Effects of selective dopamine D1 or D2 receptor blockade within nucleus accumbens subregions on ingestive behavior and associated motor activity

Behavioural Brain Research

Volumn 137, Issue 1-2, 2002, Pages 165-177

  Baldo, Brian A ^a   Sadeghian, Ken ^a   Basso, Ana Maria ^b   Kelley, Ann E ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

Dopamine D1 receptor; Dopamine D2 receptor; Feeding; Motor activity; Nucleus accumbens core; Nucleus accumbens shell; Raclopride; SCH 23390

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE 1 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR BLOCKING AGENT; RACLOPRIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; DRUG EFFECT; FEEDING; FOOD INTAKE; HUNGER; INFUSION; MALE; MOBILIZATION; MOTOR ACTIVITY; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; REARING; RECEPTOR BLOCKING;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; ANIMALS; APPETITIVE BEHAVIOR; BRAIN MAPPING; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; MALE; MOTOR ACTIVITY; NUCLEUS ACCUMBENS; RACLOPRIDE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2;

EID: 0037010772     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(02)00293-0     Document Type: Article

References (42)

1. Aberman J.E., Salamone J.D. Nucleus accumbens dopamine depletions make rats more sensitive to high ratio requirements but do not impair primary food reinforcement. Neuroscience. 92:1999;545-552.
2. Bakshi V.P., Kelley A.E. Dopaminergic regulation of feeding behavior. I. Differential effects of haloperidol infusion into three striatal subregions. Psychobiology. 19:1991;223-232.
3. Bassareo V., Di Chiara G. Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell-core compartments. Neuroscience. 89:1999;637-641.
4. Basso A.M., Kelley A.E. Feeding induced by GABA-A receptor stimulation within the nucleus accumbens shell: regional mapping and characterization of macronutrient and taste preference. Behav. Neurosci. 113:1999;324-336.
5. Berridge K.C., Robinson T.E. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain. Res. Rev. 28:1998;309-369.
6. Blackburn JR, Phillips AG, Fibiger. Dopamine and preparatory behavior. I. Effects of pimozide. Behav. Neurosci. 1987;101:352-60.
7. Blackburn J.R., Phillips A.G., Jakubovic A., Fibiger H.C. Dopamine and preparatory behavior. II. A neurochemical analysis. Behav. Neurosci. 103:1989;15-23.
8. De Olmos JS, Heimer L. The concepts of the ventral striatopallidal system and extended amygdala, In: McGinty J, editor. Advancing from the Ventral Striatum to the Extended Amygdala: Implications for Neuropsychiatry and Drug Abuse. Annals of the New York Academy of Sciences, Vol. 877, pp. 1-32.
9. Ettenberg A., Camp C.H. Haloperidol induces a partial reinforcement extinction effect in rats: implications for a dopamine involvement in food reward. Pharmacol. Biochem. Behav. 25:1986;813-821.
10. Gelissen M., Cools A.R. Effect of intracaudate haloperidol and apomorphine on switching motor patterns upon current behavior of cats. Behav. Brain. Res. 29:1988;17-26.
11. Heffner T.G., Zigmond M.J., Stricker E.M. Effects of dopaminergic agonists and antagonists on feeding in intact and 6-hydroxydopamine-treated rats. J. Pharmacol. Exp. Ther. 201:1977;386-399.
12. Heffner T.G., Hartman J.A., Seiden L.S. Feeding increases dopamine metabolism in the rat brain. Science. 208:1980;1168-1170.
13. Heimer L., Zahm D.S., Churchill L., Kalivas P.W., Wohltmann C. Specificity in the projection patterns of Acb core and shell in rat. Neuroscience. 41:1991;89-125.
14. Hernandez L., Hoebel B.G. Feeding and hypothalamic stimulation increase dopamine turnover in the nucleus accumbens. Physiol. Behav. 44:1988;599-606.
15. Kelley A.E., Swanson C.J. Feeding induced by blockade of AMPA and kainate receptors within the ventral striatum: a microinfusion mapping study. Behav. Brain. Res. 89:1997;107-113.
16. Kelley A.E., Smith-Roe S., Holahan M.R. Response-reinforcement learning is dependent on NMDA receptor activation in the nucleus accumbens core. Proc. Natl. Acad. Sci. USA. 94:1997;12174-12179.
17. Kiyatkin E.A., Gratton A. Electrochemical monitoring of extracellular dopamine in nucleus accumbens of rats lever-pressing for food. Brain Res. 652:1994;225-234.
18. Koob G.F., Riley S.J., Smith S.C., Robbins T.W. Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomtor activity, and amphetamine anorexia in the rat. J. Comp. Physiol. Psychol. 92:1978;917-927.
19. Maldonado-Irizarry C.S., Swanson C.J., Kelley A.E. Glutamate receptors in the nucleus accumbens shell control feeding behavior via the lateral hypothalamus. J. Neurosci. 15:1995;6779-6788.
20. Marshall J.F., Richardson J.S., Teitelbaum P. Nigrostriatal damage and the lateral hypothalamic syndrome. J. Comp. Physiol. Psychol. 90:1974;536-546.
21. McCullough L.D., Salamone J.D. Involvement of nucleus accumbens dopamine in the motor activity induced by periodic food presentation: a microdialysis and behavioral study. Brain Res. 592:1992;29-36.
22. Mogenson G.J., Wu M. Neuropharmacological and electrophysiological evidence implicating the mesolimbic dopamine system in feeding responses elicited by electrical stimulation of the medial forebrain bundle. Brain Res. 253:1982;243-251.
23. Parkinson J.A., Olmstead M.C., Burns L.H., Robbins T.W., Everitt B.J. Dissociations in the effects of lesions of the nucleus accumbens vore and shell on appetitive Pavlovian approach behavior and the potentiation of conditioned reinforcement and locomotor activity by D-amphetamine. J. Neurosci. 19:1999;2401-2411.
24. Pennartz C.M.A., Dolleman-Van der Weel M.J., Kitai S.T., Lopes da Silva F.H. Presynaptic dopamine D1 receptors attenuate excitatory and inhibitory limbic inputs to the shell region of the rat nucleus accumbens studied in vitro. J. Neurophysiol. 67:1992;1325-1334.
25. Phillips A.G., Atkinson L.J., Blackburn J.R., Blaha C.D. Increased extracellular dopamine in the nucleus accumbens of the rat elicited by a conditional stimulus for food: an electrochemical study. Can. J. Physiol. Pharmacol. 71:1993;387-393.
26. Radhakishun F.S., Van Ree J.M., Westerink B.H.C. Scheduled eating increases dopamine release in the nucleus accumbens of food-deprived rats as assessed with in-line brain microdialysis. Neurosci. Lett. 85:1988;351-356.
27. Salamone J.D., Zigmond M.J., Stricker E.M. Characterization of the impaired feeding behavior in rats given haloperidol or dopamine-depleting brain lesions. Neuroscience. 39:1990;17-24.
28. Salamone J.D., Cousins B.J., Bucher S. Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure. Behav. Brain Res. 65:1994;221-229.
29. Salamone J.D., Cousins M.S., Snyder B.J. Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis. Neurosci. Biobehav. Rev. 21:1997;341-359.
30. Stratford T.R., Kelley A.E. GABA in the nucleus accumbens shell participates in the central regulation of feeding behavior. J. Neurosci. 17:1997;4434-4440.
31. Stratford T.R., Kelley A.E. Evidence of a functional relationship between the nucleus accumbens shell and lateral hypothalamus subserving the control of feeding behavior. J. Neurosci. 19:1999;11040-11048.
32. Swanson C.J., Heath S., Stratford T.R., Kelley A.E. Differential behavioral responses to dopaminergic stimulation of nucleus accumbens subregions in the rat. Pharmacol. Biochem. Behav. 58:1997;933-945.
33. Ungerstedt U. Aphagia and adipsia after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine system. Acta Physiol. Scand. Suppl. 367:1971;95-122.
34. Usuda I., Tanaka K., Chiba T. Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: biotinylated dextran amine study. Brain Res. 797:1998;73-93.
35. Van den Bos R., Charria Ortiz G.A., Bergmans A.C., Cools A.R. Evidence that dopamine in the nucleus accumbens is involved in the ability of rats to switch to cue-directed behaviors. Behav. Brain Res. 42:1991;107-114.
36. Wilson C., Nomikos G.G., Collu M., Fibiger H.C. Dopaminergic correlates of motivated behavior: importance of drive. J. Neurosci. 15:1995;5169-5178.
37. Wise R.A. Neuroleptics and operant behavior: the anhedonia hypothesis. Behav. Brain Sci. 5:1982;39-87.
38. Wise R.A., Spindler J., DeWit H., Gerber G.J. Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food. Science. 201:1978;262-264.
39. Zahm DS. Functional-anatomical implications of the nucleus accumbens core and shell subterritories, In: McGinty J, editor. Advancing from the Ventral Striatum to the Extended Amygdala: Implications for Neuropsychiatry and Drug Abuse. Annals of the New York Academy of Sciences, Vol. 877, pp. 113-28.
40. Zahm D.S., Heimer L. The efferent projections of the rostral pole of the nucleus accumbens in the rat: comparison with the core and shell projection patterns. J. Comp. Neurol. 327:1993;220-232.
41. Zahm D.S., Jensen S.J., Williams E.S., Martin J.R. III. Direct comparison of projections from the central amygdaloid region and the nucleus accumbens shell. Eur. J. Neurosci. 11:1999;1119-1126.
42. Zhou Q.Y., Palmiter R.D. Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell. 83:1995;1197-1209.