Sepsis-induced myocardial depression is associated with transcriptional changes in energy metabolism and contractile related genes: A physiological and gene expression-based approach

Critical Care Medicine

Volumn 38, Issue 3, 2010, Pages 894-902

  Dos Santos, Claudia C ^a,c   Gattas, David J ^b,d   Tsoporis, James N ^f   Smeding, Lonneke ^a   Kabir, Golam ^d   Masoom, Hussain ^a,d   Akram, Ali ^a   Plotz, Frans ^e   Slutsky, Arthur S ^a,c   Husain, Mansoor ^d   Sibbald, William J ^a,b   Parker, Thomas G ^c,f  

^a UNIVERSITY OF TORONTO   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^f ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Energy metabolism and contractile proteins; Gene expression; Myocardial depression; Nitric oxide; Sepsis

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; MYOSIN HEAVY CHAIN ALPHA; MYOSIN HEAVY CHAIN BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENERGY METABOLISM; GENE EXPRESSION; HEART FUNCTION; MICROARRAY ANALYSIS; MOUSE; MYOCARDIAL DEPRESSION; MYOCARDIAL DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; TRANSCRIPTION REGULATION;

EID: 77249111174     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181ce4e50     Document Type: Article

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