Intra-Accumbens Infusion of a Muscarinic Antagonist Reduces Food Intake Without Altering the Incentive Properties of Food-Associated Cues

Behavioral Neuroscience

Volumn 124, Issue 1, 2010, Pages 44-54

  Perry, Michelle L ^a,b   Andrzejewski, Matthew E ^c   Bushek, Susan M ^b   Baldo, Brian A ^b  

^a Molecular and Cellular Pharmacology

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

accumbens; acetylcholine; feeding; muscarinic; scopolamine

Indexed keywords

MUSCARINIC RECEPTOR BLOCKING AGENT; SCOPOLAMINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSOCIATION; CHOLINERGIC ACTIVITY; CONDITIONING; CONTROLLED STUDY; FOOD INTAKE; MALE; MOTOR ACTIVITY; NONHUMAN; NUCLEUS ACCUMBENS; RAT; REINFORCEMENT; REWARD;

ANIMALS; CONDITIONING, OPERANT; CUES; EATING; FEEDING BEHAVIOR; FOOD PREFERENCES; MALE; MOTIVATION; MUSCARINIC ANTAGONISTS; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SCOPOLAMINE;

EID: 77249087739     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/a0018283     Document Type: Article

References (50)

1. Aberman J.E., and Salamone J.D. Nucleus accumbens dopamine depletions make rats more sensitive to high ratio requirements but do not impair primary food reinforcement. Neuroscience 92 (1999) 545-552
2. Aberman J.E., Ward S.J., and Salamone J.D. Effects of dopamine antagonists and accumbens dopamine depletions on time-constrained progressive-ratio performance. Pharmacology Biochemistry & Behavior 61 (1998) 341-348
3. Ahn S., and Phillips A.G. Modulation by central and basolateral amygdalar nuclei of dopaminergic correlates of feeding to satiety in the rat nucleus accumbens and medial prefrontal cortex. Journal of Neuroscience 22 (2002) 10958-10965
4. Bakshi V.P., and Kelley A. Dopaminergic regulation of feeding behavior: II. Differential effects of amphetamine microinfusion into three striatal subregions. Psychobiology 3 (1991) 233-242
5. Bakshi V.P., and Kelley A.E. Feeding induced by opioid stimulation of the ventral striatum: Role of opiate receptor subtypes. Journal of Pharmacology and Experimental Therapeutics 265 (1993) 1253-1260
6. Bakshi V.P., and Kelley A.E. Striatal regulation of morphine-induced hyperphagia: An anatomical mapping study. Psychopharmacology (Berlin) 111 (1993) 207-214
7. Baldo B.A., and Kelley A.E. Discrete neurochemical coding of distinguishable motivational processes: Insights from nucleus accumbens control of feeding. Psychopharmacology (Berlin) 191 (2007) 439-459
8. Baldo B.A., Sadeghian K., Basso A.M., and Kelley A.E. Effects of selective dopamine D1 or D2 receptor blockade within nucleus accumbens subregions on ingestive behavior and associated motor activity. Behavioural Brain Research 137 (2002) 165-177
9. Barbano M.F., Le Saux M., and Cador M. Involvement of dopamine and opioids in the motivation to eat: Influence of palatability, homeostatic state, and behavioral paradigms. Psychopharmacology (Berlin) 203 (2009) 475-487
10. Basso A.M., and Kelley A.E. Feeding induced by GABA (A) receptor stimulation within the nucleus accumbens shell: Regional mapping and characterization of macronutrient and taste preference. Behavioral Neuroscience 113 (1999) 324-336
11. Berridge K.C. Food reward: Brain substrates of wanting and liking. Neuroscience and Biobehavioral Reviews 20 (1996) 1-25
12. Berridge K.C. Motivation concepts in behavioral neuroscience. Physiology and Behavior 81 (2004) 179-209
13. Berridge K.C. The debate over dopamine's role in reward: The case for incentive salience. Psychopharmacology (Berlin) 191 (2007) 391-431
14. Berridge K.C., Robinson T.E., and Aldridge J.W. Dissecting components of reward: 'liking', 'wanting', and learning. Current Opinion in Pharmacology 9 (2009) 65-73
15. Berridge K.C., Venier I.L., and Robinson T.E. Taste reactivity analysis of 6-hydroxydopamine-induced aphagia: Implications for arousal and anhedonia hypotheses of dopamine function. Behavioral Neuroscience 103 (1989) 36-45
16. Blackburn J.R., Phillips A.G., and Fibiger H.C. Dopamine and preparatory behavior: I. Effects of pimozide. Behavioral Neuroscience 101 (1987) 352-360
17. Cunningham S.T., and Kelley A.E. Opiate infusion into nucleus accumbens: Contrasting effects on motor activity and responding for conditioned reward. Brain Research 588 (1992) 104-114
18. Hoebel B.G., Avena N.M., and Rada P. Accumbens dopamine-acetylcholine balance in approach and avoidance. Current Opinion in Pharmacology 7 (2007) 617-627
19. Joyce E.M., and Koob G.F. Amphetamine-, scopolamine- and caffeine-induced locomotor activity following 6-hydroxydopamine lesions of the mesolimbic dopamine system. Psychopharmacology (Berlin) 73 (1981) 311-313
20. Kelley A.E., Bakshi V.P., Haber S.N., Steininger T.L., Will M.J., and Zhang M. Opioid modulation of taste hedonics within the ventral striatum. Physiology and Behavior 76 (2002) 365-377
21. Kelley A.E., Baldo B.A., and Pratt W.E. A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food reward. Journal of Comparative Neurology 493 (2005) 72-85
22. Kelley A.E., Baldo B.A., Pratt W.E., and Will M.J. Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward. Physiology and Behavior 86 (2005) 773-795
23. Kelley A.E., Bless E.P., and Swanson C.J. Investigation of the effects of opiate antagonists infused into the nucleus accumbens on feeding and sucrose drinking in rats. Journal of Pharmacology and Experimental Therapeutics 278 (1996) 1499-1507
24. Kelley A.E., and Delfs J.M. Dopamine and conditioned reinforcement. I. Differential effects of amphetamine microinjections into striatal subregions. Psychopharmacology (Berlin) 103 (1991) 187-196
25. Kelley A.E., Gauthier A.M., and Lang C.G. Amphetamine microinjections into distinct striatal subregions cause dissociable effects on motor and ingestive behavior. Behavioural Brain Research 35 (1989) 27-39
26. Kelley A.E., and Stinus L. Disappearance of hoarding behavior after 6-hydroxydopamine lesions of the mesolimbic dopamine neurons and its reinstatement with L-dopa. Behavioral Neuroscience 99 (1985) 531-545
27. Mark G.P., Rada P., Pothos E., and Hoebel B.G. Effects of feeding and drinking on acetylcholine release in the nucleus accumbens, striatum, and hippocampus of freely behaving rats. Journal of Neurochemistry 58 (1992) 2269-2274
28. Mogenson G.J., Jones D.L., and Yim C.Y. From motivation to action: Functional interface between the limbic system and the motor system. Progress in Neurobiology 14 (1980) 69-97
29. Pecina S., and Berridge K.C. Central enhancement of taste pleasure by intraventricular morphine. Neurobiology (Bp) 3 (1995) 269-280
30. Pecina S., and Berridge K.C. Opioid site in nucleus accumbens shell mediates eating and hedonic "liking" for food: Map based on microinjection Fos plumes. Brain Research 863 (2000) 71-86
31. Pecina S., and Berridge K.C. Hedonic hot spot in nucleus accumbens shell: Where do mu-opioids cause increased hedonic impact of sweetness?. Journal of Neuroscience 25 (2005) 11777-11786
32. Perry M.L., Baldo B.A., Andrzejewski M.E., and Kelley A.E. Muscarinic receptor antagonism causes a functional alteration in nucleus accumbens mu-opiate-mediated feeding behavior. Behavioural Brain Research 197 (2009) 225-229
33. Pratt W.E., and Kelley A.E. Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors. Behavioral Neuroscience 118 (2004) 730-739
34. Pratt W.E., and Kelley A.E. Striatal muscarinic receptor antagonism reduces 24-h food intake in association with decreased preproenkephalin gene expression. European Journal of Neuroscience 22 (2005) 3229-3240
35. Pratt W., Spencer R., and Kelley A. Muscarinic receptor antagonism of the nucleus accumbens core causes avoidance to flavor and spatial cues. Behavioral Neuroscience 121 (2007) 1215-1223
36. Ragnauth A., Moroz M., and Bodnar R.J. Multiple opioid receptors mediate feeding elicited by mu and delta opioid receptor subtype agonists in the nucleus accumbens shell in rats. Brain Research 876 (2000) 76-87
37. Salamone J.D. The involvement of nucleus accumbens dopamine in appetitive and aversive motivation. Behavioural Brain Research 61 (1994) 117-133
38. Salamone J.D., Arizzi M.N., Sandoval M.D., Cervone K.M., and Aberman J.E. Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: Contrast between the effects of SKF 83566, raclopride, and fenfluramine on a concurrent choice task. Psychopharmacology (Berlin) 160 (2002) 371-380
39. Salamone J.D., Correa M., Farrar A., and Mingote S.M. Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology (Berlin) 191 (2007) 461-482
40. Salamone J.D., Cousins M.S., and Bucher S. Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure. Behavioural Brain Research 65 (1994) 221-229
41. Salamone J.D., Mahan K., and Rogers S. Ventrolateral striatal dopamine depletions impair feeding and food handling in rats. Pharmacology Biochemistry & Behavior 44 (1993) 605-610
42. Shannon H.E., and Peters S.C. A comparison of the effects of cholinergic and dopaminergic agents on scopolamine-induced hyperactivity in mice. Journal of Pharmacology and Experimental Therapeutics 255 (1990) 549-553
43. Will M.J., Franzblau E.B., and Kelley A.E. Nucleus accumbens mu-opioids regulate intake of a high-fat diet via activation of a distributed brain network. Journal of Neuroscience 23 (2003) 2882-2888
44. Will M.J., Pratt W.E., and Kelley A.E. Pharmacological characterization of high-fat feeding induced by opioid stimulation of the ventral striatum. Physiology & Behavior 89 (2006) 226-234
45. Wilson C., Nomikos G.G., Collu M., and Fibiger H.C. Dopaminergic correlates of motivated behavior: Importance of drive. Journal of Neuroscience 15 7, Pt. 2 (1995) 5169-5178
46. Wise R.A. Dopamine, learning and motivation. Nature Reviews Neuroscience 5 (2004) 483-494
47. Zhang M., Balmadrid C., and Kelley A.E. Nucleus accumbens opioid, GABaergic, and dopaminergic modulation of palatable food motivation: Contrasting effects revealed by a progressive ratio study in the rat. Behavioral Neuroscience 117 (2003) 202-211
48. Zhang M., Gosnell B.A., and Kelley A.E. Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens. Journal of Pharmacology and Experimental Therapeutics 285 (1998) 908-914
49. Zhang M., and Kelley A.E. Enhanced intake of high-fat food following striatal mu-opioid stimulation: Microinjection mapping and fos expression. Neuroscience 99 (2000) 267-277
50. Zhou F.M., Wilson C.J., and Dani J.A. Cholinergic interneuron characteristics and nicotinic properties in the striatum. Journal of Neurobiology 53 (2002) 590-605