flamme I., Pouyseggur J., Plate K.H., and Acker T. Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Cancer Res. 70 (2010) 357-366
-
(2010)
Cancer Res.
, vol.70
, pp. 357-366
-
-
Henze, A.T.1
Riedel, J.2
Diem, T.3
Wenner, J.4
Flamme, I.5
Pouyseggur, J.6
Plate, K.H.7
Acker, T.8
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