Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3′,4′:1,2]pyridin[3,4-b]indole-2-substituted acetates: One-pot-preparation, anti-tumor activity, docking toward DNA and 3D QSAR analysis

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 5, 2010, Pages 1910-1917

  Liu, Jiawang ^a   Zhao, Ming ^a   Qian, Keduo ^b   Zhang, Xiaoyi ^a   Lee, Kuo Hsiung ^b   Wu, Jianhui ^a   Liu, Yi Nan ^b   Peng, Shiqi ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Carboline 3 carboxylic acid; 3D QSAR; Anti tumor activity; Docking; Log P; Neurotoxicity; Organ damage

Indexed keywords

BETA CARBOLINE DERIVATIVE; DOXORUBICIN; SODIUM CHLORIDE; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOMA CELL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DNA INTERACTION; DRUG EFFICACY; DRUG POTENCY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IC 50; LUNG CARCINOMA; MALE; MOLECULAR DOCKING; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; ONE POT SYNTHESIS; ORGAN WEIGHT; PHYSICAL CHEMISTRY; PROSTATE CANCER; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SARCOMA; SUBSTITUTION REACTION; TUMOR VOLUME; WEIGHT REDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; MICE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPECTROMETRY, FLUORESCENCE;

MUS;

EID: 77249084573     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.038     Document Type: Article

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