Upgrading a natural product: Inhibition of human β-tryptase by cyclotheonamide analogues

ChemMedChem

Volumn 5, Issue 3, 2010, Pages 367-370

  Schaschke, Norbert ^a   Sommerhoff, Christian P ^b  

^a BIELEFELD UNIVERSITY   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

amino acids; Mast cells; Peptides; Proteases; Structure activity relationships

Indexed keywords

2,3 DIAMINOPROPANOIC ACID; AMIDE; BETA TRYPTASE; CYCLOTHEONAMIDE E4 DERIVATIVE; NATURAL PRODUCT; PROPIONIC ACID DERIVATIVE; SERINE PROTEINASE; TRYPSIN; TRYPTASE; TRYPTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COVALENT BOND; CRYSTAL STRUCTURE; CYCLIZATION; DEPROTECTION REACTION; DISSOCIATION CONSTANT; DRUG BINDING; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SPECIFICITY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

ANIMALS; ASTHMA; CATTLE; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; PEPTIDES, CYCLIC; SERINE PROTEINASE INHIBITORS; TRYPSIN; TRYPTASES;

EID: 77249090825     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900484     Document Type: Article

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