Down-regulation of endothelial cell estrogen receptor expression by the inflammation promoter LPS

Molecular and Cellular Endocrinology

Volumn 319, Issue 1-2, 2010, Pages 8-13

  Holm, Anders ^a   Andersson, Kristina E ^a   Nordström, Ina ^a   Hellstrand, Per ^a   Nilsson, Bengt Olof ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

17 Estradiol; Endothelial cells; Estrogen receptor and ; Inflammation; LPS

Indexed keywords

ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ISOPROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; IMMUNOREACTIVITY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STIMULATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; DEXAMETHASONE; DOWN-REGULATION; ENDOTHELIAL CELLS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; INFLAMMATION; LIPOPOLYSACCHARIDES; MICE; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 77249095014     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.01.002     Document Type: Article

References (42)

1. Ades E.W., Candal F.J., Swerlick R.A., George V.G., Summers S., Bosse D.C., and Lawley T.J. HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J. Invest. Dermatol. 99 (1992) 683-690
2. Andersson C., Lydrup M.L., Fernö M., Idvall I., Gustafsson J.A., and Nilsson B.O. Immunocytochemical demonstration of estrogen receptor β in blood vessels of the female rat. J. Endocrinol. 169 (2001) 241-247
3. Appakkudal R.A., Bradley R., and Ganju R.K. LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-κB-dependent pathway. Mol. Immunol. 46 (2009) 962-968
4. Bevers L.M., Braam B., Post J.A., van Zonneveld A.J., Rabelink T.J., Koomans H.A., Verhaar M.C., and Joles J.A. Tetrahydrobiopterin, but not l-arginine, decreases NO synthase uncoupling in cells expressing high levels of endothelial NO synthase. Hypertension 47 (2006) 87-94
5. Caulin-Glaser T., Watson C.A., Pardi R., and Bender J.R. Effects of 17β-estradiol on cytokine-induced endothelial cell adhesion molecule expression. J. Clin. Invest. 98 (1996) 36-42
6. Chen Z., Yuhanna I.S., Galcheva-Gargova Z., Karas R.H., Mendelsohn M.E., and Shaul P.W. Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. J. Clin. Invest. 103 (1999) 401-406
7. Clark A.R. Anti-inflammatory functions of glucocorticoid-induced genes. Mol. Cell. Endocrinol. 275 (2007) 79-97
8. Cornil C.A., Ball G.F., and Balthazart J. Functional significance of the rapid regulation of brain estrogen action: where do the estrogens come from?. Brain Res. 1126 (2006) 2-26
9. Darblade B., Pendaries C., Krust A., Dupont S., Fouque M.J., Rami J., Chambon P., Bayard F., and Arnal J.F. Estradiol alters nitric oxide production in the mouse aorta through the α-, but not β-estrogen receptor. Circ. Res. 90 (2002) 413-419
10. Dauphinee S.M., and Karsan A. Lipopolysaccharide signaling in endothelial cells. Lab. Invest. 86 (2006) 9-22
11. Donaghue C., Westley B.R., and May F.E. Selective promoter usage of the human estrogen receptor α gene and its regulation by estrogen. Mol. Endocrinol. 13 (1999) 1934-1950
12. Figtree G.A., McDonald D., Watkins H., and Channon K.M. Truncated estrogen receptor alpha 46-kDa isoform in human endothelial cells: relationship to acute activation of nitric oxide synthase. Circulation 107 (2003) 120-126
13. Green S., Walter P., Kumar V., Krust A., Bornert J.M., Argos P., and Chambon P. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320 (1986) 134-139
14. Greene G.L., Gilna P., Waterfield M., Baker A., Hort Y., and Shine J. Sequence and expression of human estrogen receptor complementary DNA. Science 231 (1986) 1150-1154
15. Harris H.A., Albert L.M., Leathurby Y., Malamas M.S., Mewshaw R.E., Miller C.P., Kharode Y.P., Mazolf J., Komm B.S., Winneker R.C., Frail D.E., Henderson R.A., Zhu Y., and Keith J.C. Evaluation of an estrogen receptor.beta agonist in animal models of human disease. Endocrinology 144 (2003) 4241-4249
16. Hirano S., Furutama D., and Hanafusa T. Physiologically high concentrations of 17β-estradiol enhance NF-κB activity in human T cells. Am. J. Physiol. 292 (2007) R1465-R1471
17. Hodges Y.K., Tung L., Yan X.D., Graham J.D., Horwitz K.B., and Horwitz L.D. Estrogen receptors α and β: prevalence of estrogen receptor β mRNA in human vascular smooth muscle and transcription. Circulation 101 (2000) 1792-1798
18. Jönsson D., Nebel D., Bratthall G., and Nilsson B.O. LPS-induced MCP-1 and IL-6 production is not reversed by oestrogen in human periodontal ligament cells. Arch. Oral Biol. 53 (2008) 896-902
19. Krishnaswamy G., Smith J.K., Mukkamala R., Hall K., Joyner W., Yerra L., and Chi D.S. Multifunctional cytokine expression by human coronary endothelium and regulation by monokines and glucocorticoids. Microvasc. Res. 55 (1998) 189-200
20. Kuiper G.G.J.M., Enmark E., Pelto-Huikko M., Nilsson S., and Gustafsson J.A. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 5925-5930
21. Li L., Haynes M.P., and Bender J.R. Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 4807-4812
22. Liang M., and Nilsson B.O. Proteasome-dependent degradation of ERα but not ERβ in cultured mouse aorta smooth muscle cells. Mol. Cell. Endocrinol. 224 (2004) 65-71
23. Libby P. Inflammation in atherosclerosis. Nature 420 (2002) 868-874
24. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
25. Mendelsohn M.E., and Karas R.H. The protective effects of estrogen on the cardiovascular system. New Engl. J. Med. 340 (1999) 1801-1811
26. Morikawa A., Koide N., Kato Y., Sugiyama T., Chakravortty D., Yoshida T., and Yokochi T. Augmentation of nitric oxide production by gamma interferon in a mouse vascular endothelial cell line and its modulation by tumor necrosis factor alpha and lipopolysaccharide. Infect. Immun. 68 (2000) 6209-6214
27. Nilsson S., Mäkelä S., Treuter E., Tujague M., Thomsen J., Andersson G., Enmark E., Pettersson K., Warner M., and Gustafsson J.A. Mechanisms of estrogen action. Physiol. Rev. 81 (2001) 1535-1565
28. Nilsson B.O. Modulation of the inflammatory response by estrogens with focus on the endothelium and its interactions with leukocytes. Inflamm. Res. 56 (2007) 269-273
29. Odenlund M., Ekblad E., and Nilsson B.O. Stimulation of oestrogen receptor-expressing endothelial cells with oestrogen reduces proliferation of cocultured vascular smooth muscle cells. Clin. Exp. Pharmacol. Physiol. 35 (2008) 245-248
30. Pare G., Krust A., Karas R.H., Dupont S., Aronovitz M., Chambon P., and Mendelsohn M.E. Estrogen receptor-α mediates the protective effects of estrogen against vascular injury. Circ. Res. 90 (2002) 1087-1092
31. Pendaries C., Darblade B., Rocaix P., Krust A., Chambon P., Korach K.S., Bayard F., and Arnal J.F. The AF-1 activation-function of ERα may be dispensable to mediate the effect of estradiol on endothelial NO production in mice. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 2205-2210
32. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29 (2001) e:45
33. Reid G., Denger S., Kos M., and Gannon F. Human estrogen receptor-α: regulation by synthesis, modification and degradation. Cell Mol. Life Sci. 59 (2002) 821-831
34. Sawa Y., Ueki T., Hata M., Iwasawa K., Tsuruga E., Kojima H., Ishikawa H., and Yoshida S. LPS-induced IL-6, IL-8, VCAM-1 and ICAM-1 expression in human lymphatic endothelium. J. Histochem. Cytochem. 56 (2008) 97-109
35. Seli E., Selam B., Mor G., Kayisli U.A., Pehlivan T., and Arici A. Estradiol regulates monocyte chemotactic protein-1 in human coronary artery smooth muscle cells: a mechanism for its antiatherogenic effect. Menopause 8 (2001) 296-301
36. Sierra A., Gottfried-Blackmore A., Milner T.A., McEwen B.S., and Bulloch K. Steroid hormone receptor expression and function in microglia. Glia 56 (2008) 659-674
37. Simoncini T., Hafezi-Monghadam A., Brazil D.P., Ley K., Chin W.W., and Liao J.K. Interaction of estrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature 497 (2000) 538-541
38. Stirone C., Duckles S.P., and Krause D.N. Multiple forms of estrogen receptor-α in cerebral blood vessels: regulation by estrogen. Am. J. Physiol. Endocrinol. Metab. 284 (2003) 184-192
39. Tschugguel W., Dietrich W., Zhegu Z., Stonek F., Kolbus A., and Huber J.C. Differential regulation of proteasome-dependent estrogen receptor α and β turnover in cultured human uterine artery endothelial cells. J. Clin. Endocrinol. Metab. 88 (2003) 2281-2287
40. Vegeto E., Belcredito S., Etteri S., Ghislettei S., Brusadelli A., Meda C., Krust A., Dupont S., Ciana P., Chambon P., and Maggi A. Estrogen receptor-α mediates the brain antinflammatory activity of estradiol. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 9614-9619
41. Yamaji Y., Kubota T., Sasaguri K., Sato S., Suzuki Y., Kumada H., and Umemoto T. Inflammatory cytokine gene expression in human periodontal ligament fibroblasts stimulated with bacterial lipopolysaccharides. Infect. Immun. 63 (1995) 3576-3581
42. Zeuke S., Ulmer A.J., Kusumoto S., Katus H.A., and Heine H. TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS. Cardiovasc. Res. 56 (2002) 126-134